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Q14641

- INSL4_HUMAN

UniProt

Q14641 - INSL4_HUMAN

Protein

Early placenta insulin-like peptide

Gene

INSL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May play an important role in trophoblast development and in the regulation of bone formation.

    GO - Molecular functioni

    1. insulin-like growth factor receptor binding Source: ProtInc
    2. receptor binding Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell proliferation Source: ProtInc
    3. female pregnancy Source: ProtInc
    4. multicellular organismal development Source: ProtInc
    5. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Early placenta insulin-like peptide
    Short name:
    EPIL
    Alternative name(s):
    Insulin-like peptide 4
    Placentin
    Cleaved into the following 2 chains:
    Gene namesi
    Name:INSL4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:6087. INSL4.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29894.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 25251 PublicationAdd
    BLAST
    Chaini26 – 139114Early placenta insulin-like peptidePRO_0000016155Add
    BLAST
    Peptidei26 – 5833Early placenta insulin-like peptide B chainPRO_0000016156Add
    BLAST
    Propeptidei59 – 11456C peptidePRO_0000016157Add
    BLAST
    Peptidei115 – 13925Early placenta insulin-like peptide A chainPRO_0000016158Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 125Interchain (between B and A chains)By similarity
    Disulfide bondi43 ↔ 138Interchain (between B and A chains)By similarity
    Disulfide bondi124 ↔ 129By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    MaxQBiQ14641.
    PaxDbiQ14641.
    PRIDEiQ14641.

    PTM databases

    PhosphoSiteiQ14641.

    Expressioni

    Tissue specificityi

    Expressed in placenta, uterus and in fetal perichondrium. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells.2 Publications

    Developmental stagei

    Highly expressed in the early placenta. Expression of epil peptides in the villous cytotrophoblast is different from that displayed by the syncytiotrophoblast. In fetal tissues it was identified in the perichondrium of all four limbs, vertebrae, and ribs. It was abundant in interbone ligaments.

    Gene expression databases

    BgeeiQ14641.
    CleanExiHS_INSL4.
    GenevestigatoriQ14641.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000239316.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14641.
    SMRiQ14641. Positions 109-139.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG78056.
    HOGENOMiHOG000236342.
    HOVERGENiHBG052134.
    InParanoidiQ14641.
    KOiK05255.
    OMAiMTSEFIP.
    OrthoDBiEOG7TMZTP.
    PhylomeDBiQ14641.
    TreeFamiTF333404.

    Family and domain databases

    InterProiIPR023258. Placentin.
    IPR022421. Relaxin.
    [Graphical view]
    PRINTSiPR02033. PLACENTIN.
    PR02004. RELAXIN.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q14641-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASLFRSYLP AIWLLLSQLL RESLAAELRG CGPRFGKHLL SYCPMPEKTF    50
    TTTPGGWLLE SGRPKEMVST SNNKDGQALG TTSEFIPNLS PELKKPLSEG 100
    QPSLKKIILS RKKRSGRHRF DPFCCEVICD DGTSVKLCT 139
    Length:139
    Mass (Da):15,445
    Last modified:November 1, 1996 - v1
    Checksum:i47FB61F6F86C1342
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34838 mRNA. Translation: AAB08516.1.
    AK291543 mRNA. Translation: BAF84232.1.
    AL133547 Genomic DNA. Translation: CAH70506.1.
    CH471071 Genomic DNA. Translation: EAW58772.1.
    BC026254 mRNA. Translation: AAH26254.1.
    CCDSiCCDS6459.1.
    RefSeqiNP_002186.1. NM_002195.1.
    UniGeneiHs.418506.

    Genome annotation databases

    EnsembliENST00000239316; ENSP00000239316; ENSG00000120211.
    GeneIDi3641.
    KEGGihsa:3641.
    UCSCiuc003ziy.3. human.

    Polymorphism databases

    DMDMi2497411.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34838 mRNA. Translation: AAB08516.1 .
    AK291543 mRNA. Translation: BAF84232.1 .
    AL133547 Genomic DNA. Translation: CAH70506.1 .
    CH471071 Genomic DNA. Translation: EAW58772.1 .
    BC026254 mRNA. Translation: AAH26254.1 .
    CCDSi CCDS6459.1.
    RefSeqi NP_002186.1. NM_002195.1.
    UniGenei Hs.418506.

    3D structure databases

    ProteinModelPortali Q14641.
    SMRi Q14641. Positions 109-139.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000239316.

    PTM databases

    PhosphoSitei Q14641.

    Polymorphism databases

    DMDMi 2497411.

    Proteomic databases

    MaxQBi Q14641.
    PaxDbi Q14641.
    PRIDEi Q14641.

    Protocols and materials databases

    DNASUi 3641.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000239316 ; ENSP00000239316 ; ENSG00000120211 .
    GeneIDi 3641.
    KEGGi hsa:3641.
    UCSCi uc003ziy.3. human.

    Organism-specific databases

    CTDi 3641.
    GeneCardsi GC09P005231.
    HGNCi HGNC:6087. INSL4.
    MIMi 600910. gene.
    neXtProti NX_Q14641.
    PharmGKBi PA29894.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78056.
    HOGENOMi HOG000236342.
    HOVERGENi HBG052134.
    InParanoidi Q14641.
    KOi K05255.
    OMAi MTSEFIP.
    OrthoDBi EOG7TMZTP.
    PhylomeDBi Q14641.
    TreeFami TF333404.

    Miscellaneous databases

    GeneWikii INSL4.
    GenomeRNAii 3641.
    NextBioi 14251.
    PROi Q14641.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q14641.
    CleanExi HS_INSL4.
    Genevestigatori Q14641.

    Family and domain databases

    InterProi IPR023258. Placentin.
    IPR022421. Relaxin.
    [Graphical view ]
    PRINTSi PR02033. PLACENTIN.
    PR02004. RELAXIN.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta."
      Chassin D., Laurent A., Janneau J.-L., Berger R., Bellet D.
      Genomics 29:465-470(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-40.
    7. "Identification of pro-EPIL and EPIL peptides translated from insulin-like 4 (INSL4) mRNA in human placenta."
      Bellet D., Lavaissiere L., Mock P., Laurent A., Sabourin J.-C., Bedossa P., Le Bouteiller P., Frydman R., Troalen F., Bidart J.-M.
      J. Clin. Endocrinol. Metab. 82:3169-3172(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING.
    8. "Insulin-like 4 (INSL4) gene expression in human embryonic and trophoblastic tissues."
      Laurent A., Rouillac C., Delezoide A.-L., Giovangrandi Y., Vekemans M., Bellet D., Abitbol M., Vidaud M.
      Mol. Reprod. Dev. 51:123-129(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells."
      Janneau J.-L., Maldonado-Estrada J., Tachdjian G., Miran I., Motte N., Saulnier P., Sabourin J.-C., Cote J.-F., Simon B., Frydman R., Chaouat G., Bellet D.
      J. Clin. Endocrinol. Metab. 87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, POSSIBLE INVOLVEMENT IN INVASION/MIGRATION OF TROPHOBLAST CELLS.

    Entry informationi

    Entry nameiINSL4_HUMAN
    AccessioniPrimary (citable) accession number: Q14641
    Secondary accession number(s): A8K678, Q5W127
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3