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Q14641

- INSL4_HUMAN

UniProt

Q14641 - INSL4_HUMAN

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Protein

Early placenta insulin-like peptide

Gene

INSL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play an important role in trophoblast development and in the regulation of bone formation.

GO - Molecular functioni

  1. insulin-like growth factor receptor binding Source: ProtInc
  2. receptor binding Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. cell proliferation Source: ProtInc
  3. female pregnancy Source: ProtInc
  4. multicellular organismal development Source: ProtInc
  5. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Early placenta insulin-like peptide
Short name:
EPIL
Alternative name(s):
Insulin-like peptide 4
Placentin
Cleaved into the following 2 chains:
Gene namesi
Name:INSL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:6087. INSL4.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29894.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 139114Early placenta insulin-like peptidePRO_0000016155Add
BLAST
Peptidei26 – 5833Early placenta insulin-like peptide B chainPRO_0000016156Add
BLAST
Propeptidei59 – 11456C peptidePRO_0000016157Add
BLAST
Peptidei115 – 13925Early placenta insulin-like peptide A chainPRO_0000016158Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 125Interchain (between B and A chains)By similarity
Disulfide bondi43 ↔ 138Interchain (between B and A chains)By similarity
Disulfide bondi124 ↔ 129By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

MaxQBiQ14641.
PaxDbiQ14641.
PRIDEiQ14641.

PTM databases

PhosphoSiteiQ14641.

Expressioni

Tissue specificityi

Expressed in placenta, uterus and in fetal perichondrium. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells.2 Publications

Developmental stagei

Highly expressed in the early placenta. Expression of epil peptides in the villous cytotrophoblast is different from that displayed by the syncytiotrophoblast. In fetal tissues it was identified in the perichondrium of all four limbs, vertebrae, and ribs. It was abundant in interbone ligaments.

Gene expression databases

BgeeiQ14641.
CleanExiHS_INSL4.
GenevestigatoriQ14641.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000239316.

Structurei

3D structure databases

ProteinModelPortaliQ14641.
SMRiQ14641. Positions 109-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG78056.
GeneTreeiENSGT00510000050531.
HOGENOMiHOG000236342.
HOVERGENiHBG052134.
InParanoidiQ14641.
KOiK05255.
OMAiMTSEFIP.
OrthoDBiEOG7TMZTP.
PhylomeDBiQ14641.
TreeFamiTF333404.

Family and domain databases

InterProiIPR023258. Placentin.
IPR022421. Relaxin.
[Graphical view]
PRINTSiPR02033. PLACENTIN.
PR02004. RELAXIN.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14641-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASLFRSYLP AIWLLLSQLL RESLAAELRG CGPRFGKHLL SYCPMPEKTF
60 70 80 90 100
TTTPGGWLLE SGRPKEMVST SNNKDGQALG TTSEFIPNLS PELKKPLSEG
110 120 130
QPSLKKIILS RKKRSGRHRF DPFCCEVICD DGTSVKLCT
Length:139
Mass (Da):15,445
Last modified:November 1, 1996 - v1
Checksum:i47FB61F6F86C1342
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34838 mRNA. Translation: AAB08516.1.
AK291543 mRNA. Translation: BAF84232.1.
AL133547 Genomic DNA. Translation: CAH70506.1.
CH471071 Genomic DNA. Translation: EAW58772.1.
BC026254 mRNA. Translation: AAH26254.1.
CCDSiCCDS6459.1.
RefSeqiNP_002186.1. NM_002195.1.
UniGeneiHs.418506.

Genome annotation databases

EnsembliENST00000239316; ENSP00000239316; ENSG00000120211.
GeneIDi3641.
KEGGihsa:3641.
UCSCiuc003ziy.3. human.

Polymorphism databases

DMDMi2497411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34838 mRNA. Translation: AAB08516.1 .
AK291543 mRNA. Translation: BAF84232.1 .
AL133547 Genomic DNA. Translation: CAH70506.1 .
CH471071 Genomic DNA. Translation: EAW58772.1 .
BC026254 mRNA. Translation: AAH26254.1 .
CCDSi CCDS6459.1.
RefSeqi NP_002186.1. NM_002195.1.
UniGenei Hs.418506.

3D structure databases

ProteinModelPortali Q14641.
SMRi Q14641. Positions 109-139.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000239316.

PTM databases

PhosphoSitei Q14641.

Polymorphism databases

DMDMi 2497411.

Proteomic databases

MaxQBi Q14641.
PaxDbi Q14641.
PRIDEi Q14641.

Protocols and materials databases

DNASUi 3641.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000239316 ; ENSP00000239316 ; ENSG00000120211 .
GeneIDi 3641.
KEGGi hsa:3641.
UCSCi uc003ziy.3. human.

Organism-specific databases

CTDi 3641.
GeneCardsi GC09P005231.
HGNCi HGNC:6087. INSL4.
MIMi 600910. gene.
neXtProti NX_Q14641.
PharmGKBi PA29894.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG78056.
GeneTreei ENSGT00510000050531.
HOGENOMi HOG000236342.
HOVERGENi HBG052134.
InParanoidi Q14641.
KOi K05255.
OMAi MTSEFIP.
OrthoDBi EOG7TMZTP.
PhylomeDBi Q14641.
TreeFami TF333404.

Miscellaneous databases

GeneWikii INSL4.
GenomeRNAii 3641.
NextBioi 14251.
PROi Q14641.
SOURCEi Search...

Gene expression databases

Bgeei Q14641.
CleanExi HS_INSL4.
Genevestigatori Q14641.

Family and domain databases

InterProi IPR023258. Placentin.
IPR022421. Relaxin.
[Graphical view ]
PRINTSi PR02033. PLACENTIN.
PR02004. RELAXIN.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta."
    Chassin D., Laurent A., Janneau J.-L., Berger R., Bellet D.
    Genomics 29:465-470(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-40.
  7. "Identification of pro-EPIL and EPIL peptides translated from insulin-like 4 (INSL4) mRNA in human placenta."
    Bellet D., Lavaissiere L., Mock P., Laurent A., Sabourin J.-C., Bedossa P., Le Bouteiller P., Frydman R., Troalen F., Bidart J.-M.
    J. Clin. Endocrinol. Metab. 82:3169-3172(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING.
  8. "Insulin-like 4 (INSL4) gene expression in human embryonic and trophoblastic tissues."
    Laurent A., Rouillac C., Delezoide A.-L., Giovangrandi Y., Vekemans M., Bellet D., Abitbol M., Vidaud M.
    Mol. Reprod. Dev. 51:123-129(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells."
    Janneau J.-L., Maldonado-Estrada J., Tachdjian G., Miran I., Motte N., Saulnier P., Sabourin J.-C., Cote J.-F., Simon B., Frydman R., Chaouat G., Bellet D.
    J. Clin. Endocrinol. Metab. 87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, POSSIBLE INVOLVEMENT IN INVASION/MIGRATION OF TROPHOBLAST CELLS.

Entry informationi

Entry nameiINSL4_HUMAN
AccessioniPrimary (citable) accession number: Q14641
Secondary accession number(s): A8K678, Q5W127
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3