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Protein

Interleukin-13 receptor subunit alpha-2

Gene

IL13RA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).1 Publication

GO - Molecular functioni

  • cytokine receptor activity Source: UniProtKB
  • signal transducer activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123496-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
SignaLinkiQ14627.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13 receptor subunit alpha-2
Short name:
IL-13 receptor subunit alpha-2
Short name:
IL-13R subunit alpha-2
Short name:
IL-13R-alpha-2
Short name:
IL-13RA2
Alternative name(s):
Interleukin-13-binding protein
CD_antigen: CD213a2
Gene namesi
Name:IL13RA2
Synonyms:IL13R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:5975. IL13RA2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 343ExtracellularSequence analysisAdd BLAST317
Transmembranei344 – 363HelicalSequence analysisAdd BLAST20
Topological domaini364 – 380CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: ProtInc
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3598.
OpenTargetsiENSG00000123496.
PharmGKBiPA29788.

Polymorphism and mutation databases

BioMutaiIL13RA2.
DMDMi2494720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001094227 – 380Interleukin-13 receptor subunit alpha-2Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 1131 Publication
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi145 ↔ 1551 Publication
Disulfide bondi184 ↔ 1971 Publication
Glycosylationi215N-linked (GlcNAc...)1 Publication1
Disulfide bondi269 ↔ 3161 Publication
Glycosylationi290N-linked (GlcNAc...)Sequence analysis1
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ14627.
PaxDbiQ14627.
PeptideAtlasiQ14627.
PRIDEiQ14627.

Expressioni

Gene expression databases

BgeeiENSG00000123496.
CleanExiHS_IL13RA2.
GenevisibleiQ14627. HS.

Organism-specific databases

HPAiHPA055552.

Interactioni

Protein-protein interaction databases

BioGridi109812. 106 interactors.
DIPiDIP-3340N.
IntActiQ14627. 13 interactors.

Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 41Combined sources6
Beta strandi44 – 54Combined sources11
Beta strandi68 – 75Combined sources8
Beta strandi82 – 94Combined sources13
Beta strandi101 – 108Combined sources8
Helixi111 – 114Combined sources4
Beta strandi115 – 117Combined sources3
Beta strandi124 – 128Combined sources5
Beta strandi141 – 148Combined sources8
Turni149 – 151Combined sources3
Beta strandi152 – 158Combined sources7
Beta strandi168 – 174Combined sources7
Beta strandi185 – 189Combined sources5
Beta strandi194 – 198Combined sources5
Beta strandi206 – 208Combined sources3
Beta strandi210 – 217Combined sources8
Beta strandi226 – 230Combined sources5
Helixi232 – 234Combined sources3
Beta strandi235 – 237Combined sources3
Beta strandi242 – 246Combined sources5
Beta strandi256 – 259Combined sources4
Beta strandi262 – 264Combined sources3
Beta strandi270 – 274Combined sources5
Beta strandi287 – 291Combined sources5
Beta strandi308 – 312Combined sources5
Turni314 – 316Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LB6X-ray3.05C/D1-380[»]
ProteinModelPortaliQ14627.
SMRiQ14627.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14627.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 134Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST101
Domaini139 – 235Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini240 – 333Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi322 – 326WSXWS motif5

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUDW. Eukaryota.
ENOG4111JMU. LUCA.
GeneTreeiENSGT00530000063295.
HOGENOMiHOG000004823.
HOVERGENiHBG058972.
InParanoidiQ14627.
KOiK05077.
OMAiLFYWYEG.
OrthoDBiEOG091G0FOF.
PhylomeDBiQ14627.
TreeFamiTF331549.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 3 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFVCLAIGC LYTFLISTTF GCTSSSDTEI KVNPPQDFEI VDPGYLGYLY
60 70 80 90 100
LQWQPPLSLD HFKECTVEYE LKYRNIGSET WKTIITKNLH YKDGFDLNKG
110 120 130 140 150
IEAKIHTLLP WQCTNGSEVQ SSWAETTYWI SPQGIPETKV QDMDCVYYNW
160 170 180 190 200
QYLLCSWKPG IGVLLDTNYN LFYWYEGLDH ALQCVDYIKA DGQNIGCRFP
210 220 230 240 250
YLEASDYKDF YICVNGSSEN KPIRSSYFTF QLQNIVKPLP PVYLTFTRES
260 270 280 290 300
SCEIKLKWSI PLGPIPARCF DYEIEIREDD TTLVTATVEN ETYTLKTTNE
310 320 330 340 350
TRQLCFVVRS KVNIYCSDDG IWSEWSDKQC WEGEDLSKKT LLRFWLPFGF
360 370 380
ILILVIFVTG LLLRKPNTYP KMIPEFFCDT
Length:380
Mass (Da):44,176
Last modified:November 1, 1996 - v1
Checksum:i3C6ACB1B5562C887
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8I → V in BAF84646 (PubMed:14702039).Curated1
Sequence conflicti151Q → R in BAF84646 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021256111W → R.1 PublicationCorresponds to variant rs17095919dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95302 mRNA. Translation: CAA64617.1.
U70981 mRNA. Translation: AAB17170.1.
Y08768 mRNA. Translation: CAA70021.1.
AK291957 mRNA. Translation: BAF84646.1.
AY656702 Genomic DNA. Translation: AAT49099.1.
AL121878 Genomic DNA. Translation: CAD18962.1.
BC020739 mRNA. Translation: AAH20739.1.
BC033705 mRNA. Translation: AAH33705.1.
CCDSiCCDS14565.1.
RefSeqiNP_000631.1. NM_000640.2.
UniGeneiHs.336046.

Genome annotation databases

EnsembliENST00000243213; ENSP00000243213; ENSG00000123496.
ENST00000371936; ENSP00000361004; ENSG00000123496.
GeneIDi3598.
KEGGihsa:3598.
UCSCiuc004epx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95302 mRNA. Translation: CAA64617.1.
U70981 mRNA. Translation: AAB17170.1.
Y08768 mRNA. Translation: CAA70021.1.
AK291957 mRNA. Translation: BAF84646.1.
AY656702 Genomic DNA. Translation: AAT49099.1.
AL121878 Genomic DNA. Translation: CAD18962.1.
BC020739 mRNA. Translation: AAH20739.1.
BC033705 mRNA. Translation: AAH33705.1.
CCDSiCCDS14565.1.
RefSeqiNP_000631.1. NM_000640.2.
UniGeneiHs.336046.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LB6X-ray3.05C/D1-380[»]
ProteinModelPortaliQ14627.
SMRiQ14627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109812. 106 interactors.
DIPiDIP-3340N.
IntActiQ14627. 13 interactors.

Polymorphism and mutation databases

BioMutaiIL13RA2.
DMDMi2494720.

Proteomic databases

MaxQBiQ14627.
PaxDbiQ14627.
PeptideAtlasiQ14627.
PRIDEiQ14627.

Protocols and materials databases

DNASUi3598.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243213; ENSP00000243213; ENSG00000123496.
ENST00000371936; ENSP00000361004; ENSG00000123496.
GeneIDi3598.
KEGGihsa:3598.
UCSCiuc004epx.4. human.

Organism-specific databases

CTDi3598.
DisGeNETi3598.
GeneCardsiIL13RA2.
HGNCiHGNC:5975. IL13RA2.
HPAiHPA055552.
MIMi300130. gene.
neXtProtiNX_Q14627.
OpenTargetsiENSG00000123496.
PharmGKBiPA29788.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUDW. Eukaryota.
ENOG4111JMU. LUCA.
GeneTreeiENSGT00530000063295.
HOGENOMiHOG000004823.
HOVERGENiHBG058972.
InParanoidiQ14627.
KOiK05077.
OMAiLFYWYEG.
OrthoDBiEOG091G0FOF.
PhylomeDBiQ14627.
TreeFamiTF331549.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123496-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
SignaLinkiQ14627.

Miscellaneous databases

EvolutionaryTraceiQ14627.
GeneWikiiIL13RA2.
GenomeRNAii3598.
PROiQ14627.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123496.
CleanExiHS_IL13RA2.
GenevisibleiQ14627. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 3 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI13R2_HUMAN
AccessioniPrimary (citable) accession number: Q14627
Secondary accession number(s): A8K7E2, O00667
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 163 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.