Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q14626 (I11RA_HUMAN)

Last modified November 25, 2008. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Interleukin-11 receptor alpha chain
      Short name=IL-11R-alpha
      Short name=IL-11RA
Gene names
Name: IL11RA
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.

Subunit structure

On ligand binding, forms a multimer complex with IL6ST/gp130.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. Also expressed in normal and malignant prostate epithelial cell lines.

Involvement in disease

Increased levels of IL11R are found in prostate carcinoma.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 3 subfamily.

Contains 2 fibronectin type-III domains.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Ontologies

Keywords

   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
   Molecular functionReceptor
   PTMGlycoprotein

Gene Ontology (GO)

   Cellular componentintegral to plasma membrane Ref.1

Traceable author statement. Source: ProtInc

   Molecular functionhematopoietin/interferon-class (D200-domain) cytokine receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform HCR1 (identifier: Q14626-1)

Also known as: Membrane form;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform HCR2 (identifier: Q14626-2)

Also known as: Soluble form; sIL11RA;

The sequence of this isoform differs from the canonical sequence as follows:
     391-422: Missing.
Notes: Lacks the entire cytoplasmic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 422399Interleukin-11 receptor alpha chain
PRO_0000010913

Regions

Topological domain24 – 370347Extracellular Potential
Transmembrane371 – 39121 Potential
Topological domain392 – 42231Cytoplasmic Potential
Domain27 – 11084Ig-like C2-type
Domain112 – 214103Fibronectin type-III 1
Domain218 – 31194Fibronectin type-III 2
Motif304 – 3085WSXWS motif

Amino acid modifications

Glycosylation1271N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential
Disulfide bond48 ↔ 94 By similarity
Disulfide bond120 ↔ 130 By similarity
Disulfide bond170 ↔ 180 By similarity

Natural variations

Alternative sequence391 – 42232Missing in isoform HCR2.
VSP_011879
Natural variant651P → T: dbSNP rs11575589.
VAR_019821
Natural variant3951R → W: dbSNP rs11575580.
VAR_019822

Sequences

Sequence LengthMass (Da)Tools
Isoform HCR1 (Membrane form) [UniParc].

Last modified November 23, 2004. Version 2.
Checksum: 1F8BC05C139FC326

FASTA42245,222
        10         20         30         40         50         60 
MSSSCSGLSR VLVAVATALV SASSPCPQAW GPPGVQYGQP GRSVKLCCPG VTAGDPVSWF 

        70         80         90        100        110        120 
RDGEPKLLQG PDSGLGHELV LAQADSTDEG TYICQTLDGA LGGTVTLQLG YPPARPVVSC 

       130        140        150        160        170        180 
QAADYENFSC TWSPSQISGL PTRYLTSYRK KTVLGADSQR RSPSTGPWPC PQDPLGAARC 

       190        200        210        220        230        240 
VVHGAEFWSQ YRINVTEVNP LGASTRLLDV SLQSILRPDP PQGLRVESVP GYPRRLRASW 

       250        260        270        280        290        300 
TYPASWPCQP HFLLKFRLQY RPAQHPAWST VEPAGLEEVI TDAVAGLPHA VRVSARDFLD 

       310        320        330        340        350        360 
AGTWSTWSPE AWGTPSTGTI PKEIPAWGQL HTQPEVEPQV DSPAPPRPSL QPHPRLLDHR 

       370        380        390        400        410        420 
DSVEQVAVLA SLGILSFLGL VAGALALGLW LRLRRGGKDG SPKPGFLASV IPVDRRPGAP 


NL 

« Hide

Isoform HCR2 (Soluble form) (sIL11RA) [UniParc].

Checksum: 847F8C6F5F52248D
Show »

39041,842

References

« Hide 'large scale' references
[1]"Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11."
Cherel M., Sorel M., Lebeau B., Dubois S., Moreau J.-F., Bataille R., Minvielle S., Jacques Y.
Blood 86:2534-2540(1995) [PubMed: 7670098] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS HCR1 AND HCR2).
Tissue: Muscle.
[2]"Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13."
Van Leuven F., Stas L., Hilliker C., Miyake Y., Bilinski P., Gossler A.
Genomics 31:65-70(1996) [PubMed: 8808281] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM HCR1).
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM HCR1).
[4]SeattleSNPs program for genomic applications
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-65 AND TRP-395.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM HCR1).
Tissue: Brain.
[6]"Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma."
Campbell C.L., Jiang Z., Savarese D.M., Savarese T.M.
Am. J. Pathol. 158:25-32(2001) [PubMed: 11141475] [Abstract]
Cited for: INDUCTION IN PROSTATE CARCINOMA.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

Z38102 mRNA. Translation: CAA86224.1.
Z46595 mRNA. Translation: CAA86570.1.
U32323 Genomic DNA. Translation: AAB36491.1.
U32324 mRNA. Translation: AAB36492.1.
BT009864 mRNA. Translation: AAP88866.1.
AY532110 Genomic DNA. Translation: AAS00093.1.
BC003110 mRNA. Translation: AAH03110.1.
PIRI37891.
RefSeqNP_004503.1.
NP_671518.1.
UniGeneHs.591088

3D structure databases

HSSPHSSP built from PDB template 1N26 based on UniProtKB P08887.
ModBaseSearch...

Genome annotation databases

EnsemblENSG00000137070. Homo sapiens. [Contig view]
GeneID3590.
KEGGhsa:3590.

Organism-specific databases

H-InvDBHIX0008001.
HGNCHGNC:5967. IL11RA.
MIM600939. gene.
PharmGKBPA29782.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ14626.
HOVERGENQ14626.

Gene expression databases

ArrayExpressQ14626.
CleanExHS_IL11RA.
GermOnlineENSG00000137070. Homo sapiens.

Family and domain databases

InterProIPR008957. Fibronectin_typ-III-like_fold.
IPR003961. FN_III.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR013151. Ig.
IPR007110. Ig-like.
IPR003599. Ig_sub.
[Graphical view]
Gene3DG3DSA:2.60.40.30. FN_III-like. 2 hits.
PfamPF00041. fn3. 1 hit.
PF00047. ig. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
SM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00038. Oprelvekin.
NextBio14027.
SOURCESearch...

Entry information

Entry nameI11RA_HUMAN
AccessionPrimary (citable) accession number: Q14626
Secondary accession number(s): Q16542, Q7KYJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 25, 2008
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents