Reviewed, UniProtKB/Swiss-Prot Q14626 (I11RA_HUMAN)

Names and origin

Protein names

Recommended name:
    Interleukin-11 receptor alpha chain
      Short name=IL-11R-alpha
      Short name=IL-11RA

Gene names

Name:

IL11RA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells.
Subunit structure	On ligand binding, forms a multimer complex with IL6ST/gp130.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. Also expressed in normal and malignant prostate epithelial cell lines.
Involvement in disease	Increased levels of IL11R are found in prostate carcinoma.
Sequence similarities	Belongs to the type I cytokine receptor family. Type 3 subfamily. Contains 2 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	hematopoietin/interferon-class (D200-domain) cytokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform HCR1 (identifier: Q14626-1)

Also known as: Membrane form;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform HCR2 (identifier: Q14626-2)

Also known as: Soluble form; sIL11RA;

The sequence of this isoform differs from the canonical sequence as follows:
     391-422: Missing.

Notes: Lacks the entire cytoplasmic domain.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	By similarity
	Chain	24 – 422	399	Interleukin-11 receptor alpha chain		PRO_0000010913
Regions
	Topological domain	24 – 370	347	Extracellular Potential
	Transmembrane	371 – 391	21	Potential
	Topological domain	392 – 422	31	Cytoplasmic Potential
	Domain	27 – 110	84	Ig-like C2-type
	Domain	112 – 214	103	Fibronectin type-III 1
	Domain	218 – 311	94	Fibronectin type-III 2
	Motif	304 – 308	5	WSXWS motif
Amino acid modifications
	Glycosylation	127	1	N-linked (GlcNAc...) Potential
	Glycosylation	194	1	N-linked (GlcNAc...) Potential
	Disulfide bond	48 ↔ 94		By similarity
	Disulfide bond	120 ↔ 130		By similarity
	Disulfide bond	170 ↔ 180		By similarity
Natural variations
	Alternative sequence	391 – 422	32	Missing in isoform HCR2.		VSP_011879
	Natural variant	65	1	P → T: dbSNP rs11575589.		VAR_019821
	Natural variant	395	1	R → W: dbSNP rs11575580.		VAR_019822

Sequences

	Sequence		Length	Mass (Da)
	Isoform HCR1 (Membrane form) [UniParc]. Last modified November 23, 2004. Version 2. Checksum: 1F8BC05C139FC326	FASTA	422	45,222
	10 20 30 40 50 60 MSSSCSGLSR VLVAVATALV SASSPCPQAW GPPGVQYGQP GRSVKLCCPG VTAGDPVSWF 70 80 90 100 110 120 RDGEPKLLQG PDSGLGHELV LAQADSTDEG TYICQTLDGA LGGTVTLQLG YPPARPVVSC 130 140 150 160 170 180 QAADYENFSC TWSPSQISGL PTRYLTSYRK KTVLGADSQR RSPSTGPWPC PQDPLGAARC 190 200 210 220 230 240 VVHGAEFWSQ YRINVTEVNP LGASTRLLDV SLQSILRPDP PQGLRVESVP GYPRRLRASW 250 260 270 280 290 300 TYPASWPCQP HFLLKFRLQY RPAQHPAWST VEPAGLEEVI TDAVAGLPHA VRVSARDFLD 310 320 330 340 350 360 AGTWSTWSPE AWGTPSTGTI PKEIPAWGQL HTQPEVEPQV DSPAPPRPSL QPHPRLLDHR 370 380 390 400 410 420 DSVEQVAVLA SLGILSFLGL VAGALALGLW LRLRRGGKDG SPKPGFLASV IPVDRRPGAP NL
	Isoform HCR2 (Soluble form) (sIL11RA) [UniParc]. Checksum: 847F8C6F5F52248D		390	41,842
	10 20 30 40 50 60 MSSSCSGLSR VLVAVATALV SASSPCPQAW GPPGVQYGQP GRSVKLCCPG VTAGDPVSWF 70 80 90 100 110 120 RDGEPKLLQG PDSGLGHELV LAQADSTDEG TYICQTLDGA LGGTVTLQLG YPPARPVVSC 130 140 150 160 170 180 QAADYENFSC TWSPSQISGL PTRYLTSYRK KTVLGADSQR RSPSTGPWPC PQDPLGAARC 190 200 210 220 230 240 VVHGAEFWSQ YRINVTEVNP LGASTRLLDV SLQSILRPDP PQGLRVESVP GYPRRLRASW 250 260 270 280 290 300 TYPASWPCQP HFLLKFRLQY RPAQHPAWST VEPAGLEEVI TDAVAGLPHA VRVSARDFLD 310 320 330 340 350 360 AGTWSTWSPE AWGTPSTGTI PKEIPAWGQL HTQPEVEPQV DSPAPPRPSL QPHPRLLDHR 370 380 390 DSVEQVAVLA SLGILSFLGL VAGALALGLW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11." Cherel M., Sorel M., Lebeau B., Dubois S., Moreau J.-F., Bataille R., Minvielle S., Jacques Y. Blood 86:2534-2540(1995) [PubMed: 7670098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS HCR1 AND HCR2). Tissue: Muscle.
[2]	"Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13." Van Leuven F., Stas L., Hilliker C., Miyake Y., Bilinski P., Gossler A. Genomics 31:65-70(1996) [PubMed: 8808281] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM HCR1).
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM HCR1).
[4]	SeattleSNPs program for genomic applications Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-65 AND TRP-395.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM HCR1). Tissue: Brain.
[6]	"Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma." Campbell C.L., Jiang Z., Savarese D.M., Savarese T.M. Am. J. Pathol. 158:25-32(2001) [PubMed: 11141475] [Abstract] Cited for: INDUCTION IN PROSTATE CARCINOMA.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z38102 mRNA. Translation: CAA86224.1. Z46595 mRNA. Translation: CAA86570.1. U32323 Genomic DNA. Translation: AAB36491.1. U32324 mRNA. Translation: AAB36492.1. BT009864 mRNA. Translation: AAP88866.1. AY532110 Genomic DNA. Translation: AAS00093.1. BC003110 mRNA. Translation: AAH03110.1.
PIR	I37891.
RefSeq	NP_004503.1. NP_671518.1.
UniGene	Hs.591088
3D structure databases
HSSP	HSSP built from PDB template 1N26 based on UniProtKB P08887.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000137070. Homo sapiens. [Contig view]
GeneID	3590.
KEGG	hsa:3590.
Organism-specific databases
H-InvDB	HIX0008001.
HGNC	HGNC:5967. IL11RA.
MIM	600939. gene.
PharmGKB	PA29782.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q14626.
HOVERGEN	Q14626.
Gene expression databases
ArrayExpress	Q14626.
CleanEx	HS_IL11RA.
GermOnline	ENSG00000137070. Homo sapiens.
Family and domain databases
InterPro	IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003530. Hematopoietin_rcpt_L_F3_CS. IPR013151. Ig. IPR007110. Ig-like. IPR003599. Ig_sub. [Graphical view]
Gene3D	G3DSA:2.60.40.30. FN_III-like. 2 hits.
Pfam	PF00041. fn3. 1 hit. PF00047. ig. 1 hit. [Graphical view]
SMART	SM00060. FN3. 2 hits. SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50853. FN3. 2 hits. PS01354. HEMATOPO_REC_L_F3. 1 hit. PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00038. Oprelvekin.
NextBio	14027.
SOURCE	Search...

Entry information

Entry name

I11RA_HUMAN

Accession

Primary (citable) accession number: Q14626
Secondary accession number(s): Q16542, Q7KYJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	November 23, 2004
Last modified:	November 25, 2008
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)