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Q14624 (ITIH4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inter-alpha-trypsin inhibitor heavy chain H4

Short name=ITI heavy chain H4
Short name=ITI-HC4
Short name=Inter-alpha-inhibitor heavy chain 4
Alternative name(s):
Inter-alpha-trypsin inhibitor family heavy chain-related protein
Short name=IHRP
Plasma kallikrein sensitive glycoprotein 120
Short name=Gp120
Short name=PK-120
Gene names
Name:ITIH4
Synonyms:IHRP, ITIHL1, PK120
ORF Names:PRO1851
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length930 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. Ref.14

Subunit structure

Interacts (via C-terminus) with DNAJC1 (via SANT 2 domain); this interaction protects ITIH4 against cleavage by kallikrein in vitro. Ref.5

Subcellular location

Secreted.

Tissue specificity

Liver specific. Ref.1 Ref.2

Induction

Levels increase from 1.4 to 3-fold in acute-phase processes such as in acute ischemia stroke (AIS), unstable angina and programmed surgery. In hepatocytes, induced by IL6 but not by other cytokines such as IL1B. Ref.10 Ref.14

Post-translational modification

Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment.

N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)2, but also some Hex3(HexNAc)3. N-glycosylated but not O-glycosylated in plasma. Ref.8 Ref.11 Ref.18

Miscellaneous

Possible biomarker for acute ischemic stroke (Ref.14). Peptides derived from the proline-rich potentially active peptide (PRO_0000016542) may be biomarkers for a variety of disease states including breast cancer (Ref.16).

Sequence similarities

Belongs to the ITIH family.

Contains 1 VIT domain.

Contains 1 VWFA domain.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q14624-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q14624-2)

The sequence of this isoform differs from the canonical sequence as follows:
     621-650: Missing.
     727-727: A → ACPSCSRSRAPAVPA
Note: No experimental confirmation available.
Isoform 3 (identifier: Q14624-3)

The sequence of this isoform differs from the canonical sequence as follows:
     621-650: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q14624-4)

The sequence of this isoform differs from the canonical sequence as follows:
     621-650: Missing.
     727-765: Missing.
     851-866: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Ref.8
Chain29 – 66163370 kDa inter-alpha-trypsin inhibitor heavy chain H4
PRO_0000016541
Propeptide662 – 68827Potentially active peptide
PRO_0000016542
Chain689 – 93024235 kDa inter-alpha-trypsin inhibitor heavy chain H4
PRO_0000016543

Regions

Domain29 – 148120VIT
Domain272 – 432161VWFA
Region658 – 68831Proline-rich (PRR) potential bioactive peptide
Region719 – 7257O-glycosylated at three sites

Sites

Site688 – 6892Cleavage; by kallikrein

Amino acid modifications

Glycosylation811N-linked (GlcNAc...) Ref.13 Ref.15
Glycosylation2071N-linked (GlcNAc...) Ref.11 Ref.13 Ref.15
Glycosylation5171N-linked (GlcNAc...) Ref.12 Ref.13 Ref.15
Glycosylation5771N-linked (GlcNAc...) Ref.13
Glycosylation7201O-linked (GalNAc...) Ref.18
Disulfide bond747 ↔ 925 Probable

Natural variations

Alternative sequence621 – 65030Missing in isoform 2, isoform 3 and isoform 4.
VSP_002761
Alternative sequence727 – 76539Missing in isoform 4.
VSP_044764
Alternative sequence7271A → ACPSCSRSRAPAVPA in isoform 2.
VSP_002762
Alternative sequence851 – 86616Missing in isoform 4.
VSP_044765
Natural variant851I → N. Ref.2
Corresponds to variant rs13072536 [ dbSNP | Ensembl ].
VAR_027869
Natural variant861I → N. Ref.19
VAR_013836
Natural variant6691Q → L.
Corresponds to variant rs2276814 [ dbSNP | Ensembl ].
VAR_027870
Natural variant6981P → T.
Corresponds to variant rs4687657 [ dbSNP | Ensembl ].
VAR_027871
Natural variant7141M → I.
Corresponds to variant rs2256734 [ dbSNP | Ensembl ].
VAR_027872
Natural variant7911L → P.
Corresponds to variant rs2535621 [ dbSNP | Ensembl ].
VAR_027873

Experimental info

Sequence conflict851I → K in AAD05198. Ref.3
Sequence conflict1141S → N in BAA07602. Ref.2
Sequence conflict2071N → F AA sequence Ref.8
Sequence conflict2211Q → E AA sequence Ref.8
Sequence conflict3071R → V AA sequence Ref.8
Sequence conflict3221W → Y AA sequence Ref.8
Sequence conflict3701E → G in BAH12781. Ref.6
Sequence conflict816 – 8172ET → QR AA sequence Ref.8
Sequence conflict9051S → F no nucleotide entry Ref.3
Sequence conflict9271S → T no nucleotide entry Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 5, 2009. Version 4.
Checksum: 847A9A5CB886C5A4

FASTA930103,357
        10         20         30         40         50         60 
MKPPRPVRTC SKVLVLLSLL AIHQTTTAEK NGIDIYSLTV DSRVSSRFAH TVVTSRVVNR 

        70         80         90        100        110        120 
ANTVQEATFQ MELPKKAFIT NFSMIIDGMT YPGIIKEKAE AQAQYSAAVA KGKSAGLVKA 

       130        140        150        160        170        180 
TGRNMEQFQV SVSVAPNAKI TFELVYEELL KRRLGVYELL LKVRPQQLVK HLQMDIHIFE 

       190        200        210        220        230        240 
PQGISFLETE STFMTNQLVD ALTTWQNKTK AHIRFKPTLS QQQKSPEQQE TVLDGNLIIR 

       250        260        270        280        290        300 
YDVDRAISGG SIQIENGYFV HYFAPEGLTT MPKNVVFVID KSGSMSGRKI QQTREALIKI 

       310        320        330        340        350        360 
LDDLSPRDQF NLIVFSTEAT QWRPSLVPAS AENVNKARSF AAGIQALGGT NINDAMLMAV 

       370        380        390        400        410        420 
QLLDSSNQEE RLPEGSVSLI ILLTDGDPTV GETNPRSIQN NVREAVSGRY SLFCLGFGFD 

       430        440        450        460        470        480 
VSYAFLEKLA LDNGGLARRI HEDSDSALQL QDFYQEVANP LLTAVTFEYP SNAVEEVTQN 

       490        500        510        520        530        540 
NFRLLFKGSE MVVAGKLQDR GPDVLTATVS GKLPTQNITF QTESSVAEQE AEFQSPKYIF 

       550        560        570        580        590        600 
HNFMERLWAY LTIQQLLEQT VSASDADQQA LRNQALNLSL AYSFVTPLTS MVVTKPDDQE 

       610        620        630        640        650        660 
QSQVAEKPME GESRNRNVHS GSTFFKYYLQ GAKIPKPEAS FSPRRGWNRQ AGAAGSRMNF 

       670        680        690        700        710        720 
RPGVLSSRQL GLPGPPDVPD HAAYHPFRRL AILPASAPPA TSNPDPAVSR VMNMKIEETT 

       730        740        750        760        770        780 
MTTQTPAPIQ APSAILPLPG QSVERLCVDP RHRQGPVNLL SDPEQGVEVT GQYEREKAGF 

       790        800        810        820        830        840 
SWIEVTFKNP LVWVHASPEH VVVTRNRRSS AYKWKETLFS VMPGLKMTMD KTGLLLLSDP 

       850        860        870        880        890        900 
DKVTIGLLFW DGRGEGLRLL LRDTDRFSSH VGGTLGQFYQ EVLWGSPAAS DDGRRTLRVQ 

       910        920        930 
GNDHSATRER RLDYQEGPPG VEISCWSVEL 

« Hide

Isoform 2 [UniParc].

Checksum: 79F2D903E65026CD
Show »

FASTA914101,241
Isoform 3 [UniParc].

Checksum: B18BE8E1C3BF634C
Show »

FASTA90099,857
Isoform 4 [UniParc].

Checksum: 60436CD8050B7D46
Show »

FASTA84593,852

References

« Hide 'large scale' references
[1]"cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein."
Nishimura H., Kakizaki I., Muta T., Sasaki N., Pu P.X., Yamashita T., Nagasawa S.
FEBS Lett. 357:207-211(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, TISSUE SPECIFICITY.
Tissue: Liver.
[2]"Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein."
Saguchi K., Tobe T., Hashimoto K., Sano Y., Nakano Y., Miura N.-H., Tomita M.
J. Biochem. 117:14-18(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, IDENTIFICATION, TISSUE SPECIFICITY, VARIANT ASN-85.
Tissue: Liver.
[3]"Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1)."
Saguchi K., Tobe T., Hashimoto K., Nagasaki Y., Oda E., Nakano Y., Miura N.H., Tomita M.
J. Biochem. 119:898-905(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Liver.
[5]"BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4."
Kroczynska B., King-Simmons L., Alloza L., Alava M.A., Elguindi E.C., Blond S.Y.
Biochem. Biophys. Res. Commun. 338:1467-1477(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), INTERACTION WITH DNAJC1.
[6]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"Functional prediction of the coding sequences of 79 new genes deduced by analysis of cDNA clones from human fetal liver."
Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 271-930 (ISOFORM 2).
Tissue: Fetal liver.
[8]"Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma."
Choi-Miura N.-H., Sano Y., Oda E., Nakano Y., Tobe T., Yanagishita T., Taniyama M., Katagiri T., Tomita M.
J. Biochem. 117:400-407(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 29-44; 99-119; 140-151; 163-170; 194-208; 211-243; 274-281; 290-329; 429-487; 497-567; 608-626 AND 816-831, PROTEOLYTIC PROCESSING, GLYCOSYLATION.
Tissue: Plasma.
[9]"Purification and characterization of a novel substrate for plasma kallikrein (PK-120) in human plasma."
Pu X.P., Iwamoto A., Nishimura H., Nagasawa S.
Biochim. Biophys. Acta 1208:338-343(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, PROTEOLYTIC PROCESSING.
[10]"ITIH4 serum concentration increases during acute-phase processes in human patients and is up-regulated by interleukin-6 in hepatocarcinoma HepG2 cells."
Pineiro M., Alava M.A., Gonzalez-Ramon N., Osada J., Lasierra P., Larrad L., Pineiro A., Lampreave F.
Biochem. Biophys. Res. Commun. 263:224-229(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, INDUCTION.
[11]"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H., Li X.-J., Martin D.B., Aebersold R.
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-207.
[12]"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-517.
Tissue: Plasma.
[13]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-81; ASN-207; ASN-517 AND ASN-577.
Tissue: Plasma.
[14]"Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke."
Kashyap R.S., Nayak A.R., Deshpande P.S., Kabra D., Purohit H.J., Taori G.M., Daginawala H.F.
Clin. Chim. Acta 402:160-163(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[15]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-81; ASN-207 AND ASN-517.
Tissue: Liver.
[16]"The absolute quantification of eight inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4)-derived peptides in serum from breast cancer patients."
van den Broek I., Sparidans R.W., van Winden A.W., Gast M.C., van Dulken E.J., Schellens J.H., Beijnen J.H.
Proteomics Clin. Appl. 4:931-939(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE ROLE OF ACTIVE PEPTIDE AS A BIOMARKER FOR BREAST CANCER.
[17]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT THR-720, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
[19]"SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method."
Tozaki T., Choi-Miura N.-H., Taniyama M., Kurosawa M., Tomita M.
BMC Med. Genet. 3:6-6(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ASN-86.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D38535 mRNA. Translation: BAA07536.1.
D38595 mRNA. Translation: BAA07602.1.
U43163 expand/collapse EMBL AC list , U42015, U42016, U43155, U43156, U43157, U43158, U43159, U43160, U43161, U43162 Genomic DNA. Translation: AAD05198.1.
AK298412 mRNA. Translation: BAH12781.1.
AC006254 Genomic DNA. No translation available.
AC099667 Genomic DNA. No translation available.
AF119856 mRNA. Translation: AAF69610.1.
PIRJX0368.
RefSeqNP_001159921.1. NM_001166449.1.
NP_002209.2. NM_002218.4.
UniGeneHs.709406.

3D structure databases

ProteinModelPortalQ14624.
SMRQ14624. Positions 270-439.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109906. 3 interactions.
IntActQ14624. 2 interactions.
STRING9606.ENSP00000266041.

PTM databases

PhosphoSiteQ14624.

Polymorphism databases

DMDM229463048.

Proteomic databases

PaxDbQ14624.
PRIDEQ14624.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266041; ENSP00000266041; ENSG00000055955. [Q14624-1]
ENST00000346281; ENSP00000340520; ENSG00000055955. [Q14624-2]
ENST00000406595; ENSP00000384425; ENSG00000055955. [Q14624-3]
GeneID3700.
KEGGhsa:3700.
UCSCuc003dfz.3. human. [Q14624-1]
uc011bel.2. human. [Q14624-2]

Organism-specific databases

CTD3700.
GeneCardsGC03M052846.
HGNCHGNC:6169. ITIH4.
HPACAB016676.
HPA001835.
HPA003948.
MIM600564. gene.
neXtProtNX_Q14624.
PharmGKBPA29967.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2304.
HOGENOMHOG000239381.
HOVERGENHBG057734.
InParanoidQ14624.
OrthoDBEOG7CRTP5.
PhylomeDBQ14624.
TreeFamTF328982.

Gene expression databases

ArrayExpressQ14624.
BgeeQ14624.
CleanExHS_ITIH4.
GenevestigatorQ14624.

Family and domain databases

Gene3D3.40.50.410. 1 hit.
InterProIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF53300. SSF53300. 1 hit.
PROSITEPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSITIH4. human.
GeneWikiITIH4.
GenomeRNAi3700.
NextBio14503.
PROQ14624.
SOURCESearch...

Entry information

Entry nameITIH4_HUMAN
AccessionPrimary (citable) accession number: Q14624
Secondary accession number(s): B7Z545 expand/collapse secondary AC list , E9PGN5, Q15135, Q9P190, Q9UQ54
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 132 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM