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Q14624

- ITIH4_HUMAN

UniProt

Q14624 - ITIH4_HUMAN

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Protein

Inter-alpha-trypsin inhibitor heavy chain H4

Gene

ITIH4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei688 – 6892Cleavage; by kallikrein

GO - Molecular functioni

  1. endopeptidase inhibitor activity Source: ProtInc
  2. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  1. acute-phase response Source: UniProtKB
  2. hyaluronan metabolic process Source: InterPro
  3. negative regulation of endopeptidase activity Source: GOC
  4. response to cytokine Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Acute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H4
Short name:
ITI heavy chain H4
Short name:
ITI-HC4
Short name:
Inter-alpha-inhibitor heavy chain 4
Alternative name(s):
Inter-alpha-trypsin inhibitor family heavy chain-related protein
Short name:
IHRP
Plasma kallikrein sensitive glycoprotein 120
Short name:
Gp120
Short name:
PK-120
Cleaved into the following 2 chains:
Gene namesi
Name:ITIH4
Synonyms:IHRP, ITIHL1, PK120
ORF Names:PRO1851
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:6169. ITIH4.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: UniProt
  2. cytoplasm Source: Ensembl
  3. extracellular region Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProtKB
  5. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29967.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 PublicationAdd
BLAST
Chaini29 – 66163370 kDa inter-alpha-trypsin inhibitor heavy chain H4PRO_0000016541Add
BLAST
Propeptidei662 – 68827Potentially active peptidePRO_0000016542Add
BLAST
Chaini689 – 93024235 kDa inter-alpha-trypsin inhibitor heavy chain H4PRO_0000016543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)2 Publications
Glycosylationi207 – 2071N-linked (GlcNAc...)3 Publications
Glycosylationi517 – 5171N-linked (GlcNAc...)3 Publications
Glycosylationi577 – 5771N-linked (GlcNAc...)1 Publication
Glycosylationi720 – 7201O-linked (GalNAc...)1 Publication
Disulfide bondi747 ↔ 925Curated

Post-translational modificationi

Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment.
N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)2, but also some Hex3(HexNAc)3. N-glycosylated but not O-glycosylated in plasma.6 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ14624.
PaxDbiQ14624.
PRIDEiQ14624.

PTM databases

PhosphoSiteiQ14624.

Expressioni

Tissue specificityi

Liver specific.2 Publications

Inductioni

Levels increase from 1.4 to 3-fold in acute-phase processes such as in acute ischemia stroke (AIS), unstable angina and programmed surgery. In hepatocytes, induced by IL6 but not by other cytokines such as IL1B.2 Publications

Gene expression databases

BgeeiQ14624.
CleanExiHS_ITIH4.
ExpressionAtlasiQ14624. baseline and differential.
GenevestigatoriQ14624.

Organism-specific databases

HPAiCAB016676.
HPA001835.
HPA003948.

Interactioni

Subunit structurei

Interacts (via C-terminus) with DNAJC1 (via SANT 2 domain); this interaction protects ITIH4 against cleavage by kallikrein in vitro.1 Publication

Protein-protein interaction databases

BioGridi109906. 4 interactions.
IntActiQ14624. 2 interactions.
STRINGi9606.ENSP00000266041.

Structurei

3D structure databases

ProteinModelPortaliQ14624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 148120VITPROSITE-ProRule annotationAdd
BLAST
Domaini272 – 432161VWFAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni658 – 68831Proline-rich (PRR) potential bioactive peptideAdd
BLAST
Regioni719 – 7257O-glycosylated at three sites

Sequence similaritiesi

Belongs to the ITIH family.Curated
Contains 1 VIT domain.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2304.
GeneTreeiENSGT00550000074468.
HOGENOMiHOG000239381.
HOVERGENiHBG057734.
InParanoidiQ14624.
OrthoDBiEOG7CRTP5.
PhylomeDBiQ14624.
TreeFamiTF328982.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14624-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPPRPVRTC SKVLVLLSLL AIHQTTTAEK NGIDIYSLTV DSRVSSRFAH
60 70 80 90 100
TVVTSRVVNR ANTVQEATFQ MELPKKAFIT NFSMIIDGMT YPGIIKEKAE
110 120 130 140 150
AQAQYSAAVA KGKSAGLVKA TGRNMEQFQV SVSVAPNAKI TFELVYEELL
160 170 180 190 200
KRRLGVYELL LKVRPQQLVK HLQMDIHIFE PQGISFLETE STFMTNQLVD
210 220 230 240 250
ALTTWQNKTK AHIRFKPTLS QQQKSPEQQE TVLDGNLIIR YDVDRAISGG
260 270 280 290 300
SIQIENGYFV HYFAPEGLTT MPKNVVFVID KSGSMSGRKI QQTREALIKI
310 320 330 340 350
LDDLSPRDQF NLIVFSTEAT QWRPSLVPAS AENVNKARSF AAGIQALGGT
360 370 380 390 400
NINDAMLMAV QLLDSSNQEE RLPEGSVSLI ILLTDGDPTV GETNPRSIQN
410 420 430 440 450
NVREAVSGRY SLFCLGFGFD VSYAFLEKLA LDNGGLARRI HEDSDSALQL
460 470 480 490 500
QDFYQEVANP LLTAVTFEYP SNAVEEVTQN NFRLLFKGSE MVVAGKLQDR
510 520 530 540 550
GPDVLTATVS GKLPTQNITF QTESSVAEQE AEFQSPKYIF HNFMERLWAY
560 570 580 590 600
LTIQQLLEQT VSASDADQQA LRNQALNLSL AYSFVTPLTS MVVTKPDDQE
610 620 630 640 650
QSQVAEKPME GESRNRNVHS GSTFFKYYLQ GAKIPKPEAS FSPRRGWNRQ
660 670 680 690 700
AGAAGSRMNF RPGVLSSRQL GLPGPPDVPD HAAYHPFRRL AILPASAPPA
710 720 730 740 750
TSNPDPAVSR VMNMKIEETT MTTQTPAPIQ APSAILPLPG QSVERLCVDP
760 770 780 790 800
RHRQGPVNLL SDPEQGVEVT GQYEREKAGF SWIEVTFKNP LVWVHASPEH
810 820 830 840 850
VVVTRNRRSS AYKWKETLFS VMPGLKMTMD KTGLLLLSDP DKVTIGLLFW
860 870 880 890 900
DGRGEGLRLL LRDTDRFSSH VGGTLGQFYQ EVLWGSPAAS DDGRRTLRVQ
910 920 930
GNDHSATRER RLDYQEGPPG VEISCWSVEL
Length:930
Mass (Da):103,357
Last modified:May 5, 2009 - v4
Checksum:i847A9A5CB886C5A4
GO
Isoform 2 (identifier: Q14624-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     621-650: Missing.
     727-727: A → ACPSCSRSRAPAVPA

Note: No experimental confirmation available.

Show »
Length:914
Mass (Da):101,241
Checksum:i79F2D903E65026CD
GO
Isoform 3 (identifier: Q14624-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     621-650: Missing.

Note: No experimental confirmation available.

Show »
Length:900
Mass (Da):99,857
Checksum:iB18BE8E1C3BF634C
GO
Isoform 4 (identifier: Q14624-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     621-650: Missing.
     727-765: Missing.
     851-866: Missing.

Note: No experimental confirmation available.

Show »
Length:845
Mass (Da):93,852
Checksum:i60436CD8050B7D46
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851I → K in AAD05198. (PubMed:8797089)Curated
Sequence conflicti114 – 1141S → N in BAA07602. (PubMed:7775381)Curated
Sequence conflicti207 – 2071N → F AA sequence (PubMed:7541790)Curated
Sequence conflicti221 – 2211Q → E AA sequence (PubMed:7541790)Curated
Sequence conflicti307 – 3071R → V AA sequence (PubMed:7541790)Curated
Sequence conflicti322 – 3221W → Y AA sequence (PubMed:7541790)Curated
Sequence conflicti370 – 3701E → G in BAH12781. (PubMed:16641997)Curated
Sequence conflicti816 – 8172ET → QR AA sequence (PubMed:7541790)Curated
Sequence conflicti905 – 9051S → F no nucleotide entry (PubMed:8797089)Curated
Sequence conflicti927 – 9271S → T no nucleotide entry (PubMed:8797089)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851I → N.1 Publication
Corresponds to variant rs13072536 [ dbSNP | Ensembl ].
VAR_027869
Natural varianti86 – 861I → N.1 Publication
VAR_013836
Natural varianti669 – 6691Q → L.
Corresponds to variant rs2276814 [ dbSNP | Ensembl ].
VAR_027870
Natural varianti698 – 6981P → T.
Corresponds to variant rs4687657 [ dbSNP | Ensembl ].
VAR_027871
Natural varianti714 – 7141M → I.
Corresponds to variant rs2256734 [ dbSNP | Ensembl ].
VAR_027872
Natural varianti791 – 7911L → P.
Corresponds to variant rs2535621 [ dbSNP | Ensembl ].
VAR_027873

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei621 – 65030Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_002761Add
BLAST
Alternative sequencei727 – 76539Missing in isoform 4. 1 PublicationVSP_044764Add
BLAST
Alternative sequencei727 – 7271A → ACPSCSRSRAPAVPA in isoform 2. 1 PublicationVSP_002762
Alternative sequencei851 – 86616Missing in isoform 4. 1 PublicationVSP_044765Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38535 mRNA. Translation: BAA07536.1.
D38595 mRNA. Translation: BAA07602.1.
U43163
, U42015, U42016, U43155, U43156, U43157, U43158, U43159, U43160, U43161, U43162 Genomic DNA. Translation: AAD05198.1.
AK298412 mRNA. Translation: BAH12781.1.
AC006254 Genomic DNA. No translation available.
AC099667 Genomic DNA. No translation available.
AF119856 mRNA. Translation: AAF69610.1.
CCDSiCCDS2865.1. [Q14624-1]
CCDS54596.1. [Q14624-3]
PIRiJX0368.
RefSeqiNP_001159921.1. NM_001166449.1. [Q14624-3]
NP_002209.2. NM_002218.4. [Q14624-1]
UniGeneiHs.709406.

Genome annotation databases

EnsembliENST00000266041; ENSP00000266041; ENSG00000055955. [Q14624-1]
ENST00000406595; ENSP00000384425; ENSG00000055955. [Q14624-3]
GeneIDi3700.
KEGGihsa:3700.
UCSCiuc003dfz.3. human. [Q14624-1]
uc011bel.2. human. [Q14624-2]

Polymorphism databases

DMDMi229463048.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38535 mRNA. Translation: BAA07536.1 .
D38595 mRNA. Translation: BAA07602.1 .
U43163
, U42015 , U42016 , U43155 , U43156 , U43157 , U43158 , U43159 , U43160 , U43161 , U43162 Genomic DNA. Translation: AAD05198.1 .
AK298412 mRNA. Translation: BAH12781.1 .
AC006254 Genomic DNA. No translation available.
AC099667 Genomic DNA. No translation available.
AF119856 mRNA. Translation: AAF69610.1 .
CCDSi CCDS2865.1. [Q14624-1 ]
CCDS54596.1. [Q14624-3 ]
PIRi JX0368.
RefSeqi NP_001159921.1. NM_001166449.1. [Q14624-3 ]
NP_002209.2. NM_002218.4. [Q14624-1 ]
UniGenei Hs.709406.

3D structure databases

ProteinModelPortali Q14624.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109906. 4 interactions.
IntActi Q14624. 2 interactions.
STRINGi 9606.ENSP00000266041.

PTM databases

PhosphoSitei Q14624.

Polymorphism databases

DMDMi 229463048.

Proteomic databases

MaxQBi Q14624.
PaxDbi Q14624.
PRIDEi Q14624.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266041 ; ENSP00000266041 ; ENSG00000055955 . [Q14624-1 ]
ENST00000406595 ; ENSP00000384425 ; ENSG00000055955 . [Q14624-3 ]
GeneIDi 3700.
KEGGi hsa:3700.
UCSCi uc003dfz.3. human. [Q14624-1 ]
uc011bel.2. human. [Q14624-2 ]

Organism-specific databases

CTDi 3700.
GeneCardsi GC03M052846.
HGNCi HGNC:6169. ITIH4.
HPAi CAB016676.
HPA001835.
HPA003948.
MIMi 600564. gene.
neXtProti NX_Q14624.
PharmGKBi PA29967.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2304.
GeneTreei ENSGT00550000074468.
HOGENOMi HOG000239381.
HOVERGENi HBG057734.
InParanoidi Q14624.
OrthoDBi EOG7CRTP5.
PhylomeDBi Q14624.
TreeFami TF328982.

Miscellaneous databases

ChiTaRSi ITIH4. human.
GeneWikii ITIH4.
GenomeRNAii 3700.
NextBioi 14503.
PROi Q14624.
SOURCEi Search...

Gene expression databases

Bgeei Q14624.
CleanExi HS_ITIH4.
ExpressionAtlasi Q14624. baseline and differential.
Genevestigatori Q14624.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
SMARTi SM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein."
    Nishimura H., Kakizaki I., Muta T., Sasaki N., Pu P.X., Yamashita T., Nagasawa S.
    FEBS Lett. 357:207-211(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein."
    Saguchi K., Tobe T., Hashimoto K., Sano Y., Nakano Y., Miura N.-H., Tomita M.
    J. Biochem. 117:14-18(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, IDENTIFICATION, TISSUE SPECIFICITY, VARIANT ASN-85.
    Tissue: Liver.
  3. "Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1)."
    Saguchi K., Tobe T., Hashimoto K., Nagasaki Y., Oda E., Nakano Y., Miura N.H., Tomita M.
    J. Biochem. 119:898-905(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Liver.
  5. "BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4."
    Kroczynska B., King-Simmons L., Alloza L., Alava M.A., Elguindi E.C., Blond S.Y.
    Biochem. Biophys. Res. Commun. 338:1467-1477(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), INTERACTION WITH DNAJC1.
  6. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Functional prediction of the coding sequences of 79 new genes deduced by analysis of cDNA clones from human fetal liver."
    Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 271-930 (ISOFORM 2).
    Tissue: Fetal liver.
  8. "Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma."
    Choi-Miura N.-H., Sano Y., Oda E., Nakano Y., Tobe T., Yanagishita T., Taniyama M., Katagiri T., Tomita M.
    J. Biochem. 117:400-407(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-44; 99-119; 140-151; 163-170; 194-208; 211-243; 274-281; 290-329; 429-487; 497-567; 608-626 AND 816-831, PROTEOLYTIC PROCESSING, GLYCOSYLATION.
    Tissue: Plasma.
  9. "Purification and characterization of a novel substrate for plasma kallikrein (PK-120) in human plasma."
    Pu X.P., Iwamoto A., Nishimura H., Nagasawa S.
    Biochim. Biophys. Acta 1208:338-343(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, PROTEOLYTIC PROCESSING.
  10. "ITIH4 serum concentration increases during acute-phase processes in human patients and is up-regulated by interleukin-6 in hepatocarcinoma HepG2 cells."
    Pineiro M., Alava M.A., Gonzalez-Ramon N., Osada J., Lasierra P., Larrad L., Pineiro A., Lampreave F.
    Biochem. Biophys. Res. Commun. 263:224-229(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, INDUCTION.
  11. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
    Zhang H., Li X.-J., Martin D.B., Aebersold R.
    Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-207.
  12. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
    Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
    Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-517.
    Tissue: Plasma.
  13. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-81; ASN-207; ASN-517 AND ASN-577.
    Tissue: Plasma.
  14. "Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke."
    Kashyap R.S., Nayak A.R., Deshpande P.S., Kabra D., Purohit H.J., Taori G.M., Daginawala H.F.
    Clin. Chim. Acta 402:160-163(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  15. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-81; ASN-207 AND ASN-517.
    Tissue: Liver.
  16. "The absolute quantification of eight inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4)-derived peptides in serum from breast cancer patients."
    van den Broek I., Sparidans R.W., van Winden A.W., Gast M.C., van Dulken E.J., Schellens J.H., Beijnen J.H.
    Proteomics Clin. Appl. 4:931-939(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE ROLE OF ACTIVE PEPTIDE AS A BIOMARKER FOR BREAST CANCER.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
    Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT THR-720, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
  19. "SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method."
    Tozaki T., Choi-Miura N.-H., Taniyama M., Kurosawa M., Tomita M.
    BMC Med. Genet. 3:6-6(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASN-86.

Entry informationi

Entry nameiITIH4_HUMAN
AccessioniPrimary (citable) accession number: Q14624
Secondary accession number(s): B7Z545
, E9PGN5, Q15135, Q9P190, Q9UQ54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Possible biomarker for acute ischemic stroke (PubMed:19263524). Peptides derived from the proline-rich potentially active peptide (PRO_0000016542) may be biomarkers for a variety of disease states including breast cancer (PubMed:21137033).2 Publications

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3