Q145A6 (Q145A6_BURXL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Serine hydroxymethyltransferase 1 HAMAP MF_00051
Short name=SHMT 1 HAMAP MF_00051
Short name=Serine methylase 1 HAMAP MF_00051
EC=2.1.2.1 HAMAP MF_00051

Gene names

Name:	glyA1 HAMAP MF_00051
Ordered Locus Names:	Bxeno_A0545
ORF Names:	Bxe_A3914 EMBL ABE29083.1

Organism

Burkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]

Taxonomic identifier

266265 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Interconversion of serine and glycine By similarity. RuleBase RU000585 HAMAP MF_00051
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. RuleBase RU000585 HAMAP MF_00051
Cofactor	Pyridoxal phosphate By similarity. RuleBase RU000585 HAMAP MF_00051
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051 One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU000585
Subunit structure	Homotetramer By similarity. HAMAP MF_00051
Subcellular location	Cytoplasm By similarity HAMAP MF_00051.
Sequence similarities	Belongs to the SHMT family. RuleBase RU004104 HAMAP MF_00051

Ontologies

Keywords
Biological process	One-carbon metabolism RuleBase RU000585 HAMAP MF_00051
Cellular component	Cytoplasm HAMAP MF_00051
Ligand	Pyridoxal phosphate RuleBase RU000585 HAMAP MF_00051
Molecular function	Methyltransferase EMBL ABE29083.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: HAMAP methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	230	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_00051

Sequences

	Sequence		Length	Mass (Da)
	Q145A6 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 716EE6EEDC24E1BC	FASTA	415	45,109
	10 20 30 40 50 60 MFDRAQSTIA NVDPELWKVI EQENRRQEEH IELIASENYT SPAVMAAQGS QLTNKYAEGY 70 80 90 100 110 120 PGKRYYGGCE YVDIAEQLAI DRVKQLFGAE AANVQPNSGS QANQGVFFAV LKPGDTIMGM 130 140 150 160 170 180 SLAHGGHLTH GSPVNMSGKW FNVVSYGLNE AEDIDYEAAE KLAQEHKPKL IVAGASAFSL 190 200 210 220 230 240 RIDFERMSKI ARSVGAYFMV DMAHYAGLIA AGVYPNPVPH ADFVTTTTHK SLRGPRGGVI 250 260 270 280 290 300 LMKAEFEKQI NSAIFPGIQG GPLMHVIAGK AVAFKEALSP EFKAYQQQVV ENARVLAETL 310 320 330 340 350 360 VKRGLRIVSG RTESHVMLVD LRAKKITGKA AEAALGTAHI TVNKNAIPND PEKPFVTSGV 370 380 390 400 410 RLGSPAMTTR GFGVKEAEQV GNLIADVLDN PEDAATIERV RAQVAELTQR FPVYR

References

[1]

"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility." Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L., Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J., Parnell J.J. , Ramette A., Richardson P., Seeger M., Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M. Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006) [PubMed: 17030797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000270 Genomic DNA. Translation: ABE29083.1.
RefSeq	YP_557135.1. NC_007951.1.
3D structure databases
ProteinModelPortal	Q145A6.
SMR	Q145A6. Positions 4-414.
ModBase	Search...
Protein-protein interaction databases
STRING	Q145A6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4001912.
GenomeReviews	Gene locus Bxeno_A0545 in contig CP000270_GR.
KEGG	bxe:Bxe_A3914.
PATRIC	19326459. VBIBurXen52548_0569.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG301263.
OMA	AHMTINK.
PhylomeDB	Q145A6.
ProtClustDB	PRK00011.
Family and domain databases
HAMAP	MF_00051. SHMT. [Tree]
InterPro	IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00600.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q145A6_BURXL

Accession

Primary (citable) accession number: Q145A6

Entry history

Integrated into UniProtKB/TrEMBL:	August 22, 2006
Last sequence update:	August 22, 2006
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)