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Q14596

- NBR1_HUMAN

UniProt

Q14596 - NBR1_HUMAN

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Protein

Next to BRCA1 gene 1 protein

Gene

NBR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri211 – 25747ZZ-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. mitogen-activated protein kinase binding Source: BHF-UCL
  2. ubiquitin binding Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. macroautophagy Source: UniProtKB
  2. negative regulation of osteoblast differentiation Source: BHF-UCL
  3. protein oligomerization Source: UniProtKB
  4. regulation of bone mineralization Source: BHF-UCL
  5. regulation of stress-activated MAPK cascade Source: BHF-UCL
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Next to BRCA1 gene 1 protein
Alternative name(s):
Cell migration-inducing gene 19 protein
Membrane component chromosome 17 surface marker 2
Neighbor of BRCA1 gene 1 protein
Protein 1A1-3B
Gene namesi
Name:NBR1
Synonyms:1A13B, KIAA0049, M17S2
ORF Names:MIG19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6746. NBR1.

Subcellular locationi

Cytoplasm. Cytoplasmic vesicleautophagosome. Lysosome. CytoplasmmyofibrilsarcomereM line By similarity
Note: In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation.By similarity

GO - Cellular componenti

  1. autophagic vacuole Source: Ensembl
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. cytosol Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProt
  5. late endosome Source: UniProtKB
  6. lysosome Source: UniProtKB-KW
  7. membrane Source: UniProtKB
  8. pre-autophagosomal structure Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi12 – 121K → A: No effect on interaction with SQSTM1. 1 Publication
Mutagenesisi50 – 501D → R: Loss of interaction with SQSTM1. 2 Publications
Mutagenesisi732 – 7321Y → A: Loss of interaction ATG8 family proteins. 1 Publication

Organism-specific databases

PharmGKBiPA30510.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 966966Next to BRCA1 gene 1 proteinPRO_0000096746Add
BLAST

Proteomic databases

MaxQBiQ14596.
PaxDbiQ14596.
PRIDEiQ14596.

PTM databases

PhosphoSiteiQ14596.

Expressioni

Gene expression databases

BgeeiQ14596.
CleanExiHS_NBR1.
ExpressionAtlasiQ14596. baseline and differential.
GenevestigatoriQ14596.

Organism-specific databases

HPAiHPA022999.
HPA023999.

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with TRIM55 (By similarity). Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG8P381827EBI-742698,EBI-2684From a different organism.
GABARAPO951665EBI-742698,EBI-712001
GABARAPL1Q9H0R84EBI-742698,EBI-746969
GABARAPL2P6052011EBI-742698,EBI-720116
HTTP428583EBI-742698,EBI-466029
MAP1LC3AQ9H4925EBI-742698,EBI-720768
MAP1LC3BQ9GZQ88EBI-742698,EBI-373144
MAP1LC3CQ9BXW43EBI-742698,EBI-2603996
SQSTM1Q135016EBI-742698,EBI-307104
USP8P408183EBI-742698,EBI-1050865

Protein-protein interaction databases

BioGridi110253. 183 interactions.
IntActiQ14596. 21 interactions.
MINTiMINT-2806845.
STRINGi9606.ENSP00000343479.

Structurei

Secondary structure

1
966
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 117Combined sources
Beta strandi14 – 218Combined sources
Helixi23 – 253Combined sources
Helixi28 – 3912Combined sources
Beta strandi42 – 498Combined sources
Beta strandi55 – 584Combined sources
Helixi61 – 7313Combined sources
Turni74 – 763Combined sources
Beta strandi77 – 848Combined sources
Beta strandi373 – 3808Combined sources
Beta strandi384 – 3863Combined sources
Beta strandi391 – 40010Combined sources
Beta strandi402 – 4043Combined sources
Beta strandi410 – 4189Combined sources
Beta strandi420 – 4234Combined sources
Helixi425 – 4284Combined sources
Beta strandi439 – 4479Combined sources
Beta strandi453 – 46311Combined sources
Beta strandi466 – 47813Combined sources
Helixi917 – 92711Combined sources
Helixi932 – 9398Combined sources
Turni940 – 9445Combined sources
Helixi946 – 95611Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WJ6NMR-A1-85[»]
2BKFX-ray1.56A1-85[»]
2CP8NMR-A916-956[»]
2G4SX-ray2.15A1-85[»]
2L8JNMR-B726-738[»]
2MGWNMR-A913-959[»]
2MJ5NMR-B913-959[»]
4OLEX-ray2.52A/B/C/D365-485[»]
ProteinModelPortaliQ14596.
SMRiQ14596. Positions 1-85, 365-485, 913-959.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14596.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 7129OPRAdd
BLAST
Domaini913 – 95745UBAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni542 – 63695ATG8 family protein-bindingAdd
BLAST
Regioni727 – 73812ATG8 family protein-bindingAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi703 – 71412Poly-GluAdd
BLAST

Domaini

The OPR domain mediates interaction with SQSTM1.2 Publications

Sequence similaritiesi

Contains 1 OPR domain.Curated
Contains 1 UBA domain.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri211 – 25747ZZ-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG239857.
GeneTreeiENSGT00390000016335.
HOGENOMiHOG000220861.
HOVERGENiHBG052578.
InParanoidiQ14596.
KOiK17987.
OMAiAYKALFA.
OrthoDBiEOG7FNC6V.
PhylomeDBiQ14596.
TreeFamiTF328428.

Family and domain databases

InterProiIPR000270. OPR_PB1.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS50030. UBA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14596-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVKVSFD LNTIQIKYLD
60 70 80 90 100
EENEEVSINS QGEYEEALKM AVKQGNQLQM QVHEGHHVVD EAPPPVVGAK
110 120 130 140 150
RLAARAGKKP LAHYSSLVRV LGSDMKTPED PAVQSFPLVP CDTDQPQDKP
160 170 180 190 200
PDWFTSYLET FREQVVNETV EKLEQKLHEK LVLQNPSLGS CPSEVSMPTS
210 220 230 240 250
EETLFLPENQ FSWHIACNNC QRRIVGVRYQ CSLCPSYNIC EDCEAGPYGH
260 270 280 290 300
DTNHVLLKLR RPVVGSSEPF CHSKYSTPRL PAALEQVRLQ KQVDKNFLKA
310 320 330 340 350
EKQRLRAEKK QRKAEVKELK KQLKLHRKIH LWNSIHGLQS PKSPLGRPES
360 370 380 390 400
LLQSNTLMLP LQPCTSVMPM LSAAFVDENL PDGTHLQPGT KFIKHWRMKN
410 420 430 440 450
TGNVKWSADT KLKFMWGNLT LASTEKKDVL VPCLKAGHVG VVSVEFIAPA
460 470 480 490 500
LEGTYTSHWR LSHKGQQFGP RVWCSIIVDP FPSEESPDNI EKGMISSSKT
510 520 530 540 550
DDLTCQQEET FLLAKEERQL GEVTEQTEGT AACIPQKAKN VASERELYIP
560 570 580 590 600
SVDLLTAQDL LSFELLDINI VQELERVPHN TPVDVTPCMS PLPHDSPLIE
610 620 630 640 650
KPGLGQIEEE NEGAGFKALP DSMVSVKRKA ENIASVEEAE EDLSGTQFVC
660 670 680 690 700
ETVIRSLTLD AAPDHNPPCR QKSLQMTFAL PEGPLGNEKE EIIHIAEEEA
710 720 730 740 750
VMEEEEDEED EEEEDELKDE VQSQSSASSE DYIIILPECF DTSRPLGDSM
760 770 780 790 800
YSSALSQPGL ERGAEGKPGV EAGQEPAEAG ERLPGGENQP QEHSISDILT
810 820 830 840 850
TSQTLETVPL IPEVVELPPS LPRSSPCVHH HGSPGVDLPV TIPEVSSVPD
860 870 880 890 900
QIRGEPRGSS GLVNSRQKSY DHSRHHHGSS IAGGLVKGAL SVAASAYKAL
910 920 930 940 950
FAGPPVTAQP IISEDQTAAL MAHLFEMGFC DRQLNLRLLK KHNYNILQVV
960
TELLQLNNND WYSQRY
Length:966
Mass (Da):107,413
Last modified:May 18, 2010 - v3
Checksum:i6A057E67947838EF
GO
Isoform 2 (identifier: Q14596-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     910-966: PIISEDQTAA...NNNDWYSQRY → GLWGLLSFLHLAKKCFFLKAPSEAFSWF

Note: No experimental confirmation available.

Show »
Length:937
Mass (Da):103,834
Checksum:i0228655991281A88
GO

Sequence cautioni

The sequence BAA06417.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti746 – 77025LGDSM…GKPGV → WGILCTALRSHSQAWSEVLK ASLGF in CAA54274. (PubMed:8069304)CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti923 – 9231H → R.3 Publications
Corresponds to variant rs8482 [ dbSNP | Ensembl ].
VAR_016106

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei910 – 96657PIISE…YSQRY → GLWGLLSFLHLAKKCFFLKA PSEAFSWF in isoform 2. 1 PublicationVSP_004314Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76952 mRNA. Translation: CAA54274.1.
D30756 mRNA. Translation: BAA06417.2. Different initiation.
AY450308 mRNA. Translation: AAS15047.1.
AC060780 Genomic DNA. No translation available.
AC109326 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60946.1.
BC009808 mRNA. Translation: AAH09808.1.
AF227189 mRNA. Translation: AAF74119.1.
U25764 Genomic DNA. Translation: AAA93228.1.
CCDSiCCDS45694.1. [Q14596-1]
RefSeqiNP_001278500.1. NM_001291571.1. [Q14596-2]
NP_001278501.1. NM_001291572.1.
NP_005890.2. NM_005899.4. [Q14596-1]
NP_114068.1. NM_031862.3. [Q14596-1]
UniGeneiHs.277721.
Hs.708158.

Genome annotation databases

EnsembliENST00000341165; ENSP00000343479; ENSG00000188554. [Q14596-1]
ENST00000422280; ENSP00000411250; ENSG00000188554. [Q14596-1]
ENST00000586650; ENSP00000466071; ENSG00000188554.
ENST00000589872; ENSP00000467816; ENSG00000188554. [Q14596-2]
ENST00000590996; ENSP00000466667; ENSG00000188554. [Q14596-1]
GeneIDi4077.
KEGGihsa:4077.
UCSCiuc010czd.3. human. [Q14596-1]
uc010whu.2. human. [Q14596-2]

Polymorphism databases

DMDMi296439290.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76952 mRNA. Translation: CAA54274.1 .
D30756 mRNA. Translation: BAA06417.2 . Different initiation.
AY450308 mRNA. Translation: AAS15047.1 .
AC060780 Genomic DNA. No translation available.
AC109326 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60946.1 .
BC009808 mRNA. Translation: AAH09808.1 .
AF227189 mRNA. Translation: AAF74119.1 .
U25764 Genomic DNA. Translation: AAA93228.1 .
CCDSi CCDS45694.1. [Q14596-1 ]
RefSeqi NP_001278500.1. NM_001291571.1. [Q14596-2 ]
NP_001278501.1. NM_001291572.1.
NP_005890.2. NM_005899.4. [Q14596-1 ]
NP_114068.1. NM_031862.3. [Q14596-1 ]
UniGenei Hs.277721.
Hs.708158.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WJ6 NMR - A 1-85 [» ]
2BKF X-ray 1.56 A 1-85 [» ]
2CP8 NMR - A 916-956 [» ]
2G4S X-ray 2.15 A 1-85 [» ]
2L8J NMR - B 726-738 [» ]
2MGW NMR - A 913-959 [» ]
2MJ5 NMR - B 913-959 [» ]
4OLE X-ray 2.52 A/B/C/D 365-485 [» ]
ProteinModelPortali Q14596.
SMRi Q14596. Positions 1-85, 365-485, 913-959.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110253. 183 interactions.
IntActi Q14596. 21 interactions.
MINTi MINT-2806845.
STRINGi 9606.ENSP00000343479.

PTM databases

PhosphoSitei Q14596.

Polymorphism databases

DMDMi 296439290.

Proteomic databases

MaxQBi Q14596.
PaxDbi Q14596.
PRIDEi Q14596.

Protocols and materials databases

DNASUi 4077.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341165 ; ENSP00000343479 ; ENSG00000188554 . [Q14596-1 ]
ENST00000422280 ; ENSP00000411250 ; ENSG00000188554 . [Q14596-1 ]
ENST00000586650 ; ENSP00000466071 ; ENSG00000188554 .
ENST00000589872 ; ENSP00000467816 ; ENSG00000188554 . [Q14596-2 ]
ENST00000590996 ; ENSP00000466667 ; ENSG00000188554 . [Q14596-1 ]
GeneIDi 4077.
KEGGi hsa:4077.
UCSCi uc010czd.3. human. [Q14596-1 ]
uc010whu.2. human. [Q14596-2 ]

Organism-specific databases

CTDi 4077.
GeneCardsi GC17P041322.
HGNCi HGNC:6746. NBR1.
HPAi HPA022999.
HPA023999.
MIMi 166945. gene.
neXtProti NX_Q14596.
PharmGKBi PA30510.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG239857.
GeneTreei ENSGT00390000016335.
HOGENOMi HOG000220861.
HOVERGENi HBG052578.
InParanoidi Q14596.
KOi K17987.
OMAi AYKALFA.
OrthoDBi EOG7FNC6V.
PhylomeDBi Q14596.
TreeFami TF328428.

Miscellaneous databases

EvolutionaryTracei Q14596.
GeneWikii NBR1.
GenomeRNAii 4077.
NextBioi 15978.
PROi Q14596.
SOURCEi Search...

Gene expression databases

Bgeei Q14596.
CleanExi HS_NBR1.
ExpressionAtlasi Q14596. baseline and differential.
Genevestigatori Q14596.

Family and domain databases

InterProi IPR000270. OPR_PB1.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF00564. PB1. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view ]
SMARTi SM00666. PB1. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
PROSITEi PS50030. UBA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-923.
    Tissue: Ovary.
  2. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
    Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
    DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  3. "Identification of a human migration inducing gene."
    Kim J.W.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-923.
    Tissue: Lymph.
  7. "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes."
    Dimitrov S., Brennerova M., Forejt J.
    Gene 262:89-98(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-42, VARIANT ARG-923.
    Tissue: Testis.
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 412-508.
  9. "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins."
    Lamark T., Perander M., Outzen H., Kristiansen K., Oevervatn A., Michaelsen E., Bjoerkoey G., Johansen T.
    J. Biol. Chem. 278:34568-34581(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SQSTM1, OLIGOMERIZATION, DOMAIN, MUTAGENESIS OF LYS-12 AND ASP-50.
  10. Cited for: INTERACTION WITH SQSTM1; TTN AND RNF29.
  11. "Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover."
    Waters S., Marchbank K., Solomon E., Whitehouse C., Gautel M.
    FEBS Lett. 583:1846-1852(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH USP8, UBIQUITIN-BINDING, SUBCELLULAR LOCATION.
  12. Cited for: FUNCTION, SUBCELLULAR LOCATION, DOMAIN, INTERACTION WITH SQSTM1; MAP1LC3A; MAP1LC3B; MAP1LC3C; GABARAP; GABARAPL1 AND GABARAPL2, MUTAGENESIS OF ASP-50 AND TYR-732.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Solution structure of RSGI RUH-024, a PB1 domain, and of RSGI RUH-046, a UBA domain from human next to BRCA1 gene 1 protein (KIAA0049 protein) R923H variant."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-85 AND 916-956.
  15. "Crystal structure of the PB1 domain of NBR1."
    Mueller S., Kursula I., Zou P., Wilmanns M.
    FEBS Lett. 580:341-344(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 1-85.

Entry informationi

Entry nameiNBR1_HUMAN
AccessioniPrimary (citable) accession number: Q14596
Secondary accession number(s): Q13173
, Q15026, Q5J7Q8, Q96GB6, Q9NRF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3