Q14596 (NBR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Next to BRCA1 gene 1 protein

Alternative name(s):
Cell migration-inducing gene 19 protein
Membrane component chromosome 17 surface marker 2
Neighbor of BRCA1 gene 1 protein
Protein 1A1-3B

Gene names

Name:	NBR1
Synonyms:	1A13B, KIAA0049, M17S2
ORF Names:	MIG19

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	966 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. Ref.12
Subunit structure	Homooligomer and heterooligomer. Interacts with TRIM55 By similarity. Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins. Ref.9 Ref.10 Ref.11 Ref.12
Subcellular location	Cytoplasm. Cytoplasmic vesicle › autophagosome. Lysosome. Cytoplasm › myofibril › sarcomere › M line By similarity. Note: In cardiac muscles localizes to the sarcomeric M line By similarity. Is targeted to lysosomes for degradation. Ref.11 Ref.12
Domain	The OPR domain mediates interaction with SQSTM1. Ref.9 Ref.12
Sequence similarities	Contains 1 OPR domain. Contains 1 UBA domain. Contains 1 ZZ-type zinc finger.
Caution	Was originally (Ref.1) thought to be the ovarian carcinoma antigen CA125.
Sequence caution	The sequence BAA06417.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoplasmic vesicle Lysosome
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	macroautophagy Inferred from direct assay Ref.12. Source: UniProtKB negative regulation of osteoblast differentiation Inferred from sequence or structural similarity. Source: BHF-UCL protein oligomerization Inferred from direct assay Ref.12. Source: UniProtKB regulation of bone mineralization Inferred from sequence or structural similarity. Source: BHF-UCL regulation of stress-activated MAPK cascade Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular_component	M band Inferred from electronic annotation. Source: UniProtKB-SubCell autophagic vacuole Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasmic vesicle Inferred from electronic annotation. Source: UniProtKB-KW cytosol Inferred from direct assay Ref.12. Source: UniProtKB late endosome Inferred from sequence or structural similarity. Source: UniProtKB lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell pre-autophagosomal structure Inferred from electronic annotation. Source: Compara
Molecular_function	mitogen-activated protein kinase binding Inferred from sequence or structural similarity. Source: BHF-UCL ubiquitin binding Inferred from direct assay Ref.11. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATG8	P38182	6	EBI-742698,EBI-2684	From a different organism.
GABARAP	O95166	5	EBI-742698,EBI-712001
GABARAPL1	Q9H0R8	4	EBI-742698,EBI-746969
GABARAPL2	P60520	11	EBI-742698,EBI-720116
HTT	P42858	3	EBI-742698,EBI-466029
MAP1LC3A	Q9H492	2	EBI-742698,EBI-720768
MAP1LC3B	Q9GZQ8	8	EBI-742698,EBI-373144
MAP1LC3C	Q9BXW4	3	EBI-742698,EBI-2603996
SQSTM1	Q13501	5	EBI-742698,EBI-307104

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14596-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14596-2)

The sequence of this isoform differs from the canonical sequence as follows:
     910-966: PIISEDQTAA...NNNDWYSQRY → GLWGLLSFLHLAKKCFFLKAPSEAFSWF

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 966

966

Next to BRCA1 gene 1 protein

PRO_0000096746

Regions

Domain

43 – 71

29

OPR

Domain

913 – 957

45

UBA

Zinc finger

211 – 257

47

ZZ-type

Region

542 – 636

95

ATG8 family protein-binding

Region

727 – 738

12

ATG8 family protein-binding

Compositional bias

703 – 714

12

Poly-Glu

Natural variations

Alternative sequence

910 – 966

57

PIISE…YSQRY → GLWGLLSFLHLAKKCFFLKA PSEAFSWF in isoform 2.

VSP_004314

Natural variant

923

1

H → R. Ref.1 Ref.6 Ref.7
Corresponds to variant rs8482 [ dbSNP | Ensembl ].

VAR_016106

Experimental info

Mutagenesis

12

1

K → A: No effect on interaction with SQSTM1. Ref.9

Mutagenesis

50

1

D → R: Loss of interaction with SQSTM1. Ref.9 Ref.12

Mutagenesis

732

1

Y → A: Loss of interaction ATG8 family proteins. Ref.12

Sequence conflict

746 – 770

25

LGDSM…GKPGV → WGILCTALRSHSQAWSEVLK ASLGF in CAA54274. Ref.1

Secondary structure

1

.

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.

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.

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966

Helix Strand Turn

Details...

Beta strand

5 – 11

7

Beta strand

14 – 21

8

Helix

23 – 25

3

Helix

28 – 39

12

Beta strand

42 – 49

8

Beta strand

55 – 58

4

Helix

61 – 73

13

Turn

74 – 76

3

Beta strand

77 – 84

8

Helix

917 – 927

11

Helix

932 – 939

8

Turn

940 – 944

5

Helix

946 – 956

11

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 6A057E67947838EF	FASTA	966	107,413
	10 20 30 40 50 60 MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVKVSFD LNTIQIKYLD EENEEVSINS 70 80 90 100 110 120 QGEYEEALKM AVKQGNQLQM QVHEGHHVVD EAPPPVVGAK RLAARAGKKP LAHYSSLVRV 130 140 150 160 170 180 LGSDMKTPED PAVQSFPLVP CDTDQPQDKP PDWFTSYLET FREQVVNETV EKLEQKLHEK 190 200 210 220 230 240 LVLQNPSLGS CPSEVSMPTS EETLFLPENQ FSWHIACNNC QRRIVGVRYQ CSLCPSYNIC 250 260 270 280 290 300 EDCEAGPYGH DTNHVLLKLR RPVVGSSEPF CHSKYSTPRL PAALEQVRLQ KQVDKNFLKA 310 320 330 340 350 360 EKQRLRAEKK QRKAEVKELK KQLKLHRKIH LWNSIHGLQS PKSPLGRPES LLQSNTLMLP 370 380 390 400 410 420 LQPCTSVMPM LSAAFVDENL PDGTHLQPGT KFIKHWRMKN TGNVKWSADT KLKFMWGNLT 430 440 450 460 470 480 LASTEKKDVL VPCLKAGHVG VVSVEFIAPA LEGTYTSHWR LSHKGQQFGP RVWCSIIVDP 490 500 510 520 530 540 FPSEESPDNI EKGMISSSKT DDLTCQQEET FLLAKEERQL GEVTEQTEGT AACIPQKAKN 550 560 570 580 590 600 VASERELYIP SVDLLTAQDL LSFELLDINI VQELERVPHN TPVDVTPCMS PLPHDSPLIE 610 620 630 640 650 660 KPGLGQIEEE NEGAGFKALP DSMVSVKRKA ENIASVEEAE EDLSGTQFVC ETVIRSLTLD 670 680 690 700 710 720 AAPDHNPPCR QKSLQMTFAL PEGPLGNEKE EIIHIAEEEA VMEEEEDEED EEEEDELKDE 730 740 750 760 770 780 VQSQSSASSE DYIIILPECF DTSRPLGDSM YSSALSQPGL ERGAEGKPGV EAGQEPAEAG 790 800 810 820 830 840 ERLPGGENQP QEHSISDILT TSQTLETVPL IPEVVELPPS LPRSSPCVHH HGSPGVDLPV 850 860 870 880 890 900 TIPEVSSVPD QIRGEPRGSS GLVNSRQKSY DHSRHHHGSS IAGGLVKGAL SVAASAYKAL 910 920 930 940 950 960 FAGPPVTAQP IISEDQTAAL MAHLFEMGFC DRQLNLRLLK KHNYNILQVV TELLQLNNND WYSQRY
	Isoform 2 [UniParc]. Checksum: 0228655991281A88	FASTA	937	103,834
	10 20 30 40 50 60 MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVKVSFD LNTIQIKYLD EENEEVSINS 70 80 90 100 110 120 QGEYEEALKM AVKQGNQLQM QVHEGHHVVD EAPPPVVGAK RLAARAGKKP LAHYSSLVRV 130 140 150 160 170 180 LGSDMKTPED PAVQSFPLVP CDTDQPQDKP PDWFTSYLET FREQVVNETV EKLEQKLHEK 190 200 210 220 230 240 LVLQNPSLGS CPSEVSMPTS EETLFLPENQ FSWHIACNNC QRRIVGVRYQ CSLCPSYNIC 250 260 270 280 290 300 EDCEAGPYGH DTNHVLLKLR RPVVGSSEPF CHSKYSTPRL PAALEQVRLQ KQVDKNFLKA 310 320 330 340 350 360 EKQRLRAEKK QRKAEVKELK KQLKLHRKIH LWNSIHGLQS PKSPLGRPES LLQSNTLMLP 370 380 390 400 410 420 LQPCTSVMPM LSAAFVDENL PDGTHLQPGT KFIKHWRMKN TGNVKWSADT KLKFMWGNLT 430 440 450 460 470 480 LASTEKKDVL VPCLKAGHVG VVSVEFIAPA LEGTYTSHWR LSHKGQQFGP RVWCSIIVDP 490 500 510 520 530 540 FPSEESPDNI EKGMISSSKT DDLTCQQEET FLLAKEERQL GEVTEQTEGT AACIPQKAKN 550 560 570 580 590 600 VASERELYIP SVDLLTAQDL LSFELLDINI VQELERVPHN TPVDVTPCMS PLPHDSPLIE 610 620 630 640 650 660 KPGLGQIEEE NEGAGFKALP DSMVSVKRKA ENIASVEEAE EDLSGTQFVC ETVIRSLTLD 670 680 690 700 710 720 AAPDHNPPCR QKSLQMTFAL PEGPLGNEKE EIIHIAEEEA VMEEEEDEED EEEEDELKDE 730 740 750 760 770 780 VQSQSSASSE DYIIILPECF DTSRPLGDSM YSSALSQPGL ERGAEGKPGV EAGQEPAEAG 790 800 810 820 830 840 ERLPGGENQP QEHSISDILT TSQTLETVPL IPEVVELPPS LPRSSPCVHH HGSPGVDLPV 850 860 870 880 890 900 TIPEVSSVPD QIRGEPRGSS GLVNSRQKSY DHSRHHHGSS IAGGLVKGAL SVAASAYKAL 910 920 930 FAGPPVTAQG LWGLLSFLHL AKKCFFLKAP SEAFSWF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1." Campbell I.G., Nicolai H.M., Foulkes W.D., Senger G., Stamp G.W., Allan G., Boyer C., Jones K., Bast R.C. Jr., Solomon E., Trowsdale J., Black D.M. Hum. Mol. Genet. 3:589-594(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-923. Tissue: Ovary.
[2]	"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1." Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S. DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[3]	"Identification of a human migration inducing gene." Kim J.W. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-923. Tissue: Lymph.
[7]	"Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes." Dimitrov S., Brennerova M., Forejt J. Gene 262:89-98(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-42, VARIANT ARG-923. Tissue: Testis.
[8]	"Comparison of the positional cloning methods used to isolate the BRCA1 gene." Harshman K., Bell R., Rosenthal J., Katcher H., Miki Y., Swenson J., Gholami Z., Frye C., Ding W., Dayananth P., Eddington K., Norris F.H., Bristow P.K., Phelps R., Hattier T., Stone S., Shaffer D., Bayer S. , Hussey C., Tran T., Lai M., Rosteck P.R. Jr., Skolnick M.H., Shattuck-Eidens D., Kamb A. Hum. Mol. Genet. 4:1259-1266(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 412-508.
[9]	"Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins." Lamark T., Perander M., Outzen H., Kristiansen K., Oevervatn A., Michaelsen E., Bjoerkoey G., Johansen T. J. Biol. Chem. 278:34568-34581(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SQSTM1, OLIGOMERIZATION, DOMAIN, MUTAGENESIS OF LYS-12 AND ASP-50.
[10]	"The kinase domain of titin controls muscle gene expression and protein turnover." Lange S., Xiang F., Yakovenko A., Vihola A., Hackman P., Rostkova E., Kristensen J., Brandmeier B., Franzen G., Hedberg B., Gunnarsson L.G., Hughes S.M., Marchand S., Sejersen T., Richard I., Edstroem L., Ehler E., Udd B., Gautel M. Science 308:1599-1603(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SQSTM1; TTN AND RNF29.
[11]	"Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover." Waters S., Marchbank K., Solomon E., Whitehouse C., Gautel M. FEBS Lett. 583:1846-1852(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH USP8, UBIQUITIN-BINDING, SUBCELLULAR LOCATION.
[12]	"A role for NBR1 in autophagosomal degradation of ubiquitinated substrates." Kirkin V., Lamark T., Sou Y.S., Bjorkoy G., Nunn J.L., Bruun J.A., Shvets E., McEwan D.G., Clausen T.H., Wild P., Bilusic I., Theurillat J.P., Overvatn A., Ishii T., Elazar Z., Komatsu M., Dikic I., Johansen T. Mol. Cell 33:505-516(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, DOMAIN, INTERACTION WITH SQSTM1; MAP1LC3A; MAP1LC3B; MAP1LC3C; GABARAP; GABARAPL1 AND GABARAPL2, MUTAGENESIS OF ASP-50 AND TYR-732.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[14]	"Solution structure of RSGI RUH-024, a PB1 domain, and of RSGI RUH-046, a UBA domain from human next to BRCA1 gene 1 protein (KIAA0049 protein) R923H variant." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1-85 AND 916-956.
[15]	"Crystal structure of the PB1 domain of NBR1." Mueller S., Kursula I., Zou P., Wilmanns M. FEBS Lett. 580:341-344(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 1-85.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X76952 mRNA. Translation: CAA54274.1.
D30756 mRNA. Translation: BAA06417.2. Different initiation.
AY450308 mRNA. Translation: AAS15047.1.
AC060780 Genomic DNA. No translation available.
AC109326 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60946.1.
BC009808 mRNA. Translation: AAH09808.1.
AF227189 mRNA. Translation: AAF74119.1.
U25764 Genomic DNA. Translation: AAA93228.1.

IPI

IPI00793935.
IPI00871941.

RefSeq

NP_005890.2. NM_005899.3.
NP_114064.1. NM_031858.2.
NP_114068.1. NM_031862.2.

UniGene

Hs.277721.
Hs.708158.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WJ6	NMR	-	A	1-85	[»]
2BKF	X-ray	1.56	A	1-85	[»]
2CP8	NMR	-	A	916-956	[»]
2G4S	X-ray	2.15	A	1-85	[»]
2L8J	NMR	-	B	726-738	[»]

ProteinModelPortal

Q14596.

SMR

Q14596. Positions 1-85, 913-957.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q14596. 13 interactions.

MINT

MINT-2806845.

STRING

9606.ENSP00000343479.

PTM databases

PhosphoSite

Q14596.

Polymorphism databases

DMDM

296439290.

Proteomic databases

PaxDb

Q14596.

PRIDE

Q14596.

Protocols and materials databases

DNASU

4077.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000341165; ENSP00000343479; ENSG00000188554.
ENST00000422280; ENSP00000411250; ENSG00000188554.
ENST00000586650; ENSP00000466071; ENSG00000188554.
ENST00000589872; ENSP00000467816; ENSG00000188554.
ENST00000590996; ENSP00000466667; ENSG00000188554.

GeneID

4077.

KEGG

hsa:4077.

UCSC

uc010czd.3. human.
uc010whu.2. human.

Organism-specific databases

CTD

4077.

GeneCards

GC17P041322.

HGNC

HGNC:6746. NBR1.

HPA

HPA022999.
HPA023999.

MIM

166945. gene.

neXtProt

NX_Q14596.

PharmGKB

PA30510.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG239857.

HOGENOM

HOG000220861.

HOVERGEN

HBG052578.

InParanoid

Q14596.

OMA

PDHNPPC.

OrthoDB

EOG4Z62MX.

Gene expression databases

ArrayExpress

Q14596.

Bgee

Q14596.

CleanEx

HS_NBR1.

Genevestigator

Q14596.

Family and domain databases

InterPro

IPR000270. OPR_PB1.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000433. Znf_ZZ.
[Graphical view]

Pfam

PF00564. PB1. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]

SMART

SM00666. PB1. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]

SUPFAM

SSF46934. UBA_like. 1 hit.

PROSITE

PS50030. UBA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

NBR1. human.

EvolutionaryTrace

Q14596.

GenomeRNAi

4077.

NextBio

15978.

SOURCE

Search...

Entry information

Entry name

NBR1_HUMAN

Accession

Primary (citable) accession number: Q14596
Secondary accession number(s): Q13173 , Q15026, Q5J7Q8, Q96GB6, Q9NRF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 133 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.