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Q14596

- NBR1_HUMAN

UniProt

Q14596 - NBR1_HUMAN

Protein

Next to BRCA1 gene 1 protein

Gene

NBR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri211 – 25747ZZ-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. mitogen-activated protein kinase binding Source: BHF-UCL
    2. protein binding Source: UniProtKB
    3. ubiquitin binding Source: UniProtKB
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. macroautophagy Source: UniProtKB
    2. negative regulation of osteoblast differentiation Source: BHF-UCL
    3. protein oligomerization Source: UniProtKB
    4. regulation of bone mineralization Source: BHF-UCL
    5. regulation of stress-activated MAPK cascade Source: BHF-UCL

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Next to BRCA1 gene 1 protein
    Alternative name(s):
    Cell migration-inducing gene 19 protein
    Membrane component chromosome 17 surface marker 2
    Neighbor of BRCA1 gene 1 protein
    Protein 1A1-3B
    Gene namesi
    Name:NBR1
    Synonyms:1A13B, KIAA0049, M17S2
    ORF Names:MIG19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6746. NBR1.

    Subcellular locationi

    Cytoplasm. Cytoplasmic vesicleautophagosome. Lysosome. CytoplasmmyofibrilsarcomereM line By similarity
    Note: In cardiac muscles localizes to the sarcomeric M line By similarity. Is targeted to lysosomes for degradation.By similarity

    GO - Cellular componenti

    1. autophagic vacuole Source: UniProtKB-SubCell
    2. cytoplasmic vesicle Source: UniProtKB-KW
    3. cytosol Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. late endosome Source: UniProtKB
    6. lysosome Source: UniProtKB-SubCell
    7. M band Source: UniProtKB-SubCell
    8. membrane Source: UniProtKB
    9. pre-autophagosomal structure Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Lysosome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi12 – 121K → A: No effect on interaction with SQSTM1. 1 Publication
    Mutagenesisi50 – 501D → R: Loss of interaction with SQSTM1. 2 Publications
    Mutagenesisi732 – 7321Y → A: Loss of interaction ATG8 family proteins. 1 Publication

    Organism-specific databases

    PharmGKBiPA30510.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 966966Next to BRCA1 gene 1 proteinPRO_0000096746Add
    BLAST

    Proteomic databases

    MaxQBiQ14596.
    PaxDbiQ14596.
    PRIDEiQ14596.

    PTM databases

    PhosphoSiteiQ14596.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14596.
    BgeeiQ14596.
    CleanExiHS_NBR1.
    GenevestigatoriQ14596.

    Organism-specific databases

    HPAiHPA022999.
    HPA023999.

    Interactioni

    Subunit structurei

    Homooligomer and heterooligomer. Interacts with TRIM55 By similarity. Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATG8P381827EBI-742698,EBI-2684From a different organism.
    GABARAPO951665EBI-742698,EBI-712001
    GABARAPL1Q9H0R84EBI-742698,EBI-746969
    GABARAPL2P6052011EBI-742698,EBI-720116
    HTTP428583EBI-742698,EBI-466029
    MAP1LC3AQ9H4925EBI-742698,EBI-720768
    MAP1LC3BQ9GZQ88EBI-742698,EBI-373144
    MAP1LC3CQ9BXW43EBI-742698,EBI-2603996
    SQSTM1Q135016EBI-742698,EBI-307104
    USP8P408183EBI-742698,EBI-1050865

    Protein-protein interaction databases

    BioGridi110253. 176 interactions.
    IntActiQ14596. 21 interactions.
    MINTiMINT-2806845.
    STRINGi9606.ENSP00000343479.

    Structurei

    Secondary structure

    1
    966
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 117
    Beta strandi14 – 218
    Helixi23 – 253
    Helixi28 – 3912
    Beta strandi42 – 498
    Beta strandi55 – 584
    Helixi61 – 7313
    Turni74 – 763
    Beta strandi77 – 848
    Beta strandi373 – 3808
    Beta strandi384 – 3863
    Beta strandi391 – 40010
    Beta strandi402 – 4043
    Beta strandi410 – 4189
    Beta strandi420 – 4234
    Helixi425 – 4284
    Beta strandi439 – 4479
    Beta strandi453 – 46311
    Beta strandi466 – 47813
    Helixi917 – 92711
    Helixi932 – 9398
    Turni940 – 9445
    Helixi946 – 95611

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WJ6NMR-A1-85[»]
    2BKFX-ray1.56A1-85[»]
    2CP8NMR-A916-956[»]
    2G4SX-ray2.15A1-85[»]
    2L8JNMR-B726-738[»]
    2MGWNMR-A913-959[»]
    2MJ5NMR-B913-959[»]
    4OLEX-ray2.52A/B/C/D365-485[»]
    ProteinModelPortaliQ14596.
    SMRiQ14596. Positions 1-85, 365-485, 913-957.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ14596.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 7129OPRAdd
    BLAST
    Domaini913 – 95745UBAPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni542 – 63695ATG8 family protein-bindingAdd
    BLAST
    Regioni727 – 73812ATG8 family protein-bindingAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi703 – 71412Poly-GluAdd
    BLAST

    Domaini

    The OPR domain mediates interaction with SQSTM1.2 Publications

    Sequence similaritiesi

    Contains 1 OPR domain.Curated
    Contains 1 UBA domain.PROSITE-ProRule annotation
    Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri211 – 25747ZZ-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG239857.
    HOGENOMiHOG000220861.
    HOVERGENiHBG052578.
    InParanoidiQ14596.
    KOiK17987.
    OMAiAYKALFA.
    OrthoDBiEOG7FNC6V.
    PhylomeDBiQ14596.
    TreeFamiTF328428.

    Family and domain databases

    InterProiIPR000270. OPR_PB1.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000433. Znf_ZZ.
    [Graphical view]
    PfamiPF00564. PB1. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view]
    SMARTiSM00666. PB1. 1 hit.
    SM00291. ZnF_ZZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    PROSITEiPS50030. UBA. 1 hit.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14596-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVKVSFD LNTIQIKYLD    50
    EENEEVSINS QGEYEEALKM AVKQGNQLQM QVHEGHHVVD EAPPPVVGAK 100
    RLAARAGKKP LAHYSSLVRV LGSDMKTPED PAVQSFPLVP CDTDQPQDKP 150
    PDWFTSYLET FREQVVNETV EKLEQKLHEK LVLQNPSLGS CPSEVSMPTS 200
    EETLFLPENQ FSWHIACNNC QRRIVGVRYQ CSLCPSYNIC EDCEAGPYGH 250
    DTNHVLLKLR RPVVGSSEPF CHSKYSTPRL PAALEQVRLQ KQVDKNFLKA 300
    EKQRLRAEKK QRKAEVKELK KQLKLHRKIH LWNSIHGLQS PKSPLGRPES 350
    LLQSNTLMLP LQPCTSVMPM LSAAFVDENL PDGTHLQPGT KFIKHWRMKN 400
    TGNVKWSADT KLKFMWGNLT LASTEKKDVL VPCLKAGHVG VVSVEFIAPA 450
    LEGTYTSHWR LSHKGQQFGP RVWCSIIVDP FPSEESPDNI EKGMISSSKT 500
    DDLTCQQEET FLLAKEERQL GEVTEQTEGT AACIPQKAKN VASERELYIP 550
    SVDLLTAQDL LSFELLDINI VQELERVPHN TPVDVTPCMS PLPHDSPLIE 600
    KPGLGQIEEE NEGAGFKALP DSMVSVKRKA ENIASVEEAE EDLSGTQFVC 650
    ETVIRSLTLD AAPDHNPPCR QKSLQMTFAL PEGPLGNEKE EIIHIAEEEA 700
    VMEEEEDEED EEEEDELKDE VQSQSSASSE DYIIILPECF DTSRPLGDSM 750
    YSSALSQPGL ERGAEGKPGV EAGQEPAEAG ERLPGGENQP QEHSISDILT 800
    TSQTLETVPL IPEVVELPPS LPRSSPCVHH HGSPGVDLPV TIPEVSSVPD 850
    QIRGEPRGSS GLVNSRQKSY DHSRHHHGSS IAGGLVKGAL SVAASAYKAL 900
    FAGPPVTAQP IISEDQTAAL MAHLFEMGFC DRQLNLRLLK KHNYNILQVV 950
    TELLQLNNND WYSQRY 966
    Length:966
    Mass (Da):107,413
    Last modified:May 18, 2010 - v3
    Checksum:i6A057E67947838EF
    GO
    Isoform 2 (identifier: Q14596-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         910-966: PIISEDQTAA...NNNDWYSQRY → GLWGLLSFLHLAKKCFFLKAPSEAFSWF

    Note: No experimental confirmation available.

    Show »
    Length:937
    Mass (Da):103,834
    Checksum:i0228655991281A88
    GO

    Sequence cautioni

    The sequence BAA06417.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti746 – 77025LGDSM…GKPGV → WGILCTALRSHSQAWSEVLK ASLGF in CAA54274. (PubMed:8069304)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti923 – 9231H → R.3 Publications
    Corresponds to variant rs8482 [ dbSNP | Ensembl ].
    VAR_016106

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei910 – 96657PIISE…YSQRY → GLWGLLSFLHLAKKCFFLKA PSEAFSWF in isoform 2. 1 PublicationVSP_004314Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76952 mRNA. Translation: CAA54274.1.
    D30756 mRNA. Translation: BAA06417.2. Different initiation.
    AY450308 mRNA. Translation: AAS15047.1.
    AC060780 Genomic DNA. No translation available.
    AC109326 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60946.1.
    BC009808 mRNA. Translation: AAH09808.1.
    AF227189 mRNA. Translation: AAF74119.1.
    U25764 Genomic DNA. Translation: AAA93228.1.
    CCDSiCCDS45694.1. [Q14596-1]
    RefSeqiNP_001278500.1. NM_001291571.1. [Q14596-2]
    NP_001278501.1. NM_001291572.1.
    NP_005890.2. NM_005899.4. [Q14596-1]
    NP_114068.1. NM_031862.3. [Q14596-1]
    UniGeneiHs.277721.
    Hs.708158.

    Genome annotation databases

    EnsembliENST00000341165; ENSP00000343479; ENSG00000188554. [Q14596-1]
    ENST00000422280; ENSP00000411250; ENSG00000188554. [Q14596-1]
    ENST00000586650; ENSP00000466071; ENSG00000188554.
    ENST00000589872; ENSP00000467816; ENSG00000188554. [Q14596-2]
    ENST00000590996; ENSP00000466667; ENSG00000188554. [Q14596-1]
    GeneIDi4077.
    KEGGihsa:4077.
    UCSCiuc010czd.3. human. [Q14596-1]
    uc010whu.2. human. [Q14596-2]

    Polymorphism databases

    DMDMi296439290.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76952 mRNA. Translation: CAA54274.1 .
    D30756 mRNA. Translation: BAA06417.2 . Different initiation.
    AY450308 mRNA. Translation: AAS15047.1 .
    AC060780 Genomic DNA. No translation available.
    AC109326 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60946.1 .
    BC009808 mRNA. Translation: AAH09808.1 .
    AF227189 mRNA. Translation: AAF74119.1 .
    U25764 Genomic DNA. Translation: AAA93228.1 .
    CCDSi CCDS45694.1. [Q14596-1 ]
    RefSeqi NP_001278500.1. NM_001291571.1. [Q14596-2 ]
    NP_001278501.1. NM_001291572.1.
    NP_005890.2. NM_005899.4. [Q14596-1 ]
    NP_114068.1. NM_031862.3. [Q14596-1 ]
    UniGenei Hs.277721.
    Hs.708158.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WJ6 NMR - A 1-85 [» ]
    2BKF X-ray 1.56 A 1-85 [» ]
    2CP8 NMR - A 916-956 [» ]
    2G4S X-ray 2.15 A 1-85 [» ]
    2L8J NMR - B 726-738 [» ]
    2MGW NMR - A 913-959 [» ]
    2MJ5 NMR - B 913-959 [» ]
    4OLE X-ray 2.52 A/B/C/D 365-485 [» ]
    ProteinModelPortali Q14596.
    SMRi Q14596. Positions 1-85, 365-485, 913-957.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110253. 176 interactions.
    IntActi Q14596. 21 interactions.
    MINTi MINT-2806845.
    STRINGi 9606.ENSP00000343479.

    PTM databases

    PhosphoSitei Q14596.

    Polymorphism databases

    DMDMi 296439290.

    Proteomic databases

    MaxQBi Q14596.
    PaxDbi Q14596.
    PRIDEi Q14596.

    Protocols and materials databases

    DNASUi 4077.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341165 ; ENSP00000343479 ; ENSG00000188554 . [Q14596-1 ]
    ENST00000422280 ; ENSP00000411250 ; ENSG00000188554 . [Q14596-1 ]
    ENST00000586650 ; ENSP00000466071 ; ENSG00000188554 .
    ENST00000589872 ; ENSP00000467816 ; ENSG00000188554 . [Q14596-2 ]
    ENST00000590996 ; ENSP00000466667 ; ENSG00000188554 . [Q14596-1 ]
    GeneIDi 4077.
    KEGGi hsa:4077.
    UCSCi uc010czd.3. human. [Q14596-1 ]
    uc010whu.2. human. [Q14596-2 ]

    Organism-specific databases

    CTDi 4077.
    GeneCardsi GC17P041322.
    HGNCi HGNC:6746. NBR1.
    HPAi HPA022999.
    HPA023999.
    MIMi 166945. gene.
    neXtProti NX_Q14596.
    PharmGKBi PA30510.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG239857.
    HOGENOMi HOG000220861.
    HOVERGENi HBG052578.
    InParanoidi Q14596.
    KOi K17987.
    OMAi AYKALFA.
    OrthoDBi EOG7FNC6V.
    PhylomeDBi Q14596.
    TreeFami TF328428.

    Miscellaneous databases

    ChiTaRSi NBR1. human.
    EvolutionaryTracei Q14596.
    GeneWikii NBR1.
    GenomeRNAii 4077.
    NextBioi 15978.
    PROi Q14596.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14596.
    Bgeei Q14596.
    CleanExi HS_NBR1.
    Genevestigatori Q14596.

    Family and domain databases

    InterProi IPR000270. OPR_PB1.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000433. Znf_ZZ.
    [Graphical view ]
    Pfami PF00564. PB1. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view ]
    SMARTi SM00666. PB1. 1 hit.
    SM00291. ZnF_ZZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    PROSITEi PS50030. UBA. 1 hit.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-923.
      Tissue: Ovary.
    2. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
      Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
      DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    3. "Identification of a human migration inducing gene."
      Kim J.W.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-923.
      Tissue: Lymph.
    7. "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes."
      Dimitrov S., Brennerova M., Forejt J.
      Gene 262:89-98(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-42, VARIANT ARG-923.
      Tissue: Testis.
    8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 412-508.
    9. "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins."
      Lamark T., Perander M., Outzen H., Kristiansen K., Oevervatn A., Michaelsen E., Bjoerkoey G., Johansen T.
      J. Biol. Chem. 278:34568-34581(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SQSTM1, OLIGOMERIZATION, DOMAIN, MUTAGENESIS OF LYS-12 AND ASP-50.
    10. Cited for: INTERACTION WITH SQSTM1; TTN AND RNF29.
    11. "Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover."
      Waters S., Marchbank K., Solomon E., Whitehouse C., Gautel M.
      FEBS Lett. 583:1846-1852(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH USP8, UBIQUITIN-BINDING, SUBCELLULAR LOCATION.
    12. Cited for: FUNCTION, SUBCELLULAR LOCATION, DOMAIN, INTERACTION WITH SQSTM1; MAP1LC3A; MAP1LC3B; MAP1LC3C; GABARAP; GABARAPL1 AND GABARAPL2, MUTAGENESIS OF ASP-50 AND TYR-732.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Solution structure of RSGI RUH-024, a PB1 domain, and of RSGI RUH-046, a UBA domain from human next to BRCA1 gene 1 protein (KIAA0049 protein) R923H variant."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1-85 AND 916-956.
    15. "Crystal structure of the PB1 domain of NBR1."
      Mueller S., Kursula I., Zou P., Wilmanns M.
      FEBS Lett. 580:341-344(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 1-85.

    Entry informationi

    Entry nameiNBR1_HUMAN
    AccessioniPrimary (citable) accession number: Q14596
    Secondary accession number(s): Q13173
    , Q15026, Q5J7Q8, Q96GB6, Q9NRF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 146 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3