Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Next to BRCA1 gene 1 protein

Gene

NBR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.1 Publication

Caution

Was originally thought to be the ovarian carcinoma antigen CA125.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri211 – 257ZZ-typePROSITE-ProRule annotationAdd BLAST47

GO - Molecular functioni

  • mitogen-activated protein kinase binding Source: BHF-UCL
  • ubiquitin binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ14596

Names & Taxonomyi

Protein namesi
Recommended name:
Next to BRCA1 gene 1 protein
Alternative name(s):
Cell migration-inducing gene 19 protein
Membrane component chromosome 17 surface marker 2
Neighbor of BRCA1 gene 1 protein
Protein 1A1-3B
Gene namesi
Name:NBR1
Synonyms:1A13B, KIAA0049, M17S2
ORF Names:MIG19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000188554.13
HGNCiHGNC:6746 NBR1
MIMi166945 gene
neXtProtiNX_Q14596

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi12K → A: No effect on interaction with SQSTM1. 1 Publication1
Mutagenesisi50D → R: Loss of interaction with SQSTM1. 2 Publications1
Mutagenesisi732Y → A: Loss of interaction ATG8 family proteins. 1 Publication1

Organism-specific databases

DisGeNETi4077
OpenTargetsiENSG00000188554
PharmGKBiPA30510

Polymorphism and mutation databases

BioMutaiNBR1
DMDMi296439290

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000967461 – 966Next to BRCA1 gene 1 proteinAdd BLAST966

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116PhosphoserineCombined sources1
Modified residuei590PhosphoserineBy similarity1
Modified residuei596PhosphoserineBy similarity1
Modified residuei625PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14596
MaxQBiQ14596
PaxDbiQ14596
PeptideAtlasiQ14596
PRIDEiQ14596
ProteomicsDBi60070
60071 [Q14596-2]

PTM databases

GlyConnecti363
iPTMnetiQ14596
PhosphoSitePlusiQ14596
UniCarbKBiQ14596

Expressioni

Gene expression databases

BgeeiENSG00000188554
CleanExiHS_NBR1
ExpressionAtlasiQ14596 baseline and differential
GenevisibleiQ14596 HS

Organism-specific databases

HPAiHPA022944
HPA022999
HPA023999

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with TRIM55 (By similarity). Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins.By similarity4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • mitogen-activated protein kinase binding Source: BHF-UCL
  • ubiquitin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110253, 52 interactors
IntActiQ14596, 29 interactors
MINTiQ14596
STRINGi9606.ENSP00000343479

Structurei

Secondary structure

1966
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 11Combined sources7
Beta strandi14 – 21Combined sources8
Helixi23 – 25Combined sources3
Helixi28 – 39Combined sources12
Beta strandi42 – 49Combined sources8
Beta strandi55 – 58Combined sources4
Helixi61 – 73Combined sources13
Turni74 – 76Combined sources3
Beta strandi77 – 84Combined sources8
Beta strandi373 – 380Combined sources8
Beta strandi384 – 386Combined sources3
Beta strandi391 – 400Combined sources10
Beta strandi402 – 404Combined sources3
Beta strandi410 – 418Combined sources9
Beta strandi420 – 423Combined sources4
Helixi425 – 428Combined sources4
Beta strandi439 – 447Combined sources9
Beta strandi453 – 463Combined sources11
Beta strandi466 – 478Combined sources13
Helixi917 – 927Combined sources11
Helixi932 – 939Combined sources8
Turni940 – 944Combined sources5
Helixi946 – 956Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJ6NMR-A1-85[»]
2BKFX-ray1.56A1-85[»]
2CP8NMR-A916-956[»]
2G4SX-ray2.15A1-85[»]
2L8JNMR-B726-738[»]
2MGWNMR-A913-959[»]
2MJ5NMR-B913-959[»]
4OLEX-ray2.52A/B/C/D365-485[»]
ProteinModelPortaliQ14596
SMRiQ14596
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14596

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 85PB1PROSITE-ProRule annotationAdd BLAST82
Domaini913 – 957UBAPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni542 – 636ATG8 family protein-bindingAdd BLAST95
Regioni727 – 738ATG8 family protein-bindingAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi703 – 714Poly-GluAdd BLAST12

Domaini

The PB1 domain mediates interaction with SQSTM1.2 Publications

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri211 – 257ZZ-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4351 Eukaryota
KOG4582 Eukaryota
ENOG4111TKN LUCA
GeneTreeiENSGT00390000016335
HOGENOMiHOG000220861
HOVERGENiHBG052578
InParanoidiQ14596
KOiK17987
OMAiAYKALFA
OrthoDBiEOG091G0RGJ
PhylomeDBiQ14596
TreeFamiTF328428

Family and domain databases

CDDicd14947 NBR1_like, 1 hit
cd06396 PB1_NBR1, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR032350 N_BRCA1_central
IPR033513 NBR1
IPR000270 PB1_dom
IPR034852 PB1_NBR1
IPR015940 UBA
IPR009060 UBA-like_sf
IPR000433 Znf_ZZ
PANTHERiPTHR20930:SF2 PTHR20930:SF2, 1 hit
PfamiView protein in Pfam
PF16158 N_BRCA1_IG, 1 hit
PF00564 PB1, 1 hit
PF00569 ZZ, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50030 UBA, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14596-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVKVSFD LNTIQIKYLD
60 70 80 90 100
EENEEVSINS QGEYEEALKM AVKQGNQLQM QVHEGHHVVD EAPPPVVGAK
110 120 130 140 150
RLAARAGKKP LAHYSSLVRV LGSDMKTPED PAVQSFPLVP CDTDQPQDKP
160 170 180 190 200
PDWFTSYLET FREQVVNETV EKLEQKLHEK LVLQNPSLGS CPSEVSMPTS
210 220 230 240 250
EETLFLPENQ FSWHIACNNC QRRIVGVRYQ CSLCPSYNIC EDCEAGPYGH
260 270 280 290 300
DTNHVLLKLR RPVVGSSEPF CHSKYSTPRL PAALEQVRLQ KQVDKNFLKA
310 320 330 340 350
EKQRLRAEKK QRKAEVKELK KQLKLHRKIH LWNSIHGLQS PKSPLGRPES
360 370 380 390 400
LLQSNTLMLP LQPCTSVMPM LSAAFVDENL PDGTHLQPGT KFIKHWRMKN
410 420 430 440 450
TGNVKWSADT KLKFMWGNLT LASTEKKDVL VPCLKAGHVG VVSVEFIAPA
460 470 480 490 500
LEGTYTSHWR LSHKGQQFGP RVWCSIIVDP FPSEESPDNI EKGMISSSKT
510 520 530 540 550
DDLTCQQEET FLLAKEERQL GEVTEQTEGT AACIPQKAKN VASERELYIP
560 570 580 590 600
SVDLLTAQDL LSFELLDINI VQELERVPHN TPVDVTPCMS PLPHDSPLIE
610 620 630 640 650
KPGLGQIEEE NEGAGFKALP DSMVSVKRKA ENIASVEEAE EDLSGTQFVC
660 670 680 690 700
ETVIRSLTLD AAPDHNPPCR QKSLQMTFAL PEGPLGNEKE EIIHIAEEEA
710 720 730 740 750
VMEEEEDEED EEEEDELKDE VQSQSSASSE DYIIILPECF DTSRPLGDSM
760 770 780 790 800
YSSALSQPGL ERGAEGKPGV EAGQEPAEAG ERLPGGENQP QEHSISDILT
810 820 830 840 850
TSQTLETVPL IPEVVELPPS LPRSSPCVHH HGSPGVDLPV TIPEVSSVPD
860 870 880 890 900
QIRGEPRGSS GLVNSRQKSY DHSRHHHGSS IAGGLVKGAL SVAASAYKAL
910 920 930 940 950
FAGPPVTAQP IISEDQTAAL MAHLFEMGFC DRQLNLRLLK KHNYNILQVV
960
TELLQLNNND WYSQRY
Length:966
Mass (Da):107,413
Last modified:May 18, 2010 - v3
Checksum:i6A057E67947838EF
GO
Isoform 2 (identifier: Q14596-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     910-966: PIISEDQTAA...NNNDWYSQRY → GLWGLLSFLHLAKKCFFLKAPSEAFSWF

Note: No experimental confirmation available.
Show »
Length:937
Mass (Da):103,834
Checksum:i0228655991281A88
GO

Sequence cautioni

The sequence BAA06417 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti746 – 770LGDSM…GKPGV → WGILCTALRSHSQAWSEVLK ASLGF in CAA54274 (PubMed:8069304).CuratedAdd BLAST25

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016106923H → R3 PublicationsCorresponds to variant dbSNP:rs8482Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004314910 – 966PIISE…YSQRY → GLWGLLSFLHLAKKCFFLKA PSEAFSWF in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76952 mRNA Translation: CAA54274.1
D30756 mRNA Translation: BAA06417.2 Different initiation.
AY450308 mRNA Translation: AAS15047.1
AC060780 Genomic DNA No translation available.
AC109326 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60946.1
BC009808 mRNA Translation: AAH09808.1
AF227189 mRNA Translation: AAF74119.1
U25764 Genomic DNA Translation: AAA93228.1
CCDSiCCDS45694.1 [Q14596-1]
CCDS77037.1 [Q14596-2]
RefSeqiNP_001278500.1, NM_001291571.1 [Q14596-2]
NP_001278501.1, NM_001291572.1
NP_005890.2, NM_005899.4 [Q14596-1]
NP_114068.1, NM_031862.3 [Q14596-1]
XP_011523115.1, XM_011524813.1 [Q14596-1]
XP_016880131.1, XM_017024642.1 [Q14596-1]
UniGeneiHs.277721
Hs.708158

Genome annotation databases

EnsembliENST00000341165; ENSP00000343479; ENSG00000188554 [Q14596-1]
ENST00000589872; ENSP00000467816; ENSG00000188554 [Q14596-2]
ENST00000590996; ENSP00000466667; ENSG00000188554 [Q14596-1]
GeneIDi4077
KEGGihsa:4077
UCSCiuc010czd.4 human [Q14596-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNBR1_HUMAN
AccessioniPrimary (citable) accession number: Q14596
Secondary accession number(s): Q13173
, Q15026, Q5J7Q8, Q96GB6, Q9NRF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 184 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health