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Q14593

- ZN273_HUMAN

UniProt

Q14593 - ZN273_HUMAN

Protein

Zinc finger protein 273

Gene

ZNF273

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 3 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri206 – 22823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri234 – 25623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri262 – 28423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri290 – 31223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri318 – 34023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri346 – 36823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri374 – 39623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri402 – 42322C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri430 – 45223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri458 – 48023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri486 – 50823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri514 – 53623C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri542 – 56423C2H2-type 13; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 273
    Alternative name(s):
    Zinc finger protein HZF9
    Gene namesi
    Name:ZNF273
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:13067. ZNF273.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37643.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 569569Zinc finger protein 273PRO_0000047500Add
    BLAST

    Proteomic databases

    MaxQBiQ14593.
    PaxDbiQ14593.
    PRIDEiQ14593.

    PTM databases

    PhosphoSiteiQ14593.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14593.
    BgeeiQ14593.
    CleanExiHS_ZNF273.
    GenevestigatoriQ14593.

    Interactioni

    Protein-protein interaction databases

    BioGridi116008. 3 interactions.
    IntActiQ14593. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14593.
    SMRiQ14593. Positions 30-77, 190-544.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini66 – 10843KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri206 – 22823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri234 – 25623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri262 – 28423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri290 – 31223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri318 – 34023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri346 – 36823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri374 – 39623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri402 – 42322C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri430 – 45223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri458 – 48023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri486 – 50823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri514 – 53623C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri542 – 56423C2H2-type 13; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ14593.
    KOiK09228.
    OMAiKSCCILS.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ14593.
    TreeFamiTF342117.

    Family and domain databases

    Gene3Di3.30.160.60. 13 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14593-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSAPRGPPS VAPLPAGIGR STAKTPGLPG SLEMGPLTFR DVAIEFSLEE    50
    WQCLDTSQQN LYRNVMLDNY RNLVFLGIAV SKPDLITCLE QGKEPCNMKR 100
    HAMVAKPPVV CSHFAQDLWP KQGLKDSFQK VILRRYGKYG HENLQLRKGC 150
    KSADEHKVHK RGYNGLNQCL TTTQSKIFQC DKYVKVLHKF SNSNIHKKRQ 200
    TGKKPFKCKE CGKSCCILSQ LTQHKKTATR VNFYKCKTCG KAFNQFSNLT 250
    KHKIIHPEVN PYKCEECGKA FNQSLTLTKH KKIHTEEKPY KCEDCGKVFS 300
    VFSVLTKHKI IHTGTKPYNC EECGKGFSIF STLTKHKIIH TGEKPYKCNE 350
    CGKAFNWSST LTKHKRIHTG EKPYKCEECG KAFNQSSTLT RHKIVHTGEK 400
    PYKCEECGKA FKRSTTLTKH KRIYTKEKPY KCEECGKAFS VFSTLTKHKI 450
    IHTGAKPYKC EECGSAFRAF STLTEHKRVH TGEKPYKCNE CGKAFNWSST 500
    LTKHKRIHTG EKPYKCEECG KAFNRSSNLT RHKKIHTGEK PYKPKRCDSA 550
    FDNTPNFSRH KRNHMGEKS 569

    Note: No experimental confirmation available. Derived from EST data.

    Length:569
    Mass (Da):64,971
    Last modified:September 22, 2009 - v3
    Checksum:iD07D8C3B2AF81EEF
    GO
    Isoform 2 (identifier: Q14593-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-65: Missing.

    Show »
    Length:504
    Mass (Da):58,045
    Checksum:iA19856761243F287
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti418 – 4181Missing in CAA55532. (PubMed:7865130)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti454 – 4541G → E.
    Corresponds to variant rs1830080 [ dbSNP | Ensembl ].
    VAR_059077
    Natural varianti461 – 4611E → D.1 Publication
    Corresponds to variant rs2017252 [ dbSNP | Ensembl ].
    VAR_059078

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6565Missing in isoform 2. 2 PublicationsVSP_038180Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090648 mRNA. Translation: BAG52207.1.
    DA094186 mRNA. No translation available.
    AC092161 Genomic DNA. No translation available.
    CH471204 Genomic DNA. Translation: EAW77994.1.
    BC063818 mRNA. Translation: AAH63818.1.
    X78932 mRNA. Translation: CAA55532.1.
    CCDSiCCDS5528.2. [Q14593-1]
    PIRiS47070.
    RefSeqiNP_066971.2. NM_021148.2. [Q14593-1]
    XP_006715903.1. XM_006715840.1. [Q14593-2]
    XP_006715904.1. XM_006715841.1. [Q14593-2]
    UniGeneiHs.520889.

    Genome annotation databases

    EnsembliENST00000476120; ENSP00000418719; ENSG00000198039. [Q14593-1]
    GeneIDi10793.
    KEGGihsa:10793.
    UCSCiuc003ttl.3. human. [Q14593-1]

    Polymorphism databases

    DMDMi259016458.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090648 mRNA. Translation: BAG52207.1 .
    DA094186 mRNA. No translation available.
    AC092161 Genomic DNA. No translation available.
    CH471204 Genomic DNA. Translation: EAW77994.1 .
    BC063818 mRNA. Translation: AAH63818.1 .
    X78932 mRNA. Translation: CAA55532.1 .
    CCDSi CCDS5528.2. [Q14593-1 ]
    PIRi S47070.
    RefSeqi NP_066971.2. NM_021148.2. [Q14593-1 ]
    XP_006715903.1. XM_006715840.1. [Q14593-2 ]
    XP_006715904.1. XM_006715841.1. [Q14593-2 ]
    UniGenei Hs.520889.

    3D structure databases

    ProteinModelPortali Q14593.
    SMRi Q14593. Positions 30-77, 190-544.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116008. 3 interactions.
    IntActi Q14593. 1 interaction.

    PTM databases

    PhosphoSitei Q14593.

    Polymorphism databases

    DMDMi 259016458.

    Proteomic databases

    MaxQBi Q14593.
    PaxDbi Q14593.
    PRIDEi Q14593.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000476120 ; ENSP00000418719 ; ENSG00000198039 . [Q14593-1 ]
    GeneIDi 10793.
    KEGGi hsa:10793.
    UCSCi uc003ttl.3. human. [Q14593-1 ]

    Organism-specific databases

    CTDi 10793.
    GeneCardsi GC07P064330.
    HGNCi HGNC:13067. ZNF273.
    MIMi 604756. gene.
    neXtProti NX_Q14593.
    PharmGKBi PA37643.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q14593.
    KOi K09228.
    OMAi KSCCILS.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q14593.
    TreeFami TF342117.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    ChiTaRSi ZNF273. human.
    GenomeRNAii 10793.
    NextBioi 40990.
    PROi Q14593.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14593.
    Bgeei Q14593.
    CleanExi HS_ZNF273.
    Genevestigatori Q14593.

    Family and domain databases

    Gene3Di 3.30.160.60. 13 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-175 (ISOFORM 1).
      Tissue: Cerebellum.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Uterus.
    5. "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
      Abrink M., Aveskogh M., Hellman L.
      DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 322-569 (ISOFORMS 1/2), VARIANT ASP-461.

    Entry informationi

    Entry nameiZN273_HUMAN
    AccessioniPrimary (citable) accession number: Q14593
    Secondary accession number(s): B3KQZ5, Q6P3V4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 139 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3