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Q14593

- ZN273_HUMAN

UniProt

Q14593 - ZN273_HUMAN

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Protein

Zinc finger protein 273

Gene

ZNF273

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 22823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri346 – 36823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42322C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri542 – 56423C2H2-type 13; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 273
Alternative name(s):
Zinc finger protein HZF9
Gene namesi
Name:ZNF273
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:13067. ZNF273.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Zinc finger protein 273PRO_0000047500Add
BLAST

Proteomic databases

MaxQBiQ14593.
PaxDbiQ14593.
PRIDEiQ14593.

PTM databases

PhosphoSiteiQ14593.

Expressioni

Gene expression databases

BgeeiQ14593.
CleanExiHS_ZNF273.
ExpressionAtlasiQ14593. baseline and differential.
GenevestigatoriQ14593.

Interactioni

Protein-protein interaction databases

BioGridi116008. 4 interactions.
IntActiQ14593. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ14593.
SMRiQ14593. Positions 30-77, 190-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 10843KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 22823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri234 – 25623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri290 – 31223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri346 – 36823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42322C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri514 – 53623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri542 – 56423C2H2-type 13; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074383.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14593.
KOiK09228.
OMAiKSCCILS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ14593.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14593-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSAPRGPPS VAPLPAGIGR STAKTPGLPG SLEMGPLTFR DVAIEFSLEE
60 70 80 90 100
WQCLDTSQQN LYRNVMLDNY RNLVFLGIAV SKPDLITCLE QGKEPCNMKR
110 120 130 140 150
HAMVAKPPVV CSHFAQDLWP KQGLKDSFQK VILRRYGKYG HENLQLRKGC
160 170 180 190 200
KSADEHKVHK RGYNGLNQCL TTTQSKIFQC DKYVKVLHKF SNSNIHKKRQ
210 220 230 240 250
TGKKPFKCKE CGKSCCILSQ LTQHKKTATR VNFYKCKTCG KAFNQFSNLT
260 270 280 290 300
KHKIIHPEVN PYKCEECGKA FNQSLTLTKH KKIHTEEKPY KCEDCGKVFS
310 320 330 340 350
VFSVLTKHKI IHTGTKPYNC EECGKGFSIF STLTKHKIIH TGEKPYKCNE
360 370 380 390 400
CGKAFNWSST LTKHKRIHTG EKPYKCEECG KAFNQSSTLT RHKIVHTGEK
410 420 430 440 450
PYKCEECGKA FKRSTTLTKH KRIYTKEKPY KCEECGKAFS VFSTLTKHKI
460 470 480 490 500
IHTGAKPYKC EECGSAFRAF STLTEHKRVH TGEKPYKCNE CGKAFNWSST
510 520 530 540 550
LTKHKRIHTG EKPYKCEECG KAFNRSSNLT RHKKIHTGEK PYKPKRCDSA
560
FDNTPNFSRH KRNHMGEKS

Note: No experimental confirmation available. Derived from EST data.

Length:569
Mass (Da):64,971
Last modified:September 22, 2009 - v3
Checksum:iD07D8C3B2AF81EEF
GO
Isoform 2 (identifier: Q14593-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Show »
Length:504
Mass (Da):58,045
Checksum:iA19856761243F287
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti418 – 4181Missing in CAA55532. (PubMed:7865130)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti454 – 4541G → E.
Corresponds to variant rs1830080 [ dbSNP | Ensembl ].
VAR_059077
Natural varianti461 – 4611E → D.1 Publication
Corresponds to variant rs2017252 [ dbSNP | Ensembl ].
VAR_059078

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6565Missing in isoform 2. 2 PublicationsVSP_038180Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090648 mRNA. Translation: BAG52207.1.
DA094186 mRNA. No translation available.
AC092161 Genomic DNA. No translation available.
CH471204 Genomic DNA. Translation: EAW77994.1.
BC063818 mRNA. Translation: AAH63818.1.
X78932 mRNA. Translation: CAA55532.1.
CCDSiCCDS5528.2. [Q14593-1]
PIRiS47070.
RefSeqiNP_066971.2. NM_021148.2. [Q14593-1]
XP_006715903.1. XM_006715840.1. [Q14593-2]
XP_006715904.1. XM_006715841.1. [Q14593-2]
UniGeneiHs.520889.

Genome annotation databases

EnsembliENST00000476120; ENSP00000418719; ENSG00000198039. [Q14593-1]
GeneIDi10793.
KEGGihsa:10793.
UCSCiuc003ttl.3. human. [Q14593-1]

Polymorphism databases

DMDMi259016458.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090648 mRNA. Translation: BAG52207.1 .
DA094186 mRNA. No translation available.
AC092161 Genomic DNA. No translation available.
CH471204 Genomic DNA. Translation: EAW77994.1 .
BC063818 mRNA. Translation: AAH63818.1 .
X78932 mRNA. Translation: CAA55532.1 .
CCDSi CCDS5528.2. [Q14593-1 ]
PIRi S47070.
RefSeqi NP_066971.2. NM_021148.2. [Q14593-1 ]
XP_006715903.1. XM_006715840.1. [Q14593-2 ]
XP_006715904.1. XM_006715841.1. [Q14593-2 ]
UniGenei Hs.520889.

3D structure databases

ProteinModelPortali Q14593.
SMRi Q14593. Positions 30-77, 190-544.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116008. 4 interactions.
IntActi Q14593. 1 interaction.

PTM databases

PhosphoSitei Q14593.

Polymorphism databases

DMDMi 259016458.

Proteomic databases

MaxQBi Q14593.
PaxDbi Q14593.
PRIDEi Q14593.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000476120 ; ENSP00000418719 ; ENSG00000198039 . [Q14593-1 ]
GeneIDi 10793.
KEGGi hsa:10793.
UCSCi uc003ttl.3. human. [Q14593-1 ]

Organism-specific databases

CTDi 10793.
GeneCardsi GC07P064330.
HGNCi HGNC:13067. ZNF273.
MIMi 604756. gene.
neXtProti NX_Q14593.
PharmGKBi PA37643.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00550000074383.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q14593.
KOi K09228.
OMAi KSCCILS.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q14593.
TreeFami TF342117.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF273. human.
GenomeRNAii 10793.
NextBioi 40990.
PROi Q14593.
SOURCEi Search...

Gene expression databases

Bgeei Q14593.
CleanExi HS_ZNF273.
ExpressionAtlasi Q14593. baseline and differential.
Genevestigatori Q14593.

Family and domain databases

Gene3Di 3.30.160.60. 13 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-175 (ISOFORM 1).
    Tissue: Cerebellum.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  5. "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
    Abrink M., Aveskogh M., Hellman L.
    DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 322-569 (ISOFORMS 1/2), VARIANT ASP-461.

Entry informationi

Entry nameiZN273_HUMAN
AccessioniPrimary (citable) accession number: Q14593
Secondary accession number(s): B3KQZ5, Q6P3V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3