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Protein

Zinc finger protein 273

Gene

ZNF273

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 423C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri430 – 452C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 273
Alternative name(s):
Zinc finger protein HZF9
Gene namesi
Name:ZNF273
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000198039.11.
HGNCiHGNC:13067. ZNF273.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10793.
OpenTargetsiENSG00000198039.
PharmGKBiPA37643.

Polymorphism and mutation databases

BioMutaiZNF273.
DMDMi259016458.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475001 – 569Zinc finger protein 273Add BLAST569

Proteomic databases

EPDiQ14593.
MaxQBiQ14593.
PaxDbiQ14593.
PeptideAtlasiQ14593.
PRIDEiQ14593.

PTM databases

iPTMnetiQ14593.
PhosphoSitePlusiQ14593.

Expressioni

Gene expression databases

BgeeiENSG00000198039.
CleanExiHS_ZNF273.
ExpressionAtlasiQ14593. baseline and differential.
GenevisibleiQ14593. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-5P603703EBI-3922471,EBI-10172150

Protein-protein interaction databases

BioGridi116008. 12 interactors.
IntActiQ14593. 7 interactors.
STRINGi9606.ENSP00000418719.

Structurei

3D structure databases

ProteinModelPortaliQ14593.
SMRiQ14593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 108KRABPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 423C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri430 – 452C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139354.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14593.
KOiK09228.
OMAiCNMKRHA.
OrthoDBiEOG091G02KC.
PhylomeDBiQ14593.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14593-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSAPRGPPS VAPLPAGIGR STAKTPGLPG SLEMGPLTFR DVAIEFSLEE
60 70 80 90 100
WQCLDTSQQN LYRNVMLDNY RNLVFLGIAV SKPDLITCLE QGKEPCNMKR
110 120 130 140 150
HAMVAKPPVV CSHFAQDLWP KQGLKDSFQK VILRRYGKYG HENLQLRKGC
160 170 180 190 200
KSADEHKVHK RGYNGLNQCL TTTQSKIFQC DKYVKVLHKF SNSNIHKKRQ
210 220 230 240 250
TGKKPFKCKE CGKSCCILSQ LTQHKKTATR VNFYKCKTCG KAFNQFSNLT
260 270 280 290 300
KHKIIHPEVN PYKCEECGKA FNQSLTLTKH KKIHTEEKPY KCEDCGKVFS
310 320 330 340 350
VFSVLTKHKI IHTGTKPYNC EECGKGFSIF STLTKHKIIH TGEKPYKCNE
360 370 380 390 400
CGKAFNWSST LTKHKRIHTG EKPYKCEECG KAFNQSSTLT RHKIVHTGEK
410 420 430 440 450
PYKCEECGKA FKRSTTLTKH KRIYTKEKPY KCEECGKAFS VFSTLTKHKI
460 470 480 490 500
IHTGAKPYKC EECGSAFRAF STLTEHKRVH TGEKPYKCNE CGKAFNWSST
510 520 530 540 550
LTKHKRIHTG EKPYKCEECG KAFNRSSNLT RHKKIHTGEK PYKPKRCDSA
560
FDNTPNFSRH KRNHMGEKS
Note: No experimental confirmation available. Derived from EST data.
Length:569
Mass (Da):64,971
Last modified:September 22, 2009 - v3
Checksum:iD07D8C3B2AF81EEF
GO
Isoform 2 (identifier: Q14593-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Show »
Length:504
Mass (Da):58,045
Checksum:iA19856761243F287
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti418Missing in CAA55532 (PubMed:7865130).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059077454G → E. Corresponds to variant dbSNP:rs1830080Ensembl.1
Natural variantiVAR_059078461E → D1 PublicationCorresponds to variant dbSNP:rs2017252Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0381801 – 65Missing in isoform 2. 2 PublicationsAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090648 mRNA. Translation: BAG52207.1.
DA094186 mRNA. No translation available.
AC092161 Genomic DNA. No translation available.
CH471204 Genomic DNA. Translation: EAW77994.1.
BC063818 mRNA. Translation: AAH63818.1.
X78932 mRNA. Translation: CAA55532.1.
CCDSiCCDS5528.2. [Q14593-1]
PIRiS47070.
RefSeqiNP_066971.2. NM_021148.2. [Q14593-1]
XP_016867177.1. XM_017011688.1. [Q14593-1]
XP_016867178.1. XM_017011689.1. [Q14593-2]
XP_016867179.1. XM_017011690.1. [Q14593-2]
XP_016867180.1. XM_017011691.1. [Q14593-2]
XP_016867181.1. XM_017011692.1. [Q14593-2]
XP_016867182.1. XM_017011693.1. [Q14593-2]
XP_016867183.1. XM_017011694.1. [Q14593-2]
XP_016867184.1. XM_017011695.1. [Q14593-2]
XP_016867185.1. XM_017011696.1. [Q14593-2]
XP_016867186.1. XM_017011697.1. [Q14593-2]
XP_016867187.1. XM_017011698.1. [Q14593-2]
UniGeneiHs.520889.

Genome annotation databases

EnsembliENST00000476120; ENSP00000418719; ENSG00000198039. [Q14593-1]
GeneIDi10793.
KEGGihsa:10793.
UCSCiuc003tto.4. human. [Q14593-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN273_HUMAN
AccessioniPrimary (citable) accession number: Q14593
Secondary accession number(s): B3KQZ5, Q6P3V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 22, 2009
Last modified: November 22, 2017
This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families