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Protein

Zinc finger protein 460

Gene

ZNF460

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri196 – 21823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 460
Alternative name(s):
Zinc finger protein 272
Zinc finger protein HZF8
Gene namesi
Name:ZNF460
Synonyms:ZNF272
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:21628. ZNF460.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37642.

Polymorphism and mutation databases

BioMutaiZNF460.
DMDMi85681860.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Zinc finger protein 460PRO_0000047499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki194 – 194Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki209 – 209Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki278 – 278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki306 – 306Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki362 – 362Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ14592.
MaxQBiQ14592.
PaxDbiQ14592.
PeptideAtlasiQ14592.
PRIDEiQ14592.

PTM databases

iPTMnetiQ14592.
PhosphoSiteiQ14592.

Expressioni

Tissue specificityi

Ubiquitously expressed at low levels. Highest levels are found in pancreas and liver.1 Publication

Gene expression databases

BgeeiENSG00000197714.
CleanExiHS_ZNF460.
ExpressionAtlasiQ14592. baseline and differential.
GenevisibleiQ14592. HS.

Organism-specific databases

HPAiHPA053004.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC67Q05D603EBI-2555738,EBI-748597
FGF12P613283EBI-2555738,EBI-6657662
ZNF250P15622-33EBI-2555738,EBI-10177272

Protein-protein interaction databases

BioGridi116009. 25 interactions.
IntActiQ14592. 8 interactions.
STRINGi9606.ENSP00000353491.

Structurei

3D structure databases

ProteinModelPortaliQ14592.
SMRiQ14592. Positions 177-534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 9987KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri196 – 21823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14592.
KOiK09228.
OMAiRVKPYDC.
OrthoDBiEOG091G02KC.
PhylomeDBiQ14592.
TreeFamiTF340405.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14592-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAWMAPAQ ESVTFEDVAV TFTQEEWGQL DVTQRALYVE VMLETCGLLV
60 70 80 90 100
ALGDSTKPET VEPIPSHLAL PEEVSLQEQL AQGVPRYSYL GQAMDQDGPS
110 120 130 140 150
EMQEYFLRPG TDPQSEKLHG KMSLEHEGLA TADGICSMMI QNQVSPEDAL
160 170 180 190 200
YGFDSYGPVT DSLIHEGENS YKFEEMFNEN CFLVQHEQIL PRVKPYDCPE
210 220 230 240 250
CGKAFGKSKH LLQHHIIHTG EKPYKCLECG KDFNRRSHLT RHQRTHNGDK
260 270 280 290 300
PFVCSECGRT FNRGSHLTRH QRVHSGEKPF VCNECGKAFT YRSNFVLHNK
310 320 330 340 350
SHNEKKPFAC SECGKGFYES TALIQHFIIH TGERPFKCLE CGKAFNCRSH
360 370 380 390 400
LKQHERIHTG EKPFVCSQCG KAFTHYSTYV LHERAHTGEK PFECKECGKA
410 420 430 440 450
FSIRKDLIRH FNIHTGEKPY ECLQCGKAFT RMSGLTRHQW IHTGEKPYVC
460 470 480 490 500
IQCGKAFCRT TNLIRHFSIH TGEKPYECVE CGKAFNRRSP LTRHQRIHTA
510 520 530 540 550
EKSHEPIQSG NVSCESTDLI QHSIIHTESS PVSAVNMETP SIAAHSSSLD
560
INGFIVEETL PL
Length:562
Mass (Da):63,665
Last modified:January 10, 2006 - v2
Checksum:iD74C8AA7DC4ECC79
GO
Isoform 2 (identifier: Q14592-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Note: No experimental confirmation available.
Show »
Length:521
Mass (Da):59,064
Checksum:i558C98B26DEBB274
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti451 – 4511I → T in AAR00225 (PubMed:15004467).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4141Missing in isoform 2. 1 PublicationVSP_055954Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY329492 mRNA. Translation: AAR00225.1.
AK298106 mRNA. Translation: BAG60391.1.
AC005261 Genomic DNA. No translation available.
BC109018 mRNA. Translation: AAI09019.1.
BC109019 mRNA. Translation: AAI09020.1.
BC118625 mRNA. Translation: AAI18626.1.
X78931 mRNA. Translation: CAA55531.1.
CCDSiCCDS12949.1. [Q14592-1]
PIRiS47069.
RefSeqiNP_006626.3. NM_006635.3. [Q14592-1]
XP_005258479.1. XM_005258422.3. [Q14592-2]
UniGeneiHs.99971.

Genome annotation databases

EnsembliENST00000360338; ENSP00000353491; ENSG00000197714. [Q14592-1]
ENST00000537645; ENSP00000446167; ENSG00000197714. [Q14592-2]
GeneIDi10794.
KEGGihsa:10794.
UCSCiuc002qog.3. human. [Q14592-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY329492 mRNA. Translation: AAR00225.1.
AK298106 mRNA. Translation: BAG60391.1.
AC005261 Genomic DNA. No translation available.
BC109018 mRNA. Translation: AAI09019.1.
BC109019 mRNA. Translation: AAI09020.1.
BC118625 mRNA. Translation: AAI18626.1.
X78931 mRNA. Translation: CAA55531.1.
CCDSiCCDS12949.1. [Q14592-1]
PIRiS47069.
RefSeqiNP_006626.3. NM_006635.3. [Q14592-1]
XP_005258479.1. XM_005258422.3. [Q14592-2]
UniGeneiHs.99971.

3D structure databases

ProteinModelPortaliQ14592.
SMRiQ14592. Positions 177-534.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116009. 25 interactions.
IntActiQ14592. 8 interactions.
STRINGi9606.ENSP00000353491.

PTM databases

iPTMnetiQ14592.
PhosphoSiteiQ14592.

Polymorphism and mutation databases

BioMutaiZNF460.
DMDMi85681860.

Proteomic databases

EPDiQ14592.
MaxQBiQ14592.
PaxDbiQ14592.
PeptideAtlasiQ14592.
PRIDEiQ14592.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360338; ENSP00000353491; ENSG00000197714. [Q14592-1]
ENST00000537645; ENSP00000446167; ENSG00000197714. [Q14592-2]
GeneIDi10794.
KEGGihsa:10794.
UCSCiuc002qog.3. human. [Q14592-1]

Organism-specific databases

CTDi10794.
GeneCardsiZNF460.
HGNCiHGNC:21628. ZNF460.
HPAiHPA053004.
MIMi604755. gene.
neXtProtiNX_Q14592.
PharmGKBiPA37642.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14592.
KOiK09228.
OMAiRVKPYDC.
OrthoDBiEOG091G02KC.
PhylomeDBiQ14592.
TreeFamiTF340405.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii10794.
PROiQ14592.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197714.
CleanExiHS_ZNF460.
ExpressionAtlasiQ14592. baseline and differential.
GenevisibleiQ14592. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN460_HUMAN
AccessioniPrimary (citable) accession number: Q14592
Secondary accession number(s): A4FU64
, B4DNX9, Q2VPC7, Q6VSF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 10, 2006
Last modified: September 7, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.