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Protein

Zinc finger protein 460

Gene

ZNF460

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri196 – 218C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 460
Alternative name(s):
Zinc finger protein 272
Zinc finger protein HZF8
Gene namesi
Name:ZNF460
Synonyms:ZNF272
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197714.8
HGNCiHGNC:21628 ZNF460
MIMi604755 gene
neXtProtiNX_Q14592

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197714
PharmGKBiPA37642

Polymorphism and mutation databases

BioMutaiZNF460
DMDMi85681860

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474991 – 562Zinc finger protein 460Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki194Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki207Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki209Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki300Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki306Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki362Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki371Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki446Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki455Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ14592
MaxQBiQ14592
PaxDbiQ14592
PeptideAtlasiQ14592
PRIDEiQ14592

PTM databases

iPTMnetiQ14592
PhosphoSitePlusiQ14592

Expressioni

Tissue specificityi

Ubiquitously expressed at low levels. Highest levels are found in pancreas and liver.1 Publication

Gene expression databases

BgeeiENSG00000197714
CleanExiHS_ZNF460
ExpressionAtlasiQ14592 baseline and differential
GenevisibleiQ14592 HS

Organism-specific databases

HPAiHPA053004
HPA066506

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116009, 28 interactors
IntActiQ14592, 11 interactors
STRINGi9606.ENSP00000353491

Structurei

3D structure databases

ProteinModelPortaliQ14592
SMRiQ14592
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 99KRABPROSITE-ProRule annotationAdd BLAST87

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri196 – 218C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00750000117699
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ14592
KOiK09228
OMAiRVKPYDC
OrthoDBiEOG091G02KC
PhylomeDBiQ14592
TreeFamiTF340405

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14592-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAWMAPAQ ESVTFEDVAV TFTQEEWGQL DVTQRALYVE VMLETCGLLV
60 70 80 90 100
ALGDSTKPET VEPIPSHLAL PEEVSLQEQL AQGVPRYSYL GQAMDQDGPS
110 120 130 140 150
EMQEYFLRPG TDPQSEKLHG KMSLEHEGLA TADGICSMMI QNQVSPEDAL
160 170 180 190 200
YGFDSYGPVT DSLIHEGENS YKFEEMFNEN CFLVQHEQIL PRVKPYDCPE
210 220 230 240 250
CGKAFGKSKH LLQHHIIHTG EKPYKCLECG KDFNRRSHLT RHQRTHNGDK
260 270 280 290 300
PFVCSECGRT FNRGSHLTRH QRVHSGEKPF VCNECGKAFT YRSNFVLHNK
310 320 330 340 350
SHNEKKPFAC SECGKGFYES TALIQHFIIH TGERPFKCLE CGKAFNCRSH
360 370 380 390 400
LKQHERIHTG EKPFVCSQCG KAFTHYSTYV LHERAHTGEK PFECKECGKA
410 420 430 440 450
FSIRKDLIRH FNIHTGEKPY ECLQCGKAFT RMSGLTRHQW IHTGEKPYVC
460 470 480 490 500
IQCGKAFCRT TNLIRHFSIH TGEKPYECVE CGKAFNRRSP LTRHQRIHTA
510 520 530 540 550
EKSHEPIQSG NVSCESTDLI QHSIIHTESS PVSAVNMETP SIAAHSSSLD
560
INGFIVEETL PL
Length:562
Mass (Da):63,665
Last modified:January 10, 2006 - v2
Checksum:iD74C8AA7DC4ECC79
GO
Isoform 2 (identifier: Q14592-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Note: No experimental confirmation available.
Show »
Length:521
Mass (Da):59,064
Checksum:i558C98B26DEBB274
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti451I → T in AAR00225 (PubMed:15004467).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559541 – 41Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY329492 mRNA Translation: AAR00225.1
AK298106 mRNA Translation: BAG60391.1
AC005261 Genomic DNA No translation available.
BC109018 mRNA Translation: AAI09019.1
BC109019 mRNA Translation: AAI09020.1
BC118625 mRNA Translation: AAI18626.1
X78931 mRNA Translation: CAA55531.1
CCDSiCCDS12949.1 [Q14592-1]
CCDS82404.1 [Q14592-2]
PIRiS47069
RefSeqiNP_001317551.1, NM_001330622.1 [Q14592-2]
NP_006626.3, NM_006635.3 [Q14592-1]
UniGeneiHs.99971

Genome annotation databases

EnsembliENST00000360338; ENSP00000353491; ENSG00000197714 [Q14592-1]
ENST00000537645; ENSP00000446167; ENSG00000197714 [Q14592-2]
GeneIDi10794
KEGGihsa:10794
UCSCiuc002qog.3 human [Q14592-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN460_HUMAN
AccessioniPrimary (citable) accession number: Q14592
Secondary accession number(s): A4FU64
, B4DNX9, Q2VPC7, Q6VSF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 10, 2006
Last modified: May 23, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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