Reviewed, UniProtKB/Swiss-Prot Q14591 (ZN271_HUMAN)

Names and origin

Protein names

Recommended name:
    Zinc finger protein 271
Alternative name(s):
    Zinc finger protein 7
    HZF7
    Zinc finger protein ZNFphex133
    Epstein-Barr virus-induced zinc finger protein
    ZNF-EB
    CT-ZFP48
    Zinc finger protein dp
      Short name=ZNF-dp

Gene names

Name:	ZNF271
Synonyms:	ZNFEB

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	655 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in transcriptional regulation. Plays a role in the EBV-mediated transformation process.
Subcellular location	Nucleus Probable.
Tissue specificity	Expressed in T-cell lines, thymocytes, thyroid, and pancreatic islet cells. Ref.2
Induction	By Epstein-Barr virus. Ref.2
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 19 C2H2-type zinc fingers.
Sequence caution	The sequence AAK52068.1 differs from that shown. Reason: Frameshift at position 481.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14591-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14591-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-480: MEIQFNYESQ...LHQRIHTGEK → MCVGKPSVRA...FIREFTLEKN

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 655	655	Zinc finger protein 271		PRO_0000047496
Regions
	Zinc finger	77 – 99	23	C2H2-type 1; degenerate
	Zinc finger	118 – 140	23	C2H2-type 2
	Zinc finger	146 – 168	23	C2H2-type 3
	Zinc finger	174 – 196	23	C2H2-type 4
	Zinc finger	202 – 224	23	C2H2-type 5
	Zinc finger	230 – 252	23	C2H2-type 6
	Zinc finger	258 – 280	23	C2H2-type 7
	Zinc finger	286 – 308	23	C2H2-type 8
	Zinc finger	314 – 336	23	C2H2-type 9
	Zinc finger	342 – 364	23	C2H2-type 10
	Zinc finger	370 – 392	23	C2H2-type 11
	Zinc finger	398 – 420	23	C2H2-type 12
	Zinc finger	426 – 448	23	C2H2-type 13
	Zinc finger	454 – 476	23	C2H2-type 14
	Zinc finger	482 – 504	23	C2H2-type 15
	Zinc finger	510 – 532	23	C2H2-type 16
	Zinc finger	538 – 560	23	C2H2-type 17
	Zinc finger	566 – 588	23	C2H2-type 18
	Zinc finger	594 – 616	23	C2H2-type 19
Natural variations
	Alternative sequence	1 – 480	480	MEIQF…HTGEK → MCVGKPSVRAQILFCIRESI LGRNHIHVISVAKVSVRIQT LLNIEGSTLERNPINVMSVG KLLIRAQSLFYIRGFILERN PIPVINVAKPSVGFQILLII NEFTLERSLTHVISAIKCLV EDEILLNITEFIQVRNPMNV MNVGKPLVRAPTLFFIREST LERNLMHVVIVLKALVAVQI LLSIKEYTLERNHMHVISVI KVLVKAQTSLNIREYTLVKS LIIAIVVRKPSVRVLTLFFI REFTLEKN in isoform 2.		VSP_019779
Experimental info
	Sequence conflict	134	1	I → N Ref.5
	Sequence conflict	524 – 526	3	LLA → ALT Ref.2
	Sequence conflict	524 – 526	3	LLA → ALT Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 11, 2006. Version 3. Checksum: 716775F938DBC324	FASTA	655	75,547
	10 20 30 40 50 60 MEIQFNYESQ EHHLLSDGEN KTKIGKPASE EGITAKIEPL TEESSSLRMF SRILKAKNSV 70 80 90 100 110 120 NLGINEKDQN VFKRRPHNCD EYGQSFVWST SLFRHRKTHC EKPYEWDKCG KATGEKPYSC 130 140 150 160 170 180 NWCIKSFSWS SDLIKHQRVH TGEKPYKCDE CGKAFSQSSD LIIHQRIHIG EKPYQCRHCS 190 200 210 220 230 240 KSFSQRSDLV KHQRIHTGEK PYTCNQCNKH FSQSSDVIKH QRIHTGEKPY KCDVCGKAFS 250 260 270 280 290 300 QSSDLILHQR IHTGEKPYPC NQCSKSFSQN SDLIKHRRIH TGEKPYKCNE CGKAFNQSSV 310 320 330 340 350 360 LILHQRIHTG EKPYPCDQCS KTFSRLSDLI NHQRIHTGEK PYPCNQCNKM FSRRSDLVKH 370 380 390 400 410 420 HRIHTGEKPY ECDECGKTFS QSSNLILHQR IHTGEKPYAC SDCTKSFSRR SDLVKHQRIH 430 440 450 460 470 480 TGEKPYACNQ CDKSFSQSSD LTKHQRVHSG EKPYHCNSCE KAFSQSSDLI LHQRIHTGEK 490 500 510 520 530 540 YYLCTQCSKS FSQISDLIKH QRIHTGEKPY KCSECRKAFS QCSLLALHQR IHTGKKPNPC 550 560 570 580 590 600 DECGKSFSRR SDLINHQKIH TGEKPYKCDA CGKAFSTCTD LIEHQKTHAE EKPYQCVQCS 610 620 630 640 650 RSCSQLSELT IHEEVHCGED SQNVMNVRKP LVCTPTLFST RDTVPEKNLM NAVDY
	Isoform 2. Checksum: 95673654BFAA92A9	FASTA	423	48,176
	10 20 30 40 50 60 MCVGKPSVRA QILFCIRESI LGRNHIHVIS VAKVSVRIQT LLNIEGSTLE RNPINVMSVG 70 80 90 100 110 120 KLLIRAQSLF YIRGFILERN PIPVINVAKP SVGFQILLII NEFTLERSLT HVISAIKCLV 130 140 150 160 170 180 EDEILLNITE FIQVRNPMNV MNVGKPLVRA PTLFFIREST LERNLMHVVI VLKALVAVQI 190 200 210 220 230 240 LLSIKEYTLE RNHMHVISVI KVLVKAQTSL NIREYTLVKS LIIAIVVRKP SVRVLTLFFI 250 260 270 280 290 300 REFTLEKNYY LCTQCSKSFS QISDLIKHQR IHTGEKPYKC SECRKAFSQC SLLALHQRIH 310 320 330 340 350 360 TGKKPNPCDE CGKSFSRRSD LINHQKIHTG EKPYKCDACG KAFSTCTDLI EHQKTHAEEK 370 380 390 400 410 420 PYQCVQCSRS CSQLSELTIH EEVHCGEDSQ NVMNVRKPLV CTPTLFSTRD TVPEKNLMNA VDY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human ZFP35 homologous gene ZNFphex133 maps to chromosome 11." Kobelt D., Kamp C., Vogt P.H. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Sustained expression of the novel EBV-induced zinc finger gene, ZNF-EB, is critical for the transition of B lymphocyte activation to oncogenic growth transformation." Tune C.E., Pilon M., Saiki Y., Dosch H.-M. J. Immunol. 168:680-688(2002) [PubMed: 11777961] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INDUCTION.
[3]	"Cloning of ZNF-dp gene isolated from human hair dermal papilla cell cDNA library." Kim M.K., Seo J.M., Kim Y.H., Kim J.C. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Hair follicle.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Duodenum and Ovary.
[5]	"Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937." Abrink M., Aveskogh M., Hellman L. DNA Cell Biol. 14:125-136(1995) [PubMed: 7865130] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-195.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF373036 mRNA. Translation: AAK52068.1. Frameshift. AF159567 mRNA. Translation: AAD43569.1. AF153201 mRNA. Translation: AAD38056.1. BC004510 mRNA. Translation: AAH04510.2. BC017710 mRNA. Translation: AAH17710.1. X78930 mRNA. Translation: CAA55530.1.
IPI	IPI00099531. IPI00760665.
PIR	S47065.
UniGene	Hs.314246
3D structure databases
HSSP	HSSP built from PDB template 1SP2 based on UniProtKB P08047.
ModBase	Search...
Proteomic databases
PRIDE	Q14591.
Organism-specific databases
GeneCards	GC18P031124.
HGNC	HGNC:13065. ZNF271.
MIM	604754. gene.
PharmGKB	PA37641.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q14591.
Gene expression databases
CleanEx	HS_ZNF271.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 18 hits.
Pfam	PF00096. zf-C2H2. 18 hits. [Graphical view]
ProDom	PD000003. Znf_C2H2. 17 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00355. ZnF_C2H2. 19 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 18 hits. PS50157. ZINC_FINGER_C2H2_2. 19 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	40934.
SOURCE	Search...

Entry information

Entry name

ZN271_HUMAN

Accession

Primary (citable) accession number: Q14591
Secondary accession number(s): Q96T29 , Q9BSX2, Q9UN33, Q9Y5B7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	July 11, 2006
Last modified:	June 16, 2009
This is version 94 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)