Q14591 (ZN271_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 271

Alternative name(s):
CT-ZFP48
Epstein-Barr virus-induced zinc finger protein
Short name=EBV-induced zinc finger protein
Short name=ZNF-EB
Zinc finger protein HZF7
Zinc finger protein ZNFphex133
Zinc finger protein dp
Short name=ZNF-dp

Gene names

Name:	ZNF271
Synonyms:	ZNFEB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	655 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation. Plays a role in the EBV-mediated transformation process.
Subcellular location	Nucleus Probable.
Tissue specificity	Expressed in T-cell lines, thymocytes, thyroid and pancreatic islet cells. Ref.2
Induction	By Epstein-Barr virus (EBV). Ref.2
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 19 C2H2-type zinc fingers.
Sequence caution	The sequence AAK52068.1 differs from that shown. Reason: Frameshift at position 481.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14591-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14591-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-480: MEIQFNYESQ...LHQRIHTGEK → MCVGKPSVRA...FIREFTLEKN

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 655	655	Zinc finger protein 271		PRO_0000047496
Regions
	Zinc finger	77 – 99	23	C2H2-type 1; degenerate
	Zinc finger	118 – 140	23	C2H2-type 2
	Zinc finger	146 – 168	23	C2H2-type 3
	Zinc finger	174 – 196	23	C2H2-type 4
	Zinc finger	202 – 224	23	C2H2-type 5
	Zinc finger	230 – 252	23	C2H2-type 6
	Zinc finger	258 – 280	23	C2H2-type 7
	Zinc finger	286 – 308	23	C2H2-type 8
	Zinc finger	314 – 336	23	C2H2-type 9
	Zinc finger	342 – 364	23	C2H2-type 10
	Zinc finger	370 – 392	23	C2H2-type 11
	Zinc finger	398 – 420	23	C2H2-type 12
	Zinc finger	426 – 448	23	C2H2-type 13
	Zinc finger	454 – 476	23	C2H2-type 14
	Zinc finger	482 – 504	23	C2H2-type 15
	Zinc finger	510 – 532	23	C2H2-type 16
	Zinc finger	538 – 560	23	C2H2-type 17
	Zinc finger	566 – 588	23	C2H2-type 18
	Zinc finger	594 – 616	23	C2H2-type 19
Natural variations
	Alternative sequence	1 – 480	480	MEIQF…HTGEK → MCVGKPSVRAQILFCIRESI LGRNHIHVISVAKVSVRIQT LLNIEGSTLERNPINVMSVG KLLIRAQSLFYIRGFILERN PIPVINVAKPSVGFQILLII NEFTLERSLTHVISAIKCLV EDEILLNITEFIQVRNPMNV MNVGKPLVRAPTLFFIREST LERNLMHVVIVLKALVAVQI LLSIKEYTLERNHMHVISVI KVLVKAQTSLNIREYTLVKS LIIAIVVRKPSVRVLTLFFI REFTLEKN in isoform 2.		VSP_019779
Experimental info
	Sequence conflict	134	1	I → N in CAA55530. Ref.6
	Sequence conflict	499	1	K → R in BAG51196. Ref.4
	Sequence conflict	524 – 526	3	ALT → LLA in AAD38056. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 15, 2009. Version 4. Checksum: 30657DE1C1D13338	FASTA	655	75,535
	10 20 30 40 50 60 MEIQFNYESQ EHHLLSDGEN KTKIGKPASE EGITAKIEPL TEESSSLRMF SRILKAKNSV 70 80 90 100 110 120 NLGINEKDQN VFKRRPHNCD EYGQSFVWST SLFRHRKTHC EKPYEWDKCG KATGEKPYSC 130 140 150 160 170 180 NWCIKSFSWS SDLIKHQRVH TGEKPYKCDE CGKAFSQSSD LIIHQRIHIG EKPYQCRHCS 190 200 210 220 230 240 KSFSQRSDLV KHQRIHTGEK PYTCNQCNKH FSQSSDVIKH QRIHTGEKPY KCDVCGKAFS 250 260 270 280 290 300 QSSDLILHQR IHTGEKPYPC NQCSKSFSQN SDLIKHRRIH TGEKPYKCNE CGKAFNQSSV 310 320 330 340 350 360 LILHQRIHTG EKPYPCDQCS KTFSRLSDLI NHQRIHTGEK PYPCNQCNKM FSRRSDLVKH 370 380 390 400 410 420 HRIHTGEKPY ECDECGKTFS QSSNLILHQR IHTGEKPYAC SDCTKSFSRR SDLVKHQRIH 430 440 450 460 470 480 TGEKPYACNQ CDKSFSQSSD LTKHQRVHSG EKPYHCNSCE KAFSQSSDLI LHQRIHTGEK 490 500 510 520 530 540 YYLCTQCSKS FSQISDLIKH QRIHTGEKPY KCSECRKAFS QCSALTLHQR IHTGKKPNPC 550 560 570 580 590 600 DECGKSFSRR SDLINHQKIH TGEKPYKCDA CGKAFSTCTD LIEHQKTHAE EKPYQCVQCS 610 620 630 640 650 RSCSQLSELT IHEEVHCGED SQNVMNVRKP LVCTPTLFST RDTVPEKNLM NAVDY
	Isoform 2 [UniParc]. Checksum: D4653E4C46A062B5	FASTA	423	48,164
	10 20 30 40 50 60 MCVGKPSVRA QILFCIRESI LGRNHIHVIS VAKVSVRIQT LLNIEGSTLE RNPINVMSVG 70 80 90 100 110 120 KLLIRAQSLF YIRGFILERN PIPVINVAKP SVGFQILLII NEFTLERSLT HVISAIKCLV 130 140 150 160 170 180 EDEILLNITE FIQVRNPMNV MNVGKPLVRA PTLFFIREST LERNLMHVVI VLKALVAVQI 190 200 210 220 230 240 LLSIKEYTLE RNHMHVISVI KVLVKAQTSL NIREYTLVKS LIIAIVVRKP SVRVLTLFFI 250 260 270 280 290 300 REFTLEKNYY LCTQCSKSFS QISDLIKHQR IHTGEKPYKC SECRKAFSQC SALTLHQRIH 310 320 330 340 350 360 TGKKPNPCDE CGKSFSRRSD LINHQKIHTG EKPYKCDACG KAFSTCTDLI EHQKTHAEEK 370 380 390 400 410 420 PYQCVQCSRS CSQLSELTIH EEVHCGEDSQ NVMNVRKPLV CTPTLFSTRD TVPEKNLMNA VDY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human ZFP35 homologous gene ZNFphex133 maps to chromosome 11." Kobelt D., Kamp C., Vogt P.H. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Sustained expression of the novel EBV-induced zinc finger gene, ZNF-EB, is critical for the transition of B lymphocyte activation to oncogenic growth transformation." Tune C.E., Pilon M., Saiki Y., Dosch H.-M. J. Immunol. 168:680-688(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INDUCTION.
[3]	"Cloning of ZNF-dp gene isolated from human hair dermal papilla cell cDNA library." Kim M.K., Seo J.M., Kim Y.H., Kim J.C. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Hair follicle.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Duodenum and Ovary.
[6]	"Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937." Abrink M., Aveskogh M., Hellman L. DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-195.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF373036 mRNA. Translation: AAK52068.1. Frameshift. AF159567 mRNA. Translation: AAD43569.1. AF153201 mRNA. Translation: AAD38056.1. AK023456 mRNA. Translation: BAG51196.1. BC004510 mRNA. No translation available. BC017710 mRNA. No translation available. X78930 mRNA. Translation: CAA55530.1.
IPI	IPI00099531. IPI00760665.
PIR	S47065.
UniGene	Hs.314246.
3D structure databases
ProteinModelPortal	Q14591.
SMR	Q14591. Positions 75-616.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-7027450.
STRING	9606.ENSP00000382022.
PTM databases
PhosphoSite	Q14591.
Polymorphism databases
DMDM	281185516.
Proteomic databases
PaxDb	Q14591.
PRIDE	Q14591.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc002kyp.4. human.
Organism-specific databases
GeneCards	GC18P032871.
HGNC	HGNC:13065. ZNF271.
MIM	604754. gene.
neXtProt	NX_Q14591.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOVERGEN	HBG018163.
Gene expression databases
CleanEx	HS_ZNF271.
Genevestigator	Q14591.
Family and domain databases
Gene3D	3.30.160.60. 19 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 19 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 18 hits. PS50157. ZINC_FINGER_C2H2_2. 19 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF271. human.
SOURCE	Search...

Entry information

Entry name

ZN271_HUMAN

Accession

Primary (citable) accession number: Q14591
Secondary accession number(s): B3KN34 , Q96T29, Q9BSX2, Q9UN33, Q9Y5B7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 15, 2009
Last modified:	May 1, 2013
This is version 131 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.