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Protein

Zinc finger protein 235

Gene

ZNF235

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28523C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri571 – 59323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri599 – 62123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri627 – 64923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri655 – 67723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri683 – 70523C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri711 – 73323C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 235
Alternative name(s):
Zinc finger protein 270
Zinc finger protein 93 homolog
Short name:
Zfp-93
Zinc finger protein HZF6
Gene namesi
Name:ZNF235
Synonyms:ZFP93, ZNF270
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12866. ZNF235.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37455.

Polymorphism and mutation databases

BioMutaiZNF235.
DMDMi215274192.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738Zinc finger protein 235PRO_0000047474Add
BLAST

Proteomic databases

PaxDbiQ14590.
PRIDEiQ14590.

PTM databases

iPTMnetiQ14590.
PhosphoSiteiQ14590.

Expressioni

Gene expression databases

BgeeiQ14590.
CleanExiHS_ZNF235.
ExpressionAtlasiQ14590. baseline and differential.
GenevisibleiQ14590. HS.

Organism-specific databases

HPAiHPA045582.

Interactioni

Protein-protein interaction databases

BioGridi114722. 5 interactions.
IntActiQ14590. 5 interactions.
MINTiMINT-8247407.
STRINGi9606.ENSP00000291182.

Structurei

3D structure databases

ProteinModelPortaliQ14590.
SMRiQ14590. Positions 7-49, 230-736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28523C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri543 – 56523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri571 – 59323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri599 – 62123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri627 – 64923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri655 – 67723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri683 – 70523C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri711 – 73323C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14590.
KOiK09228.
OMAiCIFAPYV.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ14590.
TreeFamiTF350845.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14590-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKFQEAVTF KDVAVAFTEE ELGLLDSAQR KLYRDVMLEN FRNLVSVGHQ
60 70 80 90 100
SFKPDMISQL EREEKLWMKE LQTQRGKHSG DRNQNEMATL HKAGLRCFSL
110 120 130 140 150
GELSCWQIKR HIASKLARSQ DSMINIEGKS SQFPKHHDSP CQVGAGESIQ
160 170 180 190 200
ASVDDNCLVN HIGDHSSIIE NQEFPTGKVP NSWSKIYLNE TQNYQRSCKQ
210 220 230 240 250
TQMKNKLCIF APYVDIFSCI SHHHDDNIVH KRDKVHSNSD CGKDTLKVSP
260 270 280 290 300
LTQRSIHTGQ KTYQGNECEE AFNDSSSLEL HKQVHLGKKS PACSTHEKDT
310 320 330 340 350
SYSSGIPVQQ SVRTGKKRYW CHECGKGFSQ SSNLQTHQRV HTGEKPYTCH
360 370 380 390 400
ECGKSFNQSS HLYAHLPIHT GEKPYRCDSC GKGFSRSTDL NIHCRVHTGE
410 420 430 440 450
KPYKCEVCGK GFTQRSHLQA HERIHTGEKP YKCGDCGKRF SCSSNLHTHQ
460 470 480 490 500
RVHTEEKPYK CDECGKCFSL SFNLHSHQRV HTGEKPYKCE ECGKGFSSAS
510 520 530 540 550
SFQSHQRVHT GEKPFRCNVC GKGFSQSSYF QAHQRVHTGE KPYKCEVCGK
560 570 580 590 600
RFNWSLNLHN HQRVHTGEKP YKCEECGKGF SQASNLQAHQ SVHTGEKPFK
610 620 630 640 650
CDACQKRFSQ ASHLQAHQRV HTGEKPYKCD TCGKAFSQRS NLQVHQIIHT
660 670 680 690 700
GEKPFKCEEC GKEFSWSAGL SAHQRVHTGE KPYTCQQCGK GFSQASHFHT
710 720 730
HQRVHTGERP YICDVCCKGF SQRSHLIYHQ RVHTGGNL
Length:738
Mass (Da):83,977
Last modified:November 25, 2008 - v3
Checksum:i51B301BFF30EB194
GO
Isoform 2 (identifier: Q14590-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-80: Missing.

Show »
Length:734
Mass (Da):83,568
Checksum:i81AB9B0C408368B5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231M → T in AAD12728 (PubMed:9570955).Curated
Sequence conflicti635 – 6351A → P in CAA55529 (PubMed:7865130).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti296 – 2961H → P.1 Publication
Corresponds to variant rs2125579 [ dbSNP | Ensembl ].
VAR_029806

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei77 – 804Missing in isoform 2. 1 PublicationVSP_022166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300317 mRNA. Translation: BAG62069.1.
AC092477 Genomic DNA. No translation available.
AC138473 Genomic DNA. No translation available.
BC117215 mRNA. Translation: AAI17216.1.
AF027513 mRNA. Translation: AAD12728.1.
AF027514 mRNA. Translation: AAD12729.1.
X78929 mRNA. Translation: CAA55529.1.
AC084239 Genomic DNA. Translation: AAG23969.1.
CCDSiCCDS33048.1. [Q14590-1]
PIRiS47068.
RefSeqiNP_004225.3. NM_004234.4. [Q14590-1]
XP_005259469.1. XM_005259412.3. [Q14590-2]
UniGeneiHs.613424.
Hs.724032.

Genome annotation databases

EnsembliENST00000291182; ENSP00000291182; ENSG00000159917. [Q14590-1]
GeneIDi9310.
KEGGihsa:9310.
UCSCiuc002oza.5. human. [Q14590-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300317 mRNA. Translation: BAG62069.1.
AC092477 Genomic DNA. No translation available.
AC138473 Genomic DNA. No translation available.
BC117215 mRNA. Translation: AAI17216.1.
AF027513 mRNA. Translation: AAD12728.1.
AF027514 mRNA. Translation: AAD12729.1.
X78929 mRNA. Translation: CAA55529.1.
AC084239 Genomic DNA. Translation: AAG23969.1.
CCDSiCCDS33048.1. [Q14590-1]
PIRiS47068.
RefSeqiNP_004225.3. NM_004234.4. [Q14590-1]
XP_005259469.1. XM_005259412.3. [Q14590-2]
UniGeneiHs.613424.
Hs.724032.

3D structure databases

ProteinModelPortaliQ14590.
SMRiQ14590. Positions 7-49, 230-736.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114722. 5 interactions.
IntActiQ14590. 5 interactions.
MINTiMINT-8247407.
STRINGi9606.ENSP00000291182.

PTM databases

iPTMnetiQ14590.
PhosphoSiteiQ14590.

Polymorphism and mutation databases

BioMutaiZNF235.
DMDMi215274192.

Proteomic databases

PaxDbiQ14590.
PRIDEiQ14590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291182; ENSP00000291182; ENSG00000159917. [Q14590-1]
GeneIDi9310.
KEGGihsa:9310.
UCSCiuc002oza.5. human. [Q14590-1]

Organism-specific databases

CTDi9310.
GeneCardsiZNF235.
HGNCiHGNC:12866. ZNF235.
HPAiHPA045582.
MIMi604749. gene.
neXtProtiNX_Q14590.
PharmGKBiPA37455.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14590.
KOiK09228.
OMAiCIFAPYV.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ14590.
TreeFamiTF350845.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii9310.
PROiQ14590.
SOURCEiSearch...

Gene expression databases

BgeeiQ14590.
CleanExiHS_ZNF235.
ExpressionAtlasiQ14590. baseline and differential.
GenevisibleiQ14590. HS.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-296.
    Tissue: Liver.
  4. "Analysis of homologous XRCC1-linked zinc-finger gene families in human and mouse: evidence for orthologous genes."
    Shannon M., Stubbs L.
    Genomics 49:112-121(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-506 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 637-738 (ISOFORMS 1/2).
  5. "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
    Abrink M., Aveskogh M., Hellman L.
    DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 456-664 (ISOFORMS 1/2).
  6. "Sequence analysis of a 1Mb region in 19q13.2 containing a zinc finger gene cluster."
    Kodoyianni V., Ge Y., Krummel G.K., Kvikstad E., Grable L., Severin J., Gordon L., Shannon M., Brower A., Olsen A.S., Smith L.M.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 637-738 (ISOFORMS 1/2).

Entry informationi

Entry nameiZN235_HUMAN
AccessioniPrimary (citable) accession number: Q14590
Secondary accession number(s): B4DTQ7
, O14898, O14899, Q17RR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 25, 2008
Last modified: June 8, 2016
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.