Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 234

Gene

ZNF234

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri148 – 17023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri176 – 19823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri540 – 56223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri568 – 59023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri596 – 61823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri624 – 64623C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri652 – 67423C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 234
Alternative name(s):
Zinc finger protein 269
Zinc finger protein HZF4
Gene namesi
Name:ZNF234
Synonyms:ZNF269
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13027. ZNF234.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37605.

Polymorphism and mutation databases

BioMutaiZNF234.
DMDMi55977851.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 700700Zinc finger protein 234PRO_0000047473Add
BLAST

Proteomic databases

PaxDbiQ14588.
PRIDEiQ14588.

PTM databases

iPTMnetiQ14588.
PhosphoSiteiQ14588.

Expressioni

Gene expression databases

BgeeiQ14588.
CleanExiHS_ZNF234.
ExpressionAtlasiQ14588. baseline and differential.
GenevisibleiQ14588. HS.

Organism-specific databases

HPAiHPA001664.

Interactioni

Protein-protein interaction databases

BioGridi115997. 4 interactions.
IntActiQ14588. 1 interaction.
STRINGi9606.ENSP00000400878.

Structurei

3D structure databases

ProteinModelPortaliQ14588.
SMRiQ14588. Positions 7-56, 141-674.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 9083KRABPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni91 – 14757KRNBAdd
BLAST

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri148 – 17023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri176 – 19823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri456 – 47823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri484 – 50623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri512 – 53423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri540 – 56223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri568 – 59023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri596 – 61823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri624 – 64623C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri652 – 67423C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14588.
KOiK09228.
OMAiLYTTHTG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ14588.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFKEGLTF KDVAVVFTEE ELGLLDPVQR NLYQDVMLEN FRNLLSVGHH
60 70 80 90 100
PFKHDVFLLE KEKKLDIMKT ATQRKGKSAD KIQSEVETVP EAGRHEELYW
110 120 130 140 150
GQIWKQIASD LIKYEDSMIS ISRFPRQGDL SCQVRAGLYT THTGQKFYQC
160 170 180 190 200
DEYKKSFTDV FNFDLHQQLH SGEKSHTCDE CGKSFCYISA LHIHQRVHMG
210 220 230 240 250
EKCYKCDVCG KEFSQSSHLQ THQRVHTVEK PFKCVECGKG FSRRSTLTVH
260 270 280 290 300
CKLHSGEKPY NCEECGRAFI HASHLQEHQR IHTGEKPFKC DTCGKNFRRR
310 320 330 340 350
SALNNHCMVH TGEKPYKCED CGKCFTCSSN LRIHQRVHTG EKPYKCEECG
360 370 380 390 400
KCFIQPSQFQ AHRRIHTGEK PYVCKVCGKG FIYSSSFQAH QGVHTGEKPY
410 420 430 440 450
KCNECGKSFR MKIHYQVHLV VHTGEKPYKC EVCGKAFRQS SYLKIHLKAH
460 470 480 490 500
SVQKPFKCEE CGQGFNQSSR LQIHQLIHTG EKPYKCEECG KGFSRRADLK
510 520 530 540 550
IHCRIHTGEK PYNCEECGKV FSQASHLLTH QRVHSGEKPF KCEECGKSFS
560 570 580 590 600
RSAHLQAHQK VHTGEKPYKC GECGKGFKWS LNLDMHQRVH TGEKPYTCGE
610 620 630 640 650
CGKHFSQASS LQLHQSVHTG EKPYKCDVCG KVFSRSSQLQ YHRRVHTGEK
660 670 680 690 700
PYKCEICGKR FSWRSNLVSH HKIHAAGTFY ENDENSKNIR ELSEGGSSTR
Length:700
Mass (Da):80,560
Last modified:November 23, 2004 - v3
Checksum:i79F266EA18821193
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti494 – 4941S → N in CAA55527 (PubMed:7865130).Curated
Sequence conflicti600 – 6001E → A in CAA55527 (PubMed:7865130).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161V → I.
Corresponds to variant rs2293587 [ dbSNP | Ensembl ].
VAR_019977
Natural varianti208 – 2081V → M.
Corresponds to variant rs11668974 [ dbSNP | Ensembl ].
VAR_052799

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289843 mRNA. Translation: BAF82532.1.
CH471126 Genomic DNA. Translation: EAW57256.1.
BC007303 mRNA. Translation: AAH07303.1.
AF228417 mRNA. Translation: AAF34785.1.
X78927 mRNA. Translation: CAA55527.1.
AC074331 Genomic DNA. Translation: AAF88104.1.
CCDSiCCDS46101.1.
PIRiI37570.
RefSeqiNP_001138296.1. NM_001144824.1.
NP_006621.1. NM_006630.2.
XP_006723037.1. XM_006722974.2.
UniGeneiHs.235992.

Genome annotation databases

EnsembliENST00000426739; ENSP00000400878; ENSG00000263002.
ENST00000592437; ENSP00000465011; ENSG00000263002.
GeneIDi10780.
KEGGihsa:10780.
UCSCiuc002oyl.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289843 mRNA. Translation: BAF82532.1.
CH471126 Genomic DNA. Translation: EAW57256.1.
BC007303 mRNA. Translation: AAH07303.1.
AF228417 mRNA. Translation: AAF34785.1.
X78927 mRNA. Translation: CAA55527.1.
AC074331 Genomic DNA. Translation: AAF88104.1.
CCDSiCCDS46101.1.
PIRiI37570.
RefSeqiNP_001138296.1. NM_001144824.1.
NP_006621.1. NM_006630.2.
XP_006723037.1. XM_006722974.2.
UniGeneiHs.235992.

3D structure databases

ProteinModelPortaliQ14588.
SMRiQ14588. Positions 7-56, 141-674.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115997. 4 interactions.
IntActiQ14588. 1 interaction.
STRINGi9606.ENSP00000400878.

PTM databases

iPTMnetiQ14588.
PhosphoSiteiQ14588.

Polymorphism and mutation databases

BioMutaiZNF234.
DMDMi55977851.

Proteomic databases

PaxDbiQ14588.
PRIDEiQ14588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426739; ENSP00000400878; ENSG00000263002.
ENST00000592437; ENSP00000465011; ENSG00000263002.
GeneIDi10780.
KEGGihsa:10780.
UCSCiuc002oyl.5. human.

Organism-specific databases

CTDi10780.
GeneCardsiZNF234.
HGNCiHGNC:13027. ZNF234.
HPAiHPA001664.
MIMi604750. gene.
neXtProtiNX_Q14588.
PharmGKBiPA37605.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14588.
KOiK09228.
OMAiLYTTHTG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ14588.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF234. human.
GenomeRNAii10780.
NextBioi40938.
PROiQ14588.
SOURCEiSearch...

Gene expression databases

BgeeiQ14588.
CleanExiHS_ZNF234.
ExpressionAtlasiQ14588. baseline and differential.
GenevisibleiQ14588. HS.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."
    Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.
    Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-73.
  5. "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
    Abrink M., Aveskogh M., Hellman L.
    DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-698.
  6. "Sequence analysis of a 1Mb region in 19q13.2 containing a zinc finger gene cluster."
    Kodoyianni V., Ge Y., Severin J., Krummel G.K., Grable L., Kvikstad E., Gordon L., Shannon M., Brower A., Olsen A.S., Smith L.M.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-698.

Entry informationi

Entry nameiZN234_HUMAN
AccessioniPrimary (citable) accession number: Q14588
Secondary accession number(s): A8K1C8
, Q96IR4, Q9NS45, Q9NYT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 160 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.