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UniProtKB - Q14588 (ZN234_HUMAN)

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Protein

Zinc finger protein 234

Gene

ZNF234

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri148 – 170C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri176 – 198C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 234
Alternative name(s):
Zinc finger protein 269
Zinc finger protein HZF4
Gene namesi
Name:ZNF234
Synonyms:ZNF269
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000263002.7.
HGNCiHGNC:13027. ZNF234.
MIMi604750. gene.
neXtProtiNX_Q14588.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000263002.
PharmGKBiPA37605.

Polymorphism and mutation databases

BioMutaiZNF234.
DMDMi55977851.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474731 – 700Zinc finger protein 234Add BLAST700

Proteomic databases

PaxDbiQ14588.
PeptideAtlasiQ14588.
PRIDEiQ14588.

PTM databases

iPTMnetiQ14588.
PhosphoSitePlusiQ14588.

Expressioni

Gene expression databases

BgeeiENSG00000263002.
CleanExiHS_ZNF234.
ExpressionAtlasiQ14588. baseline and differential.
GenevisibleiQ14588. HS.

Organism-specific databases

HPAiHPA001664.

Interactioni

Protein-protein interaction databases

BioGridi115997. 4 interactors.
IntActiQ14588. 1 interactor.
STRINGi9606.ENSP00000400878.

Structurei

3D structure databases

ProteinModelPortaliQ14588.
SMRiQ14588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 90KRABPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni91 – 147KRNBAdd BLAST57

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri148 – 170C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri176 – 198C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00870000136402.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14588.
KOiK09228.
OMAiLVSHHKI.
OrthoDBiEOG091G02KC.
PhylomeDBiQ14588.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 10 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.

Sequencei

Sequence statusi: Complete.

Q14588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFKEGLTF KDVAVVFTEE ELGLLDPVQR NLYQDVMLEN FRNLLSVGHH 
        60         70         80         90        100
PFKHDVFLLE KEKKLDIMKT ATQRKGKSAD KIQSEVETVP EAGRHEELYW 
       110        120        130        140        150
GQIWKQIASD LIKYEDSMIS ISRFPRQGDL SCQVRAGLYT THTGQKFYQC 
       160        170        180        190        200
DEYKKSFTDV FNFDLHQQLH SGEKSHTCDE CGKSFCYISA LHIHQRVHMG 
       210        220        230        240        250
EKCYKCDVCG KEFSQSSHLQ THQRVHTVEK PFKCVECGKG FSRRSTLTVH 
       260        270        280        290        300
CKLHSGEKPY NCEECGRAFI HASHLQEHQR IHTGEKPFKC DTCGKNFRRR 
       310        320        330        340        350
SALNNHCMVH TGEKPYKCED CGKCFTCSSN LRIHQRVHTG EKPYKCEECG 
       360        370        380        390        400
KCFIQPSQFQ AHRRIHTGEK PYVCKVCGKG FIYSSSFQAH QGVHTGEKPY 
       410        420        430        440        450
KCNECGKSFR MKIHYQVHLV VHTGEKPYKC EVCGKAFRQS SYLKIHLKAH 
       460        470        480        490        500
SVQKPFKCEE CGQGFNQSSR LQIHQLIHTG EKPYKCEECG KGFSRRADLK 
       510        520        530        540        550
IHCRIHTGEK PYNCEECGKV FSQASHLLTH QRVHSGEKPF KCEECGKSFS 
       560        570        580        590        600
RSAHLQAHQK VHTGEKPYKC GECGKGFKWS LNLDMHQRVH TGEKPYTCGE 
       610        620        630        640        650
CGKHFSQASS LQLHQSVHTG EKPYKCDVCG KVFSRSSQLQ YHRRVHTGEK 
       660        670        680        690        700
PYKCEICGKR FSWRSNLVSH HKIHAAGTFY ENDENSKNIR ELSEGGSSTR
Length:700
Mass (Da):80,560
Last modified:November 23, 2004 - v3
Checksum:i79F266EA18821193
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti494S → N in CAA55527 (PubMed:7865130).Curated1
Sequence conflicti600E → A in CAA55527 (PubMed:7865130).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01997716V → I. Corresponds to variant dbSNP:rs2293587Ensembl.1
Natural variantiVAR_052799208V → M. Corresponds to variant dbSNP:rs11668974Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289843 mRNA. Translation: BAF82532.1.
CH471126 Genomic DNA. Translation: EAW57256.1.
BC007303 mRNA. Translation: AAH07303.1.
AF228417 mRNA. Translation: AAF34785.1.
X78927 mRNA. Translation: CAA55527.1.
AC074331 Genomic DNA. Translation: AAF88104.1.
CCDSiCCDS46101.1.
PIRiI37570.
RefSeqiNP_001138296.1. NM_001144824.1.
NP_006621.1. NM_006630.2.
XP_006723037.1. XM_006722974.3.
XP_016881638.1. XM_017026149.1.
UniGeneiHs.235992.

Genome annotation databases

EnsembliENST00000426739; ENSP00000400878; ENSG00000263002.
ENST00000592437; ENSP00000465011; ENSG00000263002.
GeneIDi10780.
KEGGihsa:10780.
UCSCiuc002oyl.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN234_HUMAN
AccessioniPrimary (citable) accession number: Q14588
Secondary accession number(s): A8K1C8
, Q96IR4, Q9NS45, Q9NYT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 23, 2004
Last modified: February 28, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome