UniProtKB - Q14588 (ZN234_HUMAN)
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Protein
Zinc finger protein 234
Gene
ZNF234
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 148 – 170 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 176 – 198 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 204 – 226 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 232 – 254 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 260 – 282 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 288 – 310 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 316 – 338 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 344 – 366 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 372 – 394 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 400 – 422 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 428 – 450 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 456 – 478 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 484 – 506 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 512 – 534 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 540 – 562 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 568 – 590 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 596 – 618 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 624 – 646 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 652 – 674 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-212436. Generic Transcription Pathway. |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 234Alternative name(s): Zinc finger protein 269 Zinc finger protein HZF4 |
Gene namesi | Name:ZNF234 Synonyms:ZNF269 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000263002.7. |
HGNCi | HGNC:13027. ZNF234. |
MIMi | 604750. gene. |
neXtProti | NX_Q14588. |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000263002. |
PharmGKBi | PA37605. |
Polymorphism and mutation databases
BioMutai | ZNF234. |
DMDMi | 55977851. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047473 | 1 – 700 | Zinc finger protein 234Add BLAST | 700 |
Proteomic databases
PaxDbi | Q14588. |
PeptideAtlasi | Q14588. |
PRIDEi | Q14588. |
PTM databases
iPTMneti | Q14588. |
PhosphoSitePlusi | Q14588. |
Expressioni
Gene expression databases
Bgeei | ENSG00000263002. |
CleanExi | HS_ZNF234. |
ExpressionAtlasi | Q14588. baseline and differential. |
Genevisiblei | Q14588. HS. |
Organism-specific databases
HPAi | HPA001664. |
Interactioni
Protein-protein interaction databases
BioGridi | 115997. 4 interactors. |
IntActi | Q14588. 1 interactor. |
STRINGi | 9606.ENSP00000400878. |
Structurei
3D structure databases
ProteinModelPortali | Q14588. |
SMRi | Q14588. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 90 | KRABPROSITE-ProRule annotationAdd BLAST | 83 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 91 – 147 | KRNBAdd BLAST | 57 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 148 – 170 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 176 – 198 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 204 – 226 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 232 – 254 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 260 – 282 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 288 – 310 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 316 – 338 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 344 – 366 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 372 – 394 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 400 – 422 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 428 – 450 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 456 – 478 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 484 – 506 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 512 – 534 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 540 – 562 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 568 – 590 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 596 – 618 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 624 – 646 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 652 – 674 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721. Eukaryota. COG5048. LUCA. |
GeneTreei | ENSGT00870000136402. |
HOGENOMi | HOG000234617. |
HOVERGENi | HBG018163. |
InParanoidi | Q14588. |
KOi | K09228. |
OMAi | LVSHHKI. |
OrthoDBi | EOG091G02KC. |
PhylomeDBi | Q14588. |
Family and domain databases
CDDi | cd07765. KRAB_A-box. 1 hit. |
InterProi | View protein in InterPro IPR001909. KRAB. IPR036051. KRAB_dom_sf. IPR036236. Znf_C2H2_sf. IPR013087. Znf_C2H2_type. |
Pfami | View protein in Pfam PF01352. KRAB. 1 hit. |
SMARTi | View protein in SMART SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 19 hits. |
SUPFAMi | SSF109640. SSF109640. 1 hit. SSF57667. SSF57667. 10 hits. |
PROSITEi | View protein in PROSITE PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 18 hits. PS50157. ZINC_FINGER_C2H2_2. 19 hits. |
i Sequence
Sequence statusi: Complete.
Q14588-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTFKEGLTF KDVAVVFTEE ELGLLDPVQR NLYQDVMLEN FRNLLSVGHH
60 70 80 90 100
PFKHDVFLLE KEKKLDIMKT ATQRKGKSAD KIQSEVETVP EAGRHEELYW
110 120 130 140 150
GQIWKQIASD LIKYEDSMIS ISRFPRQGDL SCQVRAGLYT THTGQKFYQC
160 170 180 190 200
DEYKKSFTDV FNFDLHQQLH SGEKSHTCDE CGKSFCYISA LHIHQRVHMG
210 220 230 240 250
EKCYKCDVCG KEFSQSSHLQ THQRVHTVEK PFKCVECGKG FSRRSTLTVH
260 270 280 290 300
CKLHSGEKPY NCEECGRAFI HASHLQEHQR IHTGEKPFKC DTCGKNFRRR
310 320 330 340 350
SALNNHCMVH TGEKPYKCED CGKCFTCSSN LRIHQRVHTG EKPYKCEECG
360 370 380 390 400
KCFIQPSQFQ AHRRIHTGEK PYVCKVCGKG FIYSSSFQAH QGVHTGEKPY
410 420 430 440 450
KCNECGKSFR MKIHYQVHLV VHTGEKPYKC EVCGKAFRQS SYLKIHLKAH
460 470 480 490 500
SVQKPFKCEE CGQGFNQSSR LQIHQLIHTG EKPYKCEECG KGFSRRADLK
510 520 530 540 550
IHCRIHTGEK PYNCEECGKV FSQASHLLTH QRVHSGEKPF KCEECGKSFS
560 570 580 590 600
RSAHLQAHQK VHTGEKPYKC GECGKGFKWS LNLDMHQRVH TGEKPYTCGE
610 620 630 640 650
CGKHFSQASS LQLHQSVHTG EKPYKCDVCG KVFSRSSQLQ YHRRVHTGEK
660 670 680 690 700
PYKCEICGKR FSWRSNLVSH HKIHAAGTFY ENDENSKNIR ELSEGGSSTR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 494 | S → N in CAA55527 (PubMed:7865130).Curated | 1 | |
Sequence conflicti | 600 | E → A in CAA55527 (PubMed:7865130).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019977 | 16 | V → I. Corresponds to variant dbSNP:rs2293587Ensembl. | 1 | |
Natural variantiVAR_052799 | 208 | V → M. Corresponds to variant dbSNP:rs11668974Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK289843 mRNA. Translation: BAF82532.1. CH471126 Genomic DNA. Translation: EAW57256.1. BC007303 mRNA. Translation: AAH07303.1. AF228417 mRNA. Translation: AAF34785.1. X78927 mRNA. Translation: CAA55527.1. AC074331 Genomic DNA. Translation: AAF88104.1. |
CCDSi | CCDS46101.1. |
PIRi | I37570. |
RefSeqi | NP_001138296.1. NM_001144824.1. NP_006621.1. NM_006630.2. XP_006723037.1. XM_006722974.3. XP_016881638.1. XM_017026149.1. |
UniGenei | Hs.235992. |
Genome annotation databases
Ensembli | ENST00000426739; ENSP00000400878; ENSG00000263002. ENST00000592437; ENSP00000465011; ENSG00000263002. |
GeneIDi | 10780. |
KEGGi | hsa:10780. |
UCSCi | uc002oyl.5. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | ZN234_HUMAN | |
Accessioni | Q14588Primary (citable) accession number: Q14588 Secondary accession number(s): A8K1C8 Q9NYT7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 23, 2004 | |
Last modified: | February 28, 2018 | |
This is version 174 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |