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Protein

Zinc finger protein 267

Gene

ZNF267

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri267 – 289C2H2-type 1Add BLAST23
Zinc fingeri322 – 340C2H2-type 2; atypicalAdd BLAST19
Zinc fingeri380 – 402C2H2-type 3Add BLAST23
Zinc fingeri408 – 430C2H2-type 4Add BLAST23
Zinc fingeri436 – 458C2H2-type 5Add BLAST23
Zinc fingeri464 – 486C2H2-type 6Add BLAST23
Zinc fingeri492 – 514C2H2-type 7Add BLAST23
Zinc fingeri520 – 542C2H2-type 8Add BLAST23
Zinc fingeri548 – 570C2H2-type 9Add BLAST23
Zinc fingeri576 – 598C2H2-type 10Add BLAST23
Zinc fingeri604 – 626C2H2-type 11Add BLAST23
Zinc fingeri632 – 654C2H2-type 12Add BLAST23
Zinc fingeri660 – 682C2H2-type 13Add BLAST23
Zinc fingeri688 – 710C2H2-type 14Add BLAST23
Zinc fingeri716 – 738C2H2-type 15Add BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 267
Alternative name(s):
Zinc finger protein HZF2
Gene namesi
Name:ZNF267
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000185947.14.
HGNCiHGNC:13060. ZNF267.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10308.
OpenTargetsiENSG00000185947.
PharmGKBiPA37638.

Polymorphism and mutation databases

BioMutaiZNF267.
DMDMi296453069.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474941 – 743Zinc finger protein 267Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki66Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki135Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ14586.
PaxDbiQ14586.
PeptideAtlasiQ14586.
PRIDEiQ14586.

PTM databases

iPTMnetiQ14586.
PhosphoSitePlusiQ14586.

Expressioni

Gene expression databases

BgeeiENSG00000185947.
CleanExiHS_ZNF267.
ExpressionAtlasiQ14586. baseline and differential.
GenevisibleiQ14586. HS.

Organism-specific databases

HPAiHPA003866.

Interactioni

Protein-protein interaction databases

BioGridi115594. 6 interactors.
IntActiQ14586. 5 interactors.
STRINGi9606.ENSP00000300870.

Structurei

3D structure databases

ProteinModelPortaliQ14586.
SMRiQ14586.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri267 – 289C2H2-type 1Add BLAST23
Zinc fingeri322 – 340C2H2-type 2; atypicalAdd BLAST19
Zinc fingeri380 – 402C2H2-type 3Add BLAST23
Zinc fingeri408 – 430C2H2-type 4Add BLAST23
Zinc fingeri436 – 458C2H2-type 5Add BLAST23
Zinc fingeri464 – 486C2H2-type 6Add BLAST23
Zinc fingeri492 – 514C2H2-type 7Add BLAST23
Zinc fingeri520 – 542C2H2-type 8Add BLAST23
Zinc fingeri548 – 570C2H2-type 9Add BLAST23
Zinc fingeri576 – 598C2H2-type 10Add BLAST23
Zinc fingeri604 – 626C2H2-type 11Add BLAST23
Zinc fingeri632 – 654C2H2-type 12Add BLAST23
Zinc fingeri660 – 682C2H2-type 13Add BLAST23
Zinc fingeri688 – 710C2H2-type 14Add BLAST23
Zinc fingeri716 – 738C2H2-type 15Add BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00900000141195.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14586.
KOiK09228.
OMAiCTEASFQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ14586.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 10 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.

Sequencei

Sequence statusi: Complete.

Q14586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLTFRDVA VEFSLEEWEH LEPAQKNLYQ DVMLENYRNL VSLGLVVSKP
60 70 80 90 100
DLITFLEQRK EPWNVKSEET VAIQPDVFSH YNKDLLTEHC TEASFQKVIS
110 120 130 140 150
RRHGSCDLEN LHLRKRWKRE ECEGHNGCYD EKTFKYDQFD ESSVESLFHQ
160 170 180 190 200
QILSSCAKSY NFDQYRKVFT HSSLLNQQEE IDIWGKHHIY DKTSVLFRQV
210 220 230 240 250
STLNSYRNVF IGEKNYHCNN SEKTLNQSSS PKNHQENYFL EKQYKCKEFE
260 270 280 290 300
EVFLQSMHGQ EKQEQSYKCN KCVEVCTQSL KHIQHQTIHI RENSYSYNKY
310 320 330 340 350
DKDLSQSSNL RKQIIHNEEK PYKCEKCGDS LNHSLHLTQH QIIPTEEKPC
360 370 380 390 400
KWKECGKVFN LNCSLYLTKQ QQIDTGENLY KCKACSKSFT RSSNLIVHQR
410 420 430 440 450
IHTGEKPYKC KECGKAFRCS SYLTKHKRIH TGEKPYKCKE CGKAFNRSSC
460 470 480 490 500
LTQHQTTHTG EKLYKCKVCS KSYARSSNLI MHQRVHTGEK PYKCKECGKV
510 520 530 540 550
FSRSSCLTQH RKIHTGENLY KCKVCAKPFT CFSNLIVHER IHTGEKPYKC
560 570 580 590 600
KECGKAFPYS SHLIRHHRIH TGEKPYKCKA CSKSFSDSSG LTVHRRTHTG
610 620 630 640 650
EKPYTCKECG KAFSYSSDVI QHRRIHTGQR PYKCEECGKA FNYRSYLTTH
660 670 680 690 700
QRSHTGERPY KCEECGKAFN SRSYLTTHRR RHTGERPYKC DECGKAFSYR
710 720 730 740
SYLTTHRRSH SGERPYKCEE CGKAFNSRSY LIAHQRSHTR EKL
Length:743
Mass (Da):87,376
Last modified:May 18, 2010 - v3
Checksum:i66AA4EC827BEFAAF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31D → N in AAH36367 (PubMed:15489334).Curated1
Sequence conflicti567H → Y in AAF73867 (Ref. 1) Curated1
Sequence conflicti567H → Y in CAA55525 (PubMed:7865130).Curated1
Sequence conflicti592T → S in AAF73867 (Ref. 1) Curated1
Sequence conflicti592T → S in CAA55525 (PubMed:7865130).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057414257M → V. Corresponds to variant dbSNP:rs7202455Ensembl.1
Natural variantiVAR_059907350C → Y4 PublicationsCorresponds to variant dbSNP:rs3850114Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220492 mRNA. Translation: AAF73867.1.
AK292573 mRNA. Translation: BAF85262.1.
BC036367 mRNA. Translation: AAH36367.1.
BC127088 mRNA. Translation: AAI27089.1.
BC127089 mRNA. Translation: AAI27090.1.
X78925 mRNA. Translation: CAA55525.1.
CCDSiCCDS32440.1.
PIRiS47073.
RefSeqiNP_001252517.1. NM_001265588.1.
NP_003405.3. NM_003414.5.
UniGeneiHs.460645.

Genome annotation databases

EnsembliENST00000300870; ENSP00000300870; ENSG00000185947.
GeneIDi10308.
KEGGihsa:10308.
UCSCiuc002ecs.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN267_HUMAN
AccessioniPrimary (citable) accession number: Q14586
Secondary accession number(s): A0JNZ9, Q8NE41, Q9NRJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: November 22, 2017
This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families