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Protein

Zinc finger protein 267

Gene

ZNF267

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri267 – 28923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34019C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri576 – 59823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri604 – 62623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri632 – 65423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri660 – 68223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri688 – 71023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri716 – 73823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: GO_Central

GO - Biological processi

  1. multicellular organismal development Source: ProtInc
  2. regulation of transcription, DNA-templated Source: GO_Central
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 267
Alternative name(s):
Zinc finger protein HZF2
Gene namesi
Name:ZNF267
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13060. ZNF267.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37638.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743Zinc finger protein 267PRO_0000047494Add
BLAST

Proteomic databases

MaxQBiQ14586.
PaxDbiQ14586.
PRIDEiQ14586.

PTM databases

PhosphoSiteiQ14586.

Expressioni

Gene expression databases

BgeeiQ14586.
CleanExiHS_ZNF267.
ExpressionAtlasiQ14586. baseline and differential.
GenevestigatoriQ14586.

Organism-specific databases

HPAiHPA003866.

Interactioni

Protein-protein interaction databases

BioGridi115594. 5 interactions.
IntActiQ14586. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ14586.
SMRiQ14586. Positions 260-743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri267 – 28923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34019C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri576 – 59823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri604 – 62623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri632 – 65423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri660 – 68223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri688 – 71023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri716 – 73823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121838.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14586.
KOiK09228.
OMAiCTEASFQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ14586.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLTFRDVA VEFSLEEWEH LEPAQKNLYQ DVMLENYRNL VSLGLVVSKP
60 70 80 90 100
DLITFLEQRK EPWNVKSEET VAIQPDVFSH YNKDLLTEHC TEASFQKVIS
110 120 130 140 150
RRHGSCDLEN LHLRKRWKRE ECEGHNGCYD EKTFKYDQFD ESSVESLFHQ
160 170 180 190 200
QILSSCAKSY NFDQYRKVFT HSSLLNQQEE IDIWGKHHIY DKTSVLFRQV
210 220 230 240 250
STLNSYRNVF IGEKNYHCNN SEKTLNQSSS PKNHQENYFL EKQYKCKEFE
260 270 280 290 300
EVFLQSMHGQ EKQEQSYKCN KCVEVCTQSL KHIQHQTIHI RENSYSYNKY
310 320 330 340 350
DKDLSQSSNL RKQIIHNEEK PYKCEKCGDS LNHSLHLTQH QIIPTEEKPC
360 370 380 390 400
KWKECGKVFN LNCSLYLTKQ QQIDTGENLY KCKACSKSFT RSSNLIVHQR
410 420 430 440 450
IHTGEKPYKC KECGKAFRCS SYLTKHKRIH TGEKPYKCKE CGKAFNRSSC
460 470 480 490 500
LTQHQTTHTG EKLYKCKVCS KSYARSSNLI MHQRVHTGEK PYKCKECGKV
510 520 530 540 550
FSRSSCLTQH RKIHTGENLY KCKVCAKPFT CFSNLIVHER IHTGEKPYKC
560 570 580 590 600
KECGKAFPYS SHLIRHHRIH TGEKPYKCKA CSKSFSDSSG LTVHRRTHTG
610 620 630 640 650
EKPYTCKECG KAFSYSSDVI QHRRIHTGQR PYKCEECGKA FNYRSYLTTH
660 670 680 690 700
QRSHTGERPY KCEECGKAFN SRSYLTTHRR RHTGERPYKC DECGKAFSYR
710 720 730 740
SYLTTHRRSH SGERPYKCEE CGKAFNSRSY LIAHQRSHTR EKL
Length:743
Mass (Da):87,376
Last modified:May 18, 2010 - v3
Checksum:i66AA4EC827BEFAAF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311D → N in AAH36367 (PubMed:15489334).Curated
Sequence conflicti567 – 5671H → Y in AAF73867 (Ref. 1) Curated
Sequence conflicti567 – 5671H → Y in CAA55525 (PubMed:7865130).Curated
Sequence conflicti592 – 5921T → S in AAF73867 (Ref. 1) Curated
Sequence conflicti592 – 5921T → S in CAA55525 (PubMed:7865130).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti257 – 2571M → V.
Corresponds to variant rs7202455 [ dbSNP | Ensembl ].
VAR_057414
Natural varianti350 – 3501C → Y.4 Publications
Corresponds to variant rs3850114 [ dbSNP | Ensembl ].
VAR_059907

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220492 mRNA. Translation: AAF73867.1.
AK292573 mRNA. Translation: BAF85262.1.
BC036367 mRNA. Translation: AAH36367.1.
BC127088 mRNA. Translation: AAI27089.1.
BC127089 mRNA. Translation: AAI27090.1.
X78925 mRNA. Translation: CAA55525.1.
CCDSiCCDS32440.1.
PIRiS47073.
RefSeqiNP_001252517.1. NM_001265588.1.
NP_003405.3. NM_003414.5.
UniGeneiHs.460645.

Genome annotation databases

EnsembliENST00000300870; ENSP00000300870; ENSG00000185947.
GeneIDi10308.
KEGGihsa:10308.
UCSCiuc002ecs.5. human.

Polymorphism databases

DMDMi296453069.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220492 mRNA. Translation: AAF73867.1.
AK292573 mRNA. Translation: BAF85262.1.
BC036367 mRNA. Translation: AAH36367.1.
BC127088 mRNA. Translation: AAI27089.1.
BC127089 mRNA. Translation: AAI27090.1.
X78925 mRNA. Translation: CAA55525.1.
CCDSiCCDS32440.1.
PIRiS47073.
RefSeqiNP_001252517.1. NM_001265588.1.
NP_003405.3. NM_003414.5.
UniGeneiHs.460645.

3D structure databases

ProteinModelPortaliQ14586.
SMRiQ14586. Positions 260-743.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115594. 5 interactions.
IntActiQ14586. 5 interactions.

PTM databases

PhosphoSiteiQ14586.

Polymorphism databases

DMDMi296453069.

Proteomic databases

MaxQBiQ14586.
PaxDbiQ14586.
PRIDEiQ14586.

Protocols and materials databases

DNASUi10308.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300870; ENSP00000300870; ENSG00000185947.
GeneIDi10308.
KEGGihsa:10308.
UCSCiuc002ecs.5. human.

Organism-specific databases

CTDi10308.
GeneCardsiGC16P031885.
HGNCiHGNC:13060. ZNF267.
HPAiHPA003866.
MIMi604752. gene.
neXtProtiNX_Q14586.
PharmGKBiPA37638.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121838.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14586.
KOiK09228.
OMAiCTEASFQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ14586.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikiiZNF267.
GenomeRNAii10308.
NextBioi39067.
PROiQ14586.
SOURCEiSearch...

Gene expression databases

BgeeiQ14586.
CleanExiHS_ZNF267.
ExpressionAtlasiQ14586. baseline and differential.
GenevestigatoriQ14586.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a nitric oxide regulated krueppel-like zinc finger protein using motif directed differential display."
    Schaefer U., Schneider A., Neugebauer E.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TYR-350.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-350.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-350.
    Tissue: Testis.
  4. "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
    Abrink M., Aveskogh M., Hellman L.
    DNA Cell Biol. 14:125-136(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-743, VARIANT TYR-350.

Entry informationi

Entry nameiZN267_HUMAN
AccessioniPrimary (citable) accession number: Q14586
Secondary accession number(s): A0JNZ9, Q8NE41, Q9NRJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: February 4, 2015
This is version 155 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.