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Q14586

- ZN267_HUMAN

UniProt

Q14586 - ZN267_HUMAN

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Protein
Zinc finger protein 267
Gene
ZNF267
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri267 – 28923C2H2-type 1
Add
BLAST
Zinc fingeri322 – 34019C2H2-type 2; atypical
Add
BLAST
Zinc fingeri380 – 40223C2H2-type 3
Add
BLAST
Zinc fingeri408 – 43023C2H2-type 4
Add
BLAST
Zinc fingeri436 – 45823C2H2-type 5
Add
BLAST
Zinc fingeri464 – 48623C2H2-type 6
Add
BLAST
Zinc fingeri492 – 51423C2H2-type 7
Add
BLAST
Zinc fingeri520 – 54223C2H2-type 8
Add
BLAST
Zinc fingeri548 – 57023C2H2-type 9
Add
BLAST
Zinc fingeri576 – 59823C2H2-type 10
Add
BLAST
Zinc fingeri604 – 62623C2H2-type 11
Add
BLAST
Zinc fingeri632 – 65423C2H2-type 12
Add
BLAST
Zinc fingeri660 – 68223C2H2-type 13
Add
BLAST
Zinc fingeri688 – 71023C2H2-type 14
Add
BLAST
Zinc fingeri716 – 73823C2H2-type 15
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. multicellular organismal development Source: ProtInc
  2. regulation of transcription, DNA-templated Source: RefGenome
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 267
Alternative name(s):
Zinc finger protein HZF2
Gene namesi
Name:ZNF267
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:13060. ZNF267.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37638.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743Zinc finger protein 267
PRO_0000047494Add
BLAST

Proteomic databases

MaxQBiQ14586.
PaxDbiQ14586.
PRIDEiQ14586.

PTM databases

PhosphoSiteiQ14586.

Expressioni

Gene expression databases

BgeeiQ14586.
CleanExiHS_ZNF267.
GenevestigatoriQ14586.

Organism-specific databases

HPAiHPA003866.

Interactioni

Protein-protein interaction databases

BioGridi115594. 5 interactions.
IntActiQ14586. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ14586.
SMRiQ14586. Positions 260-743.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRAB
Add
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14586.
KOiK09228.
OMAiCTEASFQ.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ14586.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14586-1 [UniParc]FASTAAdd to Basket

« Hide

MGLLTFRDVA VEFSLEEWEH LEPAQKNLYQ DVMLENYRNL VSLGLVVSKP    50
DLITFLEQRK EPWNVKSEET VAIQPDVFSH YNKDLLTEHC TEASFQKVIS 100
RRHGSCDLEN LHLRKRWKRE ECEGHNGCYD EKTFKYDQFD ESSVESLFHQ 150
QILSSCAKSY NFDQYRKVFT HSSLLNQQEE IDIWGKHHIY DKTSVLFRQV 200
STLNSYRNVF IGEKNYHCNN SEKTLNQSSS PKNHQENYFL EKQYKCKEFE 250
EVFLQSMHGQ EKQEQSYKCN KCVEVCTQSL KHIQHQTIHI RENSYSYNKY 300
DKDLSQSSNL RKQIIHNEEK PYKCEKCGDS LNHSLHLTQH QIIPTEEKPC 350
KWKECGKVFN LNCSLYLTKQ QQIDTGENLY KCKACSKSFT RSSNLIVHQR 400
IHTGEKPYKC KECGKAFRCS SYLTKHKRIH TGEKPYKCKE CGKAFNRSSC 450
LTQHQTTHTG EKLYKCKVCS KSYARSSNLI MHQRVHTGEK PYKCKECGKV 500
FSRSSCLTQH RKIHTGENLY KCKVCAKPFT CFSNLIVHER IHTGEKPYKC 550
KECGKAFPYS SHLIRHHRIH TGEKPYKCKA CSKSFSDSSG LTVHRRTHTG 600
EKPYTCKECG KAFSYSSDVI QHRRIHTGQR PYKCEECGKA FNYRSYLTTH 650
QRSHTGERPY KCEECGKAFN SRSYLTTHRR RHTGERPYKC DECGKAFSYR 700
SYLTTHRRSH SGERPYKCEE CGKAFNSRSY LIAHQRSHTR EKL 743
Length:743
Mass (Da):87,376
Last modified:May 18, 2010 - v3
Checksum:i66AA4EC827BEFAAF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti257 – 2571M → V.
Corresponds to variant rs7202455 [ dbSNP | Ensembl ].
VAR_057414
Natural varianti350 – 3501C → Y.4 Publications
Corresponds to variant rs3850114 [ dbSNP | Ensembl ].
VAR_059907

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311D → N in AAH36367. 1 Publication
Sequence conflicti567 – 5671H → Y in AAF73867. 1 Publication
Sequence conflicti567 – 5671H → Y in CAA55525. 1 Publication
Sequence conflicti592 – 5921T → S in AAF73867. 1 Publication
Sequence conflicti592 – 5921T → S in CAA55525. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220492 mRNA. Translation: AAF73867.1.
AK292573 mRNA. Translation: BAF85262.1.
BC036367 mRNA. Translation: AAH36367.1.
BC127088 mRNA. Translation: AAI27089.1.
BC127089 mRNA. Translation: AAI27090.1.
X78925 mRNA. Translation: CAA55525.1.
CCDSiCCDS32440.1.
PIRiS47073.
RefSeqiNP_001252517.1. NM_001265588.1.
NP_003405.3. NM_003414.5.
UniGeneiHs.460645.

Genome annotation databases

EnsembliENST00000300870; ENSP00000300870; ENSG00000185947.
GeneIDi10308.
KEGGihsa:10308.
UCSCiuc002ecs.5. human.

Polymorphism databases

DMDMi296453069.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220492 mRNA. Translation: AAF73867.1 .
AK292573 mRNA. Translation: BAF85262.1 .
BC036367 mRNA. Translation: AAH36367.1 .
BC127088 mRNA. Translation: AAI27089.1 .
BC127089 mRNA. Translation: AAI27090.1 .
X78925 mRNA. Translation: CAA55525.1 .
CCDSi CCDS32440.1.
PIRi S47073.
RefSeqi NP_001252517.1. NM_001265588.1.
NP_003405.3. NM_003414.5.
UniGenei Hs.460645.

3D structure databases

ProteinModelPortali Q14586.
SMRi Q14586. Positions 260-743.
ModBasei Search...

Protein-protein interaction databases

BioGridi 115594. 5 interactions.
IntActi Q14586. 5 interactions.

PTM databases

PhosphoSitei Q14586.

Polymorphism databases

DMDMi 296453069.

Proteomic databases

MaxQBi Q14586.
PaxDbi Q14586.
PRIDEi Q14586.

Protocols and materials databases

DNASUi 10308.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300870 ; ENSP00000300870 ; ENSG00000185947 .
GeneIDi 10308.
KEGGi hsa:10308.
UCSCi uc002ecs.5. human.

Organism-specific databases

CTDi 10308.
GeneCardsi GC16P031885.
HGNCi HGNC:13060. ZNF267.
HPAi HPA003866.
MIMi 604752. gene.
neXtProti NX_Q14586.
PharmGKBi PA37638.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q14586.
KOi K09228.
OMAi CTEASFQ.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q14586.
TreeFami TF341817.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikii ZNF267.
GenomeRNAii 10308.
NextBioi 39067.
PROi Q14586.
SOURCEi Search...

Gene expression databases

Bgeei Q14586.
CleanExi HS_ZNF267.
Genevestigatori Q14586.

Family and domain databases

Gene3Di 3.30.160.60. 16 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a nitric oxide regulated krueppel-like zinc finger protein using motif directed differential display."
    Schaefer U., Schneider A., Neugebauer E.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TYR-350.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-350.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-350.
    Tissue: Testis.
  4. "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
    Abrink M., Aveskogh M., Hellman L.
    DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-743, VARIANT TYR-350.

Entry informationi

Entry nameiZN267_HUMAN
AccessioniPrimary (citable) accession number: Q14586
Secondary accession number(s): A0JNZ9, Q8NE41, Q9NRJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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