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Q14586

- ZN267_HUMAN

UniProt

Q14586 - ZN267_HUMAN

Protein

Zinc finger protein 267

Gene

ZNF267

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri267 – 28923C2H2-type 1PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri322 – 34019C2H2-type 2; atypicalPROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri380 – 40223C2H2-type 3PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri408 – 43023C2H2-type 4PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri436 – 45823C2H2-type 5PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri464 – 48623C2H2-type 6PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri492 – 51423C2H2-type 7PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri520 – 54223C2H2-type 8PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri548 – 57023C2H2-type 9PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri576 – 59823C2H2-type 10PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri604 – 62623C2H2-type 11PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri632 – 65423C2H2-type 12PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri660 – 68223C2H2-type 13PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri688 – 71023C2H2-type 14PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri716 – 73823C2H2-type 15PROSITE-ProRule annotationsAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. multicellular organismal development Source: ProtInc
    2. regulation of transcription, DNA-templated Source: RefGenome
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 267
    Alternative name(s):
    Zinc finger protein HZF2
    Gene namesi
    Name:ZNF267
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Organism-specific databases

    HGNCiHGNC:13060. ZNF267.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37638.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 743743Zinc finger protein 267PRO_0000047494Add
    BLAST

    Proteomic databases

    MaxQBiQ14586.
    PaxDbiQ14586.
    PRIDEiQ14586.

    PTM databases

    PhosphoSiteiQ14586.

    Expressioni

    Gene expression databases

    BgeeiQ14586.
    CleanExiHS_ZNF267.
    GenevestigatoriQ14586.

    Organism-specific databases

    HPAiHPA003866.

    Interactioni

    Protein-protein interaction databases

    BioGridi115594. 5 interactions.
    IntActiQ14586. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14586.
    SMRiQ14586. Positions 260-743.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 7572KRABPROSITE-ProRule annotationsAdd
    BLAST

    Sequence similaritiesi

    Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotations
    Contains 1 KRAB domain.PROSITE-ProRule annotations

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri267 – 28923C2H2-type 1PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri322 – 34019C2H2-type 2; atypicalPROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri380 – 40223C2H2-type 3PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri408 – 43023C2H2-type 4PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri436 – 45823C2H2-type 5PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri464 – 48623C2H2-type 6PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri492 – 51423C2H2-type 7PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri520 – 54223C2H2-type 8PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri548 – 57023C2H2-type 9PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri576 – 59823C2H2-type 10PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri604 – 62623C2H2-type 11PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri632 – 65423C2H2-type 12PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri660 – 68223C2H2-type 13PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri688 – 71023C2H2-type 14PROSITE-ProRule annotationsAdd
    BLAST
    Zinc fingeri716 – 73823C2H2-type 15PROSITE-ProRule annotationsAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ14586.
    KOiK09228.
    OMAiCTEASFQ.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ14586.
    TreeFamiTF341817.

    Family and domain databases

    Gene3Di3.30.160.60. 16 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 15 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 14 hits.
    PS50157. ZINC_FINGER_C2H2_2. 14 hits.
    [Graphical view]
    ProtoNetiSearch...

    Sequencei

    Sequence statusi: Complete.

    Q14586-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLLTFRDVA VEFSLEEWEH LEPAQKNLYQ DVMLENYRNL VSLGLVVSKP    50
    DLITFLEQRK EPWNVKSEET VAIQPDVFSH YNKDLLTEHC TEASFQKVIS 100
    RRHGSCDLEN LHLRKRWKRE ECEGHNGCYD EKTFKYDQFD ESSVESLFHQ 150
    QILSSCAKSY NFDQYRKVFT HSSLLNQQEE IDIWGKHHIY DKTSVLFRQV 200
    STLNSYRNVF IGEKNYHCNN SEKTLNQSSS PKNHQENYFL EKQYKCKEFE 250
    EVFLQSMHGQ EKQEQSYKCN KCVEVCTQSL KHIQHQTIHI RENSYSYNKY 300
    DKDLSQSSNL RKQIIHNEEK PYKCEKCGDS LNHSLHLTQH QIIPTEEKPC 350
    KWKECGKVFN LNCSLYLTKQ QQIDTGENLY KCKACSKSFT RSSNLIVHQR 400
    IHTGEKPYKC KECGKAFRCS SYLTKHKRIH TGEKPYKCKE CGKAFNRSSC 450
    LTQHQTTHTG EKLYKCKVCS KSYARSSNLI MHQRVHTGEK PYKCKECGKV 500
    FSRSSCLTQH RKIHTGENLY KCKVCAKPFT CFSNLIVHER IHTGEKPYKC 550
    KECGKAFPYS SHLIRHHRIH TGEKPYKCKA CSKSFSDSSG LTVHRRTHTG 600
    EKPYTCKECG KAFSYSSDVI QHRRIHTGQR PYKCEECGKA FNYRSYLTTH 650
    QRSHTGERPY KCEECGKAFN SRSYLTTHRR RHTGERPYKC DECGKAFSYR 700
    SYLTTHRRSH SGERPYKCEE CGKAFNSRSY LIAHQRSHTR EKL 743
    Length:743
    Mass (Da):87,376
    Last modified:May 18, 2010 - v3
    Checksum:i66AA4EC827BEFAAF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti257 – 2571M → V.
    Corresponds to variant rs7202455 [ dbSNP | Ensembl ].
    VAR_057414
    Natural varianti350 – 3501C → Y.4 Publications
    Corresponds to variant rs3850114 [ dbSNP | Ensembl ].
    VAR_059907

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311D → N in AAH36367. (PubMed:15489334)Curated
    Sequence conflicti567 – 5671H → Y in AAF73867. 1 PublicationCurated
    Sequence conflicti567 – 5671H → Y in CAA55525. (PubMed:7865130)Curated
    Sequence conflicti592 – 5921T → S in AAF73867. 1 PublicationCurated
    Sequence conflicti592 – 5921T → S in CAA55525. (PubMed:7865130)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220492 mRNA. Translation: AAF73867.1.
    AK292573 mRNA. Translation: BAF85262.1.
    BC036367 mRNA. Translation: AAH36367.1.
    BC127088 mRNA. Translation: AAI27089.1.
    BC127089 mRNA. Translation: AAI27090.1.
    X78925 mRNA. Translation: CAA55525.1.
    CCDSiCCDS32440.1.
    PIRiS47073.
    RefSeqiNP_001252517.1. NM_001265588.1.
    NP_003405.3. NM_003414.5.
    UniGeneiHs.460645.

    Genome annotation databases

    EnsembliENST00000300870; ENSP00000300870; ENSG00000185947.
    GeneIDi10308.
    KEGGihsa:10308.
    UCSCiuc002ecs.5. human.

    Polymorphism databases

    DMDMi296453069.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220492 mRNA. Translation: AAF73867.1 .
    AK292573 mRNA. Translation: BAF85262.1 .
    BC036367 mRNA. Translation: AAH36367.1 .
    BC127088 mRNA. Translation: AAI27089.1 .
    BC127089 mRNA. Translation: AAI27090.1 .
    X78925 mRNA. Translation: CAA55525.1 .
    CCDSi CCDS32440.1.
    PIRi S47073.
    RefSeqi NP_001252517.1. NM_001265588.1.
    NP_003405.3. NM_003414.5.
    UniGenei Hs.460645.

    3D structure databases

    ProteinModelPortali Q14586.
    SMRi Q14586. Positions 260-743.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115594. 5 interactions.
    IntActi Q14586. 5 interactions.

    PTM databases

    PhosphoSitei Q14586.

    Polymorphism databases

    DMDMi 296453069.

    Proteomic databases

    MaxQBi Q14586.
    PaxDbi Q14586.
    PRIDEi Q14586.

    Protocols and materials databases

    DNASUi 10308.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300870 ; ENSP00000300870 ; ENSG00000185947 .
    GeneIDi 10308.
    KEGGi hsa:10308.
    UCSCi uc002ecs.5. human.

    Organism-specific databases

    CTDi 10308.
    GeneCardsi GC16P031885.
    HGNCi HGNC:13060. ZNF267.
    HPAi HPA003866.
    MIMi 604752. gene.
    neXtProti NX_Q14586.
    PharmGKBi PA37638.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q14586.
    KOi K09228.
    OMAi CTEASFQ.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q14586.
    TreeFami TF341817.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GeneWikii ZNF267.
    GenomeRNAii 10308.
    NextBioi 39067.
    PROi Q14586.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q14586.
    CleanExi HS_ZNF267.
    Genevestigatori Q14586.

    Family and domain databases

    Gene3Di 3.30.160.60. 16 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 15 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 14 hits.
    PS50157. ZINC_FINGER_C2H2_2. 14 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a nitric oxide regulated krueppel-like zinc finger protein using motif directed differential display."
      Schaefer U., Schneider A., Neugebauer E.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TYR-350.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-350.
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-350.
      Tissue: Testis.
    4. "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
      Abrink M., Aveskogh M., Hellman L.
      DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-743, VARIANT TYR-350.

    Entry informationi

    Entry nameiZN267_HUMAN
    AccessioniPrimary (citable) accession number: Q14586
    Secondary accession number(s): A0JNZ9, Q8NE41, Q9NRJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 151 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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