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Q14586 (ZN267_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 149. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 267
Alternative name(s):
Zinc finger protein HZF2
Gene names
Name:ZNF267
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length743 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 15 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 743743Zinc finger protein 267
PRO_0000047494

Regions

Domain4 – 7572KRAB
Zinc finger267 – 28923C2H2-type 1
Zinc finger322 – 34019C2H2-type 2; atypical
Zinc finger380 – 40223C2H2-type 3
Zinc finger408 – 43023C2H2-type 4
Zinc finger436 – 45823C2H2-type 5
Zinc finger464 – 48623C2H2-type 6
Zinc finger492 – 51423C2H2-type 7
Zinc finger520 – 54223C2H2-type 8
Zinc finger548 – 57023C2H2-type 9
Zinc finger576 – 59823C2H2-type 10
Zinc finger604 – 62623C2H2-type 11
Zinc finger632 – 65423C2H2-type 12
Zinc finger660 – 68223C2H2-type 13
Zinc finger688 – 71023C2H2-type 14
Zinc finger716 – 73823C2H2-type 15

Natural variations

Natural variant2571M → V.
Corresponds to variant rs7202455 [ dbSNP | Ensembl ].
VAR_057414
Natural variant3501C → Y. Ref.1 Ref.2 Ref.3 Ref.4
Corresponds to variant rs3850114 [ dbSNP | Ensembl ].
VAR_059907

Experimental info

Sequence conflict311D → N in AAH36367. Ref.3
Sequence conflict5671H → Y in AAF73867. Ref.1
Sequence conflict5671H → Y in CAA55525. Ref.4
Sequence conflict5921T → S in AAF73867. Ref.1
Sequence conflict5921T → S in CAA55525. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q14586 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 66AA4EC827BEFAAF

FASTA74387,376
        10         20         30         40         50         60 
MGLLTFRDVA VEFSLEEWEH LEPAQKNLYQ DVMLENYRNL VSLGLVVSKP DLITFLEQRK 

        70         80         90        100        110        120 
EPWNVKSEET VAIQPDVFSH YNKDLLTEHC TEASFQKVIS RRHGSCDLEN LHLRKRWKRE 

       130        140        150        160        170        180 
ECEGHNGCYD EKTFKYDQFD ESSVESLFHQ QILSSCAKSY NFDQYRKVFT HSSLLNQQEE 

       190        200        210        220        230        240 
IDIWGKHHIY DKTSVLFRQV STLNSYRNVF IGEKNYHCNN SEKTLNQSSS PKNHQENYFL 

       250        260        270        280        290        300 
EKQYKCKEFE EVFLQSMHGQ EKQEQSYKCN KCVEVCTQSL KHIQHQTIHI RENSYSYNKY 

       310        320        330        340        350        360 
DKDLSQSSNL RKQIIHNEEK PYKCEKCGDS LNHSLHLTQH QIIPTEEKPC KWKECGKVFN 

       370        380        390        400        410        420 
LNCSLYLTKQ QQIDTGENLY KCKACSKSFT RSSNLIVHQR IHTGEKPYKC KECGKAFRCS 

       430        440        450        460        470        480 
SYLTKHKRIH TGEKPYKCKE CGKAFNRSSC LTQHQTTHTG EKLYKCKVCS KSYARSSNLI 

       490        500        510        520        530        540 
MHQRVHTGEK PYKCKECGKV FSRSSCLTQH RKIHTGENLY KCKVCAKPFT CFSNLIVHER 

       550        560        570        580        590        600 
IHTGEKPYKC KECGKAFPYS SHLIRHHRIH TGEKPYKCKA CSKSFSDSSG LTVHRRTHTG 

       610        620        630        640        650        660 
EKPYTCKECG KAFSYSSDVI QHRRIHTGQR PYKCEECGKA FNYRSYLTTH QRSHTGERPY 

       670        680        690        700        710        720 
KCEECGKAFN SRSYLTTHRR RHTGERPYKC DECGKAFSYR SYLTTHRRSH SGERPYKCEE 

       730        740 
CGKAFNSRSY LIAHQRSHTR EKL 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a nitric oxide regulated krueppel-like zinc finger protein using motif directed differential display."
Schaefer U., Schneider A., Neugebauer E.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT TYR-350.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-350.
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TYR-350.
Tissue: Testis.
[4]"Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
Abrink M., Aveskogh M., Hellman L.
DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-743, VARIANT TYR-350.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF220492 mRNA. Translation: AAF73867.1.
AK292573 mRNA. Translation: BAF85262.1.
BC036367 mRNA. Translation: AAH36367.1.
BC127088 mRNA. Translation: AAI27089.1.
BC127089 mRNA. Translation: AAI27090.1.
X78925 mRNA. Translation: CAA55525.1.
CCDSCCDS32440.1.
PIRS47073.
RefSeqNP_001252517.1. NM_001265588.1.
NP_003405.3. NM_003414.5.
UniGeneHs.460645.

3D structure databases

ProteinModelPortalQ14586.
SMRQ14586. Positions 260-743.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115594. 5 interactions.
IntActQ14586. 5 interactions.

PTM databases

PhosphoSiteQ14586.

Polymorphism databases

DMDM296453069.

Proteomic databases

MaxQBQ14586.
PaxDbQ14586.
PRIDEQ14586.

Protocols and materials databases

DNASU10308.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300870; ENSP00000300870; ENSG00000185947.
GeneID10308.
KEGGhsa:10308.
UCSCuc002ecs.5. human.

Organism-specific databases

CTD10308.
GeneCardsGC16P031885.
HGNCHGNC:13060. ZNF267.
HPAHPA003866.
MIM604752. gene.
neXtProtNX_Q14586.
PharmGKBPA37638.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ14586.
KOK09228.
OMACTEASFQ.
OrthoDBEOG7KSX7Q.
PhylomeDBQ14586.
TreeFamTF341817.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

BgeeQ14586.
CleanExHS_ZNF267.
GenevestigatorQ14586.

Family and domain databases

Gene3D3.30.160.60. 16 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF267.
GenomeRNAi10308.
NextBio39067.
PROQ14586.
SOURCESearch...

Entry information

Entry nameZN267_HUMAN
AccessionPrimary (citable) accession number: Q14586
Secondary accession number(s): A0JNZ9, Q8NE41, Q9NRJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM