ID ZN345_HUMAN Reviewed; 488 AA. AC Q14585; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 27-MAR-2024, entry version 203. DE RecName: Full=Zinc finger protein 345; DE AltName: Full=Zinc finger protein HZF10; GN Name=ZNF345; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=7865130; DOI=10.1089/dna.1995.14.125; RA Abrink M., Aveskogh M., Hellman L.; RT "Isolation of cDNA clones for 42 different Kruppel-related zinc finger RT proteins expressed in the human monoblast cell line U-937."; RL DNA Cell Biol. 14:125-136(1995). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May be involved in transcriptional regulation. CC -!- INTERACTION: CC Q14585; G5E9A7: DMWD; NbExp=3; IntAct=EBI-2818408, EBI-10976677; CC Q14585; O95967: EFEMP2; NbExp=3; IntAct=EBI-2818408, EBI-743414; CC Q14585; P02545: LMNA; NbExp=3; IntAct=EBI-2818408, EBI-351935; CC Q14585; Q15287: RNPS1; NbExp=3; IntAct=EBI-2818408, EBI-395959; CC Q14585; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-2818408, EBI-5235340; CC Q14585; Q86WV8: TSC1; NbExp=3; IntAct=EBI-2818408, EBI-12806590; CC Q14585; P15622-3: ZNF250; NbExp=3; IntAct=EBI-2818408, EBI-10177272; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X78933; CAA55533.1; -; mRNA. DR EMBL; BC032863; AAH32863.1; -; mRNA. DR CCDS; CCDS12497.1; -. DR PIR; S47072; S47072. DR RefSeq; NP_001229401.1; NM_001242472.1. DR RefSeq; NP_001229403.1; NM_001242474.1. DR RefSeq; NP_001229404.1; NM_001242475.1. DR RefSeq; NP_001229405.1; NM_001242476.1. DR RefSeq; NP_003410.1; NM_003419.4. DR RefSeq; XP_011525006.1; XM_011526704.2. DR RefSeq; XP_016882057.1; XM_017026568.1. DR RefSeq; XP_016882058.1; XM_017026569.1. DR RefSeq; XP_016882059.1; XM_017026570.1. DR RefSeq; XP_016882060.1; XM_017026571.1. DR RefSeq; XP_016882061.1; XM_017026572.1. DR RefSeq; XP_016882062.1; XM_017026573.1. DR AlphaFoldDB; Q14585; -. DR SMR; Q14585; -. DR BioGRID; 117374; 6. DR IntAct; Q14585; 8. DR STRING; 9606.ENSP00000431202; -. DR iPTMnet; Q14585; -. DR PhosphoSitePlus; Q14585; -. DR BioMuta; ZNF345; -. DR DMDM; 11136080; -. DR jPOST; Q14585; -. DR MassIVE; Q14585; -. DR MaxQB; Q14585; -. DR PaxDb; 9606-ENSP00000431202; -. DR PeptideAtlas; Q14585; -. DR ProteomicsDB; 60058; -. DR Antibodypedia; 47728; 88 antibodies from 13 providers. DR DNASU; 25850; -. DR Ensembl; ENST00000331800.9; ENSP00000331120.5; ENSG00000251247.13. DR Ensembl; ENST00000420450.6; ENSP00000431216.1; ENSG00000251247.13. DR Ensembl; ENST00000529555.1; ENSP00000431202.1; ENSG00000251247.13. DR Ensembl; ENST00000532141.6; ENSP00000431289.2; ENSG00000251247.13. DR Ensembl; ENST00000589046.1; ENSP00000465431.1; ENSG00000251247.13. DR GeneID; 25850; -. DR KEGG; hsa:25850; -. DR MANE-Select; ENST00000420450.6; ENSP00000431216.1; NM_001242472.2; NP_001229401.1. DR UCSC; uc002oex.4; human. DR AGR; HGNC:16367; -. DR CTD; 25850; -. DR GeneCards; ZNF345; -. DR HGNC; HGNC:16367; ZNF345. DR HPA; ENSG00000251247; Low tissue specificity. DR neXtProt; NX_Q14585; -. DR OpenTargets; ENSG00000251247; -. DR PharmGKB; PA38128; -. DR VEuPathDB; HostDB:ENSG00000251247; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000163308; -. DR HOGENOM; CLU_002678_0_2_1; -. DR InParanoid; Q14585; -. DR OMA; MERLTKH; -. DR OrthoDB; 5398332at2759; -. DR PhylomeDB; Q14585; -. DR PathwayCommons; Q14585; -. DR SignaLink; Q14585; -. DR BioGRID-ORCS; 25850; 18 hits in 1162 CRISPR screens. DR ChiTaRS; ZNF345; human. DR GenomeRNAi; 25850; -. DR Pharos; Q14585; Tdark. DR PRO; PR:Q14585; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; Q14585; Protein. DR Bgee; ENSG00000251247; Expressed in right testis and 118 other cell types or tissues. DR ExpressionAtlas; Q14585; baseline and differential. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; TAS:ProtInc. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0006359; P:regulation of transcription by RNA polymerase III; TAS:ProtInc. DR GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc. DR GO; GO:0006383; P:transcription by RNA polymerase III; TAS:ProtInc. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 15. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR24381; ZINC FINGER PROTEIN; 1. DR PANTHER; PTHR24381:SF431; ZINC FINGER PROTEIN 78; 1. DR Pfam; PF00096; zf-C2H2; 11. DR Pfam; PF13465; zf-H2C2_2; 2. DR SMART; SM00355; ZnF_C2H2; 15. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15. DR Genevisible; Q14585; HS. PE 1: Evidence at protein level; KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; KW Transcription; Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1..488 FT /note="Zinc finger protein 345" FT /id="PRO_0000047544" FT ZN_FING 62..84 FT /note="C2H2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 90..112 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 118..140 FT /note="C2H2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 146..168 FT /note="C2H2-type 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 174..196 FT /note="C2H2-type 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 202..224 FT /note="C2H2-type 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 230..252 FT /note="C2H2-type 7" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 258..280 FT /note="C2H2-type 8" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 286..308 FT /note="C2H2-type 9" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 314..336 FT /note="C2H2-type 10" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 342..364 FT /note="C2H2-type 11" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 370..392 FT /note="C2H2-type 12" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 398..420 FT /note="C2H2-type 13" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 426..448 FT /note="C2H2-type 14" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 454..476 FT /note="C2H2-type 15" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" SQ SEQUENCE 488 AA; 55383 MW; 0BDC436E4451285B CRC64; MENLTKHSIE CSSFRGDWEC KNQFERKQGS QEGHFSEMIF TPEDMPTFSI QHQRIHTDEK LLECKECGKD FSFVSVLVRH QRIHTGEKPY ECKECGKAFG SGANLAYHQR IHTGEKPFEC KECGKAFGSG SNLTHHQRIH TGEKPYECKE CGKAFSFGSG LIRHQIIHSG EKPYECKECG KSFSFESALI RHHRIHTGEK PYECIDCGKA FGSGSNLTQH RRIHTGEKPY ECKACGMAFS SGSALTRHQR IHTGEKPYIC NECGKAFSFG SALTRHQRIH TGEKPYVCKE CGKAFNSGSD LTQHQRIHTG EKPYECKECE KAFRSGSKLI QHQRMHTGEK PYECKECGKT FSSGSDLTQH HRIHTGEKPY ECKECGKAFG SGSKLIQHQL IHTGERPYEC KECGKSFSSG SALNRHQRIH TGEKPYECKE CGKAFYSGSS LTQHQRIHTG EKLYECKNCG KAYGRDSEFQ QHKKSHNGKK LCELETIN //