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Q14585

- ZN345_HUMAN

UniProt

Q14585 - ZN345_HUMAN

Protein

Zinc finger protein 345

Gene

ZNF345

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri62 – 8423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri90 – 11223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri118 – 14023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri146 – 16823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri174 – 19623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri202 – 22423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri230 – 25223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri258 – 28023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri286 – 30823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri314 – 33623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri342 – 36423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri370 – 39223C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42023C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri426 – 44823C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri454 – 47623C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
    2. regulation of transcription, DNA-templated Source: RefGenome
    3. regulation of transcription from RNA polymerase III promoter Source: ProtInc
    4. transcription from RNA polymerase III promoter Source: ProtInc
    5. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 345
    Alternative name(s):
    Zinc finger protein HZF10
    Gene namesi
    Name:ZNF345
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:16367. ZNF345.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38128.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Zinc finger protein 345PRO_0000047544Add
    BLAST

    Proteomic databases

    PaxDbiQ14585.
    PRIDEiQ14585.

    PTM databases

    PhosphoSiteiQ14585.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14585.
    BgeeiQ14585.
    CleanExiHS_ZNF345.
    GenevestigatoriQ14585.

    Organism-specific databases

    HPAiHPA025816.

    Interactioni

    Protein-protein interaction databases

    IntActiQ14585. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14585.
    SMRiQ14585. Positions 59-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri62 – 8423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri90 – 11223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri118 – 14023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri146 – 16823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri174 – 19623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri202 – 22423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri230 – 25223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri258 – 28023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri286 – 30823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri314 – 33623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri342 – 36423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri370 – 39223C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42023C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri426 – 44823C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri454 – 47623C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ14585.
    OMAiKQGSQEG.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ14585.

    Family and domain databases

    Gene3Di3.30.160.60. 16 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 15 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 15 hits.
    PS50157. ZINC_FINGER_C2H2_2. 15 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14585-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENLTKHSIE CSSFRGDWEC KNQFERKQGS QEGHFSEMIF TPEDMPTFSI    50
    QHQRIHTDEK LLECKECGKD FSFVSVLVRH QRIHTGEKPY ECKECGKAFG 100
    SGANLAYHQR IHTGEKPFEC KECGKAFGSG SNLTHHQRIH TGEKPYECKE 150
    CGKAFSFGSG LIRHQIIHSG EKPYECKECG KSFSFESALI RHHRIHTGEK 200
    PYECIDCGKA FGSGSNLTQH RRIHTGEKPY ECKACGMAFS SGSALTRHQR 250
    IHTGEKPYIC NECGKAFSFG SALTRHQRIH TGEKPYVCKE CGKAFNSGSD 300
    LTQHQRIHTG EKPYECKECE KAFRSGSKLI QHQRMHTGEK PYECKECGKT 350
    FSSGSDLTQH HRIHTGEKPY ECKECGKAFG SGSKLIQHQL IHTGERPYEC 400
    KECGKSFSSG SALNRHQRIH TGEKPYECKE CGKAFYSGSS LTQHQRIHTG 450
    EKLYECKNCG KAYGRDSEFQ QHKKSHNGKK LCELETIN 488
    Length:488
    Mass (Da):55,383
    Last modified:November 1, 1996 - v1
    Checksum:i0BDC436E4451285B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78933 mRNA. Translation: CAA55533.1.
    BC032863 mRNA. Translation: AAH32863.1.
    CCDSiCCDS12497.1.
    PIRiS47072.
    RefSeqiNP_001229401.1. NM_001242472.1.
    NP_001229403.1. NM_001242474.1.
    NP_001229404.1. NM_001242475.1.
    NP_001229405.1. NM_001242476.1.
    NP_003410.1. NM_003419.4.
    XP_006723195.1. XM_006723132.1.
    UniGeneiHs.362324.

    Genome annotation databases

    EnsembliENST00000420450; ENSP00000431216; ENSG00000251247.
    ENST00000529555; ENSP00000431202; ENSG00000251247.
    ENST00000589046; ENSP00000465431; ENSG00000251247.
    GeneIDi25850.
    KEGGihsa:25850.
    UCSCiuc002oex.3. human.

    Polymorphism databases

    DMDMi11136080.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78933 mRNA. Translation: CAA55533.1 .
    BC032863 mRNA. Translation: AAH32863.1 .
    CCDSi CCDS12497.1.
    PIRi S47072.
    RefSeqi NP_001229401.1. NM_001242472.1.
    NP_001229403.1. NM_001242474.1.
    NP_001229404.1. NM_001242475.1.
    NP_001229405.1. NM_001242476.1.
    NP_003410.1. NM_003419.4.
    XP_006723195.1. XM_006723132.1.
    UniGenei Hs.362324.

    3D structure databases

    ProteinModelPortali Q14585.
    SMRi Q14585. Positions 59-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q14585. 1 interaction.

    PTM databases

    PhosphoSitei Q14585.

    Polymorphism databases

    DMDMi 11136080.

    Proteomic databases

    PaxDbi Q14585.
    PRIDEi Q14585.

    Protocols and materials databases

    DNASUi 25850.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000420450 ; ENSP00000431216 ; ENSG00000251247 .
    ENST00000529555 ; ENSP00000431202 ; ENSG00000251247 .
    ENST00000589046 ; ENSP00000465431 ; ENSG00000251247 .
    GeneIDi 25850.
    KEGGi hsa:25850.
    UCSCi uc002oex.3. human.

    Organism-specific databases

    CTDi 25850.
    GeneCardsi GC19P037341.
    HGNCi HGNC:16367. ZNF345.
    HPAi HPA025816.
    neXtProti NX_Q14585.
    PharmGKBi PA38128.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q14585.
    OMAi KQGSQEG.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q14585.

    Miscellaneous databases

    GenomeRNAii 25850.
    NextBioi 47189.
    PROi Q14585.

    Gene expression databases

    ArrayExpressi Q14585.
    Bgeei Q14585.
    CleanExi HS_ZNF345.
    Genevestigatori Q14585.

    Family and domain databases

    Gene3Di 3.30.160.60. 16 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 15 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 15 hits.
    PS50157. ZINC_FINGER_C2H2_2. 15 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
      Abrink M., Aveskogh M., Hellman L.
      DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiZN345_HUMAN
    AccessioniPrimary (citable) accession number: Q14585
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 136 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3