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Q14585

- ZN345_HUMAN

UniProt

Q14585 - ZN345_HUMAN

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Protein

Zinc finger protein 345

Gene

ZNF345

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri62 – 8423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri90 – 11223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri118 – 14023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 16823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri174 – 19623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  2. regulation of transcription, DNA-templated Source: RefGenome
  3. regulation of transcription from RNA polymerase III promoter Source: ProtInc
  4. transcription from RNA polymerase III promoter Source: ProtInc
  5. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 345
Alternative name(s):
Zinc finger protein HZF10
Gene namesi
Name:ZNF345
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:16367. ZNF345.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38128.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Zinc finger protein 345PRO_0000047544Add
BLAST

Proteomic databases

PaxDbiQ14585.
PRIDEiQ14585.

PTM databases

PhosphoSiteiQ14585.

Expressioni

Gene expression databases

BgeeiQ14585.
CleanExiHS_ZNF345.
ExpressionAtlasiQ14585. baseline and differential.
GenevestigatoriQ14585.

Organism-specific databases

HPAiHPA025816.

Interactioni

Protein-protein interaction databases

IntActiQ14585. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ14585.
SMRiQ14585. Positions 59-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri62 – 8423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri90 – 11223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri118 – 14023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 16823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri174 – 19623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri230 – 25223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri258 – 28023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri286 – 30823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri314 – 33623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119035.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ14585.
OMAiKQGSQEG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ14585.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 15 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14585-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENLTKHSIE CSSFRGDWEC KNQFERKQGS QEGHFSEMIF TPEDMPTFSI
60 70 80 90 100
QHQRIHTDEK LLECKECGKD FSFVSVLVRH QRIHTGEKPY ECKECGKAFG
110 120 130 140 150
SGANLAYHQR IHTGEKPFEC KECGKAFGSG SNLTHHQRIH TGEKPYECKE
160 170 180 190 200
CGKAFSFGSG LIRHQIIHSG EKPYECKECG KSFSFESALI RHHRIHTGEK
210 220 230 240 250
PYECIDCGKA FGSGSNLTQH RRIHTGEKPY ECKACGMAFS SGSALTRHQR
260 270 280 290 300
IHTGEKPYIC NECGKAFSFG SALTRHQRIH TGEKPYVCKE CGKAFNSGSD
310 320 330 340 350
LTQHQRIHTG EKPYECKECE KAFRSGSKLI QHQRMHTGEK PYECKECGKT
360 370 380 390 400
FSSGSDLTQH HRIHTGEKPY ECKECGKAFG SGSKLIQHQL IHTGERPYEC
410 420 430 440 450
KECGKSFSSG SALNRHQRIH TGEKPYECKE CGKAFYSGSS LTQHQRIHTG
460 470 480
EKLYECKNCG KAYGRDSEFQ QHKKSHNGKK LCELETIN
Length:488
Mass (Da):55,383
Last modified:November 1, 1996 - v1
Checksum:i0BDC436E4451285B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78933 mRNA. Translation: CAA55533.1.
BC032863 mRNA. Translation: AAH32863.1.
CCDSiCCDS12497.1.
PIRiS47072.
RefSeqiNP_001229401.1. NM_001242472.1.
NP_001229403.1. NM_001242474.1.
NP_001229404.1. NM_001242475.1.
NP_001229405.1. NM_001242476.1.
NP_003410.1. NM_003419.4.
XP_006723195.1. XM_006723132.1.
UniGeneiHs.362324.

Genome annotation databases

EnsembliENST00000420450; ENSP00000431216; ENSG00000251247.
ENST00000529555; ENSP00000431202; ENSG00000251247.
ENST00000589046; ENSP00000465431; ENSG00000251247.
ENST00000612719; ENSP00000482400; ENSG00000251247.
ENST00000614069; ENSP00000477522; ENSG00000251247.
GeneIDi25850.
KEGGihsa:25850.
UCSCiuc002oex.3. human.

Polymorphism databases

DMDMi11136080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78933 mRNA. Translation: CAA55533.1 .
BC032863 mRNA. Translation: AAH32863.1 .
CCDSi CCDS12497.1.
PIRi S47072.
RefSeqi NP_001229401.1. NM_001242472.1.
NP_001229403.1. NM_001242474.1.
NP_001229404.1. NM_001242475.1.
NP_001229405.1. NM_001242476.1.
NP_003410.1. NM_003419.4.
XP_006723195.1. XM_006723132.1.
UniGenei Hs.362324.

3D structure databases

ProteinModelPortali Q14585.
SMRi Q14585. Positions 59-449.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q14585. 1 interaction.

PTM databases

PhosphoSitei Q14585.

Polymorphism databases

DMDMi 11136080.

Proteomic databases

PaxDbi Q14585.
PRIDEi Q14585.

Protocols and materials databases

DNASUi 25850.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000420450 ; ENSP00000431216 ; ENSG00000251247 .
ENST00000529555 ; ENSP00000431202 ; ENSG00000251247 .
ENST00000589046 ; ENSP00000465431 ; ENSG00000251247 .
ENST00000612719 ; ENSP00000482400 ; ENSG00000251247 .
ENST00000614069 ; ENSP00000477522 ; ENSG00000251247 .
GeneIDi 25850.
KEGGi hsa:25850.
UCSCi uc002oex.3. human.

Organism-specific databases

CTDi 25850.
GeneCardsi GC19P037341.
HGNCi HGNC:16367. ZNF345.
HPAi HPA025816.
neXtProti NX_Q14585.
PharmGKBi PA38128.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119035.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q14585.
OMAi KQGSQEG.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q14585.

Miscellaneous databases

GenomeRNAii 25850.
NextBioi 47189.
PROi Q14585.

Gene expression databases

Bgeei Q14585.
CleanExi HS_ZNF345.
ExpressionAtlasi Q14585. baseline and differential.
Genevestigatori Q14585.

Family and domain databases

Gene3Di 3.30.160.60. 16 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 15 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
    Abrink M., Aveskogh M., Hellman L.
    DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN345_HUMAN
AccessioniPrimary (citable) accession number: Q14585
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3