Q14585 (ZN345_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 345

Alternative name(s):
Zinc finger protein HZF10

Gene names

Name:

ZNF345

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 15 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of transcription from RNA polymerase II promoter Traceable author statement PubMed 9278146. Source: ProtInc regulation of transcription from RNA polymerase III promoter Traceable author statement PubMed 9278146. Source: ProtInc transcription from RNA polymerase II promoter Traceable author statement PubMed 9278146. Source: ProtInc transcription from RNA polymerase III promoter Traceable author statement PubMed 9278146. Source: ProtInc
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Zinc finger protein 345		PRO_0000047544
Regions
	Zinc finger	62 – 84	23	C2H2-type 1
	Zinc finger	90 – 112	23	C2H2-type 2
	Zinc finger	118 – 140	23	C2H2-type 3
	Zinc finger	146 – 168	23	C2H2-type 4
	Zinc finger	174 – 196	23	C2H2-type 5
	Zinc finger	202 – 224	23	C2H2-type 6
	Zinc finger	230 – 252	23	C2H2-type 7
	Zinc finger	258 – 280	23	C2H2-type 8
	Zinc finger	286 – 308	23	C2H2-type 9
	Zinc finger	314 – 336	23	C2H2-type 10
	Zinc finger	342 – 364	23	C2H2-type 11
	Zinc finger	370 – 392	23	C2H2-type 12
	Zinc finger	398 – 420	23	C2H2-type 13
	Zinc finger	426 – 448	23	C2H2-type 14
	Zinc finger	454 – 476	23	C2H2-type 15

Sequences

	Sequence		Length	Mass (Da)
	Q14585 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 0BDC436E4451285B	FASTA	488	55,383
	10 20 30 40 50 60 MENLTKHSIE CSSFRGDWEC KNQFERKQGS QEGHFSEMIF TPEDMPTFSI QHQRIHTDEK 70 80 90 100 110 120 LLECKECGKD FSFVSVLVRH QRIHTGEKPY ECKECGKAFG SGANLAYHQR IHTGEKPFEC 130 140 150 160 170 180 KECGKAFGSG SNLTHHQRIH TGEKPYECKE CGKAFSFGSG LIRHQIIHSG EKPYECKECG 190 200 210 220 230 240 KSFSFESALI RHHRIHTGEK PYECIDCGKA FGSGSNLTQH RRIHTGEKPY ECKACGMAFS 250 260 270 280 290 300 SGSALTRHQR IHTGEKPYIC NECGKAFSFG SALTRHQRIH TGEKPYVCKE CGKAFNSGSD 310 320 330 340 350 360 LTQHQRIHTG EKPYECKECE KAFRSGSKLI QHQRMHTGEK PYECKECGKT FSSGSDLTQH 370 380 390 400 410 420 HRIHTGEKPY ECKECGKAFG SGSKLIQHQL IHTGERPYEC KECGKSFSSG SALNRHQRIH 430 440 450 460 470 480 TGEKPYECKE CGKAFYSGSS LTQHQRIHTG EKLYECKNCG KAYGRDSEFQ QHKKSHNGKK LCELETIN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937." Abrink M., Aveskogh M., Hellman L. DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X78933 mRNA. Translation: CAA55533.1. BC032863 mRNA. Translation: AAH32863.1.
IPI	IPI00031592.
PIR	S47072.
RefSeq	NP_001229401.1. NM_001242472.1. NP_001229403.1. NM_001242474.1. NP_001229404.1. NM_001242475.1. NP_001229405.1. NM_001242476.1. NP_003410.1. NM_003419.4.
UniGene	Hs.362324.
3D structure databases
ProteinModelPortal	Q14585.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14585. 1 interaction.
PTM databases
PhosphoSite	Q14585.
Polymorphism databases
DMDM	11136080.
Proteomic databases
PaxDb	Q14585.
PRIDE	Q14585.
Protocols and materials databases
DNASU	25850.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000420450; ENSP00000431216; ENSG00000251247. ENST00000529555; ENSP00000431202; ENSG00000251247. ENST00000589046; ENSP00000465431; ENSG00000251247.
GeneID	25850.
KEGG	hsa:25850.
UCSC	uc002oex.3. human.
Organism-specific databases
CTD	25850.
GeneCards	GC19P037341.
HGNC	HGNC:16367. ZNF345.
HPA	HPA025816.
neXtProt	NX_Q14585.
PharmGKB	PA38128.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q14585.
OMA	DFSFVSV.
OrthoDB	EOG4W0XCR.
PhylomeDB	Q14585.
Gene expression databases
ArrayExpress	Q14585.
Bgee	Q14585.
CleanEx	HS_ZNF345.
Genevestigator	Q14585.
GermOnline	ENSG00000167637. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 16 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 15 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 15 hits. PS50157. ZINC_FINGER_C2H2_2. 15 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	25850.
NextBio	47189.

Entry information

Entry name

ZN345_HUMAN

Accession

Primary (citable) accession number: Q14585

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 127 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.