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Protein

Zinc finger protein 345

Gene

ZNF345

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri62 – 84C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri90 – 112C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri118 – 140C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: ProtInc
  • regulation of transcription by RNA polymerase III Source: ProtInc
  • transcription by RNA polymerase II Source: ProtInc
  • transcription by RNA polymerase III Source: ProtInc

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 345
Alternative name(s):
Zinc finger protein HZF10
Gene namesi
Name:ZNF345
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000251247.9
HGNCiHGNC:16367 ZNF345
neXtProtiNX_Q14585

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000251247
PharmGKBiPA38128

Polymorphism and mutation databases

BioMutaiZNF345
DMDMi11136080

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475441 – 488Zinc finger protein 345Add BLAST488

Proteomic databases

MaxQBiQ14585
PaxDbiQ14585
PeptideAtlasiQ14585
PRIDEiQ14585
ProteomicsDBi60058

PTM databases

iPTMnetiQ14585
PhosphoSitePlusiQ14585

Expressioni

Gene expression databases

BgeeiENSG00000251247
CleanExiHS_ZNF345
ExpressionAtlasiQ14585 baseline and differential
GenevisibleiQ14585 HS

Organism-specific databases

HPAiHPA025816

Interactioni

Protein-protein interaction databases

IntActiQ14585, 1 interactor
STRINGi9606.ENSP00000431202

Structurei

3D structure databases

ProteinModelPortaliQ14585
SMRiQ14585
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri62 – 84C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri90 – 112C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri118 – 140C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ14585
OMAiECKACGM
OrthoDBiEOG091G02KC
PhylomeDBiQ14585

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequencei

Sequence statusi: Complete.

Q14585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLTKHSIE CSSFRGDWEC KNQFERKQGS QEGHFSEMIF TPEDMPTFSI
60 70 80 90 100
QHQRIHTDEK LLECKECGKD FSFVSVLVRH QRIHTGEKPY ECKECGKAFG
110 120 130 140 150
SGANLAYHQR IHTGEKPFEC KECGKAFGSG SNLTHHQRIH TGEKPYECKE
160 170 180 190 200
CGKAFSFGSG LIRHQIIHSG EKPYECKECG KSFSFESALI RHHRIHTGEK
210 220 230 240 250
PYECIDCGKA FGSGSNLTQH RRIHTGEKPY ECKACGMAFS SGSALTRHQR
260 270 280 290 300
IHTGEKPYIC NECGKAFSFG SALTRHQRIH TGEKPYVCKE CGKAFNSGSD
310 320 330 340 350
LTQHQRIHTG EKPYECKECE KAFRSGSKLI QHQRMHTGEK PYECKECGKT
360 370 380 390 400
FSSGSDLTQH HRIHTGEKPY ECKECGKAFG SGSKLIQHQL IHTGERPYEC
410 420 430 440 450
KECGKSFSSG SALNRHQRIH TGEKPYECKE CGKAFYSGSS LTQHQRIHTG
460 470 480
EKLYECKNCG KAYGRDSEFQ QHKKSHNGKK LCELETIN
Length:488
Mass (Da):55,383
Last modified:November 1, 1996 - v1
Checksum:i0BDC436E4451285B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78933 mRNA Translation: CAA55533.1
BC032863 mRNA Translation: AAH32863.1
CCDSiCCDS12497.1
PIRiS47072
RefSeqiNP_001229401.1, NM_001242472.1
NP_001229403.1, NM_001242474.1
NP_001229404.1, NM_001242475.1
NP_001229405.1, NM_001242476.1
NP_003410.1, NM_003419.4
XP_011525006.1, XM_011526704.2
XP_016882057.1, XM_017026568.1
XP_016882058.1, XM_017026569.1
XP_016882059.1, XM_017026570.1
XP_016882060.1, XM_017026571.1
XP_016882061.1, XM_017026572.1
XP_016882062.1, XM_017026573.1
UniGeneiHs.362324

Genome annotation databases

EnsembliENST00000420450; ENSP00000431216; ENSG00000251247
ENST00000529555; ENSP00000431202; ENSG00000251247
ENST00000589046; ENSP00000465431; ENSG00000251247
ENST00000612719; ENSP00000482400; ENSG00000251247
ENST00000614069; ENSP00000477522; ENSG00000251247
GeneIDi25850
KEGGihsa:25850
UCSCiuc002oex.4 human

Similar proteinsi

Entry informationi

Entry nameiZN345_HUMAN
AccessioniPrimary (citable) accession number: Q14585
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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