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Q14585 (ZN345_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 345
Alternative name(s):
Zinc finger protein HZF10
Gene names
Name:ZNF345
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 15 C2H2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Zinc finger protein 345
PRO_0000047544

Regions

Zinc finger62 – 8423C2H2-type 1
Zinc finger90 – 11223C2H2-type 2
Zinc finger118 – 14023C2H2-type 3
Zinc finger146 – 16823C2H2-type 4
Zinc finger174 – 19623C2H2-type 5
Zinc finger202 – 22423C2H2-type 6
Zinc finger230 – 25223C2H2-type 7
Zinc finger258 – 28023C2H2-type 8
Zinc finger286 – 30823C2H2-type 9
Zinc finger314 – 33623C2H2-type 10
Zinc finger342 – 36423C2H2-type 11
Zinc finger370 – 39223C2H2-type 12
Zinc finger398 – 42023C2H2-type 13
Zinc finger426 – 44823C2H2-type 14
Zinc finger454 – 47623C2H2-type 15

Sequences

Sequence LengthMass (Da)Tools
Q14585 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 0BDC436E4451285B

FASTA48855,383
        10         20         30         40         50         60 
MENLTKHSIE CSSFRGDWEC KNQFERKQGS QEGHFSEMIF TPEDMPTFSI QHQRIHTDEK 

        70         80         90        100        110        120 
LLECKECGKD FSFVSVLVRH QRIHTGEKPY ECKECGKAFG SGANLAYHQR IHTGEKPFEC 

       130        140        150        160        170        180 
KECGKAFGSG SNLTHHQRIH TGEKPYECKE CGKAFSFGSG LIRHQIIHSG EKPYECKECG 

       190        200        210        220        230        240 
KSFSFESALI RHHRIHTGEK PYECIDCGKA FGSGSNLTQH RRIHTGEKPY ECKACGMAFS 

       250        260        270        280        290        300 
SGSALTRHQR IHTGEKPYIC NECGKAFSFG SALTRHQRIH TGEKPYVCKE CGKAFNSGSD 

       310        320        330        340        350        360 
LTQHQRIHTG EKPYECKECE KAFRSGSKLI QHQRMHTGEK PYECKECGKT FSSGSDLTQH 

       370        380        390        400        410        420 
HRIHTGEKPY ECKECGKAFG SGSKLIQHQL IHTGERPYEC KECGKSFSSG SALNRHQRIH 

       430        440        450        460        470        480 
TGEKPYECKE CGKAFYSGSS LTQHQRIHTG EKLYECKNCG KAYGRDSEFQ QHKKSHNGKK 


LCELETIN 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
Abrink M., Aveskogh M., Hellman L.
DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78933 mRNA. Translation: CAA55533.1.
BC032863 mRNA. Translation: AAH32863.1.
PIRS47072.
RefSeqNP_001229401.1. NM_001242472.1.
NP_001229403.1. NM_001242474.1.
NP_001229404.1. NM_001242475.1.
NP_001229405.1. NM_001242476.1.
NP_003410.1. NM_003419.4.
UniGeneHs.362324.

3D structure databases

ProteinModelPortalQ14585.
SMRQ14585. Positions 59-449.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ14585. 1 interaction.

PTM databases

PhosphoSiteQ14585.

Polymorphism databases

DMDM11136080.

Proteomic databases

PaxDbQ14585.
PRIDEQ14585.

Protocols and materials databases

DNASU25850.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000420450; ENSP00000431216; ENSG00000251247.
ENST00000529555; ENSP00000431202; ENSG00000251247.
ENST00000589046; ENSP00000465431; ENSG00000251247.
GeneID25850.
KEGGhsa:25850.
UCSCuc002oex.3. human.

Organism-specific databases

CTD25850.
GeneCardsGC19P037341.
HGNCHGNC:16367. ZNF345.
HPAHPA025816.
neXtProtNX_Q14585.
PharmGKBPA38128.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ14585.
OMAKQGSQEG.
OrthoDBEOG7KSX7Q.
PhylomeDBQ14585.

Gene expression databases

ArrayExpressQ14585.
BgeeQ14585.
CleanExHS_ZNF345.
GenevestigatorQ14585.

Family and domain databases

Gene3D3.30.160.60. 16 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 15 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi25850.
NextBio47189.
PROQ14585.

Entry information

Entry nameZN345_HUMAN
AccessionPrimary (citable) accession number: Q14585
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM