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Protein

Zinc finger protein 266

Gene

ZNF266

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri156 – 17823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 266
Alternative name(s):
Zinc finger protein HZF1
Gene namesi
Name:ZNF266
Synonyms:KIAA2007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13059. ZNF266.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37637.

Polymorphism and mutation databases

DMDMi85681859.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Zinc finger protein 266PRO_0000047493Add
BLAST

Proteomic databases

MaxQBiQ14584.
PaxDbiQ14584.
PRIDEiQ14584.

PTM databases

iPTMnetiQ14584.
PhosphoSiteiQ14584.

Expressioni

Gene expression databases

BgeeiQ14584.
CleanExiHS_ZNF266.
ExpressionAtlasiQ14584. baseline and differential.
GenevisibleiQ14584. HS.

Organism-specific databases

HPAiHPA026836.
HPA054110.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-7115319,EBI-739624
KRT40Q6A1625EBI-7115319,EBI-10171697
KRTAP10-7P604095EBI-7115319,EBI-10172290
KRTAP5-9P263713EBI-7115319,EBI-3958099
MDFIQ997503EBI-7115319,EBI-724076
TRIM41Q8WV446EBI-7115319,EBI-725997

Protein-protein interaction databases

BioGridi115998. 10 interactions.
IntActiQ14584. 8 interactions.
MINTiMINT-8247409.
STRINGi9606.ENSP00000354680.

Structurei

3D structure databases

ProteinModelPortaliQ14584.
SMRiQ14584. Positions 71-546.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4242KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri156 – 17823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri184 – 20623C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOVERGENiHBG018163.
InParanoidiQ14584.
OMAiDFQASEW.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ14584.
TreeFamiTF342172.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR003656. Znf_BED.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00614. ZnF_BED. 2 hits.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLENYKNLAT VGYQLFKPSL ISWLEQEESR TVQRGDFQAS EWKVQLKTKE
60 70 80 90 100
LALQQDVLGE PTSSGIQMIG SHNGGEVSDV KQCGDVSSEH SCLKTHVRTQ
110 120 130 140 150
NSENTFECYL YGVDFLTLHK KTSTGEQRSV FSQCGKAFSL NPDVVCQRTC
160 170 180 190 200
TGEKAFDCSD SGKSFINHSH LQGHLRTHNG ESLHEWKECG RGFIHSTDLA
210 220 230 240 250
VRIQTHRSEK PYKCKECGKG FRYSAYLNIH MGTHTGDNPY ECKECGKAFT
260 270 280 290 300
RSCQLTQHRK THTGEKPYKC KDCGRAFTVS SCLSQHMKIH VGEKPYECKE
310 320 330 340 350
CGIAFTRSSQ LTEHLKTHTA KDPFECKICG KSFRNSSCLS DHFRIHTGIK
360 370 380 390 400
PYKCKDCGKA FTQNSDLTKH ARTHSGERPY ECKECGKAFA RSSRLSEHTR
410 420 430 440 450
THTGEKPFEC VKCGKAFAIS SNLSGHLRIH TGEKPFECLE CGKAFTHSSS
460 470 480 490 500
LNNHMRTHSA KKPFTCMECG KAFKFPTCVN LHMRIHTGEK PYKCKQCGKS
510 520 530 540
FSYSNSFQLH ERTHTGEKPY ECKECGKAFS SSSSFRNHER RHADERLSA
Length:549
Mass (Da):62,116
Last modified:January 10, 2006 - v2
Checksum:i59670F5DF8CFD81F
GO

Sequence cautioni

The sequence AK027480 differs from that shown. Reason: Frameshift at position 461. Curated
The sequence AK027480 differs from that shown. Reason: Erroneous termination at position 536. Translated as Arg.Curated
The sequence BAC23104.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2571Q → E in AAH17407 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti519 – 5191P → L.
Corresponds to variant rs10515 [ dbSNP | Ensembl ].
VAR_014828

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY376240 mRNA. Translation: AAQ82907.1.
AB095928 mRNA. Translation: BAC23104.1. Different initiation.
BC017407 mRNA. Translation: AAH17407.2.
BC071628 mRNA. Translation: AAH71628.1.
BC112919 mRNA. Translation: AAI12920.1.
BC146837 mRNA. Translation: AAI46838.1.
BC126255 mRNA. Translation: AAI26256.1.
AK027480 mRNA. No translation available.
X78924 mRNA. Translation: CAA55524.1.
CCDSiCCDS12213.1.
PIRiS47067.
RefSeqiNP_001258243.1. NM_001271314.1.
NP_006622.2. NM_006631.3.
XP_005259770.1. XM_005259713.2.
XP_005259773.1. XM_005259716.2.
XP_006722688.1. XM_006722625.2.
XP_006722689.1. XM_006722626.2.
XP_006722690.1. XM_006722627.2.
XP_006722693.1. XM_006722630.2.
XP_011525947.1. XM_011527645.1.
XP_011525948.1. XM_011527646.1.
XP_011525949.1. XM_011527647.1.
XP_011525950.1. XM_011527648.1.
XP_011525951.1. XM_011527649.1.
XP_011525952.1. XM_011527650.1.
UniGeneiHs.656185.
Hs.743560.

Genome annotation databases

EnsembliENST00000588221; ENSP00000468491; ENSG00000174652.
ENST00000588933; ENSP00000467151; ENSG00000174652.
ENST00000590306; ENSP00000467315; ENSG00000174652.
ENST00000592292; ENSP00000467403; ENSG00000174652.
ENST00000592904; ENSP00000466714; ENSG00000174652.
GeneIDi10781.
KEGGihsa:10781.
UCSCiuc002mlo.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY376240 mRNA. Translation: AAQ82907.1.
AB095928 mRNA. Translation: BAC23104.1. Different initiation.
BC017407 mRNA. Translation: AAH17407.2.
BC071628 mRNA. Translation: AAH71628.1.
BC112919 mRNA. Translation: AAI12920.1.
BC146837 mRNA. Translation: AAI46838.1.
BC126255 mRNA. Translation: AAI26256.1.
AK027480 mRNA. No translation available.
X78924 mRNA. Translation: CAA55524.1.
CCDSiCCDS12213.1.
PIRiS47067.
RefSeqiNP_001258243.1. NM_001271314.1.
NP_006622.2. NM_006631.3.
XP_005259770.1. XM_005259713.2.
XP_005259773.1. XM_005259716.2.
XP_006722688.1. XM_006722625.2.
XP_006722689.1. XM_006722626.2.
XP_006722690.1. XM_006722627.2.
XP_006722693.1. XM_006722630.2.
XP_011525947.1. XM_011527645.1.
XP_011525948.1. XM_011527646.1.
XP_011525949.1. XM_011527647.1.
XP_011525950.1. XM_011527648.1.
XP_011525951.1. XM_011527649.1.
XP_011525952.1. XM_011527650.1.
UniGeneiHs.656185.
Hs.743560.

3D structure databases

ProteinModelPortaliQ14584.
SMRiQ14584. Positions 71-546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115998. 10 interactions.
IntActiQ14584. 8 interactions.
MINTiMINT-8247409.
STRINGi9606.ENSP00000354680.

PTM databases

iPTMnetiQ14584.
PhosphoSiteiQ14584.

Polymorphism and mutation databases

DMDMi85681859.

Proteomic databases

MaxQBiQ14584.
PaxDbiQ14584.
PRIDEiQ14584.

Protocols and materials databases

DNASUi10781.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000588221; ENSP00000468491; ENSG00000174652.
ENST00000588933; ENSP00000467151; ENSG00000174652.
ENST00000590306; ENSP00000467315; ENSG00000174652.
ENST00000592292; ENSP00000467403; ENSG00000174652.
ENST00000592904; ENSP00000466714; ENSG00000174652.
GeneIDi10781.
KEGGihsa:10781.
UCSCiuc002mlo.5. human.

Organism-specific databases

CTDi10781.
GeneCardsiZNF266.
HGNCiHGNC:13059. ZNF266.
HPAiHPA026836.
HPA054110.
MIMi604751. gene.
neXtProtiNX_Q14584.
PharmGKBiPA37637.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOVERGENiHBG018163.
InParanoidiQ14584.
OMAiDFQASEW.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ14584.
TreeFamiTF342172.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF266. human.
GenomeRNAii10781.
PROiQ14584.
SOURCEiSearch...

Gene expression databases

BgeeiQ14584.
CleanExiHS_ZNF266.
ExpressionAtlasiQ14584. baseline and differential.
GenevisibleiQ14584. HS.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR003656. Znf_BED.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00614. ZnF_BED. 2 hits.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new isoform of KIAA2007 protein in testis."
    Lu L., Huang X.Y., Yin L.L., Xu M., Li J.M., Zhou Z.M., Sha J.H.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Ohara O.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Embryonic stem cell, Eye and Skin.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-549.
  5. "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937."
    Abrink M., Aveskogh M., Hellman L.
    DNA Cell Biol. 14:125-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 350-549.

Entry informationi

Entry nameiZN266_HUMAN
AccessioniPrimary (citable) accession number: Q14584
Secondary accession number(s): A0AV90
, A4FU85, Q6IQ07, Q6U8A5, Q8IVG3, Q8WVX1, Q96SX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 10, 2006
Last modified: June 8, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.