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Protein

Max dimerization protein 4

Gene

MXD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of cell proliferation Source: ProtInc
  • negative regulation of transcription by RNA polymerase II Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ14582

Names & Taxonomyi

Protein namesi
Recommended name:
Max dimerization protein 4
Short name:
Max dimerizer 4
Alternative name(s):
Class C basic helix-loop-helix protein 12
Short name:
bHLHc12
Max-associated protein 4
Max-interacting transcriptional repressor MAD4
Gene namesi
Name:MXD4
Synonyms:BHLHC12, MAD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000123933.14
HGNCiHGNC:13906 MXD4
neXtProtiNX_Q14582

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10608
OpenTargetsiENSG00000123933
PharmGKBiPA134914966

Polymorphism and mutation databases

BioMutaiMXD4
DMDMi6016524

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272661 – 209Max dimerization protein 4Add BLAST209

Proteomic databases

PaxDbiQ14582
PeptideAtlasiQ14582
PRIDEiQ14582
TopDownProteomicsiQ14582

PTM databases

iPTMnetiQ14582
PhosphoSitePlusiQ14582

Expressioni

Gene expression databases

BgeeiENSG00000123933
CleanExiHS_MXD4
ExpressionAtlasiQ14582 baseline and differential
GenevisibleiQ14582 HS

Organism-specific databases

HPAiHPA053363

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TCP10LQ8TDR46EBI-3943670,EBI-3923210

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115854, 7 interactors
ELMiQ14582
IntActiQ14582, 4 interactors
MINTiQ14582
STRINGi9606.ENSP00000337889

Structurei

3D structure databases

ProteinModelPortaliQ14582
SMRiQ14582
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 105bHLHPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 23Interaction with SIN3A and SIN3BBy similarityAdd BLAST18

Phylogenomic databases

eggNOGiKOG2483 Eukaryota
ENOG4111V1C LUCA
GeneTreeiENSGT00510000046360
HOVERGENiHBG006314
InParanoidiQ14582
KOiK09114
OMAiRLQPHHC
OrthoDBiEOG091G0QBK
PhylomeDBiQ14582
TreeFamiTF315654

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q14582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELNSLLILL EAAEYLERRD REAEHGYASV LPFDGDFARE KTKAAGLVRK
60 70 80 90 100
APNNRSSHNE LEKHRRAKLR LYLEQLKQLV PLGPDSTRHT TLSLLKRAKV
110 120 130 140 150
HIKKLEEQDR RALSIKEQLQ QEHRFLKRRL EQLSVQSVER VRTDSTGSAV
160 170 180 190 200
STDDSEQEVD IEGMEFGPGE LDSVGSSSDA DDHYSLQSGT GGDSGFGPHC

RRLGRPALS
Length:209
Mass (Da):23,528
Last modified:July 15, 1999 - v2
Checksum:iACFAFB44EB0FE7A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040963 mRNA Translation: AAB97009.1
AF082740 mRNA Translation: AAF98553.1
BT019969 mRNA Translation: AAV38772.1
BT019970 mRNA Translation: AAV38773.1
Z49250 Genomic DNA Translation: CAA89217.1
AL158068 Genomic DNA No translation available.
BC068060 mRNA Translation: AAH68060.1
CCDSiCCDS3361.1
RefSeqiNP_006445.1, NM_006454.2
UniGeneiHs.655020

Genome annotation databases

EnsembliENST00000337190; ENSP00000337889; ENSG00000123933
GeneIDi10608
KEGGihsa:10608
UCSCiuc003geu.2 human

Similar proteinsi

Entry informationi

Entry nameiMAD4_HUMAN
AccessioniPrimary (citable) accession number: Q14582
Secondary accession number(s): A2A335, Q5TZX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 15, 1999
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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