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Protein

Max dimerization protein 4

Gene

MXD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • protein dimerization activity Source: InterPro
  • transcription corepressor activity Source: ProtInc

GO - Biological processi

  • negative regulation of cell proliferation Source: ProtInc
  • negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ14582.

Names & Taxonomyi

Protein namesi
Recommended name:
Max dimerization protein 4
Short name:
Max dimerizer 4
Alternative name(s):
Class C basic helix-loop-helix protein 12
Short name:
bHLHc12
Max-associated protein 4
Max-interacting transcriptional repressor MAD4
Gene namesi
Name:MXD4
Synonyms:BHLHC12, MAD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000123933.14.
HGNCiHGNC:13906. MXD4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10608.
OpenTargetsiENSG00000123933.
PharmGKBiPA134914966.

Polymorphism and mutation databases

BioMutaiMXD4.
DMDMi6016524.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272661 – 209Max dimerization protein 4Add BLAST209

Proteomic databases

EPDiQ14582.
PaxDbiQ14582.
PeptideAtlasiQ14582.
PRIDEiQ14582.
TopDownProteomicsiQ14582.

PTM databases

iPTMnetiQ14582.
PhosphoSitePlusiQ14582.

Expressioni

Gene expression databases

BgeeiENSG00000123933.
CleanExiHS_MXD4.
ExpressionAtlasiQ14582. baseline and differential.
GenevisibleiQ14582. HS.

Organism-specific databases

HPAiHPA053363.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TCP10LQ8TDR46EBI-3943670,EBI-3923210

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115854. 7 interactors.
ELMiQ14582.
IntActiQ14582. 4 interactors.
STRINGi9606.ENSP00000337889.

Structurei

3D structure databases

ProteinModelPortaliQ14582.
SMRiQ14582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 105bHLHPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 23Interaction with SIN3A and SIN3BBy similarityAdd BLAST18

Phylogenomic databases

eggNOGiKOG2483. Eukaryota.
ENOG4111V1C. LUCA.
GeneTreeiENSGT00510000046360.
HOVERGENiHBG006314.
InParanoidiQ14582.
KOiK09114.
OMAiRLQPHHC.
OrthoDBiEOG091G0QBK.
PhylomeDBiQ14582.
TreeFamiTF315654.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR036638. HLH_DNA-bd_sf.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELNSLLILL EAAEYLERRD REAEHGYASV LPFDGDFARE KTKAAGLVRK
60 70 80 90 100
APNNRSSHNE LEKHRRAKLR LYLEQLKQLV PLGPDSTRHT TLSLLKRAKV
110 120 130 140 150
HIKKLEEQDR RALSIKEQLQ QEHRFLKRRL EQLSVQSVER VRTDSTGSAV
160 170 180 190 200
STDDSEQEVD IEGMEFGPGE LDSVGSSSDA DDHYSLQSGT GGDSGFGPHC

RRLGRPALS
Length:209
Mass (Da):23,528
Last modified:July 15, 1999 - v2
Checksum:iACFAFB44EB0FE7A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040963 mRNA. Translation: AAB97009.1.
AF082740 mRNA. Translation: AAF98553.1.
BT019969 mRNA. Translation: AAV38772.1.
BT019970 mRNA. Translation: AAV38773.1.
Z49250 Genomic DNA. Translation: CAA89217.1.
AL158068 Genomic DNA. No translation available.
BC068060 mRNA. Translation: AAH68060.1.
CCDSiCCDS3361.1.
RefSeqiNP_006445.1. NM_006454.2.
UniGeneiHs.655020.

Genome annotation databases

EnsembliENST00000337190; ENSP00000337889; ENSG00000123933.
GeneIDi10608.
KEGGihsa:10608.
UCSCiuc003geu.2. human.

Similar proteinsi

Entry informationi

Entry nameiMAD4_HUMAN
AccessioniPrimary (citable) accession number: Q14582
Secondary accession number(s): A2A335, Q5TZX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 15, 1999
Last modified: October 25, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM