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Q14576

- ELAV3_HUMAN

UniProt

Q14576 - ELAV3_HUMAN

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Protein
ELAV-like protein 3
Gene
ELAVL3, HUC, PLE21
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 By similarity. May be involved in neuronal differentiation and maintenance.1 Publication

GO - Molecular functioni

  1. AU-rich element binding Source: UniProtKB
  2. nucleotide binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 3
Alternative name(s):
Hu-antigen C
Short name:
HuC
Paraneoplastic cerebellar degeneration-associated antigen
Paraneoplastic limbic encephalitis antigen 21
Gene namesi
Name:ELAVL3
Synonyms:HUC, PLE21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:3314. ELAVL3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27742.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367ELAV-like protein 3
PRO_0000081581Add
BLAST

Proteomic databases

PaxDbiQ14576.
PRIDEiQ14576.

PTM databases

PhosphoSiteiQ14576.

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

ArrayExpressiQ14576.
BgeeiQ14576.
CleanExiHS_ELAVL3.
GenevestigatoriQ14576.

Organism-specific databases

HPAiCAB013066.

Interactioni

Protein-protein interaction databases

BioGridi108310. 10 interactions.
IntActiQ14576. 7 interactions.
MINTiMINT-1471958.
STRINGi9606.ENSP00000352162.

Structurei

3D structure databases

ProteinModelPortaliQ14576.
SMRiQ14576. Positions 36-208, 266-363.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 11779RRM 1
Add
BLAST
Domaini125 – 20581RRM 2
Add
BLAST
Domaini284 – 36279RRM 3
Add
BLAST

Domaini

RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences By similarity.

Sequence similaritiesi

Belongs to the RRM elav family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0724.
HOGENOMiHOG000231162.
HOVERGENiHBG002295.
InParanoidiQ14576.
KOiK13208.
OMAiRYTGPLH.
OrthoDBiEOG77T14R.
PhylomeDBiQ14576.
TreeFamiTF313377.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14576-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM    50
TQDEFKSLFG SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL 100
NGLKLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMSQKE MEQLFSQYGR 150
IITSRILVDQ VTGVSRGVGF IRFDKRIEAE EAIKGLNGQK PLGAAEPITV 200
KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD NLLNMAYGVK 250
SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL 300
WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL 350
GERVLQVSFK TSKQHKA 367
Length:367
Mass (Da):39,547
Last modified:May 27, 2002 - v3
Checksum:i03FB3BD4D112B326
GO
Isoform 2 (identifier: Q14576-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-257: Missing.

Show »
Length:360
Mass (Da):38,865
Checksum:i9D649E3D50AC1797
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei251 – 2577Missing in isoform 2.
VSP_005789

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 256PALPNG → RPAQR in BAA21838. 1 Publication
Sequence conflicti78 – 792QS → RD in AAA58677. 1 Publication
Sequence conflicti78 – 792QS → RD in AAK67714. 1 Publication
Sequence conflicti88 – 881S → P in AAA58677. 1 Publication
Sequence conflicti88 – 881S → P in AAK67714. 1 Publication
Sequence conflicti195 – 1951A → R in BAA21838. 1 Publication
Sequence conflicti248 – 2481G → A in BAA21838. 1 Publication
Sequence conflicti282 – 2821Missing in AAA58677. 1 Publication
Sequence conflicti282 – 2821Missing in BAA21838. 1 Publication
Sequence conflicti295 – 2973ADE → PDQ in BAA21838. 1 Publication
Sequence conflicti330 – 3301V → M in BAA21838. 1 Publication
Sequence conflicti351 – 3511G → A in AAA58677. 1 Publication
Sequence conflicti352 – 3521E → Q in BAA21838. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26405 mRNA. Translation: AAA58677.1.
AY036909 mRNA. Translation: AAK67714.1.
AC008481 Genomic DNA. No translation available.
BC014144 mRNA. No translation available.
D26158 mRNA. Translation: BAA21838.1.
CCDSiCCDS32912.1. [Q14576-1]
CCDS45978.1. [Q14576-2]
RefSeqiNP_001411.2. NM_001420.3. [Q14576-1]
NP_115657.2. NM_032281.2. [Q14576-2]
XP_006722746.1. XM_006722683.1. [Q14576-2]
UniGeneiHs.1701.

Genome annotation databases

EnsembliENST00000359227; ENSP00000352162; ENSG00000196361. [Q14576-1]
ENST00000438662; ENSP00000390878; ENSG00000196361. [Q14576-2]
GeneIDi1995.
KEGGihsa:1995.
UCSCiuc002mrx.1. human. [Q14576-2]
uc002mry.1. human. [Q14576-1]

Polymorphism databases

DMDMi21264436.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26405 mRNA. Translation: AAA58677.1 .
AY036909 mRNA. Translation: AAK67714.1 .
AC008481 Genomic DNA. No translation available.
BC014144 mRNA. No translation available.
D26158 mRNA. Translation: BAA21838.1 .
CCDSi CCDS32912.1. [Q14576-1 ]
CCDS45978.1. [Q14576-2 ]
RefSeqi NP_001411.2. NM_001420.3. [Q14576-1 ]
NP_115657.2. NM_032281.2. [Q14576-2 ]
XP_006722746.1. XM_006722683.1. [Q14576-2 ]
UniGenei Hs.1701.

3D structure databases

ProteinModelPortali Q14576.
SMRi Q14576. Positions 36-208, 266-363.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108310. 10 interactions.
IntActi Q14576. 7 interactions.
MINTi MINT-1471958.
STRINGi 9606.ENSP00000352162.

PTM databases

PhosphoSitei Q14576.

Polymorphism databases

DMDMi 21264436.

Proteomic databases

PaxDbi Q14576.
PRIDEi Q14576.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359227 ; ENSP00000352162 ; ENSG00000196361 . [Q14576-1 ]
ENST00000438662 ; ENSP00000390878 ; ENSG00000196361 . [Q14576-2 ]
GeneIDi 1995.
KEGGi hsa:1995.
UCSCi uc002mrx.1. human. [Q14576-2 ]
uc002mry.1. human. [Q14576-1 ]

Organism-specific databases

CTDi 1995.
GeneCardsi GC19M011562.
HGNCi HGNC:3314. ELAVL3.
HPAi CAB013066.
MIMi 603458. gene.
neXtProti NX_Q14576.
PharmGKBi PA27742.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0724.
HOGENOMi HOG000231162.
HOVERGENi HBG002295.
InParanoidi Q14576.
KOi K13208.
OMAi RYTGPLH.
OrthoDBi EOG77T14R.
PhylomeDBi Q14576.
TreeFami TF313377.

Miscellaneous databases

ChiTaRSi ELAVL3. human.
GeneWikii ELAVL3.
GenomeRNAii 1995.
NextBioi 8067.
PROi Q14576.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q14576.
Bgeei Q14576.
CleanExi HS_ELAVL3.
Genevestigatori Q14576.

Family and domain databases

Gene3Di 3.30.70.330. 3 hits.
InterProi IPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 3 hits.
[Graphical view ]
PRINTSi PR00961. HUDSXLRNA.
SMARTi SM00360. RRM. 3 hits.
[Graphical view ]
TIGRFAMsi TIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEi PS50102. RRM. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Manley T., Furneaux H.M.
    Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Isolation of HuC cDNA."
    Zhang B., Yuan J.G., Qiang B.Q.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma."
    Sakai K., Gofuku M., Kitagawa Y., Ogasawara T., Hirose G., Yamazaki M., Koh C.S., Yanagisawa N., Steinman L.
    Biochem. Biophys. Res. Commun. 199:1200-1208(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-367 (ISOFORM 2).
    Tissue: Hippocampus.
  6. "RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay."
    King P.H.
    Nucleic Acids Res. 28:E20-E20(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiELAV3_HUMAN
AccessioniPrimary (citable) accession number: Q14576
Secondary accession number(s): Q16135, Q96CL8, Q96QS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 27, 2002
Last modified: July 9, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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