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Protein

ELAV-like protein 3

Gene

ELAVL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.By similarity1 Publication

GO - Molecular functioni

  • AU-rich element binding Source: UniProtKB
  • nucleotide binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 3
Alternative name(s):
Hu-antigen C
Short name:
HuC
Paraneoplastic cerebellar degeneration-associated antigen
Paraneoplastic limbic encephalitis antigen 21
Gene namesi
Name:ELAVL3
Synonyms:HUC, PLE21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3314. ELAVL3.

Pathology & Biotechi

Organism-specific databases

DisGeNETi1995.
OpenTargetsiENSG00000196361.
PharmGKBiPA27742.

Polymorphism and mutation databases

BioMutaiELAVL3.
DMDMi21264436.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815811 – 367ELAV-like protein 3Add BLAST367

Proteomic databases

MaxQBiQ14576.
PaxDbiQ14576.
PeptideAtlasiQ14576.
PRIDEiQ14576.

PTM databases

iPTMnetiQ14576.
PhosphoSitePlusiQ14576.

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

BgeeiENSG00000196361.
CleanExiHS_ELAVL3.
ExpressionAtlasiQ14576. baseline and differential.
GenevisibleiQ14576. HS.

Organism-specific databases

HPAiCAB013066.

Interactioni

Protein-protein interaction databases

BioGridi108310. 11 interactors.
IntActiQ14576. 7 interactors.
MINTiMINT-1471958.
STRINGi9606.ENSP00000352162.

Structurei

3D structure databases

ProteinModelPortaliQ14576.
SMRiQ14576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 117RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini125 – 205RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini284 – 362RRM 3PROSITE-ProRule annotationAdd BLAST79

Domaini

RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).By similarity

Sequence similaritiesi

Belongs to the RRM elav family.Curated
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0145. Eukaryota.
ENOG410XP7S. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000231162.
HOVERGENiHBG002295.
InParanoidiQ14576.
KOiK13208.
OMAiCTEPITV.
OrthoDBiEOG091G0G9L.
PhylomeDBiQ14576.
TreeFamiTF313377.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
SM00361. RRM_1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14576-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM
60 70 80 90 100
TQDEFKSLFG SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL
110 120 130 140 150
NGLKLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMSQKE MEQLFSQYGR
160 170 180 190 200
IITSRILVDQ VTGVSRGVGF IRFDKRIEAE EAIKGLNGQK PLGAAEPITV
210 220 230 240 250
KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD NLLNMAYGVK
260 270 280 290 300
SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL
310 320 330 340 350
WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL
360
GERVLQVSFK TSKQHKA
Length:367
Mass (Da):39,547
Last modified:May 27, 2002 - v3
Checksum:i03FB3BD4D112B326
GO
Isoform 2 (identifier: Q14576-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-257: Missing.

Show »
Length:360
Mass (Da):38,865
Checksum:i9D649E3D50AC1797
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20 – 25PALPNG → RPAQR in BAA21838 (PubMed:15489334).Curated6
Sequence conflicti78 – 79QS → RD in AAA58677 (Ref. 1) Curated2
Sequence conflicti78 – 79QS → RD in AAK67714 (Ref. 2) Curated2
Sequence conflicti88S → P in AAA58677 (Ref. 1) Curated1
Sequence conflicti88S → P in AAK67714 (Ref. 2) Curated1
Sequence conflicti195A → R in BAA21838 (PubMed:15489334).Curated1
Sequence conflicti248G → A in BAA21838 (PubMed:15489334).Curated1
Sequence conflicti282Missing in AAA58677 (Ref. 1) Curated1
Sequence conflicti282Missing in BAA21838 (PubMed:15489334).Curated1
Sequence conflicti295 – 297ADE → PDQ in BAA21838 (PubMed:15489334).Curated3
Sequence conflicti330V → M in BAA21838 (PubMed:15489334).Curated1
Sequence conflicti351G → A in AAA58677 (Ref. 1) Curated1
Sequence conflicti352E → Q in BAA21838 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005789251 – 257Missing in isoform 2. 3 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26405 mRNA. Translation: AAA58677.1.
AY036909 mRNA. Translation: AAK67714.1.
AC008481 Genomic DNA. No translation available.
BC014144 mRNA. No translation available.
D26158 mRNA. Translation: BAA21838.1.
CCDSiCCDS32912.1. [Q14576-1]
CCDS45978.1. [Q14576-2]
RefSeqiNP_001411.2. NM_001420.3. [Q14576-1]
NP_115657.2. NM_032281.2. [Q14576-2]
UniGeneiHs.1701.

Genome annotation databases

EnsembliENST00000359227; ENSP00000352162; ENSG00000196361. [Q14576-1]
ENST00000438662; ENSP00000390878; ENSG00000196361. [Q14576-2]
GeneIDi1995.
KEGGihsa:1995.
UCSCiuc002mrx.2. human. [Q14576-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26405 mRNA. Translation: AAA58677.1.
AY036909 mRNA. Translation: AAK67714.1.
AC008481 Genomic DNA. No translation available.
BC014144 mRNA. No translation available.
D26158 mRNA. Translation: BAA21838.1.
CCDSiCCDS32912.1. [Q14576-1]
CCDS45978.1. [Q14576-2]
RefSeqiNP_001411.2. NM_001420.3. [Q14576-1]
NP_115657.2. NM_032281.2. [Q14576-2]
UniGeneiHs.1701.

3D structure databases

ProteinModelPortaliQ14576.
SMRiQ14576.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108310. 11 interactors.
IntActiQ14576. 7 interactors.
MINTiMINT-1471958.
STRINGi9606.ENSP00000352162.

PTM databases

iPTMnetiQ14576.
PhosphoSitePlusiQ14576.

Polymorphism and mutation databases

BioMutaiELAVL3.
DMDMi21264436.

Proteomic databases

MaxQBiQ14576.
PaxDbiQ14576.
PeptideAtlasiQ14576.
PRIDEiQ14576.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359227; ENSP00000352162; ENSG00000196361. [Q14576-1]
ENST00000438662; ENSP00000390878; ENSG00000196361. [Q14576-2]
GeneIDi1995.
KEGGihsa:1995.
UCSCiuc002mrx.2. human. [Q14576-1]

Organism-specific databases

CTDi1995.
DisGeNETi1995.
GeneCardsiELAVL3.
HGNCiHGNC:3314. ELAVL3.
HPAiCAB013066.
MIMi603458. gene.
neXtProtiNX_Q14576.
OpenTargetsiENSG00000196361.
PharmGKBiPA27742.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0145. Eukaryota.
ENOG410XP7S. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000231162.
HOVERGENiHBG002295.
InParanoidiQ14576.
KOiK13208.
OMAiCTEPITV.
OrthoDBiEOG091G0G9L.
PhylomeDBiQ14576.
TreeFamiTF313377.

Miscellaneous databases

GeneWikiiELAVL3.
GenomeRNAii1995.
PROiQ14576.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196361.
CleanExiHS_ELAVL3.
ExpressionAtlasiQ14576. baseline and differential.
GenevisibleiQ14576. HS.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
SM00361. RRM_1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELAV3_HUMAN
AccessioniPrimary (citable) accession number: Q14576
Secondary accession number(s): Q16135, Q96CL8, Q96QS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 27, 2002
Last modified: November 2, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.