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Protein

ELAV-like protein 3

Gene

ELAVL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.By similarity1 Publication

GO - Molecular functioni

  • AU-rich element binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 3
Alternative name(s):
Hu-antigen C
Short name:
HuC
Paraneoplastic cerebellar degeneration-associated antigen
Paraneoplastic limbic encephalitis antigen 21
Gene namesi
Name:ELAVL3
Synonyms:HUC, PLE21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196361.9
HGNCiHGNC:3314 ELAVL3
MIMi603458 gene
neXtProtiNX_Q14576

Pathology & Biotechi

Organism-specific databases

DisGeNETi1995
OpenTargetsiENSG00000196361
PharmGKBiPA27742

Polymorphism and mutation databases

BioMutaiELAVL3
DMDMi21264436

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815811 – 367ELAV-like protein 3Add BLAST367

Proteomic databases

EPDiQ14576
MaxQBiQ14576
PaxDbiQ14576
PeptideAtlasiQ14576
PRIDEiQ14576

PTM databases

iPTMnetiQ14576
PhosphoSitePlusiQ14576

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

BgeeiENSG00000196361
CleanExiHS_ELAVL3
ExpressionAtlasiQ14576 baseline and differential
GenevisibleiQ14576 HS

Organism-specific databases

HPAiCAB013066
HPA045610

Interactioni

Protein-protein interaction databases

BioGridi108310, 11 interactors
IntActiQ14576, 7 interactors
STRINGi9606.ENSP00000352162

Structurei

3D structure databases

ProteinModelPortaliQ14576
SMRiQ14576
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 117RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini125 – 205RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini284 – 362RRM 3PROSITE-ProRule annotationAdd BLAST79

Domaini

RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).By similarity

Sequence similaritiesi

Belongs to the RRM elav family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0145 Eukaryota
ENOG410XP7S LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000231162
HOVERGENiHBG002295
InParanoidiQ14576
KOiK13208
OMAiYGVKSSP
OrthoDBiEOG091G0G9L
PhylomeDBiQ14576
TreeFamiTF313377

Family and domain databases

CDDicd12650 RRM1_Hu, 1 hit
cd12655 RRM3_HuC, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006548 ELAD_HU_SF
IPR034775 ELAV/Hu_RRM1
IPR034915 HuC_RRM3
IPR002343 Hud_Sxl_RNA
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SM00361 RRM_1, 2 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01661 ELAV_HUD_SF, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14576-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM
60 70 80 90 100
TQDEFKSLFG SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL
110 120 130 140 150
NGLKLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMSQKE MEQLFSQYGR
160 170 180 190 200
IITSRILVDQ VTGVSRGVGF IRFDKRIEAE EAIKGLNGQK PLGAAEPITV
210 220 230 240 250
KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD NLLNMAYGVK
260 270 280 290 300
SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL
310 320 330 340 350
WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL
360
GERVLQVSFK TSKQHKA
Length:367
Mass (Da):39,547
Last modified:May 27, 2002 - v3
Checksum:i03FB3BD4D112B326
GO
Isoform 2 (identifier: Q14576-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     251-257: Missing.

Show »
Length:360
Mass (Da):38,865
Checksum:i9D649E3D50AC1797
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20 – 25PALPNG → RPAQR in BAA21838 (PubMed:15489334).Curated6
Sequence conflicti78 – 79QS → RD in AAA58677 (Ref. 1) Curated2
Sequence conflicti78 – 79QS → RD in AAK67714 (Ref. 2) Curated2
Sequence conflicti88S → P in AAA58677 (Ref. 1) Curated1
Sequence conflicti88S → P in AAK67714 (Ref. 2) Curated1
Sequence conflicti195A → R in BAA21838 (PubMed:15489334).Curated1
Sequence conflicti248G → A in BAA21838 (PubMed:15489334).Curated1
Sequence conflicti282Missing in AAA58677 (Ref. 1) Curated1
Sequence conflicti282Missing in BAA21838 (PubMed:15489334).Curated1
Sequence conflicti295 – 297ADE → PDQ in BAA21838 (PubMed:15489334).Curated3
Sequence conflicti330V → M in BAA21838 (PubMed:15489334).Curated1
Sequence conflicti351G → A in AAA58677 (Ref. 1) Curated1
Sequence conflicti352E → Q in BAA21838 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005789251 – 257Missing in isoform 2. 3 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26405 mRNA Translation: AAA58677.1
AY036909 mRNA Translation: AAK67714.1
AC008481 Genomic DNA No translation available.
BC014144 mRNA No translation available.
D26158 mRNA Translation: BAA21838.1
CCDSiCCDS32912.1 [Q14576-1]
CCDS45978.1 [Q14576-2]
RefSeqiNP_001411.2, NM_001420.3 [Q14576-1]
NP_115657.2, NM_032281.2 [Q14576-2]
UniGeneiHs.1701

Genome annotation databases

EnsembliENST00000359227; ENSP00000352162; ENSG00000196361 [Q14576-1]
ENST00000438662; ENSP00000390878; ENSG00000196361 [Q14576-2]
GeneIDi1995
KEGGihsa:1995
UCSCiuc002mrx.2 human [Q14576-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiELAV3_HUMAN
AccessioniPrimary (citable) accession number: Q14576
Secondary accession number(s): Q16135, Q96CL8, Q96QS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 27, 2002
Last modified: March 28, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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