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Q14576 (ELAV3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ELAV-like protein 3
Alternative name(s):
Hu-antigen C
Short name=HuC
Paraneoplastic cerebellar degeneration-associated antigen
Paraneoplastic limbic encephalitis antigen 21
Gene names
Name:ELAVL3
Synonyms:HUC, PLE21
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 By similarity. May be involved in neuronal differentiation and maintenance. Ref.6

Tissue specificity

Brain specific.

Domain

RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences By similarity.

Sequence similarities

Belongs to the RRM elav family.

Contains 3 RRM (RNA recognition motif) domains.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Coding sequence diversityAlternative splicing
   DomainRepeat
   LigandRNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

nervous system development

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionAU-rich element binding

Inferred from direct assay Ref.6. Source: UniProtKB

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q14576-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q14576-2)

The sequence of this isoform differs from the canonical sequence as follows:
     251-257: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367ELAV-like protein 3
PRO_0000081581

Regions

Domain39 – 11779RRM 1
Domain125 – 20581RRM 2
Domain284 – 36279RRM 3

Natural variations

Alternative sequence251 – 2577Missing in isoform 2.
VSP_005789

Experimental info

Sequence conflict20 – 256PALPNG → RPAQR in BAA21838. Ref.4
Sequence conflict78 – 792QS → RD in AAA58677. Ref.1
Sequence conflict78 – 792QS → RD in AAK67714. Ref.2
Sequence conflict881S → P in AAA58677. Ref.1
Sequence conflict881S → P in AAK67714. Ref.2
Sequence conflict1951A → R in BAA21838. Ref.4
Sequence conflict2481G → A in BAA21838. Ref.4
Sequence conflict2821Missing in AAA58677. Ref.1
Sequence conflict2821Missing in BAA21838. Ref.4
Sequence conflict295 – 2973ADE → PDQ in BAA21838. Ref.4
Sequence conflict3301V → M in BAA21838. Ref.4
Sequence conflict3511G → A in AAA58677. Ref.1
Sequence conflict3521E → Q in BAA21838. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 27, 2002. Version 3.
Checksum: 03FB3BD4D112B326

FASTA36739,547
        10         20         30         40         50         60 
MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM TQDEFKSLFG 

        70         80         90        100        110        120 
SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL NGLKLQTKTI KVSYARPSSA 

       130        140        150        160        170        180 
SIRDANLYVS GLPKTMSQKE MEQLFSQYGR IITSRILVDQ VTGVSRGVGF IRFDKRIEAE 

       190        200        210        220        230        240 
EAIKGLNGQK PLGAAEPITV KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD 

       250        260        270        280        290        300 
NLLNMAYGVK SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL 

       310        320        330        340        350        360 
WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL GERVLQVSFK 


TSKQHKA 

« Hide

Isoform 2 [UniParc].

Checksum: 9D649E3D50AC1797
Show »

FASTA36038,865

References

« Hide 'large scale' references
[1]Manley T., Furneaux H.M.
Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"Isolation of HuC cDNA."
Zhang B., Yuan J.G., Qiang B.Q.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Tissue: Brain.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[5]"A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma."
Sakai K., Gofuku M., Kitagawa Y., Ogasawara T., Hirose G., Yamazaki M., Koh C.S., Yanagisawa N., Steinman L.
Biochem. Biophys. Res. Commun. 199:1200-1208(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-367 (ISOFORM 2).
Tissue: Hippocampus.
[6]"RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay."
King P.H.
Nucleic Acids Res. 28:E20-E20(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L26405 mRNA. Translation: AAA58677.1.
AY036909 mRNA. Translation: AAK67714.1.
AC008481 Genomic DNA. No translation available.
BC014144 mRNA. No translation available.
D26158 mRNA. Translation: BAA21838.1.
CCDSCCDS32912.1. [Q14576-1]
CCDS45978.1. [Q14576-2]
RefSeqNP_001411.2. NM_001420.3. [Q14576-1]
NP_115657.2. NM_032281.2. [Q14576-2]
XP_006722746.1. XM_006722683.1. [Q14576-2]
UniGeneHs.1701.

3D structure databases

ProteinModelPortalQ14576.
SMRQ14576. Positions 36-208, 266-363.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108310. 10 interactions.
IntActQ14576. 7 interactions.
MINTMINT-1471958.
STRING9606.ENSP00000352162.

PTM databases

PhosphoSiteQ14576.

Polymorphism databases

DMDM21264436.

Proteomic databases

PaxDbQ14576.
PRIDEQ14576.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359227; ENSP00000352162; ENSG00000196361. [Q14576-1]
ENST00000438662; ENSP00000390878; ENSG00000196361. [Q14576-2]
GeneID1995.
KEGGhsa:1995.
UCSCuc002mrx.1. human. [Q14576-2]
uc002mry.1. human. [Q14576-1]

Organism-specific databases

CTD1995.
GeneCardsGC19M011562.
HGNCHGNC:3314. ELAVL3.
HPACAB013066.
MIM603458. gene.
neXtProtNX_Q14576.
PharmGKBPA27742.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0724.
HOGENOMHOG000231162.
HOVERGENHBG002295.
InParanoidQ14576.
KOK13208.
OMARYTGPLH.
OrthoDBEOG77T14R.
PhylomeDBQ14576.
TreeFamTF313377.

Gene expression databases

ArrayExpressQ14576.
BgeeQ14576.
CleanExHS_ELAVL3.
GenevestigatorQ14576.

Family and domain databases

Gene3D3.30.70.330. 3 hits.
InterProIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSPR00961. HUDSXLRNA.
SMARTSM00360. RRM. 3 hits.
[Graphical view]
TIGRFAMsTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSELAVL3. human.
GeneWikiELAVL3.
GenomeRNAi1995.
NextBio8067.
PROQ14576.
SOURCESearch...

Entry information

Entry nameELAV3_HUMAN
AccessionPrimary (citable) accession number: Q14576
Secondary accession number(s): Q16135, Q96CL8, Q96QS9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 27, 2002
Last modified: July 9, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM