Q14576 (ELAV3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ELAV-like protein 3

Alternative name(s):
Hu-antigen C
Short name=HuC
Paraneoplastic cerebellar degeneration-associated antigen
Paraneoplastic limbic encephalitis antigen 21

Gene names

Name:	ELAVL3
Synonyms:	HUC, PLE21

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 By similarity. May be involved in neuronal differentiation and maintenance. Ref.6
Tissue specificity	Brain specific.
Domain	RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences By similarity.
Sequence similarities	Belongs to the RRM elav family. Contains 3 RRM (RNA recognition motif) domains.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	RNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	AU-rich element binding Inferred from direct assay Ref.6. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14576-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14576-2)

The sequence of this isoform differs from the canonical sequence as follows:
     251-257: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	ELAV-like protein 3		PRO_0000081581
Regions
	Domain	39 – 117	79	RRM 1
	Domain	125 – 205	81	RRM 2
	Domain	284 – 362	79	RRM 3
Natural variations
	Alternative sequence	251 – 257	7	Missing in isoform 2.		VSP_005789
Experimental info
	Sequence conflict	20 – 25	6	PALPNG → RPAQR in BAA21838. Ref.4
	Sequence conflict	78 – 79	2	QS → RD in AAA58677. Ref.1
	Sequence conflict	78 – 79	2	QS → RD in AAK67714. Ref.2
	Sequence conflict	88	1	S → P in AAA58677. Ref.1
	Sequence conflict	88	1	S → P in AAK67714. Ref.2
	Sequence conflict	195	1	A → R in BAA21838. Ref.4
	Sequence conflict	248	1	G → A in BAA21838. Ref.4
	Sequence conflict	282	1	Missing in AAA58677. Ref.1
	Sequence conflict	282	1	Missing in BAA21838. Ref.4
	Sequence conflict	295 – 297	3	ADE → PDQ in BAA21838. Ref.4
	Sequence conflict	330	1	V → M in BAA21838. Ref.4
	Sequence conflict	351	1	G → A in AAA58677. Ref.1
	Sequence conflict	352	1	E → Q in BAA21838. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 27, 2002. Version 3. Checksum: 03FB3BD4D112B326	FASTA	367	39,547
	10 20 30 40 50 60 MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM TQDEFKSLFG 70 80 90 100 110 120 SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL NGLKLQTKTI KVSYARPSSA 130 140 150 160 170 180 SIRDANLYVS GLPKTMSQKE MEQLFSQYGR IITSRILVDQ VTGVSRGVGF IRFDKRIEAE 190 200 210 220 230 240 EAIKGLNGQK PLGAAEPITV KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD 250 260 270 280 290 300 NLLNMAYGVK SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL 310 320 330 340 350 360 WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL GERVLQVSFK TSKQHKA
	Isoform 2 [UniParc]. Checksum: 9D649E3D50AC1797	FASTA	360	38,865
	10 20 30 40 50 60 MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM TQDEFKSLFG 70 80 90 100 110 120 SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL NGLKLQTKTI KVSYARPSSA 130 140 150 160 170 180 SIRDANLYVS GLPKTMSQKE MEQLFSQYGR IITSRILVDQ VTGVSRGVGF IRFDKRIEAE 190 200 210 220 230 240 EAIKGLNGQK PLGAAEPITV KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD 250 260 270 280 290 300 NLLNMAYGVK RFSPIAIDGM SGLAGVGLSG GAAGAGWCIF VYNLSPEADE SVLWQLFGPF 310 320 330 340 350 360 GAVTNVKVIR DFTTNKCKGF GFVTMTNYDE AAMAIASLNG YRLGERVLQV SFKTSKQHKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Manley T., Furneaux H.M. Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Isolation of HuC cDNA." Zhang B., Yuan J.G., Qiang B.Q. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma." Sakai K., Gofuku M., Kitagawa Y., Ogasawara T., Hirose G., Yamazaki M., Koh C.S., Yanagisawa N., Steinman L. Biochem. Biophys. Res. Commun. 199:1200-1208(1994) [PubMed: 7511893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-367 (ISOFORM 2). Tissue: Hippocampus.
[6]	"RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay." King P.H. Nucleic Acids Res. 28:E20-E20(2000) [PubMed: 10710437] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L26405 mRNA. Translation: AAA58677.1. AY036909 mRNA. Translation: AAK67714.1. AC008481 Genomic DNA. No translation available. BC014144 mRNA. No translation available. D26158 mRNA. Translation: BAA21838.1.
IPI	IPI00031552. IPI00140449.
RefSeq	NP_001411.2. NM_001420.3. NP_115657.2. NM_032281.2.
UniGene	Hs.1701.
3D structure databases
ProteinModelPortal	Q14576.
SMR	Q14576. Positions 36-366.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14576. 7 interactions.
MINT	MINT-1471958.
STRING	Q14576.
PTM databases
PhosphoSite	Q14576.
Polymorphism databases
DMDM	21264436.
Proteomic databases
PRIDE	Q14576.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359227; ENSP00000352162; ENSG00000196361.
GeneID	1995.
KEGG	hsa:1995.
UCSC	uc002mrx.1. human. uc002mry.1. human.
Organism-specific databases
CTD	1995.
GeneCards	GC19M011562.
H-InvDB	HIX0014771.
HGNC	HGNC:3314. ELAVL3.
HPA	CAB013066.
MIM	603458. gene.
neXtProt	NX_Q14576.
PharmGKB	PA27742.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0724.
GeneTree	ENSGT00560000077064.
HOGENOM	HOG000231162.
HOVERGEN	HBG002295.
InParanoid	Q14576.
KO	K13208.
OMA	ISTMETQ.
PhylomeDB	Q14576.
Gene expression databases
ArrayExpress	Q14576.
Bgee	Q14576.
CleanEx	HS_ELAVL3.
Genevestigator	Q14576.
GermOnline	ENSG00000196361. Homo sapiens.
Family and domain databases
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 3 hits.
InterPro	IPR006548. ELAD_HUD_SF. IPR002343. Hud_Sxl_RNA. IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. [Graphical view]
Pfam	PF00076. RRM_1. 3 hits. [Graphical view]
PRINTS	PR00961. HUDSXLRNA.
SMART	SM00360. RRM. 3 hits. [Graphical view]
TIGRFAMs	TIGR01661. ELAV_HUD_SF. 1 hit.
PROSITE	PS50102. RRM. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	8067.
SOURCE	Search...

Entry information

Entry name

ELAV3_HUMAN

Accession

Primary (citable) accession number: Q14576
Secondary accession number(s): Q16135, Q96CL8, Q96QS9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	May 27, 2002
Last modified:	May 16, 2012
This is version 110 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.