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Q14576

- ELAV3_HUMAN

UniProt

Q14576 - ELAV3_HUMAN

Protein

ELAV-like protein 3

Gene

ELAVL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 3 (27 May 2002)
      Previous versions | rss
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    Functioni

    Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 By similarity. May be involved in neuronal differentiation and maintenance.By similarity1 Publication

    GO - Molecular functioni

    1. AU-rich element binding Source: UniProtKB
    2. nucleotide binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. nervous system development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ELAV-like protein 3
    Alternative name(s):
    Hu-antigen C
    Short name:
    HuC
    Paraneoplastic cerebellar degeneration-associated antigen
    Paraneoplastic limbic encephalitis antigen 21
    Gene namesi
    Name:ELAVL3
    Synonyms:HUC, PLE21
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:3314. ELAVL3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27742.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367ELAV-like protein 3PRO_0000081581Add
    BLAST

    Proteomic databases

    PaxDbiQ14576.
    PRIDEiQ14576.

    PTM databases

    PhosphoSiteiQ14576.

    Expressioni

    Tissue specificityi

    Brain specific.

    Gene expression databases

    ArrayExpressiQ14576.
    BgeeiQ14576.
    CleanExiHS_ELAVL3.
    GenevestigatoriQ14576.

    Organism-specific databases

    HPAiCAB013066.

    Interactioni

    Protein-protein interaction databases

    BioGridi108310. 10 interactions.
    IntActiQ14576. 7 interactions.
    MINTiMINT-1471958.
    STRINGi9606.ENSP00000352162.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14576.
    SMRiQ14576. Positions 36-208, 266-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 11779RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini125 – 20581RRM 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini284 – 36279RRM 3PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences By similarity.By similarity

    Sequence similaritiesi

    Belongs to the RRM elav family.Curated
    Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0724.
    HOGENOMiHOG000231162.
    HOVERGENiHBG002295.
    InParanoidiQ14576.
    KOiK13208.
    OMAiRYTGPLH.
    OrthoDBiEOG77T14R.
    PhylomeDBiQ14576.
    TreeFamiTF313377.

    Family and domain databases

    Gene3Di3.30.70.330. 3 hits.
    InterProiIPR006548. ELAD_HUD_SF.
    IPR002343. Hud_Sxl_RNA.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 3 hits.
    [Graphical view]
    PRINTSiPR00961. HUDSXLRNA.
    SMARTiSM00360. RRM. 3 hits.
    [Graphical view]
    TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
    PROSITEiPS50102. RRM. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14576-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM    50
    TQDEFKSLFG SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL 100
    NGLKLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMSQKE MEQLFSQYGR 150
    IITSRILVDQ VTGVSRGVGF IRFDKRIEAE EAIKGLNGQK PLGAAEPITV 200
    KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD NLLNMAYGVK 250
    SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL 300
    WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL 350
    GERVLQVSFK TSKQHKA 367
    Length:367
    Mass (Da):39,547
    Last modified:May 27, 2002 - v3
    Checksum:i03FB3BD4D112B326
    GO
    Isoform 2 (identifier: Q14576-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         251-257: Missing.

    Show »
    Length:360
    Mass (Da):38,865
    Checksum:i9D649E3D50AC1797
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 256PALPNG → RPAQR in BAA21838. (PubMed:15489334)Curated
    Sequence conflicti78 – 792QS → RD in AAA58677. 1 PublicationCurated
    Sequence conflicti78 – 792QS → RD in AAK67714. 1 PublicationCurated
    Sequence conflicti88 – 881S → P in AAA58677. 1 PublicationCurated
    Sequence conflicti88 – 881S → P in AAK67714. 1 PublicationCurated
    Sequence conflicti195 – 1951A → R in BAA21838. (PubMed:15489334)Curated
    Sequence conflicti248 – 2481G → A in BAA21838. (PubMed:15489334)Curated
    Sequence conflicti282 – 2821Missing in AAA58677. 1 PublicationCurated
    Sequence conflicti282 – 2821Missing in BAA21838. (PubMed:15489334)Curated
    Sequence conflicti295 – 2973ADE → PDQ in BAA21838. (PubMed:15489334)Curated
    Sequence conflicti330 – 3301V → M in BAA21838. (PubMed:15489334)Curated
    Sequence conflicti351 – 3511G → A in AAA58677. 1 PublicationCurated
    Sequence conflicti352 – 3521E → Q in BAA21838. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei251 – 2577Missing in isoform 2. 3 PublicationsVSP_005789

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26405 mRNA. Translation: AAA58677.1.
    AY036909 mRNA. Translation: AAK67714.1.
    AC008481 Genomic DNA. No translation available.
    BC014144 mRNA. No translation available.
    D26158 mRNA. Translation: BAA21838.1.
    CCDSiCCDS32912.1. [Q14576-1]
    CCDS45978.1. [Q14576-2]
    RefSeqiNP_001411.2. NM_001420.3. [Q14576-1]
    NP_115657.2. NM_032281.2. [Q14576-2]
    XP_006722746.1. XM_006722683.1. [Q14576-2]
    UniGeneiHs.1701.

    Genome annotation databases

    GeneIDi1995.
    KEGGihsa:1995.
    UCSCiuc002mrx.1. human. [Q14576-2]
    uc002mry.1. human. [Q14576-1]

    Polymorphism databases

    DMDMi21264436.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26405 mRNA. Translation: AAA58677.1 .
    AY036909 mRNA. Translation: AAK67714.1 .
    AC008481 Genomic DNA. No translation available.
    BC014144 mRNA. No translation available.
    D26158 mRNA. Translation: BAA21838.1 .
    CCDSi CCDS32912.1. [Q14576-1 ]
    CCDS45978.1. [Q14576-2 ]
    RefSeqi NP_001411.2. NM_001420.3. [Q14576-1 ]
    NP_115657.2. NM_032281.2. [Q14576-2 ]
    XP_006722746.1. XM_006722683.1. [Q14576-2 ]
    UniGenei Hs.1701.

    3D structure databases

    ProteinModelPortali Q14576.
    SMRi Q14576. Positions 36-208, 266-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108310. 10 interactions.
    IntActi Q14576. 7 interactions.
    MINTi MINT-1471958.
    STRINGi 9606.ENSP00000352162.

    PTM databases

    PhosphoSitei Q14576.

    Polymorphism databases

    DMDMi 21264436.

    Proteomic databases

    PaxDbi Q14576.
    PRIDEi Q14576.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1995.
    KEGGi hsa:1995.
    UCSCi uc002mrx.1. human. [Q14576-2 ]
    uc002mry.1. human. [Q14576-1 ]

    Organism-specific databases

    CTDi 1995.
    GeneCardsi GC19M011562.
    HGNCi HGNC:3314. ELAVL3.
    HPAi CAB013066.
    MIMi 603458. gene.
    neXtProti NX_Q14576.
    PharmGKBi PA27742.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0724.
    HOGENOMi HOG000231162.
    HOVERGENi HBG002295.
    InParanoidi Q14576.
    KOi K13208.
    OMAi RYTGPLH.
    OrthoDBi EOG77T14R.
    PhylomeDBi Q14576.
    TreeFami TF313377.

    Miscellaneous databases

    ChiTaRSi ELAVL3. human.
    GeneWikii ELAVL3.
    GenomeRNAii 1995.
    NextBioi 8067.
    PROi Q14576.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14576.
    Bgeei Q14576.
    CleanExi HS_ELAVL3.
    Genevestigatori Q14576.

    Family and domain databases

    Gene3Di 3.30.70.330. 3 hits.
    InterProi IPR006548. ELAD_HUD_SF.
    IPR002343. Hud_Sxl_RNA.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 3 hits.
    [Graphical view ]
    PRINTSi PR00961. HUDSXLRNA.
    SMARTi SM00360. RRM. 3 hits.
    [Graphical view ]
    TIGRFAMsi TIGR01661. ELAV_HUD_SF. 1 hit.
    PROSITEi PS50102. RRM. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Manley T., Furneaux H.M.
      Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "Isolation of HuC cDNA."
      Zhang B., Yuan J.G., Qiang B.Q.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Tissue: Brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma."
      Sakai K., Gofuku M., Kitagawa Y., Ogasawara T., Hirose G., Yamazaki M., Koh C.S., Yanagisawa N., Steinman L.
      Biochem. Biophys. Res. Commun. 199:1200-1208(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-367 (ISOFORM 2).
      Tissue: Hippocampus.
    6. "RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay."
      King P.H.
      Nucleic Acids Res. 28:E20-E20(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiELAV3_HUMAN
    AccessioniPrimary (citable) accession number: Q14576
    Secondary accession number(s): Q16135, Q96CL8, Q96QS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 27, 2002
    Last modified: October 1, 2014
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3