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Protein

Inositol 1,4,5-trisphosphate receptor type 3

Gene

ITPR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000096433-MONOMER.
ReactomeiR-HSA-112043. PLC beta mediated events.
R-HSA-114508. Effects of PIP2 hydrolysis.
R-HSA-139853. Elevation of cytosolic Ca2+ levels.
R-HSA-1489509. DAG and IP3 signaling.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-422356. Regulation of insulin secretion.
R-HSA-5218921. VEGFR2 mediated cell proliferation.
R-HSA-5578775. Ion homeostasis.
R-HSA-5607763. CLEC7A (Dectin-1) induces NFAT activation.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 3
Alternative name(s):
IP3 receptor isoform 3
Short name:
IP3R 3
Short name:
InsP3R3
Type 3 inositol 1,4,5-trisphosphate receptor
Short name:
Type 3 InsP3 receptor
Gene namesi
Name:ITPR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:6182. ITPR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2202CytoplasmicSequence analysisAdd BLAST2202
Transmembranei2203 – 2223HelicalSequence analysisAdd BLAST21
Topological domaini2224 – 2235ExtracellularSequence analysisAdd BLAST12
Transmembranei2236 – 2256HelicalSequence analysisAdd BLAST21
Topological domaini2257 – 2264CytoplasmicSequence analysis8
Transmembranei2265 – 2285HelicalSequence analysisAdd BLAST21
Topological domaini2286 – 2325ExtracellularSequence analysisAdd BLAST40
Transmembranei2326 – 2346HelicalSequence analysisAdd BLAST21
Topological domaini2347 – 2368CytoplasmicSequence analysisAdd BLAST22
Transmembranei2369 – 2389HelicalSequence analysisAdd BLAST21
Topological domaini2390 – 2496ExtracellularSequence analysisAdd BLAST107
Transmembranei2497 – 2517HelicalSequence analysisAdd BLAST21
Topological domaini2518 – 2671CytoplasmicSequence analysisAdd BLAST154

GO - Cellular componenti

  • apical part of cell Source: BHF-UCL
  • brush border Source: BHF-UCL
  • cytoplasm Source: BHF-UCL
  • endoplasmic reticulum Source: BHF-UCL
  • endoplasmic reticulum membrane Source: UniProtKB
  • integral component of plasma membrane Source: BHF-UCL
  • membrane Source: UniProtKB
  • myelin sheath Source: BHF-UCL
  • neuronal cell body Source: BHF-UCL
  • nuclear outer membrane Source: BHF-UCL
  • nucleolus Source: Ensembl
  • nucleoplasm Source: Ensembl
  • plasma membrane Source: UniProtKB
  • platelet dense tubular network membrane Source: Reactome
  • receptor complex Source: MGI
  • sarcoplasmic reticulum Source: GO_Central
  • secretory granule membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3710.
MalaCardsiITPR3.
OpenTargetsiENSG00000096433.
PharmGKBiPA29980.

Chemistry databases

ChEMBLiCHEMBL3904.
DrugBankiDB00201. Caffeine.

Polymorphism and mutation databases

BioMutaiITPR3.
DMDMi209572633.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539281 – 2671Inositol 1,4,5-trisphosphate receptor type 3Add BLAST2671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei916PhosphoserineCombined sources1
Modified residuei934PhosphoserineCombined sources1
Modified residuei1813PhosphoserineCombined sources1
Modified residuei1832PhosphoserineCombined sources1
Modified residuei1834PhosphoserineCombined sources1
Modified residuei2609PhosphoserineCombined sources1
Modified residuei2670PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14573.
MaxQBiQ14573.
PaxDbiQ14573.
PeptideAtlasiQ14573.
PRIDEiQ14573.

PTM databases

iPTMnetiQ14573.
PhosphoSitePlusiQ14573.
SwissPalmiQ14573.

Expressioni

Tissue specificityi

Expressed in intestinal crypt and villus epithelial cells.

Gene expression databases

BgeeiENSG00000096433.
CleanExiHS_ITPR3.
GenevisibleiQ14573. HS.

Organism-specific databases

HPAiHPA003915.
HPA064704.

Interactioni

Subunit structurei

Homotetramer. Interacts with TRPC1, TRPC3 and TRPC4. Interacts with TRPV4 (PubMed:18826956). Interacts with SIGMAR1 (By similarity). Interacts with PML and AKT1 (By similarity). Interacts with LRMP (via coiled-coil domain) (By similarity). Interacts with CABP1 (PubMed:12032348). Interacts with TMBIM4/LFG4 (PubMed:19553469). Interacts with CEMIP (PubMed:23936024). Interacts with TESPA1 (By similarity). Interacts with TMEM203 (PubMed:25996873). Interacts with BOK; regulates ITPR3 expression (By similarity).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRPC3Q135075EBI-351055,EBI-520807

Protein-protein interaction databases

BioGridi109915. 49 interactors.
IntActiQ14573. 29 interactors.
MINTiMINT-4991384.
STRINGi9606.ENSP00000363435.

Chemistry databases

BindingDBiQ14573.

Structurei

3D structure databases

ProteinModelPortaliQ14573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 173MIR 1PROSITE-ProRule annotationAdd BLAST61
Domaini174 – 224MIR 2PROSITE-ProRule annotationAdd BLAST51
Domaini232 – 288MIR 3PROSITE-ProRule annotationAdd BLAST57
Domaini295 – 372MIR 4PROSITE-ProRule annotationAdd BLAST78
Domaini378 – 434MIR 5PROSITE-ProRule annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni266 – 270Inositol 1,4,5-trisphosphate bindingBy similarity5
Regioni507 – 510Inositol 1,4,5-trisphosphate bindingBy similarity4
Regioni567 – 569Inositol 1,4,5-trisphosphate bindingBy similarity3

Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

Sequence similaritiesi

Belongs to the InsP3 receptor family.Curated
Contains 5 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3533. Eukaryota.
ENOG410XR97. LUCA.
GeneTreeiENSGT00760000119152.
HOGENOMiHOG000007660.
HOVERGENiHBG052158.
InParanoidiQ14573.
KOiK04960.
OMAiFVHELFY.
OrthoDBiEOG091G00T2.
PhylomeDBiQ14573.
TreeFamiTF312815.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 2 hits.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK
60 70 80 90 100
KFRDCLFKVC PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME
110 120 130 140 150
QKQNDTENKK VHGDVVKYGS VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV
160 170 180 190 200
TLDATGNEGS WLFIQPFWKL RSNGDNVVVG DKVILNPVNA GQPLHASNYE
210 220 230 240 250
LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV VRLFHAEQEK
260 270 280 290 300
FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
310 320 330 340 350
NGLYRFKHLA TGNYLAAEEN PSYKGDASDP KAAGMGAQGR TGRRNAGEKI
360 370 380 390 400
KYCLVAVPHG NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS
410 420 430 440 450
TNVPIDIEEE RPIRLMLGTC PTKEDKEAFA IVSVPVSEIR DLDFANDASS
460 470 480 490 500
MLASAVEKLN EGFISQNDRR FVIQLLEDLV FFVSDVPNNG QNVLDIMVTK
510 520 530 540 550
PNRERQKLMR EQNILKQVFG ILKAPFREKG GEGPLVRLEE LSDQKNAPYQ
560 570 580 590 600
HMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH
610 620 630 640 650
NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NHIAIPVTQE
660 670 680 690 700
LICKCVLDPK NSDILIRTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDKN
710 720 730 740 750
NEHHEKSVRQ LAQEARAGNA HDENVLSYYR YQLKLFARMC LDRQYLAIDE
760 770 780 790 800
ISQQLGVDLI FLCMADEMLP FDLRASFCHL MLHVHVDRDP QELVTPVKFA
810 820 830 840 850
RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ANTMEFVEDY LNNVVSEAVP
860 870 880 890 900
FANEEKNKLT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCVQGPPA
910 920 930 940 950
MLQAYEDPGG KNVRRSIQGV GHMMSTMVLS RKQSVFSAPS LSAGASAAEP
960 970 980 990 1000
LDRSKFEENE DIVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE
1010 1020 1030 1040 1050
VFPMQDSGAD GTAPAFDSTT ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE
1060 1070 1080 1090 1100
GGRMFLRVLI HLTMHDYAPL VSGALQLLFK HFSQRQEAMH TFKQVQLLIS
1110 1120 1130 1140 1150
AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSGKGEEVE AGAAKDKKER
1160 1170 1180 1190 1200
PTDEEGFLHP PGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM
1210 1220 1230 1240 1250
DAHKVMLDLL QIPYDKGDAK MMEILRYTHQ FLQKFCAGNP GNQALLHKHL
1260 1270 1280 1290 1300
HLFLTPGLLE AETMQHIFLN NYQLCSEISE PVLQHFVHLL ATHGRHVQYL
1310 1320 1330 1340 1350
DFLHTVIKAE GKYVKKCQDM IMTELTNAGD DVVVFYNDKA SLAHLLDMMK
1360 1370 1380 1390 1400
AARDGVEDHS PLMYHISLVD LLAACAEGKN VYTEIKCTSL LPLEDVVSVV
1410 1420 1430 1440 1450
THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL FENFTLDMAR
1460 1470 1480 1490 1500
VCSKREKRVA DPTLEKYVLS VVLDTINAFF SSPFSENSTS LQTHQTIVVQ
1510 1520 1530 1540 1550
LLQSTTRLLE CPWLQQQHKG SVEACIRTLA MVAKGRAILL PMDLDAHISS
1560 1570 1580 1590 1600
MLSSGASCAA AAQRNASSYK ATTRAFPRVT PTANQWDYKN IIEKLQDIIT
1610 1620 1630 1640 1650
ALEERLKPLV QAELSVLVDV LHWPELLFLE GSEAYQRCES GGFLSKLIQH
1660 1670 1680 1690 1700
TKDLMESEEK LCIKVLRTLQ QMLLKKTKYG DRGNQLRKML LQNYLQNRKS
1710 1720 1730 1740 1750
TSRGDLPDPI GTGLDPDWSA IAATQCRLDK EGATKLVCDL ITSTKNEKIF
1760 1770 1780 1790 1800
QESIGLAIHL LDGGNTEIQK SFHNLMMSDK KSERFFKVLH DRMKRAQQET
1810 1820 1830 1840 1850
KSTVAVNMND LGSQPHEDRE PVDPTTKGRV ASFSIPGSSS RYSLGPSLRR
1860 1870 1880 1890 1900
GHEVSERVQS SEMGTSVLIM QPILRFLQLL CENHNRDLQN FLRCQNNKTN
1910 1920 1930 1940 1950
YNLVCETLQF LDIMCGSTTG GLGLLGLYIN EDNVGLVIQT LETLTEYCQG
1960 1970 1980 1990 2000
PCHENQTCIV THESNGIDII TALILNDISP LCKYRMDLVL QLKDNASKLL
2010 2020 2030 2040 2050
LALMESRHDS ENAERILISL RPQELVDVIK KAYLQEEERE NSEVSPREVG
2060 2070 2080 2090 2100
HNIYILALQL SRHNKQLQHL LKPVKRIQEE EAEGISSMLS LNNKQLSQML
2110 2120 2130 2140 2150
KSSAPAQEEE EDPLAYYENH TSQIEIVRQD RSMEQIVFPV PGICQFLTEE
2160 2170 2180 2190 2200
TKHRLFTTTE QDEQGSKVSD FFDQSSFLHN EMEWQRKLRS MPLIYWFSRR
2210 2220 2230 2240 2250
MTLWGSISFN LAVFINIIIA FFYPYMEGAS TGVLDSPLIS LLFWILICFS
2260 2270 2280 2290 2300
IAALFTKRYS IRPLIVALIL RSIYYLGIGP TLNILGALNL TNKIVFVVSF
2310 2320 2330 2340 2350
VGNRGTFIRG YKAMVMDMEF LYHVGYILTS VLGLFAHELF YSILLFDLIY
2360 2370 2380 2390 2400
REETLFNVIK SVTRNGRSIL LTALLALILV YLFSIVGFLF LKDDFILEVD
2410 2420 2430 2440 2450
RLPNNHSTAS PLGMPHGAAA FVDTCSGDKM DCVSGLSVPE VLEEDRELDS
2460 2470 2480 2490 2500
TERACDTLLM CIVTVMNHGL RNGGGVGDIL RKPSKDESLF PARVVYDLLF
2510 2520 2530 2540 2550
FFIVIIIVLN LIFGVIIDTF ADLRSEKQKK EEILKTTCFI CGLERDKFDN
2560 2570 2580 2590 2600
KTVSFEEHIK LEHNMWNYLY FIVLVRVKNK TDYTGPESYV AQMIKNKNLD
2610 2620 2630 2640 2650
WFPRMRAMSL VSNEGEGEQN EIRILQDKLN STMKLVSHLT AQLNELKEQM
2660 2670
TEQRKRRQRL GFVDVQNCIS R
Length:2,671
Mass (Da):304,106
Last modified:October 14, 2008 - v2
Checksum:i04D1957A53320EEE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti524A → V in AAC50064 (PubMed:8288584).Curated1
Sequence conflicti562H → Y in AAC50064 (PubMed:8288584).Curated1
Sequence conflicti989Y → H in BAA05385 (PubMed:8081734).Curated1
Sequence conflicti1143A → T in AAC50064 (PubMed:8288584).Curated1
Sequence conflicti1391L → V in AAC50064 (PubMed:8288584).Curated1
Sequence conflicti1496 – 1497TI → PV in AAC50064 (PubMed:8288584).Curated2
Sequence conflicti1674L → V in AAC50064 (PubMed:8288584).Curated1
Sequence conflicti2187 – 2188KL → NV in BAA05385 (PubMed:8081734).Curated2
Sequence conflicti2187 – 2188KL → NV in AAC50064 (PubMed:8288584).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049604374L → W.Corresponds to variant rs2229646dbSNPEnsembl.1
Natural variantiVAR_046978667R → Q.Corresponds to variant rs11963294dbSNPEnsembl.1
Natural variantiVAR_046979742D → E.Corresponds to variant rs2229633dbSNPEnsembl.1
Natural variantiVAR_0469801029G → V.Corresponds to variant rs2296333dbSNPEnsembl.1
Natural variantiVAR_0469811552L → V.Corresponds to variant rs9461899dbSNPEnsembl.1
Natural variantiVAR_0469821850R → Q.Corresponds to variant rs12528378dbSNPEnsembl.1
Natural variantiVAR_0469832398E → Q.Corresponds to variant rs2229641dbSNPEnsembl.1
Natural variantiVAR_0469842436L → V.1 PublicationCorresponds to variant rs2229642dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26351 mRNA. Translation: BAA05385.1.
U01062 mRNA. Translation: AAC50064.1.
AL139044 Genomic DNA. Translation: CAI16455.1.
CH471081 Genomic DNA. Translation: EAX03744.1.
CCDSiCCDS4783.1.
PIRiA49873.
RefSeqiNP_002215.2. NM_002224.3.
UniGeneiHs.65758.

Genome annotation databases

EnsembliENST00000374316; ENSP00000363435; ENSG00000096433.
ENST00000605930; ENSP00000475177; ENSG00000096433.
GeneIDi3710.
KEGGihsa:3710.
UCSCiuc063nyh.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26351 mRNA. Translation: BAA05385.1.
U01062 mRNA. Translation: AAC50064.1.
AL139044 Genomic DNA. Translation: CAI16455.1.
CH471081 Genomic DNA. Translation: EAX03744.1.
CCDSiCCDS4783.1.
PIRiA49873.
RefSeqiNP_002215.2. NM_002224.3.
UniGeneiHs.65758.

3D structure databases

ProteinModelPortaliQ14573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109915. 49 interactors.
IntActiQ14573. 29 interactors.
MINTiMINT-4991384.
STRINGi9606.ENSP00000363435.

Chemistry databases

BindingDBiQ14573.
ChEMBLiCHEMBL3904.
DrugBankiDB00201. Caffeine.

PTM databases

iPTMnetiQ14573.
PhosphoSitePlusiQ14573.
SwissPalmiQ14573.

Polymorphism and mutation databases

BioMutaiITPR3.
DMDMi209572633.

Proteomic databases

EPDiQ14573.
MaxQBiQ14573.
PaxDbiQ14573.
PeptideAtlasiQ14573.
PRIDEiQ14573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374316; ENSP00000363435; ENSG00000096433.
ENST00000605930; ENSP00000475177; ENSG00000096433.
GeneIDi3710.
KEGGihsa:3710.
UCSCiuc063nyh.1. human.

Organism-specific databases

CTDi3710.
DisGeNETi3710.
GeneCardsiITPR3.
H-InvDBHIX0005781.
HGNCiHGNC:6182. ITPR3.
HPAiHPA003915.
HPA064704.
MalaCardsiITPR3.
MIMi147267. gene.
neXtProtiNX_Q14573.
OpenTargetsiENSG00000096433.
PharmGKBiPA29980.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3533. Eukaryota.
ENOG410XR97. LUCA.
GeneTreeiENSGT00760000119152.
HOGENOMiHOG000007660.
HOVERGENiHBG052158.
InParanoidiQ14573.
KOiK04960.
OMAiFVHELFY.
OrthoDBiEOG091G00T2.
PhylomeDBiQ14573.
TreeFamiTF312815.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000096433-MONOMER.
ReactomeiR-HSA-112043. PLC beta mediated events.
R-HSA-114508. Effects of PIP2 hydrolysis.
R-HSA-139853. Elevation of cytosolic Ca2+ levels.
R-HSA-1489509. DAG and IP3 signaling.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-422356. Regulation of insulin secretion.
R-HSA-5218921. VEGFR2 mediated cell proliferation.
R-HSA-5578775. Ion homeostasis.
R-HSA-5607763. CLEC7A (Dectin-1) induces NFAT activation.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

ChiTaRSiITPR3. human.
GeneWikiiITPR3.
GenomeRNAii3710.
PROiQ14573.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000096433.
CleanExiHS_ITPR3.
GenevisibleiQ14573. HS.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 2 hits.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITPR3_HUMAN
AccessioniPrimary (citable) accession number: Q14573
Secondary accession number(s): Q14649, Q5TAQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 170 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.