Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q14573

- ITPR3_HUMAN

UniProt

Q14573 - ITPR3_HUMAN

Protein

Inositol 1,4,5-trisphosphate receptor type 3

Gene

ITPR3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

    GO - Molecular functioni

    1. inositol 1,3,4,5 tetrakisphosphate binding Source: BHF-UCL
    2. inositol 1,4,5 trisphosphate binding Source: BHF-UCL
    3. inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: UniProtKB
    4. inositol hexakisphosphate binding Source: BHF-UCL
    5. intracellular ligand-gated calcium channel activity Source: UniProtKB
    6. phosphatidylinositol binding Source: Ensembl
    7. protein binding Source: UniProtKB

    GO - Biological processi

    1. activation of phospholipase C activity Source: Reactome
    2. blood coagulation Source: Reactome
    3. calcium ion transport into cytosol Source: UniProtKB
    4. energy reserve metabolic process Source: Reactome
    5. epidermal growth factor receptor signaling pathway Source: Reactome
    6. Fc-epsilon receptor signaling pathway Source: Reactome
    7. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
    8. fibroblast growth factor receptor signaling pathway Source: Reactome
    9. G-protein coupled receptor signaling pathway Source: BHF-UCL
    10. innate immune response Source: Reactome
    11. long-term synaptic potentiation Source: Ensembl
    12. memory Source: Ensembl
    13. neurotrophin TRK receptor signaling pathway Source: Reactome
    14. platelet activation Source: Reactome
    15. positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
    16. protein heterooligomerization Source: BHF-UCL
    17. protein homooligomerization Source: BHF-UCL
    18. regulation of insulin secretion Source: Reactome
    19. response to calcium ion Source: BHF-UCL
    20. sensory perception of bitter taste Source: Ensembl
    21. sensory perception of sweet taste Source: Ensembl
    22. sensory perception of umami taste Source: Ensembl
    23. signal transduction Source: Reactome
    24. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_111064. DAG and IP3 signaling.
    REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_15426. PLC beta mediated events.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_162. Elevation of cytosolic Ca2+ levels.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_172761. Ca2+ pathway.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18325. Regulation of insulin secretion.
    REACT_2202. Effects of PIP2 hydrolysis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol 1,4,5-trisphosphate receptor type 3
    Alternative name(s):
    IP3 receptor isoform 3
    Short name:
    IP3R 3
    Short name:
    InsP3R3
    Type 3 inositol 1,4,5-trisphosphate receptor
    Short name:
    Type 3 InsP3 receptor
    Gene namesi
    Name:ITPR3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:6182. ITPR3.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: BHF-UCL
    2. brush border Source: BHF-UCL
    3. cytoplasm Source: BHF-UCL
    4. endoplasmic reticulum Source: BHF-UCL
    5. endoplasmic reticulum membrane Source: UniProtKB
    6. integral component of plasma membrane Source: BHF-UCL
    7. membrane Source: UniProtKB
    8. myelin sheath Source: BHF-UCL
    9. neuronal cell body Source: BHF-UCL
    10. nuclear outer membrane Source: BHF-UCL
    11. nucleolus Source: Ensembl
    12. nucleoplasm Source: Ensembl
    13. plasma membrane Source: UniProtKB
    14. platelet dense tubular network membrane Source: Reactome
    15. receptor complex Source: MGI

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29980.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 26712671Inositol 1,4,5-trisphosphate receptor type 3PRO_0000153928Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei916 – 9161Phosphoserine2 Publications
    Modified residuei934 – 9341Phosphoserine1 Publication
    Modified residuei1813 – 18131Phosphoserine1 Publication
    Modified residuei1832 – 18321Phosphoserine1 Publication
    Modified residuei2583 – 25831PhosphotyrosineSequence Analysis
    Modified residuei2670 – 26701Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ14573.
    PaxDbiQ14573.
    PeptideAtlasiQ14573.
    PRIDEiQ14573.

    PTM databases

    PhosphoSiteiQ14573.

    Expressioni

    Tissue specificityi

    Expressed in intestinal crypt and villus epithelial cells.

    Gene expression databases

    ArrayExpressiQ14573.
    BgeeiQ14573.
    CleanExiHS_ITPR3.
    GenevestigatoriQ14573.

    Organism-specific databases

    HPAiHPA003915.

    Interactioni

    Subunit structurei

    Homotetramer. Interacts with SIGMAR1, PML, AKT1, TRPC1, TRPC3 and TRPC4 By similarity. Interacts with LRMP (via coiled-coil domain) By similarity. Interacts with CABP1. Interacts with TMBIM4/LFG4. Interacts with CEMIP. Interacts with TESPA1 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRPC3Q135075EBI-351055,EBI-520807

    Protein-protein interaction databases

    BioGridi109915. 17 interactions.
    IntActiQ14573. 9 interactions.
    MINTiMINT-4991384.
    STRINGi9606.ENSP00000363435.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14573.
    SMRiQ14573. Positions 4-579.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 22022202CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini2224 – 223512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini2257 – 22648CytoplasmicSequence Analysis
    Topological domaini2286 – 232540ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini2347 – 236822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini2390 – 2496107ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini2518 – 2671154CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2203 – 222321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2236 – 225621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2265 – 228521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2326 – 234621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2369 – 238921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei2497 – 251721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini113 – 17361MIR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini174 – 22451MIR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini232 – 28857MIR 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini295 – 37278MIR 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini378 – 43457MIR 5PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni266 – 2705Inositol 1,4,5-trisphosphate bindingBy similarity
    Regioni507 – 5104Inositol 1,4,5-trisphosphate bindingBy similarity
    Regioni567 – 5693Inositol 1,4,5-trisphosphate bindingBy similarity

    Domaini

    The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

    Sequence similaritiesi

    Belongs to the InsP3 receptor family.Curated
    Contains 5 MIR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280601.
    HOGENOMiHOG000007660.
    HOVERGENiHBG052158.
    InParanoidiQ14573.
    KOiK04960.
    OMAiKGDAKMM.
    OrthoDBiEOG76HQ0M.
    PhylomeDBiQ14573.
    TreeFamiTF312815.

    Family and domain databases

    Gene3Di1.25.10.30. 2 hits.
    InterProiIPR014821. Ins145_P3_rcpt.
    IPR000493. InsP3_rcpt-bd.
    IPR005821. Ion_trans_dom.
    IPR016093. MIR_motif.
    IPR013662. RIH_assoc-dom.
    IPR000699. RIH_dom.
    IPR015925. Ryanodine_recept-rel.
    [Graphical view]
    PANTHERiPTHR13715. PTHR13715. 1 hit.
    PfamiPF08709. Ins145_P3_rec. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF02815. MIR. 1 hit.
    PF08454. RIH_assoc. 1 hit.
    PF01365. RYDR_ITPR. 2 hits.
    [Graphical view]
    PRINTSiPR00779. INSP3RECEPTR.
    SMARTiSM00472. MIR. 4 hits.
    [Graphical view]
    SUPFAMiSSF100909. SSF100909. 2 hits.
    SSF82109. SSF82109. 2 hits.
    PROSITEiPS50919. MIR. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14573-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK     50
    KFRDCLFKVC PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME 100
    QKQNDTENKK VHGDVVKYGS VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV 150
    TLDATGNEGS WLFIQPFWKL RSNGDNVVVG DKVILNPVNA GQPLHASNYE 200
    LSDNAGCKEV NSVNCNTSWK INLFMQFRDH LEEVLKGGDV VRLFHAEQEK 250
    FLTCDEYKGK LQVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW 300
    NGLYRFKHLA TGNYLAAEEN PSYKGDASDP KAAGMGAQGR TGRRNAGEKI 350
    KYCLVAVPHG NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS 400
    TNVPIDIEEE RPIRLMLGTC PTKEDKEAFA IVSVPVSEIR DLDFANDASS 450
    MLASAVEKLN EGFISQNDRR FVIQLLEDLV FFVSDVPNNG QNVLDIMVTK 500
    PNRERQKLMR EQNILKQVFG ILKAPFREKG GEGPLVRLEE LSDQKNAPYQ 550
    HMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH 600
    NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NHIAIPVTQE 650
    LICKCVLDPK NSDILIRTEL RPVKEMAQSH EYLSIEYSEE EVWLTWTDKN 700
    NEHHEKSVRQ LAQEARAGNA HDENVLSYYR YQLKLFARMC LDRQYLAIDE 750
    ISQQLGVDLI FLCMADEMLP FDLRASFCHL MLHVHVDRDP QELVTPVKFA 800
    RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ANTMEFVEDY LNNVVSEAVP 850
    FANEEKNKLT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCVQGPPA 900
    MLQAYEDPGG KNVRRSIQGV GHMMSTMVLS RKQSVFSAPS LSAGASAAEP 950
    LDRSKFEENE DIVVMETKLK ILEILQFILN VRLDYRISYL LSVFKKEFVE 1000
    VFPMQDSGAD GTAPAFDSTT ANMNLDRIGE QAEAMFGVGK TSSMLEVDDE 1050
    GGRMFLRVLI HLTMHDYAPL VSGALQLLFK HFSQRQEAMH TFKQVQLLIS 1100
    AQDVENYKVI KSELDRLRTM VEKSELWVDK KGSGKGEEVE AGAAKDKKER 1150
    PTDEEGFLHP PGEKSSENYQ IVKGILERLN KMCGVGEQMR KKQQRLLKNM 1200
    DAHKVMLDLL QIPYDKGDAK MMEILRYTHQ FLQKFCAGNP GNQALLHKHL 1250
    HLFLTPGLLE AETMQHIFLN NYQLCSEISE PVLQHFVHLL ATHGRHVQYL 1300
    DFLHTVIKAE GKYVKKCQDM IMTELTNAGD DVVVFYNDKA SLAHLLDMMK 1350
    AARDGVEDHS PLMYHISLVD LLAACAEGKN VYTEIKCTSL LPLEDVVSVV 1400
    THEDCITEVK MAYVNFVNHC YVDTEVEMKE IYTSNHIWTL FENFTLDMAR 1450
    VCSKREKRVA DPTLEKYVLS VVLDTINAFF SSPFSENSTS LQTHQTIVVQ 1500
    LLQSTTRLLE CPWLQQQHKG SVEACIRTLA MVAKGRAILL PMDLDAHISS 1550
    MLSSGASCAA AAQRNASSYK ATTRAFPRVT PTANQWDYKN IIEKLQDIIT 1600
    ALEERLKPLV QAELSVLVDV LHWPELLFLE GSEAYQRCES GGFLSKLIQH 1650
    TKDLMESEEK LCIKVLRTLQ QMLLKKTKYG DRGNQLRKML LQNYLQNRKS 1700
    TSRGDLPDPI GTGLDPDWSA IAATQCRLDK EGATKLVCDL ITSTKNEKIF 1750
    QESIGLAIHL LDGGNTEIQK SFHNLMMSDK KSERFFKVLH DRMKRAQQET 1800
    KSTVAVNMND LGSQPHEDRE PVDPTTKGRV ASFSIPGSSS RYSLGPSLRR 1850
    GHEVSERVQS SEMGTSVLIM QPILRFLQLL CENHNRDLQN FLRCQNNKTN 1900
    YNLVCETLQF LDIMCGSTTG GLGLLGLYIN EDNVGLVIQT LETLTEYCQG 1950
    PCHENQTCIV THESNGIDII TALILNDISP LCKYRMDLVL QLKDNASKLL 2000
    LALMESRHDS ENAERILISL RPQELVDVIK KAYLQEEERE NSEVSPREVG 2050
    HNIYILALQL SRHNKQLQHL LKPVKRIQEE EAEGISSMLS LNNKQLSQML 2100
    KSSAPAQEEE EDPLAYYENH TSQIEIVRQD RSMEQIVFPV PGICQFLTEE 2150
    TKHRLFTTTE QDEQGSKVSD FFDQSSFLHN EMEWQRKLRS MPLIYWFSRR 2200
    MTLWGSISFN LAVFINIIIA FFYPYMEGAS TGVLDSPLIS LLFWILICFS 2250
    IAALFTKRYS IRPLIVALIL RSIYYLGIGP TLNILGALNL TNKIVFVVSF 2300
    VGNRGTFIRG YKAMVMDMEF LYHVGYILTS VLGLFAHELF YSILLFDLIY 2350
    REETLFNVIK SVTRNGRSIL LTALLALILV YLFSIVGFLF LKDDFILEVD 2400
    RLPNNHSTAS PLGMPHGAAA FVDTCSGDKM DCVSGLSVPE VLEEDRELDS 2450
    TERACDTLLM CIVTVMNHGL RNGGGVGDIL RKPSKDESLF PARVVYDLLF 2500
    FFIVIIIVLN LIFGVIIDTF ADLRSEKQKK EEILKTTCFI CGLERDKFDN 2550
    KTVSFEEHIK LEHNMWNYLY FIVLVRVKNK TDYTGPESYV AQMIKNKNLD 2600
    WFPRMRAMSL VSNEGEGEQN EIRILQDKLN STMKLVSHLT AQLNELKEQM 2650
    TEQRKRRQRL GFVDVQNCIS R 2671
    Length:2,671
    Mass (Da):304,106
    Last modified:October 14, 2008 - v2
    Checksum:i04D1957A53320EEE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti524 – 5241A → V in AAC50064. (PubMed:8288584)Curated
    Sequence conflicti562 – 5621H → Y in AAC50064. (PubMed:8288584)Curated
    Sequence conflicti989 – 9891Y → H in BAA05385. (PubMed:8081734)Curated
    Sequence conflicti1143 – 11431A → T in AAC50064. (PubMed:8288584)Curated
    Sequence conflicti1391 – 13911L → V in AAC50064. (PubMed:8288584)Curated
    Sequence conflicti1496 – 14972TI → PV in AAC50064. (PubMed:8288584)Curated
    Sequence conflicti1674 – 16741L → V in AAC50064. (PubMed:8288584)Curated
    Sequence conflicti2187 – 21882KL → NV in BAA05385. (PubMed:8081734)Curated
    Sequence conflicti2187 – 21882KL → NV in AAC50064. (PubMed:8288584)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti374 – 3741L → W.
    Corresponds to variant rs2229646 [ dbSNP | Ensembl ].
    VAR_049604
    Natural varianti667 – 6671R → Q.
    Corresponds to variant rs11963294 [ dbSNP | Ensembl ].
    VAR_046978
    Natural varianti742 – 7421D → E.
    Corresponds to variant rs2229633 [ dbSNP | Ensembl ].
    VAR_046979
    Natural varianti1029 – 10291G → V.
    Corresponds to variant rs2296333 [ dbSNP | Ensembl ].
    VAR_046980
    Natural varianti1552 – 15521L → V.
    Corresponds to variant rs9461899 [ dbSNP | Ensembl ].
    VAR_046981
    Natural varianti1850 – 18501R → Q.
    Corresponds to variant rs12528378 [ dbSNP | Ensembl ].
    VAR_046982
    Natural varianti2398 – 23981E → Q.
    Corresponds to variant rs2229641 [ dbSNP | Ensembl ].
    VAR_046983
    Natural varianti2436 – 24361L → V.1 Publication
    Corresponds to variant rs2229642 [ dbSNP | Ensembl ].
    VAR_046984

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26351 mRNA. Translation: BAA05385.1.
    U01062 mRNA. Translation: AAC50064.1.
    AL139044 Genomic DNA. Translation: CAI16455.1.
    CH471081 Genomic DNA. Translation: EAX03744.1.
    CCDSiCCDS4783.1.
    PIRiA49873.
    RefSeqiNP_002215.2. NM_002224.3.
    UniGeneiHs.65758.

    Genome annotation databases

    EnsembliENST00000374316; ENSP00000363435; ENSG00000096433.
    ENST00000605930; ENSP00000475177; ENSG00000096433.
    GeneIDi3710.
    KEGGihsa:3710.
    UCSCiuc021ywr.1. human.

    Polymorphism databases

    DMDMi209572633.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26351 mRNA. Translation: BAA05385.1 .
    U01062 mRNA. Translation: AAC50064.1 .
    AL139044 Genomic DNA. Translation: CAI16455.1 .
    CH471081 Genomic DNA. Translation: EAX03744.1 .
    CCDSi CCDS4783.1.
    PIRi A49873.
    RefSeqi NP_002215.2. NM_002224.3.
    UniGenei Hs.65758.

    3D structure databases

    ProteinModelPortali Q14573.
    SMRi Q14573. Positions 4-579.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109915. 17 interactions.
    IntActi Q14573. 9 interactions.
    MINTi MINT-4991384.
    STRINGi 9606.ENSP00000363435.

    Chemistry

    BindingDBi Q14573.
    ChEMBLi CHEMBL2111451.
    GuidetoPHARMACOLOGYi 745.

    PTM databases

    PhosphoSitei Q14573.

    Polymorphism databases

    DMDMi 209572633.

    Proteomic databases

    MaxQBi Q14573.
    PaxDbi Q14573.
    PeptideAtlasi Q14573.
    PRIDEi Q14573.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374316 ; ENSP00000363435 ; ENSG00000096433 .
    ENST00000605930 ; ENSP00000475177 ; ENSG00000096433 .
    GeneIDi 3710.
    KEGGi hsa:3710.
    UCSCi uc021ywr.1. human.

    Organism-specific databases

    CTDi 3710.
    GeneCardsi GC06P033588.
    H-InvDB HIX0005781.
    HGNCi HGNC:6182. ITPR3.
    HPAi HPA003915.
    MIMi 147267. gene.
    neXtProti NX_Q14573.
    PharmGKBi PA29980.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG280601.
    HOGENOMi HOG000007660.
    HOVERGENi HBG052158.
    InParanoidi Q14573.
    KOi K04960.
    OMAi KGDAKMM.
    OrthoDBi EOG76HQ0M.
    PhylomeDBi Q14573.
    TreeFami TF312815.

    Enzyme and pathway databases

    Reactomei REACT_111064. DAG and IP3 signaling.
    REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_15426. PLC beta mediated events.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_162. Elevation of cytosolic Ca2+ levels.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_172761. Ca2+ pathway.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18325. Regulation of insulin secretion.
    REACT_2202. Effects of PIP2 hydrolysis.

    Miscellaneous databases

    ChiTaRSi ITPR3. human.
    GeneWikii ITPR3.
    GenomeRNAii 3710.
    NextBioi 14543.
    PROi Q14573.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14573.
    Bgeei Q14573.
    CleanExi HS_ITPR3.
    Genevestigatori Q14573.

    Family and domain databases

    Gene3Di 1.25.10.30. 2 hits.
    InterProi IPR014821. Ins145_P3_rcpt.
    IPR000493. InsP3_rcpt-bd.
    IPR005821. Ion_trans_dom.
    IPR016093. MIR_motif.
    IPR013662. RIH_assoc-dom.
    IPR000699. RIH_dom.
    IPR015925. Ryanodine_recept-rel.
    [Graphical view ]
    PANTHERi PTHR13715. PTHR13715. 1 hit.
    Pfami PF08709. Ins145_P3_rec. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF02815. MIR. 1 hit.
    PF08454. RIH_assoc. 1 hit.
    PF01365. RYDR_ITPR. 2 hits.
    [Graphical view ]
    PRINTSi PR00779. INSP3RECEPTR.
    SMARTi SM00472. MIR. 4 hits.
    [Graphical view ]
    SUPFAMi SSF100909. SSF100909. 2 hits.
    SSF82109. SSF82109. 2 hits.
    PROSITEi PS50919. MIR. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors."
      Yamamoto-Hino M., Sugiyama T., Hikiti K., Mattei M.-G., Hasegawa K., Sekine S., Sakurada K., Miyawaki A., Furuichi T., Hasegawa M., Mikoshiba K.
      Recept. Channels 2:9-22(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-2436.
    2. "Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium."
      Maranto A.R.
      J. Biol. Chem. 269:1222-1230(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels."
      Yang J., McBride S., Mak D.-O.D., Vardi N., Palczewski K., Haeseleer F., Foskett J.K.
      Proc. Natl. Acad. Sci. U.S.A. 99:7711-7716(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CABP1.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-916; SER-934 AND SER-1832, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: INTERACTION WITH TMBIM4/LFG4.
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1813, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-916 AND SER-2670, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors."
      Tiwari A., Schneider M., Fiorino A., Haider R., Okoniewski M.J., Roschitzki B., Uzozie A., Menigatti M., Jiricny J., Marra G.
      PLoS ONE 8:E69473-E69473(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CEMIP.

    Entry informationi

    Entry nameiITPR3_HUMAN
    AccessioniPrimary (citable) accession number: Q14573
    Secondary accession number(s): Q14649, Q5TAQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3