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Q14571

- ITPR2_HUMAN

UniProt

Q14571 - ITPR2_HUMAN

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Protein

Inositol 1,4,5-trisphosphate receptor type 2

Gene
ITPR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA By similarity.

GO - Molecular functioni

  1. calcium ion transmembrane transporter activity Source: ProtInc
  2. inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: ProtInc
  3. phosphatidylinositol binding Source: Ensembl

GO - Biological processi

  1. activation of phospholipase C activity Source: Reactome
  2. blood coagulation Source: Reactome
  3. cellular response to cAMP Source: Ensembl
  4. cellular response to ethanol Source: Ensembl
  5. energy reserve metabolic process Source: Reactome
  6. epidermal growth factor receptor signaling pathway Source: Reactome
  7. Fc-epsilon receptor signaling pathway Source: Reactome
  8. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  9. fibroblast growth factor receptor signaling pathway Source: Reactome
  10. innate immune response Source: Reactome
  11. neurotrophin TRK receptor signaling pathway Source: Reactome
  12. platelet activation Source: Reactome
  13. regulation of insulin secretion Source: Reactome
  14. response to hypoxia Source: BHF-UCL
  15. signal transduction Source: Reactome
  16. small molecule metabolic process Source: Reactome
  17. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_111064. DAG and IP3 signaling.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_15426. PLC beta mediated events.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_162. Elevation of cytosolic Ca2+ levels.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18325. Regulation of insulin secretion.
REACT_2202. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 2
Alternative name(s):
IP3 receptor isoform 2
Short name:
IP3R 2
Short name:
InsP3R2
Type 2 inositol 1,4,5-trisphosphate receptor
Short name:
Type 2 InsP3 receptor
Gene namesi
Name:ITPR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6181. ITPR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22272227Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei2228 – 224821Helical; Reviewed predictionAdd
BLAST
Topological domaini2249 – 226012Extracellular Reviewed predictionAdd
BLAST
Transmembranei2261 – 228121Helical; Reviewed predictionAdd
BLAST
Topological domaini2282 – 230726Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei2308 – 232821Helical; Reviewed predictionAdd
BLAST
Topological domaini2329 – 235123Extracellular Reviewed predictionAdd
BLAST
Transmembranei2352 – 237221Helical; Reviewed predictionAdd
BLAST
Topological domaini2373 – 239422Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei2395 – 241521Helical; Reviewed predictionAdd
BLAST
Topological domaini2416 – 2521106Extracellular Reviewed predictionAdd
BLAST
Transmembranei2522 – 254221Helical; Reviewed predictionAdd
BLAST
Topological domaini2543 – 2701159Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. endoplasmic reticulum membrane Source: Reactome
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: BHF-UCL
  5. platelet dense tubular network membrane Source: Reactome
  6. receptor complex Source: MGI
  7. sarcoplasmic reticulum membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29979.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27012701Inositol 1,4,5-trisphosphate receptor type 2PRO_0000153924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei937 – 9371Phosphoserine; by PKA By similarity
Modified residuei1160 – 11601Phosphoserine1 Publication
Modified residuei2607 – 26071Phosphotyrosine Reviewed prediction

Post-translational modificationi

Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14571.
PaxDbiQ14571.
PRIDEiQ14571.

PTM databases

PhosphoSiteiQ14571.

Expressioni

Tissue specificityi

Isoform Short is found in skeletal muscle and heart.

Gene expression databases

ArrayExpressiQ14571.
BgeeiQ14571.
CleanExiHS_ITPR2.
GenevestigatoriQ14571.

Organism-specific databases

HPAiCAB022437.

Interactioni

Subunit structurei

Homotetramer By similarity. Interacts with CABP1.1 Publication

Protein-protein interaction databases

BioGridi109914. 2 interactions.
IntActiQ14571. 2 interactions.
MINTiMINT-157881.
STRINGi9606.ENSP00000370744.

Structurei

3D structure databases

ProteinModelPortaliQ14571.
SMRiQ14571. Positions 5-578.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 16655MIR 1Add
BLAST
Domaini173 – 22351MIR 2Add
BLAST
Domaini231 – 28757MIR 3Add
BLAST
Domaini294 – 37279MIR 4Add
BLAST
Domaini378 – 43457MIR 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 2695Inositol 1,4,5-trisphosphate binding By similarity
Regioni507 – 5104Inositol 1,4,5-trisphosphate binding By similarity
Regioni567 – 5693Inositol 1,4,5-trisphosphate binding By similarity

Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

Sequence similaritiesi

Belongs to the InsP3 receptor family.
Contains 5 MIR domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280601.
HOGENOMiHOG000007660.
HOVERGENiHBG052158.
InParanoidiQ14571.
KOiK04959.
OMAiQSAFRIY.
OrthoDBiEOG76HQ0M.
PhylomeDBiQ14571.
TreeFamiTF312815.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q14571-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTEKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP     50
KKFRDCLFKV CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ 100
KQNESENKKL LGEIVKYSNV IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS 150
LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD KVVLMPVNAG QPLHASNIEL 200
LDNPGCKEVN AVNCNTSWKI TLFMKYSSYR EDVLKGGDVV RLFHAEQEKF 250
LTCDEYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN 300
SLFRFKHLAT GNYLAAELNP DYRDAQNEGK NVRDGVPPTS KKKRQAGEKI 350
MYTLVSVPHG NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS 400
TSIPIDTDEE RPVMLKIGTC QTKEDKEAFA IVSVPLSEVR DLDFANDANK 450
VLATTVKKLE NGTITQNERR FVTKLLEDLI FFVADVPNNG QEVLDVVITK 500
PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED LGDQRYAPYK 550
YMLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH 600
NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NTTAIPVTQE 650
LICKFMLSPG NADILIQTKV VSMQADNPME SSILSDDIDD EEVWLYWIDS 700
NKEPHGKAIR HLAQEAKEGT KADLEVLTYY RYQLNLFARM CLDRQYLAIN 750
QISTQLSVDL ILRCVSDESL PFDLRASFCR LMLHMHVDRD PQESVVPVRY 800
ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE YLKEVVNQPF 850
PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM 900
SSYFERLSKF QDGGNNVMRT IHGVGEMMTQ MVLSRGSIFP MSVPDVPPSI 950
HPSKQGSPTE HEDVTVMDTK LKIIEILQFI LSVRLDYRIS YMLSIYKKEF 1000
GEDNDNAETS ASGSPDTLLP SAIVPDIDEI AAQAETMFAG RKEKNPVQLD 1050
DEGGRTFLRV LIHLIMHDYP PLLSGALQLL FKHFSQRAEV LQAFKQVQLL 1100
VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSSNYENGE IGESQVKGGE 1150
EPIEESNILS PVQDGTKKPQ IDSNKSNNYR IVKEILIRLS KLCVQNKKCR 1200
NQHQRLLKNM GAHSVVLDLL QIPYEKNDEK MNEVMNLAHT FLQNFCRGNP 1250
QNQVLLHKHL NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI 1300
ETHGRHVEYL RFLQTIVKAD GKYVKKCQDM VMTELINGGE DVLIFYNDRA 1350
SFPILLHMMC SERDRGDESG PLAYHITLVE LLAACTEGKN VYTEIKCNSL 1400
LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE IYTSNHIWKL 1450
FENFLVDMAR VCNTTTDRKH ADIFLEKCVT ESIMNIVSGF FNSPFSDNST 1500
SLQTHQPVFI QLLQSAFRIY NCTWPNPAQK ASVESCIRTL AEVAKNRGIA 1550
IPVDLDSQVN TLFMKSHSNM VQRAAMGWRL SARSGPRFKE ALGGPAWDYR 1600
NIIEKLQDVV ASLEHQFSPM MQAEFSVLVD VLYSPELLFP EGSDARIRCG 1650
AFMSKLINHT KKLMEKEEKL CIKILQTLRE MLEKKDSFVE EGNTLRKILL 1700
NRYFKGDYSI GVNGHLSGAY SKTAQVGGSF SGQDSDKMGI SMSDIQCLLD 1750
KEGASELVID VIVNTKNDRI FSEGIFLGIA LLEGGNTQTQ YSFYQQLHEQ 1800
KKSEKFFKVL YDRMKAAQKE IRSTVTVNTI DLGNKKRDDD NELMTSGPRM 1850
RVRDSTLHLK EGMKGQLTEA SSATSKAYCV YRREMDPEID IMCTGPEAGN 1900
TEEKSAEEVT MSPAIAIMQP ILRFLQLLCE NHNRELQNFL RNQNNKTNYN 1950
LVCETLQFLD CICGSTTGGL GLLGLYINEK NVALVNQNLE SLTEYCQGPC 2000
HENQTCIATH ESNGIDIIIA LILNDINPLG KYRMDLVLQL KNNASKLLLA 2050
IMESRHDSEN AERILFNMRP RELVDVMKNA YNQGLECDHG DDEGGDDGVS 2100
PKDVGHNIYI LAHQLARHNK LLQQMLKPGS DPDEGDEALK YYANHTAQIE 2150
IVRHDRTMEQ IVFPVPNICE YLTRESKCRV FNTTERDEQG SKVNDFFQQT 2200
EDLYNEMKWQ KKIRNNPALF WFSRHISLWG SISFNLAVFI NLAVALFYPF 2250
GDDGDEGTLS PLFSVLLWIA VAICTSMLFF FSKPVGIRPF LVSIMLRSIY 2300
TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV ILDMAFLYHV 2350
AYVLVCMLGL FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV 2400
LALILVYLFS IIGFLFLKDD FTMEVDRLKN RTPVTGSHQV PTMTLTTMME 2450
ACAKENCSPT IPASNTADEE YEDGIERTCD TLLMCIVTVL NQGLRNGGGV 2500
GDVLRRPSKD EPLFAARVVY DLLFYFIVII IVLNLIFGVI IDTFADLRSE 2550
KQKKEEILKT TCFICGLERD KFDNKTVSFE EHIKSEHNMW HYLYFIVLVK 2600
VKDPTEYTGP ESYVAQMIVE KNLDWFPRMR AMSLVSNEGD SEQNEIRSLQ 2650
EKLESTMSLV KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN TPHVNHHMPP 2700
H 2701
Length:2,701
Mass (Da):308,064
Last modified:September 22, 2009 - v2
Checksum:i373BA20228A159BC
GO
Isoform Short (identifier: Q14571-2) [UniParc]FASTAAdd to Basket

Also known as: TIPR

The sequence of this isoform differs from the canonical sequence as follows:
     176-181: IVVGDK → DASFWI
     182-2701: Missing.

Show »
Length:181
Mass (Da):20,608
Checksum:i146A91D12CE51863
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti453 – 4531A → V.
Corresponds to variant rs41453348 [ dbSNP | Ensembl ].
VAR_055963
Natural varianti1143 – 11431E → D.
Corresponds to variant rs16931091 [ dbSNP | Ensembl ].
VAR_055964
Natural varianti1898 – 18981A → V.
Corresponds to variant rs2230382 [ dbSNP | Ensembl ].
VAR_055965

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei176 – 1816IVVGDK → DASFWI in isoform Short. VSP_002699
Alternative sequencei182 – 27012520Missing in isoform Short. VSP_002700Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti597 – 5971A → P in BAA05384. 1 Publication
Sequence conflicti1070 – 10701P → A in BAA05384. 1 Publication
Sequence conflicti1178 – 11781N → K in BAA05384. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26350 mRNA. Translation: BAA05384.1.
AB012610 mRNA. Translation: BAA33961.1.
AC023051 Genomic DNA. No translation available.
AC023425 Genomic DNA. No translation available.
AC024093 Genomic DNA. No translation available.
AC024145 Genomic DNA. No translation available.
AC055720 Genomic DNA. No translation available.
CCDSiCCDS41764.1. [Q14571-1]
RefSeqiNP_002214.2. NM_002223.2. [Q14571-1]
UniGeneiHs.512235.

Genome annotation databases

EnsembliENST00000242737; ENSP00000242737; ENSG00000123104. [Q14571-2]
ENST00000381340; ENSP00000370744; ENSG00000123104. [Q14571-1]
GeneIDi3709.
KEGGihsa:3709.
UCSCiuc001rhg.3. human. [Q14571-1]
uc001rhh.1. human. [Q14571-2]

Polymorphism databases

DMDMi259016258.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26350 mRNA. Translation: BAA05384.1 .
AB012610 mRNA. Translation: BAA33961.1 .
AC023051 Genomic DNA. No translation available.
AC023425 Genomic DNA. No translation available.
AC024093 Genomic DNA. No translation available.
AC024145 Genomic DNA. No translation available.
AC055720 Genomic DNA. No translation available.
CCDSi CCDS41764.1. [Q14571-1 ]
RefSeqi NP_002214.2. NM_002223.2. [Q14571-1 ]
UniGenei Hs.512235.

3D structure databases

ProteinModelPortali Q14571.
SMRi Q14571. Positions 5-578.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109914. 2 interactions.
IntActi Q14571. 2 interactions.
MINTi MINT-157881.
STRINGi 9606.ENSP00000370744.

Chemistry

BindingDBi Q14571.
ChEMBLi CHEMBL2111451.
GuidetoPHARMACOLOGYi 744.

PTM databases

PhosphoSitei Q14571.

Polymorphism databases

DMDMi 259016258.

Proteomic databases

MaxQBi Q14571.
PaxDbi Q14571.
PRIDEi Q14571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000242737 ; ENSP00000242737 ; ENSG00000123104 . [Q14571-2 ]
ENST00000381340 ; ENSP00000370744 ; ENSG00000123104 . [Q14571-1 ]
GeneIDi 3709.
KEGGi hsa:3709.
UCSCi uc001rhg.3. human. [Q14571-1 ]
uc001rhh.1. human. [Q14571-2 ]

Organism-specific databases

CTDi 3709.
GeneCardsi GC12M026390.
H-InvDB HIX0036661.
HGNCi HGNC:6181. ITPR2.
HPAi CAB022437.
MIMi 600144. gene.
neXtProti NX_Q14571.
PharmGKBi PA29979.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG280601.
HOGENOMi HOG000007660.
HOVERGENi HBG052158.
InParanoidi Q14571.
KOi K04959.
OMAi QSAFRIY.
OrthoDBi EOG76HQ0M.
PhylomeDBi Q14571.
TreeFami TF312815.

Enzyme and pathway databases

Reactomei REACT_111064. DAG and IP3 signaling.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_15426. PLC beta mediated events.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_162. Elevation of cytosolic Ca2+ levels.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18325. Regulation of insulin secretion.
REACT_2202. Effects of PIP2 hydrolysis.

Miscellaneous databases

ChiTaRSi ITPR2. human.
GeneWikii ITPR2.
GenomeRNAii 3709.
NextBioi 14539.
PROi Q14571.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q14571.
Bgeei Q14571.
CleanExi HS_ITPR2.
Genevestigatori Q14571.

Family and domain databases

Gene3Di 1.25.10.30. 2 hits.
InterProi IPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view ]
PANTHERi PTHR13715. PTHR13715. 1 hit.
Pfami PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view ]
PRINTSi PR00779. INSP3RECEPTR.
SMARTi SM00472. MIR. 4 hits.
[Graphical view ]
SUPFAMi SSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEi PS50919. MIR. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors."
    Yamamoto-Hino M., Sugiyama T., Hikiti K., Mattei M.-G., Hasegawa K., Sekine S., Sakurada K., Miyawaki A., Furuichi T., Hasegawa M., Mikoshiba K.
    Recept. Channels 2:9-22(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
  2. "Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor."
    Futatsugi A., Kuwajima G., Mikoshiba K.
    Biochem. J. 334:559-563(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Tissue: Heart.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels."
    Yang J., McBride S., Mak D.-O.D., Vardi N., Palczewski K., Haeseleer F., Foskett J.K.
    Proc. Natl. Acad. Sci. U.S.A. 99:7711-7716(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CABP1.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1160, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiITPR2_HUMAN
AccessioniPrimary (citable) accession number: Q14571
Secondary accession number(s): O94773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 22, 2009
Last modified: September 3, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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