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Q14571

- ITPR2_HUMAN

UniProt

Q14571 - ITPR2_HUMAN

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Protein

Inositol 1,4,5-trisphosphate receptor type 2

Gene

ITPR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA By similarity.By similarity

GO - Molecular functioni

  1. calcium ion transmembrane transporter activity Source: ProtInc
  2. inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: ProtInc
  3. phosphatidylinositol binding Source: Ensembl

GO - Biological processi

  1. activation of phospholipase C activity Source: Reactome
  2. blood coagulation Source: Reactome
  3. cellular response to cAMP Source: Ensembl
  4. cellular response to ethanol Source: Ensembl
  5. energy reserve metabolic process Source: Reactome
  6. epidermal growth factor receptor signaling pathway Source: Reactome
  7. Fc-epsilon receptor signaling pathway Source: Reactome
  8. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  9. fibroblast growth factor receptor signaling pathway Source: Reactome
  10. innate immune response Source: Reactome
  11. inositol phosphate-mediated signaling Source: GOC
  12. neurotrophin TRK receptor signaling pathway Source: Reactome
  13. platelet activation Source: Reactome
  14. regulation of insulin secretion Source: Reactome
  15. response to hypoxia Source: BHF-UCL
  16. signal transduction Source: Reactome
  17. small molecule metabolic process Source: Reactome
  18. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_111064. DAG and IP3 signaling.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_15426. PLC beta mediated events.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_162. Elevation of cytosolic Ca2+ levels.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18325. Regulation of insulin secretion.
REACT_2202. Effects of PIP2 hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 2
Alternative name(s):
IP3 receptor isoform 2
Short name:
IP3R 2
Short name:
InsP3R2
Type 2 inositol 1,4,5-trisphosphate receptor
Short name:
Type 2 InsP3 receptor
Gene namesi
Name:ITPR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6181. ITPR2.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. endoplasmic reticulum membrane Source: Reactome
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: UniProtKB
  5. plasma membrane Source: BHF-UCL
  6. platelet dense tubular network membrane Source: Reactome
  7. receptor complex Source: MGI
  8. sarcoplasmic reticulum membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29979.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27012701Inositol 1,4,5-trisphosphate receptor type 2PRO_0000153924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei937 – 9371Phosphoserine; by PKABy similarity
Modified residuei1160 – 11601Phosphoserine1 Publication
Modified residuei2607 – 26071PhosphotyrosineSequence Analysis

Post-translational modificationi

Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14571.
PaxDbiQ14571.
PRIDEiQ14571.

PTM databases

PhosphoSiteiQ14571.

Expressioni

Tissue specificityi

Isoform Short is found in skeletal muscle and heart.

Gene expression databases

BgeeiQ14571.
CleanExiHS_ITPR2.
ExpressionAtlasiQ14571. baseline and differential.
GenevestigatoriQ14571.

Organism-specific databases

HPAiCAB022437.

Interactioni

Subunit structurei

Homotetramer By similarity. Interacts with CABP1.By similarity1 Publication

Protein-protein interaction databases

BioGridi109914. 9 interactions.
IntActiQ14571. 2 interactions.
MINTiMINT-157881.
STRINGi9606.ENSP00000370744.

Structurei

3D structure databases

ProteinModelPortaliQ14571.
SMRiQ14571. Positions 5-578.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22272227CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini2249 – 226012ExtracellularSequence AnalysisAdd
BLAST
Topological domaini2282 – 230726CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini2329 – 235123ExtracellularSequence AnalysisAdd
BLAST
Topological domaini2373 – 239422CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini2416 – 2521106ExtracellularSequence AnalysisAdd
BLAST
Topological domaini2543 – 2701159CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2228 – 224821HelicalSequence AnalysisAdd
BLAST
Transmembranei2261 – 228121HelicalSequence AnalysisAdd
BLAST
Transmembranei2308 – 232821HelicalSequence AnalysisAdd
BLAST
Transmembranei2352 – 237221HelicalSequence AnalysisAdd
BLAST
Transmembranei2395 – 241521HelicalSequence AnalysisAdd
BLAST
Transmembranei2522 – 254221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 16655MIR 1PROSITE-ProRule annotationAdd
BLAST
Domaini173 – 22351MIR 2PROSITE-ProRule annotationAdd
BLAST
Domaini231 – 28757MIR 3PROSITE-ProRule annotationAdd
BLAST
Domaini294 – 37279MIR 4PROSITE-ProRule annotationAdd
BLAST
Domaini378 – 43457MIR 5PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 2695Inositol 1,4,5-trisphosphate bindingBy similarity
Regioni507 – 5104Inositol 1,4,5-trisphosphate bindingBy similarity
Regioni567 – 5693Inositol 1,4,5-trisphosphate bindingBy similarity

Domaini

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

Sequence similaritiesi

Belongs to the InsP3 receptor family.Curated
Contains 5 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280601.
GeneTreeiENSGT00760000119152.
HOGENOMiHOG000007660.
HOVERGENiHBG052158.
InParanoidiQ14571.
KOiK04959.
OMAiQSAFRIY.
OrthoDBiEOG76HQ0M.
PhylomeDBiQ14571.
TreeFamiTF312815.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
PRINTSiPR00779. INSP3RECEPTR.
SMARTiSM00472. MIR. 4 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50919. MIR. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q14571-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP
60 70 80 90 100
KKFRDCLFKV CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ
110 120 130 140 150
KQNESENKKL LGEIVKYSNV IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS
160 170 180 190 200
LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD KVVLMPVNAG QPLHASNIEL
210 220 230 240 250
LDNPGCKEVN AVNCNTSWKI TLFMKYSSYR EDVLKGGDVV RLFHAEQEKF
260 270 280 290 300
LTCDEYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN
310 320 330 340 350
SLFRFKHLAT GNYLAAELNP DYRDAQNEGK NVRDGVPPTS KKKRQAGEKI
360 370 380 390 400
MYTLVSVPHG NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS
410 420 430 440 450
TSIPIDTDEE RPVMLKIGTC QTKEDKEAFA IVSVPLSEVR DLDFANDANK
460 470 480 490 500
VLATTVKKLE NGTITQNERR FVTKLLEDLI FFVADVPNNG QEVLDVVITK
510 520 530 540 550
PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED LGDQRYAPYK
560 570 580 590 600
YMLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH
610 620 630 640 650
NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NTTAIPVTQE
660 670 680 690 700
LICKFMLSPG NADILIQTKV VSMQADNPME SSILSDDIDD EEVWLYWIDS
710 720 730 740 750
NKEPHGKAIR HLAQEAKEGT KADLEVLTYY RYQLNLFARM CLDRQYLAIN
760 770 780 790 800
QISTQLSVDL ILRCVSDESL PFDLRASFCR LMLHMHVDRD PQESVVPVRY
810 820 830 840 850
ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE YLKEVVNQPF
860 870 880 890 900
PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM
910 920 930 940 950
SSYFERLSKF QDGGNNVMRT IHGVGEMMTQ MVLSRGSIFP MSVPDVPPSI
960 970 980 990 1000
HPSKQGSPTE HEDVTVMDTK LKIIEILQFI LSVRLDYRIS YMLSIYKKEF
1010 1020 1030 1040 1050
GEDNDNAETS ASGSPDTLLP SAIVPDIDEI AAQAETMFAG RKEKNPVQLD
1060 1070 1080 1090 1100
DEGGRTFLRV LIHLIMHDYP PLLSGALQLL FKHFSQRAEV LQAFKQVQLL
1110 1120 1130 1140 1150
VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSSNYENGE IGESQVKGGE
1160 1170 1180 1190 1200
EPIEESNILS PVQDGTKKPQ IDSNKSNNYR IVKEILIRLS KLCVQNKKCR
1210 1220 1230 1240 1250
NQHQRLLKNM GAHSVVLDLL QIPYEKNDEK MNEVMNLAHT FLQNFCRGNP
1260 1270 1280 1290 1300
QNQVLLHKHL NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI
1310 1320 1330 1340 1350
ETHGRHVEYL RFLQTIVKAD GKYVKKCQDM VMTELINGGE DVLIFYNDRA
1360 1370 1380 1390 1400
SFPILLHMMC SERDRGDESG PLAYHITLVE LLAACTEGKN VYTEIKCNSL
1410 1420 1430 1440 1450
LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE IYTSNHIWKL
1460 1470 1480 1490 1500
FENFLVDMAR VCNTTTDRKH ADIFLEKCVT ESIMNIVSGF FNSPFSDNST
1510 1520 1530 1540 1550
SLQTHQPVFI QLLQSAFRIY NCTWPNPAQK ASVESCIRTL AEVAKNRGIA
1560 1570 1580 1590 1600
IPVDLDSQVN TLFMKSHSNM VQRAAMGWRL SARSGPRFKE ALGGPAWDYR
1610 1620 1630 1640 1650
NIIEKLQDVV ASLEHQFSPM MQAEFSVLVD VLYSPELLFP EGSDARIRCG
1660 1670 1680 1690 1700
AFMSKLINHT KKLMEKEEKL CIKILQTLRE MLEKKDSFVE EGNTLRKILL
1710 1720 1730 1740 1750
NRYFKGDYSI GVNGHLSGAY SKTAQVGGSF SGQDSDKMGI SMSDIQCLLD
1760 1770 1780 1790 1800
KEGASELVID VIVNTKNDRI FSEGIFLGIA LLEGGNTQTQ YSFYQQLHEQ
1810 1820 1830 1840 1850
KKSEKFFKVL YDRMKAAQKE IRSTVTVNTI DLGNKKRDDD NELMTSGPRM
1860 1870 1880 1890 1900
RVRDSTLHLK EGMKGQLTEA SSATSKAYCV YRREMDPEID IMCTGPEAGN
1910 1920 1930 1940 1950
TEEKSAEEVT MSPAIAIMQP ILRFLQLLCE NHNRELQNFL RNQNNKTNYN
1960 1970 1980 1990 2000
LVCETLQFLD CICGSTTGGL GLLGLYINEK NVALVNQNLE SLTEYCQGPC
2010 2020 2030 2040 2050
HENQTCIATH ESNGIDIIIA LILNDINPLG KYRMDLVLQL KNNASKLLLA
2060 2070 2080 2090 2100
IMESRHDSEN AERILFNMRP RELVDVMKNA YNQGLECDHG DDEGGDDGVS
2110 2120 2130 2140 2150
PKDVGHNIYI LAHQLARHNK LLQQMLKPGS DPDEGDEALK YYANHTAQIE
2160 2170 2180 2190 2200
IVRHDRTMEQ IVFPVPNICE YLTRESKCRV FNTTERDEQG SKVNDFFQQT
2210 2220 2230 2240 2250
EDLYNEMKWQ KKIRNNPALF WFSRHISLWG SISFNLAVFI NLAVALFYPF
2260 2270 2280 2290 2300
GDDGDEGTLS PLFSVLLWIA VAICTSMLFF FSKPVGIRPF LVSIMLRSIY
2310 2320 2330 2340 2350
TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV ILDMAFLYHV
2360 2370 2380 2390 2400
AYVLVCMLGL FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV
2410 2420 2430 2440 2450
LALILVYLFS IIGFLFLKDD FTMEVDRLKN RTPVTGSHQV PTMTLTTMME
2460 2470 2480 2490 2500
ACAKENCSPT IPASNTADEE YEDGIERTCD TLLMCIVTVL NQGLRNGGGV
2510 2520 2530 2540 2550
GDVLRRPSKD EPLFAARVVY DLLFYFIVII IVLNLIFGVI IDTFADLRSE
2560 2570 2580 2590 2600
KQKKEEILKT TCFICGLERD KFDNKTVSFE EHIKSEHNMW HYLYFIVLVK
2610 2620 2630 2640 2650
VKDPTEYTGP ESYVAQMIVE KNLDWFPRMR AMSLVSNEGD SEQNEIRSLQ
2660 2670 2680 2690 2700
EKLESTMSLV KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN TPHVNHHMPP

H
Length:2,701
Mass (Da):308,064
Last modified:September 22, 2009 - v2
Checksum:i373BA20228A159BC
GO
Isoform Short (identifier: Q14571-2) [UniParc]FASTAAdd to Basket

Also known as: TIPR

The sequence of this isoform differs from the canonical sequence as follows:
     176-181: IVVGDK → DASFWI
     182-2701: Missing.

Show »
Length:181
Mass (Da):20,608
Checksum:i146A91D12CE51863
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti597 – 5971A → P in BAA05384. (PubMed:8081734)Curated
Sequence conflicti1070 – 10701P → A in BAA05384. (PubMed:8081734)Curated
Sequence conflicti1178 – 11781N → K in BAA05384. (PubMed:8081734)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti453 – 4531A → V.
Corresponds to variant rs41453348 [ dbSNP | Ensembl ].
VAR_055963
Natural varianti1143 – 11431E → D.
Corresponds to variant rs16931091 [ dbSNP | Ensembl ].
VAR_055964
Natural varianti1898 – 18981A → V.
Corresponds to variant rs2230382 [ dbSNP | Ensembl ].
VAR_055965

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei176 – 1816IVVGDK → DASFWI in isoform Short. 1 PublicationVSP_002699
Alternative sequencei182 – 27012520Missing in isoform Short. 1 PublicationVSP_002700Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26350 mRNA. Translation: BAA05384.1.
AB012610 mRNA. Translation: BAA33961.1.
AC023051 Genomic DNA. No translation available.
AC023425 Genomic DNA. No translation available.
AC024093 Genomic DNA. No translation available.
AC024145 Genomic DNA. No translation available.
AC055720 Genomic DNA. No translation available.
CCDSiCCDS41764.1. [Q14571-1]
RefSeqiNP_002214.2. NM_002223.2. [Q14571-1]
UniGeneiHs.512235.

Genome annotation databases

EnsembliENST00000242737; ENSP00000242737; ENSG00000123104. [Q14571-2]
ENST00000381340; ENSP00000370744; ENSG00000123104. [Q14571-1]
GeneIDi3709.
KEGGihsa:3709.
UCSCiuc001rhg.3. human. [Q14571-1]
uc001rhh.1. human. [Q14571-2]

Polymorphism databases

DMDMi259016258.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26350 mRNA. Translation: BAA05384.1 .
AB012610 mRNA. Translation: BAA33961.1 .
AC023051 Genomic DNA. No translation available.
AC023425 Genomic DNA. No translation available.
AC024093 Genomic DNA. No translation available.
AC024145 Genomic DNA. No translation available.
AC055720 Genomic DNA. No translation available.
CCDSi CCDS41764.1. [Q14571-1 ]
RefSeqi NP_002214.2. NM_002223.2. [Q14571-1 ]
UniGenei Hs.512235.

3D structure databases

ProteinModelPortali Q14571.
SMRi Q14571. Positions 5-578.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109914. 9 interactions.
IntActi Q14571. 2 interactions.
MINTi MINT-157881.
STRINGi 9606.ENSP00000370744.

Chemistry

BindingDBi Q14571.
ChEMBLi CHEMBL2111451.
DrugBanki DB00201. Caffeine.
GuidetoPHARMACOLOGYi 744.

PTM databases

PhosphoSitei Q14571.

Polymorphism databases

DMDMi 259016258.

Proteomic databases

MaxQBi Q14571.
PaxDbi Q14571.
PRIDEi Q14571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000242737 ; ENSP00000242737 ; ENSG00000123104 . [Q14571-2 ]
ENST00000381340 ; ENSP00000370744 ; ENSG00000123104 . [Q14571-1 ]
GeneIDi 3709.
KEGGi hsa:3709.
UCSCi uc001rhg.3. human. [Q14571-1 ]
uc001rhh.1. human. [Q14571-2 ]

Organism-specific databases

CTDi 3709.
GeneCardsi GC12M026390.
H-InvDB HIX0036661.
HGNCi HGNC:6181. ITPR2.
HPAi CAB022437.
MIMi 600144. gene.
neXtProti NX_Q14571.
PharmGKBi PA29979.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG280601.
GeneTreei ENSGT00760000119152.
HOGENOMi HOG000007660.
HOVERGENi HBG052158.
InParanoidi Q14571.
KOi K04959.
OMAi QSAFRIY.
OrthoDBi EOG76HQ0M.
PhylomeDBi Q14571.
TreeFami TF312815.

Enzyme and pathway databases

Reactomei REACT_111064. DAG and IP3 signaling.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_15426. PLC beta mediated events.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_162. Elevation of cytosolic Ca2+ levels.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18325. Regulation of insulin secretion.
REACT_2202. Effects of PIP2 hydrolysis.

Miscellaneous databases

ChiTaRSi ITPR2. human.
GeneWikii ITPR2.
GenomeRNAii 3709.
NextBioi 14539.
PROi Q14571.
SOURCEi Search...

Gene expression databases

Bgeei Q14571.
CleanExi HS_ITPR2.
ExpressionAtlasi Q14571. baseline and differential.
Genevestigatori Q14571.

Family and domain databases

Gene3Di 1.25.10.30. 2 hits.
InterProi IPR016024. ARM-type_fold.
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view ]
PANTHERi PTHR13715. PTHR13715. 1 hit.
Pfami PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view ]
PRINTSi PR00779. INSP3RECEPTR.
SMARTi SM00472. MIR. 4 hits.
[Graphical view ]
SUPFAMi SSF100909. SSF100909. 2 hits.
SSF48371. SSF48371. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEi PS50919. MIR. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors."
    Yamamoto-Hino M., Sugiyama T., Hikiti K., Mattei M.-G., Hasegawa K., Sekine S., Sakurada K., Miyawaki A., Furuichi T., Hasegawa M., Mikoshiba K.
    Recept. Channels 2:9-22(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
  2. "Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor."
    Futatsugi A., Kuwajima G., Mikoshiba K.
    Biochem. J. 334:559-563(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Tissue: Heart.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels."
    Yang J., McBride S., Mak D.-O.D., Vardi N., Palczewski K., Haeseleer F., Foskett J.K.
    Proc. Natl. Acad. Sci. U.S.A. 99:7711-7716(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CABP1.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1160, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiITPR2_HUMAN
AccessioniPrimary (citable) accession number: Q14571
Secondary accession number(s): O94773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3