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Q14568 (HS902_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative heat shock protein HSP 90-alpha A2
Alternative name(s):
Heat shock 90 kDa protein 1 alpha-like 3
Gene names
Name:HSP90AA2
Synonyms:HSPCAL3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the heat shock protein 90 family.

Caution

Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.

Ontologies

Keywords
   Biological processStress response
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: InterPro

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Putative heat shock protein HSP 90-alpha A2
PRO_0000324325

Regions

Compositional bias223 – 26846Glu-rich
Compositional bias238 – 29356Lys-rich

Sites

Binding site511ATP By similarity
Binding site931ATP By similarity
Binding site1121ATP By similarity
Binding site1381ATP; via amide nitrogen By similarity

Amino acid modifications

Modified residue2631Phosphoserine Ref.5

Natural variations

Natural variant2351T → A. Ref.2
Corresponds to variant rs1826330 [ dbSNP | Ensembl ].
VAR_039732
Natural variant3121C → Y.
Corresponds to variant rs2726836 [ dbSNP | Ensembl ].
VAR_039733

Experimental info

Sequence conflict2731D → DK in AAA36024. Ref.2
Sequence conflict3081Y → I in AAA36024. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q14568 [UniParc].

Last modified March 18, 2008. Version 2.
Checksum: 2583C15C04090C65

FASTA34339,365
        10         20         30         40         50         60 
MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS NSSDALDKIW 

        70         80         90        100        110        120 
YESLTDPSKL DSGKELHINL IPNKQDQTLT IVDTGIGMTK ADLINNLGTI AKSGTKAFME 

       130        140        150        160        170        180 
ALQAGADISM IGQFGVSFYS AYLVAEKVTV ITKHNDDEQY AWESSAGGSF TVRTDTGERM 

       190        200        210        220        230        240 
GRGTKVILHL KEDQTEYLEE QRIKEIVKKH SQLIGYPITL FVEKECDKEV SDDETEEKED 

       250        260        270        280        290        300 
KEEEKEKEEK ESKDKPEIED VGSDEEEEKK DGDKKKKKTK EKYIDQEELN KTKPIWTRNP 

       310        320        330        340 
DDITNEEYGE FCKNLTNDWE DHLAVKHFSV EGQLEFRALL FVP 

« Hide

References

« Hide 'large scale' references
[1]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene."
Walter T., Drabent B., Krebs H., Tomalak M., Heiss S., Benecke B.J.J.
Gene 83:105-115(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-311, VARIANT ALA-235.
[3]"Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14."
Ozawa K., Murakami Y., Eki T., Soeda E., Yokoyama K.
Genomics 12:214-220(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.
[4]"The HSP90 family of genes in the human genome: insights into their divergence and evolution."
Chen B., Piel W.H., Gui L., Bruford E., Monteiro A.
Genomics 86:627-637(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.
[5]"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC103796 Genomic DNA. No translation available.
M30627 mRNA. Translation: AAA36024.1.
PIRJQ0129.
UniGeneHs.523560.

3D structure databases

ProteinModelPortalQ14568.
SMRQ14568. Positions 10-343.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ14568. 4 interactions.

PTM databases

PhosphoSiteQ14568.

Polymorphism databases

DMDM172046850.

Proteomic databases

PaxDbQ14568.
PRIDEQ14568.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC11M027866.
HGNCHGNC:5256. HSP90AA2.
HPACAB002058.
MIM140575. gene.
neXtProtNX_Q14568.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0326.
HOVERGENHBG007374.
InParanoidQ14568.

Gene expression databases

CleanExHS_HSP90AA2.
GenevestigatorQ14568.

Family and domain databases

Gene3D3.30.565.10. 2 hits.
InterProIPR003594. HATPase_ATP-bd.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERPTHR11528. PTHR11528. 1 hit.
PfamPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PRINTSPR00775. HEATSHOCK90.
SMARTSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEPS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ14568.
SOURCESearch...

Entry information

Entry nameHS902_HUMAN
AccessionPrimary (citable) accession number: Q14568
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: March 19, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM