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Protein

Heat shock protein HSP 90-alpha A2

Gene

HSP90AA2P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51ATPBy similarity1
Binding sitei93ATPBy similarity1
Binding sitei112ATPBy similarity1
Binding sitei138ATP; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32003-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein HSP 90-alpha A2Curated
Alternative name(s):
Heat shock 90 kDa protein 1 alpha-like 3Curated
Heat shock protein HSP 90-alpha A2 pseudogeneCurated
Gene namesi
Name:HSP90AA2PImported
Synonyms:HSP90AA2Imported, HSPCAL3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:5256. HSP90AA2P.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi3324.

Polymorphism and mutation databases

DMDMi172046850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003243251 – 343Heat shock protein HSP 90-alpha A2Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei263PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14568.
MaxQBiQ14568.
PeptideAtlasiQ14568.
PRIDEiQ14568.
TopDownProteomicsiQ14568.

PTM databases

iPTMnetiQ14568.
PhosphoSitePlusiQ14568.
SwissPalmiQ14568.

Expressioni

Gene expression databases

CleanExiHS_HSP90AA2.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ14568. 4 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ14568.
SMRiQ14568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi223 – 268Glu-richAdd BLAST46
Compositional biasi238 – 293Lys-richAdd BLAST56

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

HOVERGENiHBG007374.
InParanoidiQ14568.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS
60 70 80 90 100
NSSDALDKIW YESLTDPSKL DSGKELHINL IPNKQDQTLT IVDTGIGMTK
110 120 130 140 150
ADLINNLGTI AKSGTKAFME ALQAGADISM IGQFGVSFYS AYLVAEKVTV
160 170 180 190 200
ITKHNDDEQY AWESSAGGSF TVRTDTGERM GRGTKVILHL KEDQTEYLEE
210 220 230 240 250
QRIKEIVKKH SQLIGYPITL FVEKECDKEV SDDETEEKED KEEEKEKEEK
260 270 280 290 300
ESKDKPEIED VGSDEEEEKK DGDKKKKKTK EKYIDQEELN KTKPIWTRNP
310 320 330 340
DDITNEEYGE FCKNLTNDWE DHLAVKHFSV EGQLEFRALL FVP
Length:343
Mass (Da):39,365
Last modified:March 18, 2008 - v2
Checksum:i2583C15C04090C65
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti273D → DK in AAA36024 (PubMed:2591742).Curated1
Sequence conflicti308Y → I in AAA36024 (PubMed:2591742).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039732235T → A.1 PublicationCorresponds to variant rs1826330dbSNPEnsembl.1
Natural variantiVAR_039733312C → Y.Corresponds to variant rs2726836dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103796 Genomic DNA. No translation available.
M30627 mRNA. Translation: AAA36024.1.
PIRiJQ0129.
UniGeneiHs.523560.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103796 Genomic DNA. No translation available.
M30627 mRNA. Translation: AAA36024.1.
PIRiJQ0129.
UniGeneiHs.523560.

3D structure databases

ProteinModelPortaliQ14568.
SMRiQ14568.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ14568. 4 interactors.

PTM databases

iPTMnetiQ14568.
PhosphoSitePlusiQ14568.
SwissPalmiQ14568.

Polymorphism and mutation databases

DMDMi172046850.

Proteomic databases

EPDiQ14568.
MaxQBiQ14568.
PeptideAtlasiQ14568.
PRIDEiQ14568.
TopDownProteomicsiQ14568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi3324.
GeneCardsiHSP90AA2P.
HGNCiHGNC:5256. HSP90AA2P.
MIMi140575. gene.
neXtProtiNX_Q14568.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG007374.
InParanoidiQ14568.

Enzyme and pathway databases

BioCyciZFISH:G66-32003-MONOMER.

Miscellaneous databases

PROiQ14568.
SOURCEiSearch...

Gene expression databases

CleanExiHS_HSP90AA2.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHS902_HUMAN
AccessioniPrimary (citable) accession number: Q14568
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.