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Protein

Heat shock protein HSP 90-alpha A2

Gene

HSP90AA2P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511ATPBy similarity
Binding sitei93 – 931ATPBy similarity
Binding sitei112 – 1121ATPBy similarity
Binding sitei138 – 1381ATP; via amide nitrogenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein HSP 90-alpha A2Curated
Alternative name(s):
Heat shock 90 kDa protein 1 alpha-like 3Curated
Heat shock protein HSP 90-alpha A2 pseudogeneCurated
Gene namesi
Name:HSP90AA2PImported
Synonyms:HSP90AA2Imported, HSPCAL3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:5256. HSP90AA2P.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi172046850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Heat shock protein HSP 90-alpha A2PRO_0000324325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei263 – 2631Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14568.
PaxDbiQ14568.
PRIDEiQ14568.

PTM databases

PhosphoSiteiQ14568.

Expressioni

Gene expression databases

CleanExiHS_HSP90AA2.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ14568. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ14568.
SMRiQ14568. Positions 10-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi223 – 26846Glu-richAdd
BLAST
Compositional biasi238 – 29356Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

eggNOGiCOG0326.
HOVERGENiHBG007374.
InParanoidiQ14568.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS
60 70 80 90 100
NSSDALDKIW YESLTDPSKL DSGKELHINL IPNKQDQTLT IVDTGIGMTK
110 120 130 140 150
ADLINNLGTI AKSGTKAFME ALQAGADISM IGQFGVSFYS AYLVAEKVTV
160 170 180 190 200
ITKHNDDEQY AWESSAGGSF TVRTDTGERM GRGTKVILHL KEDQTEYLEE
210 220 230 240 250
QRIKEIVKKH SQLIGYPITL FVEKECDKEV SDDETEEKED KEEEKEKEEK
260 270 280 290 300
ESKDKPEIED VGSDEEEEKK DGDKKKKKTK EKYIDQEELN KTKPIWTRNP
310 320 330 340
DDITNEEYGE FCKNLTNDWE DHLAVKHFSV EGQLEFRALL FVP
Length:343
Mass (Da):39,365
Last modified:March 18, 2008 - v2
Checksum:i2583C15C04090C65
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti273 – 2731D → DK in AAA36024 (PubMed:2591742).Curated
Sequence conflicti308 – 3081Y → I in AAA36024 (PubMed:2591742).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti235 – 2351T → A.1 Publication
Corresponds to variant rs1826330 [ dbSNP | Ensembl ].
VAR_039732
Natural varianti312 – 3121C → Y.
Corresponds to variant rs2726836 [ dbSNP | Ensembl ].
VAR_039733

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103796 Genomic DNA. No translation available.
M30627 mRNA. Translation: AAA36024.1.
PIRiJQ0129.
UniGeneiHs.523560.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC103796 Genomic DNA. No translation available.
M30627 mRNA. Translation: AAA36024.1.
PIRiJQ0129.
UniGeneiHs.523560.

3D structure databases

ProteinModelPortaliQ14568.
SMRiQ14568. Positions 10-343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ14568. 4 interactions.

PTM databases

PhosphoSiteiQ14568.

Polymorphism and mutation databases

DMDMi172046850.

Proteomic databases

MaxQBiQ14568.
PaxDbiQ14568.
PRIDEiQ14568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC11M027866.
HGNCiHGNC:5256. HSP90AA2P.
MIMi140575. gene.
neXtProtiNX_Q14568.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0326.
HOVERGENiHBG007374.
InParanoidiQ14568.

Miscellaneous databases

PROiQ14568.
SOURCEiSearch...

Gene expression databases

CleanExiHS_HSP90AA2.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
InterProiIPR003594. HATPase_C.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene."
    Walter T., Drabent B., Krebs H., Tomalak M., Heiss S., Benecke B.J.J.
    Gene 83:105-115(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-311, VARIANT ALA-235.
  3. "Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14."
    Ozawa K., Murakami Y., Eki T., Soeda E., Yokoyama K.
    Genomics 12:214-220(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  4. "The HSP90 family of genes in the human genome: insights into their divergence and evolution."
    Chen B., Piel W.H., Gui L., Bruford E., Monteiro A.
    Genomics 86:627-637(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  5. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiHS902_HUMAN
AccessioniPrimary (citable) accession number: Q14568
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: July 22, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.