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Q14568

- HS902_HUMAN

UniProt

Q14568 - HS902_HUMAN

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Protein

Putative heat shock protein HSP 90-alpha A2

Gene
HSP90AA2, HSPCAL3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511ATP By similarity
Binding sitei93 – 931ATP By similarity
Binding sitei112 – 1121ATP By similarity
Binding sitei138 – 1381ATP; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: InterPro
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative heat shock protein HSP 90-alpha A2
Alternative name(s):
Heat shock 90 kDa protein 1 alpha-like 3
Gene namesi
Synonyms:HSPCAL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:5256. HSP90AA2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Putative heat shock protein HSP 90-alpha A2PRO_0000324325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei263 – 2631Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14568.
PaxDbiQ14568.
PRIDEiQ14568.

PTM databases

PhosphoSiteiQ14568.

Expressioni

Gene expression databases

CleanExiHS_HSP90AA2.
GenevestigatoriQ14568.

Organism-specific databases

HPAiCAB002058.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

IntActiQ14568. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ14568.
SMRiQ14568. Positions 10-343.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi223 – 26846Glu-richAdd
BLAST
Compositional biasi238 – 29356Lys-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0326.
HOVERGENiHBG007374.
InParanoidiQ14568.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
InterProiIPR003594. HATPase_ATP-bd.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view]
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS00298. HSP90. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14568-1 [UniParc]FASTAAdd to Basket

« Hide

MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS    50
NSSDALDKIW YESLTDPSKL DSGKELHINL IPNKQDQTLT IVDTGIGMTK 100
ADLINNLGTI AKSGTKAFME ALQAGADISM IGQFGVSFYS AYLVAEKVTV 150
ITKHNDDEQY AWESSAGGSF TVRTDTGERM GRGTKVILHL KEDQTEYLEE 200
QRIKEIVKKH SQLIGYPITL FVEKECDKEV SDDETEEKED KEEEKEKEEK 250
ESKDKPEIED VGSDEEEEKK DGDKKKKKTK EKYIDQEELN KTKPIWTRNP 300
DDITNEEYGE FCKNLTNDWE DHLAVKHFSV EGQLEFRALL FVP 343
Length:343
Mass (Da):39,365
Last modified:March 18, 2008 - v2
Checksum:i2583C15C04090C65
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti235 – 2351T → A.1 Publication
Corresponds to variant rs1826330 [ dbSNP | Ensembl ].
VAR_039732
Natural varianti312 – 3121C → Y.
Corresponds to variant rs2726836 [ dbSNP | Ensembl ].
VAR_039733

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti273 – 2731D → DK in AAA36024. 1 Publication
Sequence conflicti308 – 3081Y → I in AAA36024. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC103796 Genomic DNA. No translation available.
M30627 mRNA. Translation: AAA36024.1.
PIRiJQ0129.
UniGeneiHs.523560.

Polymorphism databases

DMDMi172046850.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC103796 Genomic DNA. No translation available.
M30627 mRNA. Translation: AAA36024.1 .
PIRi JQ0129.
UniGenei Hs.523560.

3D structure databases

ProteinModelPortali Q14568.
SMRi Q14568. Positions 10-343.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q14568. 4 interactions.

PTM databases

PhosphoSitei Q14568.

Polymorphism databases

DMDMi 172046850.

Proteomic databases

MaxQBi Q14568.
PaxDbi Q14568.
PRIDEi Q14568.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC11M027866.
HGNCi HGNC:5256. HSP90AA2.
HPAi CAB002058.
MIMi 140575. gene.
neXtProti NX_Q14568.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0326.
HOVERGENi HBG007374.
InParanoidi Q14568.

Miscellaneous databases

PROi Q14568.
SOURCEi Search...

Gene expression databases

CleanExi HS_HSP90AA2.
Genevestigatori Q14568.

Family and domain databases

Gene3Di 3.30.565.10. 2 hits.
InterProi IPR003594. HATPase_ATP-bd.
IPR019805. Heat_shock_protein_90_CS.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view ]
PANTHERi PTHR11528. PTHR11528. 1 hit.
Pfami PF02518. HATPase_c. 1 hit.
PF00183. HSP90. 1 hit.
[Graphical view ]
PRINTSi PR00775. HEATSHOCK90.
SMARTi SM00387. HATPase_c. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEi PS00298. HSP90. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene."
    Walter T., Drabent B., Krebs H., Tomalak M., Heiss S., Benecke B.J.J.
    Gene 83:105-115(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-311, VARIANT ALA-235.
  3. "Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14."
    Ozawa K., Murakami Y., Eki T., Soeda E., Yokoyama K.
    Genomics 12:214-220(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  4. "The HSP90 family of genes in the human genome: insights into their divergence and evolution."
    Chen B., Piel W.H., Gui L., Bruford E., Monteiro A.
    Genomics 86:627-637(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  5. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiHS902_HUMAN
AccessioniPrimary (citable) accession number: Q14568
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 14, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3