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Q14568

- HS902_HUMAN

UniProt

Q14568 - HS902_HUMAN

Protein

Putative heat shock protein HSP 90-alpha A2

Gene

HSP90AA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511ATPBy similarity
    Binding sitei93 – 931ATPBy similarity
    Binding sitei112 – 1121ATPBy similarity
    Binding sitei138 – 1381ATP; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: InterPro
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative heat shock protein HSP 90-alpha A2
    Alternative name(s):
    Heat shock 90 kDa protein 1 alpha-like 3
    Gene namesi
    Name:HSP90AA2
    Synonyms:HSPCAL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:5256. HSP90AA2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Putative heat shock protein HSP 90-alpha A2PRO_0000324325Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei263 – 2631Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ14568.
    PaxDbiQ14568.
    PRIDEiQ14568.

    PTM databases

    PhosphoSiteiQ14568.

    Expressioni

    Gene expression databases

    CleanExiHS_HSP90AA2.
    GenevestigatoriQ14568.

    Organism-specific databases

    HPAiCAB002058.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ14568. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14568.
    SMRiQ14568. Positions 10-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi223 – 26846Glu-richAdd
    BLAST
    Compositional biasi238 – 29356Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the heat shock protein 90 family.Curated

    Phylogenomic databases

    eggNOGiCOG0326.
    HOVERGENiHBG007374.
    InParanoidiQ14568.

    Family and domain databases

    Gene3Di3.30.565.10. 2 hits.
    InterProiIPR003594. HATPase_ATP-bd.
    IPR019805. Heat_shock_protein_90_CS.
    IPR001404. Hsp90_fam.
    IPR020575. Hsp90_N.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view]
    PANTHERiPTHR11528. PTHR11528. 1 hit.
    PfamiPF02518. HATPase_c. 1 hit.
    PF00183. HSP90. 1 hit.
    [Graphical view]
    PRINTSiPR00775. HEATSHOCK90.
    SMARTiSM00387. HATPase_c. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEiPS00298. HSP90. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14568-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS    50
    NSSDALDKIW YESLTDPSKL DSGKELHINL IPNKQDQTLT IVDTGIGMTK 100
    ADLINNLGTI AKSGTKAFME ALQAGADISM IGQFGVSFYS AYLVAEKVTV 150
    ITKHNDDEQY AWESSAGGSF TVRTDTGERM GRGTKVILHL KEDQTEYLEE 200
    QRIKEIVKKH SQLIGYPITL FVEKECDKEV SDDETEEKED KEEEKEKEEK 250
    ESKDKPEIED VGSDEEEEKK DGDKKKKKTK EKYIDQEELN KTKPIWTRNP 300
    DDITNEEYGE FCKNLTNDWE DHLAVKHFSV EGQLEFRALL FVP 343
    Length:343
    Mass (Da):39,365
    Last modified:March 18, 2008 - v2
    Checksum:i2583C15C04090C65
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti273 – 2731D → DK in AAA36024. (PubMed:2591742)Curated
    Sequence conflicti308 – 3081Y → I in AAA36024. (PubMed:2591742)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti235 – 2351T → A.1 Publication
    Corresponds to variant rs1826330 [ dbSNP | Ensembl ].
    VAR_039732
    Natural varianti312 – 3121C → Y.
    Corresponds to variant rs2726836 [ dbSNP | Ensembl ].
    VAR_039733

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC103796 Genomic DNA. No translation available.
    M30627 mRNA. Translation: AAA36024.1.
    PIRiJQ0129.
    UniGeneiHs.523560.

    Polymorphism databases

    DMDMi172046850.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC103796 Genomic DNA. No translation available.
    M30627 mRNA. Translation: AAA36024.1 .
    PIRi JQ0129.
    UniGenei Hs.523560.

    3D structure databases

    ProteinModelPortali Q14568.
    SMRi Q14568. Positions 10-343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q14568. 4 interactions.

    PTM databases

    PhosphoSitei Q14568.

    Polymorphism databases

    DMDMi 172046850.

    Proteomic databases

    MaxQBi Q14568.
    PaxDbi Q14568.
    PRIDEi Q14568.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC11M027866.
    HGNCi HGNC:5256. HSP90AA2.
    HPAi CAB002058.
    MIMi 140575. gene.
    neXtProti NX_Q14568.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0326.
    HOVERGENi HBG007374.
    InParanoidi Q14568.

    Miscellaneous databases

    PROi Q14568.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_HSP90AA2.
    Genevestigatori Q14568.

    Family and domain databases

    Gene3Di 3.30.565.10. 2 hits.
    InterProi IPR003594. HATPase_ATP-bd.
    IPR019805. Heat_shock_protein_90_CS.
    IPR001404. Hsp90_fam.
    IPR020575. Hsp90_N.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view ]
    PANTHERi PTHR11528. PTHR11528. 1 hit.
    Pfami PF02518. HATPase_c. 1 hit.
    PF00183. HSP90. 1 hit.
    [Graphical view ]
    PRINTSi PR00775. HEATSHOCK90.
    SMARTi SM00387. HATPase_c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEi PS00298. HSP90. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene."
      Walter T., Drabent B., Krebs H., Tomalak M., Heiss S., Benecke B.J.J.
      Gene 83:105-115(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-311, VARIANT ALA-235.
    3. "Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14."
      Ozawa K., Murakami Y., Eki T., Soeda E., Yokoyama K.
      Genomics 12:214-220(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.
    4. "The HSP90 family of genes in the human genome: insights into their divergence and evolution."
      Chen B., Piel W.H., Gui L., Bruford E., Monteiro A.
      Genomics 86:627-637(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.
    5. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiHS902_HUMAN
    AccessioniPrimary (citable) accession number: Q14568
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3