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Q14563

- SEM3A_HUMAN

UniProt

Q14563 - SEM3A_HUMAN

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Protein

Semaphorin-3A

Gene

SEMA3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.1 Publication

GO - Molecular functioni

  1. chemorepellent activity Source: BHF-UCL
  2. neuropilin binding Source: BHF-UCL
  3. receptor activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: Ensembl
  2. axonal fasciculation Source: Ensembl
  3. axon extension involved in axon guidance Source: BHF-UCL
  4. axon guidance Source: BHF-UCL
  5. axonogenesis involved in innervation Source: BHF-UCL
  6. branchiomotor neuron axon guidance Source: Ensembl
  7. dendrite morphogenesis Source: Ensembl
  8. dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
  9. facial nerve structural organization Source: Ensembl
  10. gonadotrophin-releasing hormone neuronal migration to the hypothalamus Source: Ensembl
  11. negative regulation of axon extension involved in axon guidance Source: Ensembl
  12. negative regulation of epithelial cell migration Source: Ensembl
  13. nerve development Source: BHF-UCL
  14. neural crest cell migration involved in autonomic nervous system development Source: BHF-UCL
  15. neural crest cell migration involved in sympathetic nervous system development Source: Ensembl
  16. neuron migration Source: BHF-UCL
  17. olfactory bulb development Source: UniProtKB
  18. positive regulation of male gonad development Source: Ensembl
  19. positive regulation of neuron migration Source: Ensembl
  20. regulation of axon extension involved in axon guidance Source: UniProtKB
  21. regulation of heart rate Source: Ensembl
  22. semaphorin-plexin signaling pathway Source: BHF-UCL
  23. semaphorin-plexin signaling pathway involved in axon guidance Source: Ensembl
  24. semaphorin-plexin signaling pathway involved in neuron projection guidance Source: BHF-UCL
  25. sensory system development Source: BHF-UCL
  26. sympathetic ganglion development Source: BHF-UCL
  27. sympathetic nervous system development Source: BHF-UCL
  28. sympathetic neuron projection extension Source: BHF-UCL
  29. sympathetic neuron projection guidance Source: BHF-UCL
  30. trigeminal nerve structural organization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_19199. CRMPs in Sema3A signaling.
REACT_19236. Sema3A PAK dependent Axon repulsion.
REACT_19279. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3A
Alternative name(s):
Semaphorin III
Short name:
Sema III
Gene namesi
Name:SEMA3A
Synonyms:SEMAD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:10723. SEMA3A.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. axon Source: Ensembl
  2. dendrite Source: Ensembl
  3. extracellular region Source: Reactome
  4. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Hypogonadotropic hypogonadism 16 with or without anosmia (HH16) [MIM:614897]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).2 Publications
Note: The disease may be caused by mutations affecting distinct genetic loci, including the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti66 – 661R → W in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs199979628 [ dbSNP | Ensembl ].
VAR_069200
Natural varianti153 – 1531N → S in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs139295139 [ dbSNP | Ensembl ].
VAR_069201
Natural varianti400 – 4001I → V in HH16; phenotype consistent with Kallmann syndrome; digenic; found in a patient also carrying mutation Cys-268 in PROKR2. 1 Publication
Corresponds to variant rs36026860 [ dbSNP | Ensembl ].
VAR_069202
Natural varianti435 – 4351V → I in HH16; phenotype consistent with Kallmann syndrome; digenic; found in patients also carrying mutation Cys-268 in PROKR2 or mutation Arg-687 in FGFR1. 1 Publication
Corresponds to variant rs147436181 [ dbSNP | Ensembl ].
VAR_069203
Natural varianti688 – 6881T → A in HH16; phenotype consistent with Kallmann syndrome; digenic; found in a patient also carrying mutation Asp-217 in KAL1. 1 Publication
Corresponds to variant rs318240751 [ dbSNP | Ensembl ].
VAR_069204
Natural varianti730 – 7301R → Q in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs318240752 [ dbSNP | Ensembl ].
VAR_069205
Natural varianti733 – 7331R → H in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs318240753 [ dbSNP | Ensembl ].
VAR_069206

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

MIMi614897. phenotype.
Orphaneti478. Kallmann syndrome.
PharmGKBiPA35645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 771751Semaphorin-3APRO_0000032303Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi103 ↔ 114By similarity
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi132 ↔ 141By similarity
Disulfide bondi269 ↔ 381By similarity
Disulfide bondi293 ↔ 341By similarity
Disulfide bondi517 ↔ 535By similarity
Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi649 ↔ 722By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ14563.
PaxDbiQ14563.
PRIDEiQ14563.

PTM databases

PhosphoSiteiQ14563.

Expressioni

Gene expression databases

BgeeiQ14563.
CleanExiHS_SEMA3A.
ExpressionAtlasiQ14563. baseline and differential.
GenevestigatoriQ14563.

Organism-specific databases

HPAiHPA029447.
HPA052235.

Interactioni

Subunit structurei

Interacts with PLXND1.By similarity

Protein-protein interaction databases

BioGridi115650. 1 interaction.
DIPiDIP-5744N.
STRINGi9606.ENSP00000265362.

Structurei

3D structure databases

ProteinModelPortaliQ14563.
SMRiQ14563. Positions 26-663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 514484SemaPROSITE-ProRule annotationAdd
BLAST
Domaini580 – 66485Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi727 – 76943Arg/Lys-rich (basic)Add
BLAST

Domaini

Strong binding to neuropilin is mediated by the carboxy third of the protein.

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG305380.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ14563.
KOiK06840.
OMAiREPTTIS.
OrthoDBiEOG7VMP4F.
PhylomeDBiQ14563.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14563-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGWLTRIVCL FWGVLLTARA NYQNGKNNVP RLKLSYKEML ESNNVITFNG
60 70 80 90 100
LANSSSYHTF LLDEERSRLY VGAKDHIFSF DLVNIKDFQK IVWPVSYTRR
110 120 130 140 150
DECKWAGKDI LKECANFIKV LKAYNQTHLY ACGTGAFHPI CTYIEIGHHP
160 170 180 190 200
EDNIFKLENS HFENGRGKSP YDPKLLTASL LIDGELYSGT AADFMGRDFA
210 220 230 240 250
IFRTLGHHHP IRTEQHDSRW LNDPKFISAH LISESDNPED DKVYFFFREN
260 270 280 290 300
AIDGEHSGKA THARIGQICK NDFGGHRSLV NKWTTFLKAR LICSVPGPNG
310 320 330 340 350
IDTHFDELQD VFLMNFKDPK NPVVYGVFTT SSNIFKGSAV CMYSMSDVRR
360 370 380 390 400
VFLGPYAHRD GPNYQWVPYQ GRVPYPRPGT CPSKTFGGFD STKDLPDDVI
410 420 430 440 450
TFARSHPAMY NPVFPMNNRP IVIKTDVNYQ FTQIVVDRVD AEDGQYDVMF
460 470 480 490 500
IGTDVGTVLK VVSIPKETWY DLEEVLLEEM TVFREPTAIS AMELSTKQQQ
510 520 530 540 550
LYIGSTAGVA QLPLHRCDIY GKACAECCLA RDPYCAWDGS ACSRYFPTAK
560 570 580 590 600
RRTRRQDIRN GDPLTHCSDL HHDNHHGHSP EERIIYGVEN SSTFLECSPK
610 620 630 640 650
SQRALVYWQF QRRNEERKEE IRVDDHIIRT DQGLLLRSLQ QKDSGNYLCH
660 670 680 690 700
AVEHGFIQTL LKVTLEVIDT EHLEELLHKD DDGDGSKTKE MSNSMTPSQK
710 720 730 740 750
VWYRDFMQLI NHPNLNTMDE FCEQVWKRDR KQRRQRPGHT PGNSNKWKHL
760 770
QENKKGRNRR THEFERAPRS V
Length:771
Mass (Da):88,889
Last modified:November 1, 1996 - v1
Checksum:i9985F8D3EAED8456
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti66 – 661R → W in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs199979628 [ dbSNP | Ensembl ].
VAR_069200
Natural varianti131 – 1311A → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036283
Natural varianti153 – 1531N → S in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs139295139 [ dbSNP | Ensembl ].
VAR_069201
Natural varianti396 – 3961P → S Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064749
Natural varianti400 – 4001I → V in HH16; phenotype consistent with Kallmann syndrome; digenic; found in a patient also carrying mutation Cys-268 in PROKR2. 1 Publication
Corresponds to variant rs36026860 [ dbSNP | Ensembl ].
VAR_069202
Natural varianti435 – 4351V → I in HH16; phenotype consistent with Kallmann syndrome; digenic; found in patients also carrying mutation Cys-268 in PROKR2 or mutation Arg-687 in FGFR1. 1 Publication
Corresponds to variant rs147436181 [ dbSNP | Ensembl ].
VAR_069203
Natural varianti688 – 6881T → A in HH16; phenotype consistent with Kallmann syndrome; digenic; found in a patient also carrying mutation Asp-217 in KAL1. 1 Publication
Corresponds to variant rs318240751 [ dbSNP | Ensembl ].
VAR_069204
Natural varianti730 – 7301R → Q in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs318240752 [ dbSNP | Ensembl ].
VAR_069205
Natural varianti733 – 7331R → H in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs318240753 [ dbSNP | Ensembl ].
VAR_069206

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26081 mRNA. Translation: AAA65938.1.
AC004451 Genomic DNA. Translation: AAS00353.1.
AC004848 Genomic DNA. Translation: AAC78622.1.
CCDSiCCDS5599.1.
PIRiD49423.
RefSeqiNP_006071.1. NM_006080.2.
XP_005250167.1. XM_005250110.1.
XP_005250168.1. XM_005250111.2.
XP_006715901.1. XM_006715838.1.
XP_006715902.1. XM_006715839.1.
UniGeneiHs.252451.

Genome annotation databases

EnsembliENST00000265362; ENSP00000265362; ENSG00000075213.
ENST00000436949; ENSP00000415260; ENSG00000075213.
ENST00000448879; ENSP00000402093; ENSG00000075213.
GeneIDi10371.
KEGGihsa:10371.
UCSCiuc003uhz.3. human.

Polymorphism databases

DMDMi8134674.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26081 mRNA. Translation: AAA65938.1 .
AC004451 Genomic DNA. Translation: AAS00353.1 .
AC004848 Genomic DNA. Translation: AAC78622.1 .
CCDSi CCDS5599.1.
PIRi D49423.
RefSeqi NP_006071.1. NM_006080.2.
XP_005250167.1. XM_005250110.1.
XP_005250168.1. XM_005250111.2.
XP_006715901.1. XM_006715838.1.
XP_006715902.1. XM_006715839.1.
UniGenei Hs.252451.

3D structure databases

ProteinModelPortali Q14563.
SMRi Q14563. Positions 26-663.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115650. 1 interaction.
DIPi DIP-5744N.
STRINGi 9606.ENSP00000265362.

PTM databases

PhosphoSitei Q14563.

Polymorphism databases

DMDMi 8134674.

Proteomic databases

MaxQBi Q14563.
PaxDbi Q14563.
PRIDEi Q14563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265362 ; ENSP00000265362 ; ENSG00000075213 .
ENST00000436949 ; ENSP00000415260 ; ENSG00000075213 .
ENST00000448879 ; ENSP00000402093 ; ENSG00000075213 .
GeneIDi 10371.
KEGGi hsa:10371.
UCSCi uc003uhz.3. human.

Organism-specific databases

CTDi 10371.
GeneCardsi GC07M083587.
HGNCi HGNC:10723. SEMA3A.
HPAi HPA029447.
HPA052235.
MIMi 603961. gene.
614897. phenotype.
neXtProti NX_Q14563.
Orphaneti 478. Kallmann syndrome.
PharmGKBi PA35645.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG305380.
GeneTreei ENSGT00760000118854.
HOGENOMi HOG000039964.
HOVERGENi HBG055071.
InParanoidi Q14563.
KOi K06840.
OMAi REPTTIS.
OrthoDBi EOG7VMP4F.
PhylomeDBi Q14563.
TreeFami TF316102.

Enzyme and pathway databases

Reactomei REACT_19199. CRMPs in Sema3A signaling.
REACT_19236. Sema3A PAK dependent Axon repulsion.
REACT_19279. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.

Miscellaneous databases

ChiTaRSi SEMA3A. human.
GeneWikii SEMA3A.
GenomeRNAii 10371.
NextBioi 39311.
PROi Q14563.
SOURCEi Search...

Gene expression databases

Bgeei Q14563.
CleanExi HS_SEMA3A.
ExpressionAtlasi Q14563. baseline and differential.
Genevestigatori Q14563.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
PANTHERi PTHR11036. PTHR11036. 1 hit.
Pfami PF01403. Sema. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules."
    Kolodkin A.L., Matthes D.J., Goodman C.S.
    Cell 75:1389-1399(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development."
    Young J., Metay C., Bouligand J., Tou B., Francou B., Maione L., Tosca L., Sarfati J., Brioude F., Esteva B., Briand-Suleau A., Brisset S., Goossens M., Tachdjian G., Guiochon-Mantel A.
    Hum. Reprod. 27:1460-1465(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN HH16, FUNCTION.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-131.
  5. Cited for: VARIANT SER-396.
  6. Cited for: VARIANTS HH16 TRP-66; SER-153; VAL-400; ILE-435; ALA-688; GLN-730 AND HIS-733, CHARACTERIZATION OF VARIANTS HH16 TRP-66; SER-153; VAL-400; ILE-435; ALA-688; GLN-730 AND HIS-733.

Entry informationi

Entry nameiSEM3A_HUMAN
AccessioniPrimary (citable) accession number: Q14563
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3