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Q14563

- SEM3A_HUMAN

UniProt

Q14563 - SEM3A_HUMAN

Protein

Semaphorin-3A

Gene

SEMA3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.1 Publication

    GO - Molecular functioni

    1. chemorepellent activity Source: BHF-UCL
    2. neuropilin binding Source: BHF-UCL
    3. receptor activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: Ensembl
    2. axonal fasciculation Source: Ensembl
    3. axon extension involved in axon guidance Source: BHF-UCL
    4. axon guidance Source: BHF-UCL
    5. axonogenesis involved in innervation Source: BHF-UCL
    6. dendrite morphogenesis Source: Ensembl
    7. dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
    8. negative regulation of axon extension involved in axon guidance Source: Ensembl
    9. negative regulation of epithelial cell migration Source: Ensembl
    10. nerve development Source: BHF-UCL
    11. neural crest cell migration involved in autonomic nervous system development Source: BHF-UCL
    12. neuron migration Source: BHF-UCL
    13. olfactory bulb development Source: UniProtKB
    14. positive regulation of neuron migration Source: Ensembl
    15. regulation of axon extension involved in axon guidance Source: UniProtKB
    16. regulation of heart rate Source: Ensembl
    17. semaphorin-plexin signaling pathway Source: BHF-UCL
    18. semaphorin-plexin signaling pathway involved in neuron projection guidance Source: BHF-UCL
    19. sensory system development Source: BHF-UCL
    20. sympathetic ganglion development Source: BHF-UCL
    21. sympathetic nervous system development Source: BHF-UCL
    22. sympathetic neuron projection extension Source: BHF-UCL
    23. sympathetic neuron projection guidance Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Enzyme and pathway databases

    ReactomeiREACT_19199. CRMPs in Sema3A signaling.
    REACT_19236. Sema3A PAK dependent Axon repulsion.
    REACT_19279. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Semaphorin-3A
    Alternative name(s):
    Semaphorin III
    Short name:
    Sema III
    Gene namesi
    Name:SEMA3A
    Synonyms:SEMAD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:10723. SEMA3A.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. dendrite Source: Ensembl
    3. extracellular region Source: Reactome
    4. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Hypogonadotropic hypogonadism 16 with or without anosmia (HH16) [MIM:614897]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).2 Publications
    Note: The disease may be caused by mutations affecting distinct genetic loci, including the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti66 – 661R → W in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs199979628 [ dbSNP | Ensembl ].
    VAR_069200
    Natural varianti153 – 1531N → S in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs139295139 [ dbSNP | Ensembl ].
    VAR_069201
    Natural varianti400 – 4001I → V in HH16; phenotype consistent with Kallmann syndrome; digenic; found in a patient also carrying mutation Cys-268 in PROKR2. 1 Publication
    Corresponds to variant rs36026860 [ dbSNP | Ensembl ].
    VAR_069202
    Natural varianti435 – 4351V → I in HH16; phenotype consistent with Kallmann syndrome; digenic; found in patients also carrying mutation Cys-268 in PROKR2 or mutation Arg-687 in FGFR1. 1 Publication
    Corresponds to variant rs147436181 [ dbSNP | Ensembl ].
    VAR_069203
    Natural varianti688 – 6881T → A in HH16; phenotype consistent with Kallmann syndrome; digenic; found in a patient also carrying mutation Asp-217 in KAL1. 1 Publication
    Corresponds to variant rs318240751 [ dbSNP | Ensembl ].
    VAR_069204
    Natural varianti730 – 7301R → Q in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs318240752 [ dbSNP | Ensembl ].
    VAR_069205
    Natural varianti733 – 7331R → H in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs318240753 [ dbSNP | Ensembl ].
    VAR_069206

    Keywords - Diseasei

    Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

    Organism-specific databases

    MIMi614897. phenotype.
    Orphaneti478. Kallmann syndrome.
    PharmGKBiPA35645.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 771751Semaphorin-3APRO_0000032303Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi103 ↔ 114By similarity
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi132 ↔ 141By similarity
    Disulfide bondi269 ↔ 381By similarity
    Disulfide bondi293 ↔ 341By similarity
    Disulfide bondi517 ↔ 535By similarity
    Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi649 ↔ 722By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ14563.
    PaxDbiQ14563.
    PRIDEiQ14563.

    PTM databases

    PhosphoSiteiQ14563.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14563.
    BgeeiQ14563.
    CleanExiHS_SEMA3A.
    GenevestigatoriQ14563.

    Organism-specific databases

    HPAiHPA029447.
    HPA052235.

    Interactioni

    Subunit structurei

    Interacts with PLXND1.By similarity

    Protein-protein interaction databases

    BioGridi115650. 1 interaction.
    DIPiDIP-5744N.
    STRINGi9606.ENSP00000265362.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14563.
    SMRiQ14563. Positions 26-663.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 514484SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini580 – 66485Ig-like C2-typeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi727 – 76943Arg/Lys-rich (basic)Add
    BLAST

    Domaini

    Strong binding to neuropilin is mediated by the carboxy third of the protein.

    Sequence similaritiesi

    Belongs to the semaphorin family.Curated
    Contains 1 PSI domain.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG305380.
    HOGENOMiHOG000039964.
    HOVERGENiHBG055071.
    InParanoidiQ14563.
    KOiK06840.
    OMAiREPTTIS.
    OrthoDBiEOG7VMP4F.
    PhylomeDBiQ14563.
    TreeFamiTF316102.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PANTHERiPTHR11036. PTHR11036. 1 hit.
    PfamiPF01403. Sema. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q14563-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGWLTRIVCL FWGVLLTARA NYQNGKNNVP RLKLSYKEML ESNNVITFNG    50
    LANSSSYHTF LLDEERSRLY VGAKDHIFSF DLVNIKDFQK IVWPVSYTRR 100
    DECKWAGKDI LKECANFIKV LKAYNQTHLY ACGTGAFHPI CTYIEIGHHP 150
    EDNIFKLENS HFENGRGKSP YDPKLLTASL LIDGELYSGT AADFMGRDFA 200
    IFRTLGHHHP IRTEQHDSRW LNDPKFISAH LISESDNPED DKVYFFFREN 250
    AIDGEHSGKA THARIGQICK NDFGGHRSLV NKWTTFLKAR LICSVPGPNG 300
    IDTHFDELQD VFLMNFKDPK NPVVYGVFTT SSNIFKGSAV CMYSMSDVRR 350
    VFLGPYAHRD GPNYQWVPYQ GRVPYPRPGT CPSKTFGGFD STKDLPDDVI 400
    TFARSHPAMY NPVFPMNNRP IVIKTDVNYQ FTQIVVDRVD AEDGQYDVMF 450
    IGTDVGTVLK VVSIPKETWY DLEEVLLEEM TVFREPTAIS AMELSTKQQQ 500
    LYIGSTAGVA QLPLHRCDIY GKACAECCLA RDPYCAWDGS ACSRYFPTAK 550
    RRTRRQDIRN GDPLTHCSDL HHDNHHGHSP EERIIYGVEN SSTFLECSPK 600
    SQRALVYWQF QRRNEERKEE IRVDDHIIRT DQGLLLRSLQ QKDSGNYLCH 650
    AVEHGFIQTL LKVTLEVIDT EHLEELLHKD DDGDGSKTKE MSNSMTPSQK 700
    VWYRDFMQLI NHPNLNTMDE FCEQVWKRDR KQRRQRPGHT PGNSNKWKHL 750
    QENKKGRNRR THEFERAPRS V 771
    Length:771
    Mass (Da):88,889
    Last modified:November 1, 1996 - v1
    Checksum:i9985F8D3EAED8456
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti66 – 661R → W in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs199979628 [ dbSNP | Ensembl ].
    VAR_069200
    Natural varianti131 – 1311A → T in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036283
    Natural varianti153 – 1531N → S in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs139295139 [ dbSNP | Ensembl ].
    VAR_069201
    Natural varianti396 – 3961P → S Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
    VAR_064749
    Natural varianti400 – 4001I → V in HH16; phenotype consistent with Kallmann syndrome; digenic; found in a patient also carrying mutation Cys-268 in PROKR2. 1 Publication
    Corresponds to variant rs36026860 [ dbSNP | Ensembl ].
    VAR_069202
    Natural varianti435 – 4351V → I in HH16; phenotype consistent with Kallmann syndrome; digenic; found in patients also carrying mutation Cys-268 in PROKR2 or mutation Arg-687 in FGFR1. 1 Publication
    Corresponds to variant rs147436181 [ dbSNP | Ensembl ].
    VAR_069203
    Natural varianti688 – 6881T → A in HH16; phenotype consistent with Kallmann syndrome; digenic; found in a patient also carrying mutation Asp-217 in KAL1. 1 Publication
    Corresponds to variant rs318240751 [ dbSNP | Ensembl ].
    VAR_069204
    Natural varianti730 – 7301R → Q in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs318240752 [ dbSNP | Ensembl ].
    VAR_069205
    Natural varianti733 – 7331R → H in HH16; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs318240753 [ dbSNP | Ensembl ].
    VAR_069206

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26081 mRNA. Translation: AAA65938.1.
    AC004451 Genomic DNA. Translation: AAS00353.1.
    AC004848 Genomic DNA. Translation: AAC78622.1.
    CCDSiCCDS5599.1.
    PIRiD49423.
    RefSeqiNP_006071.1. NM_006080.2.
    XP_005250167.1. XM_005250110.1.
    XP_005250168.1. XM_005250111.2.
    XP_006715901.1. XM_006715838.1.
    XP_006715902.1. XM_006715839.1.
    UniGeneiHs.252451.

    Genome annotation databases

    EnsembliENST00000265362; ENSP00000265362; ENSG00000075213.
    ENST00000436949; ENSP00000415260; ENSG00000075213.
    ENST00000448879; ENSP00000402093; ENSG00000075213.
    GeneIDi10371.
    KEGGihsa:10371.
    UCSCiuc003uhz.3. human.

    Polymorphism databases

    DMDMi8134674.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L26081 mRNA. Translation: AAA65938.1 .
    AC004451 Genomic DNA. Translation: AAS00353.1 .
    AC004848 Genomic DNA. Translation: AAC78622.1 .
    CCDSi CCDS5599.1.
    PIRi D49423.
    RefSeqi NP_006071.1. NM_006080.2.
    XP_005250167.1. XM_005250110.1.
    XP_005250168.1. XM_005250111.2.
    XP_006715901.1. XM_006715838.1.
    XP_006715902.1. XM_006715839.1.
    UniGenei Hs.252451.

    3D structure databases

    ProteinModelPortali Q14563.
    SMRi Q14563. Positions 26-663.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115650. 1 interaction.
    DIPi DIP-5744N.
    STRINGi 9606.ENSP00000265362.

    PTM databases

    PhosphoSitei Q14563.

    Polymorphism databases

    DMDMi 8134674.

    Proteomic databases

    MaxQBi Q14563.
    PaxDbi Q14563.
    PRIDEi Q14563.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265362 ; ENSP00000265362 ; ENSG00000075213 .
    ENST00000436949 ; ENSP00000415260 ; ENSG00000075213 .
    ENST00000448879 ; ENSP00000402093 ; ENSG00000075213 .
    GeneIDi 10371.
    KEGGi hsa:10371.
    UCSCi uc003uhz.3. human.

    Organism-specific databases

    CTDi 10371.
    GeneCardsi GC07M083587.
    HGNCi HGNC:10723. SEMA3A.
    HPAi HPA029447.
    HPA052235.
    MIMi 603961. gene.
    614897. phenotype.
    neXtProti NX_Q14563.
    Orphaneti 478. Kallmann syndrome.
    PharmGKBi PA35645.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG305380.
    HOGENOMi HOG000039964.
    HOVERGENi HBG055071.
    InParanoidi Q14563.
    KOi K06840.
    OMAi REPTTIS.
    OrthoDBi EOG7VMP4F.
    PhylomeDBi Q14563.
    TreeFami TF316102.

    Enzyme and pathway databases

    Reactomei REACT_19199. CRMPs in Sema3A signaling.
    REACT_19236. Sema3A PAK dependent Axon repulsion.
    REACT_19279. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.

    Miscellaneous databases

    ChiTaRSi SEMA3A. human.
    GeneWikii SEMA3A.
    GenomeRNAii 10371.
    NextBioi 39311.
    PROi Q14563.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14563.
    Bgeei Q14563.
    CleanExi HS_SEMA3A.
    Genevestigatori Q14563.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR016201. Plexin-like_fold.
    IPR001627. Semap_dom.
    IPR027231. Semaphorin.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    PANTHERi PTHR11036. PTHR11036. 1 hit.
    Pfami PF01403. Sema. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00423. PSI. 1 hit.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules."
      Kolodkin A.L., Matthes D.J., Goodman C.S.
      Cell 75:1389-1399(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development."
      Young J., Metay C., Bouligand J., Tou B., Francou B., Maione L., Tosca L., Sarfati J., Brioude F., Esteva B., Briand-Suleau A., Brisset S., Goossens M., Tachdjian G., Guiochon-Mantel A.
      Hum. Reprod. 27:1460-1465(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN HH16, FUNCTION.
    4. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-131.
    5. Cited for: VARIANT SER-396.
    6. Cited for: VARIANTS HH16 TRP-66; SER-153; VAL-400; ILE-435; ALA-688; GLN-730 AND HIS-733, CHARACTERIZATION OF VARIANTS HH16 TRP-66; SER-153; VAL-400; ILE-435; ALA-688; GLN-730 AND HIS-733.

    Entry informationi

    Entry nameiSEM3A_HUMAN
    AccessioniPrimary (citable) accession number: Q14563
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3