Phosphoribosyl pyrophosphate synthetase-associated protein 1

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Reviewed, UniProtKB/Swiss-Prot Q14558 (KPRA_HUMAN)

Last modified June 16, 2009. Version 74. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Phosphoribosyl pyrophosphate synthetase-associated protein 1
      Short name=PRPP synthetase-associated protein 1
Alternative name(s):
    39 kDa phosphoribosypyrophosphate synthetase-associated protein
      Short name=PAP39

Gene names

Name:

PRPSAP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.
Subunit structure	Binds to PRPS1 and PRPS2.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the ribose-phosphate pyrophosphokinase family.

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Ontologies

Keywords
Biological process	Nucleotide biosynthesis
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	enzyme inhibitor activity Traceable author statement. Source: ProtInc magnesium ion binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct ribose phosphate diphosphokinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
CD2BP2	O95400	1	EBI-724449,EBI-768015
ILK	Q13418	1	EBI-724449,EBI-747644
NUAK1	O60285	1	EBI-724449,EBI-1046789
PRKRA	O75569	1	EBI-724449,EBI-713955
PSPH	P78330	1	EBI-724449,EBI-1042956
PTP4A3	O75365	1	EBI-724449,EBI-1043866
TMBIM4	Q9HC24	1	EBI-724449,EBI-1045545

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 356

356

Phosphoribosyl pyrophosphate synthetase-associated protein 1

PRO_0000141079

Amino acid modifications

Modified residue

215

Phosphoserine Ref.3

Experimental info

Sequence conflict

S → L in BAA09612. Ref.1

Sequence conflict

S → F in BAA09612. Ref.1

Secondary structure

356

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q14558-1 [UniParc].

Last modified October 25, 2002. Version 2.
Checksum: 38CC87AB2C555717
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FASTA

356

39,394

        10         20         30         40         50         60 
MNAARTGYRV FSANSTAACT ELAKRITERL GAELGKSVVY QETNGETRVE IKESVRGQDI 

        70         80         90        100        110        120 
FIIQTIPRDV NTAVMELLIM AYALKTACAR NIIGVIPYFP YSKQSKMRKR GSIVCKLLAS 

       130        140        150        160        170        180 
MLAKAGLTHI ITMDLHQKEI QGFFSFPVDN LRASPFLLQY IQEEIPNYRN AVIVAKSPDA 

       190        200        210        220        230        240 
AKRAQSYAER LRLGLAVIHG EAQCTELDMD DGRHSPPMVK NATVHPGLEL PLMMAKEKPP 

       250        260        270        280        290        300 
ITVVGDVGGR IAIIVDDIID DVESFVAAAE ILKERGAYKI YVMATHGILS AEAPRLIEES 

       310        320        330        340        350 
SVDEVVVTNT VPHEVQKLQC PKIKTVDISL ILSEAIRRIH NGESMAYLFR NITVDD

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing of human complementary DNA for the phosphoribosylpyrophosphate synthetase-associated protein 39." Ishizuka T., Kita K., Sonoda T., Ishijima S., Sawa K., Suzuki N., Tatibana M. Biochim. Biophys. Acta 1306:27-30(1996) [PubMed: 8611620] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hepatoma.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215, MASS SPECTROMETRY.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

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Cross-references

Sequence databases

D61391 mRNA. Translation: BAA09612.1.
BC009012 mRNA. Translation: AAH09012.1.

IPI

IPI00291578.

PIR

S71460.

UniGene

Hs.77498

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2C4K	X-ray	2.65	A/B/C/D/E/F	5-351	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q14558. 13 interactions.

PTM databases

PhosphoSite

Q14558.

Proteomic databases

PRIDE

Q14558.

Genome annotation databases

Ensembl

ENSG00000161542. Homo sapiens. [Contig view]

Organism-specific databases

GeneCards

GC17M071818.

H-InvDB

HIX0014196.

HGNC

HGNC:9466. PRPSAP1.

MIM

601249. gene.

PharmGKB

PA33821.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q14558.

HOVERGEN

Q14558.

OMA

Q14558. CAKNIIG.

Gene expression databases

ArrayExpress

Q14558.

Bgee

Q14558.

CleanEx

HS_PRPSAP1.

GermOnline

ENSG00000161542. Homo sapiens.

Family and domain databases

InterPro

IPR000836. PRibTrfase.
IPR005946. PRPP_kinase.
[Graphical view]

Pfam

PF00156. Pribosyltran. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01251. ribP_PPkin. 1 hit.

ProtoNet

Search...

Other Resources

NextBio

21898.

SOURCE

Search...

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Entry information

Entry name

KPRA_HUMAN

Accession

Primary (citable) accession number: Q14558
Secondary accession number(s): Q96H06

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	October 25, 2002
Last modified:	June 16, 2009
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents