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Q14554

- PDIA5_HUMAN

UniProt

Q14554 - PDIA5_HUMAN

Protein

Protein disulfide-isomerase A5

Gene

PDIA5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB
    2. protein disulfide isomerase activity Source: UniProtKB

    GO - Biological processi

    1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
    2. cell redox homeostasis Source: InterPro
    3. cellular protein metabolic process Source: Reactome
    4. endoplasmic reticulum unfolded protein response Source: Reactome
    5. oxidation-reduction process Source: UniProtKB
    6. protein folding Source: UniProtKB
    7. response to endoplasmic reticulum stress Source: RefGenome

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    ReactomeiREACT_18273. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide-isomerase A5 (EC:5.3.4.1)
    Alternative name(s):
    Protein disulfide isomerase-related protein
    Gene namesi
    Name:PDIA5
    Synonyms:PDIR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:24811. PDIA5.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum lumen Source: UniProtKB
    3. endoplasmic reticulum membrane Source: Reactome

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671191.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 519498Protein disulfide-isomerase A5PRO_0000034233Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi182 ↔ 185Redox-activePROSITE-ProRule annotation
    Disulfide bondi305 ↔ 308Redox-activePROSITE-ProRule annotation
    Disulfide bondi426 ↔ 429Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ14554.
    PaxDbiQ14554.
    PRIDEiQ14554.

    PTM databases

    PhosphoSiteiQ14554.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14554.
    BgeeiQ14554.
    CleanExiHS_PDIA5.
    GenevestigatoriQ14554.

    Organism-specific databases

    HPAiHPA030353.
    HPA030354.
    HPA030355.
    HPA030356.

    Interactioni

    Protein-protein interaction databases

    BioGridi116154. 6 interactions.
    IntActiQ14554. 12 interactions.
    MINTiMINT-2868874.
    STRINGi9606.ENSP00000323313.

    Structurei

    Secondary structure

    1
    519
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi36 – 4510
    Beta strandi47 – 5610
    Helixi57 – 7317
    Turni74 – 774
    Beta strandi79 – 846
    Helixi88 – 969
    Beta strandi108 – 1147
    Beta strandi117 – 1215
    Helixi128 – 1369

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4I6XX-ray1.50A29-150[»]
    ProteinModelPortaliQ14554.
    SMRiQ14554. Positions 29-502.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini134 – 261128Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini270 – 384115Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini378 – 506129Thioredoxin 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi516 – 5194Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 3 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    HOGENOMiHOG000039967.
    HOVERGENiHBG053547.
    InParanoidiQ14554.
    KOiK09583.
    OMAiYYHYGKF.
    PhylomeDBiQ14554.
    TreeFamiTF106379.

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 3 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 4 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14554-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARAGPAWLL LAIWVVLPSW LSSAKVSSLI ERISDPKDLK KLLRTRNNVL    50
    VLYSKSEVAA ENHLRLLSTV AQAVKGQGTI CWVDCGDAES RKLCKKMKVD 100
    LSPKDKKVEL FHYQDGAFHT EYNRAVTFKS IVAFLKDPKG PPLWEEDPGA 150
    KDVVHLDSEK DFRRLLKKEE KPLLIMFYAP WCSMCKRMMP HFQKAATQLR 200
    GHAVLAGMNV YSSEFENIKE EYSVRGFPTI CYFEKGRFLF QYDNYGSTAE 250
    DIVEWLKNPQ PPQPQVPETP WADEGGSVYH LTDEDFDQFV KEHSSVLVMF 300
    HAPWCGHCKK MKPEFEKAAE ALHGEADSSG VLAAVDATVN KALAERFHIS 350
    EFPTLKYFKN GEKYAVPVLR TKKKFLEWMQ NPEAPPPPEP TWEEQQTSVL 400
    HLVGDNFRET LKKKKHTLVM FYAPWCPHCK KVIPHFTATA DAFKDDRKIA 450
    CAAVDCVKDK NQDLCQQEAV KGYPTFHYYH YGKFAEKYDS DRTELGFTNY 500
    IRALREGDHE RLGKKKEEL 519
    Length:519
    Mass (Da):59,594
    Last modified:November 1, 1997 - v1
    Checksum:i6083FBEB8C019658
    GO
    Isoform 2 (identifier: Q14554-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         258-261: NPQP → KVWP
         262-518: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:262
    Mass (Da):30,124
    Checksum:i5F1F4564D9DB3955
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti391 – 3911T → M.
    Corresponds to variant rs2292661 [ dbSNP | Ensembl ].
    VAR_052581

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei258 – 2614NPQP → KVWP in isoform 2. 1 PublicationVSP_056536
    Alternative sequencei262 – 518257Missing in isoform 2. 1 PublicationVSP_056537Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49490 mRNA. Translation: BAA08451.1.
    AC063922 Genomic DNA. No translation available.
    AC083797 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79452.1.
    CH471052 Genomic DNA. Translation: EAW79453.1.
    CH471052 Genomic DNA. Translation: EAW79454.1.
    CH471052 Genomic DNA. Translation: EAW79456.1.
    BC001625 mRNA. Translation: AAH01625.1.
    CCDSiCCDS3020.1.
    PIRiS66673.
    RefSeqiNP_006801.1. NM_006810.3.
    UniGeneiHs.477352.

    Genome annotation databases

    EnsembliENST00000316218; ENSP00000323313; ENSG00000065485.
    ENST00000489923; ENSP00000417520; ENSG00000065485.
    GeneIDi10954.
    KEGGihsa:10954.
    UCSCiuc003egc.2. human.

    Polymorphism databases

    DMDMi2501208.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49490 mRNA. Translation: BAA08451.1 .
    AC063922 Genomic DNA. No translation available.
    AC083797 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79452.1 .
    CH471052 Genomic DNA. Translation: EAW79453.1 .
    CH471052 Genomic DNA. Translation: EAW79454.1 .
    CH471052 Genomic DNA. Translation: EAW79456.1 .
    BC001625 mRNA. Translation: AAH01625.1 .
    CCDSi CCDS3020.1.
    PIRi S66673.
    RefSeqi NP_006801.1. NM_006810.3.
    UniGenei Hs.477352.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4I6X X-ray 1.50 A 29-150 [» ]
    ProteinModelPortali Q14554.
    SMRi Q14554. Positions 29-502.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116154. 6 interactions.
    IntActi Q14554. 12 interactions.
    MINTi MINT-2868874.
    STRINGi 9606.ENSP00000323313.

    PTM databases

    PhosphoSitei Q14554.

    Polymorphism databases

    DMDMi 2501208.

    Proteomic databases

    MaxQBi Q14554.
    PaxDbi Q14554.
    PRIDEi Q14554.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316218 ; ENSP00000323313 ; ENSG00000065485 .
    ENST00000489923 ; ENSP00000417520 ; ENSG00000065485 .
    GeneIDi 10954.
    KEGGi hsa:10954.
    UCSCi uc003egc.2. human.

    Organism-specific databases

    CTDi 10954.
    GeneCardsi GC03P122785.
    HGNCi HGNC:24811. PDIA5.
    HPAi HPA030353.
    HPA030354.
    HPA030355.
    HPA030356.
    neXtProti NX_Q14554.
    PharmGKBi PA142671191.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0526.
    HOGENOMi HOG000039967.
    HOVERGENi HBG053547.
    InParanoidi Q14554.
    KOi K09583.
    OMAi YYHYGKF.
    PhylomeDBi Q14554.
    TreeFami TF106379.

    Enzyme and pathway databases

    Reactomei REACT_18273. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    ChiTaRSi PDIA5. human.
    GenomeRNAii 10954.
    NextBioi 41621.
    PROi Q14554.

    Gene expression databases

    ArrayExpressi Q14554.
    Bgeei Q14554.
    CleanExi HS_PDIA5.
    Genevestigatori Q14554.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 3 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 4 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the cDNA encoding a novel protein disulfide isomerase-related protein (PDIR)."
      Hayano T., Kikuchi M.
      FEBS Lett. 372:210-214(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPDIA5_HUMAN
    AccessioniPrimary (citable) accession number: Q14554
    Secondary accession number(s): D3DN95, Q9BV43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3