Q14554 (PDIA5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein disulfide-isomerase A5
EC=5.3.4.1

Alternative name(s):
Protein disulfide isomerase-related protein

Gene names

Name:	PDIA5
Synonyms:	PDIR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	519 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Catalyzes the rearrangement of -S-S- bonds in proteins.
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Belongs to the protein disulfide isomerase family. Contains 3 thioredoxin domains.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Coding sequence diversity	Polymorphism
Domain	Redox-active center Repeat Signal
Molecular function	Isomerase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of signaling protein activity involved in unfolded protein response Traceable author statement. Source: Reactome cell redox homeostasis Inferred from electronic annotation. Source: InterPro glycerol ether metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	endoplasmic reticulum lumen Traceable author statement Ref.1. Source: UniProtKB endoplasmic reticulum membrane Traceable author statement. Source: Reactome
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro oxidoreductase activity Traceable author statement Ref.1. Source: UniProtKB protein disulfide isomerase activity Traceable author statement Ref.1. Source: UniProtKB protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 519	498	Protein disulfide-isomerase A5		PRO_0000034233
Regions
	Domain	134 – 261	128	Thioredoxin 1
	Domain	270 – 384	115	Thioredoxin 2
	Domain	378 – 506	129	Thioredoxin 3
	Motif	516 – 519	4	Prevents secretion from ER Potential
Amino acid modifications
	Disulfide bond	182 ↔ 185		Redox-active By similarity
	Disulfide bond	305 ↔ 308		Redox-active By similarity
	Disulfide bond	426 ↔ 429		Redox-active By similarity
Natural variations
	Natural variant	391	1	T → M. Corresponds to variant rs2292661 [ dbSNP | Ensembl ].		VAR_052581

Sequences

	Sequence		Length	Mass (Da)
	Q14554 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 6083FBEB8C019658	FASTA	519	59,594
	10 20 30 40 50 60 MARAGPAWLL LAIWVVLPSW LSSAKVSSLI ERISDPKDLK KLLRTRNNVL VLYSKSEVAA 70 80 90 100 110 120 ENHLRLLSTV AQAVKGQGTI CWVDCGDAES RKLCKKMKVD LSPKDKKVEL FHYQDGAFHT 130 140 150 160 170 180 EYNRAVTFKS IVAFLKDPKG PPLWEEDPGA KDVVHLDSEK DFRRLLKKEE KPLLIMFYAP 190 200 210 220 230 240 WCSMCKRMMP HFQKAATQLR GHAVLAGMNV YSSEFENIKE EYSVRGFPTI CYFEKGRFLF 250 260 270 280 290 300 QYDNYGSTAE DIVEWLKNPQ PPQPQVPETP WADEGGSVYH LTDEDFDQFV KEHSSVLVMF 310 320 330 340 350 360 HAPWCGHCKK MKPEFEKAAE ALHGEADSSG VLAAVDATVN KALAERFHIS EFPTLKYFKN 370 380 390 400 410 420 GEKYAVPVLR TKKKFLEWMQ NPEAPPPPEP TWEEQQTSVL HLVGDNFRET LKKKKHTLVM 430 440 450 460 470 480 FYAPWCPHCK KVIPHFTATA DAFKDDRKIA CAAVDCVKDK NQDLCQQEAV KGYPTFHYYH 490 500 510 YGKFAEKYDS DRTELGFTNY IRALREGDHE RLGKKKEEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the cDNA encoding a novel protein disulfide isomerase-related protein (PDIR)." Hayano T., Kikuchi M. FEBS Lett. 372:210-214(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D49490 mRNA. Translation: BAA08451.1. CH471052 Genomic DNA. Translation: EAW79452.1. CH471052 Genomic DNA. Translation: EAW79454.1.
IPI	IPI00031479.
PIR	S66673.
RefSeq	NP_006801.1. NM_006810.3.
UniGene	Hs.477352.
3D structure databases
ProteinModelPortal	Q14554.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14554. 6 interactions.
MINT	MINT-2868874.
STRING	9606.ENSP00000323313.
PTM databases
PhosphoSite	Q14554.
Polymorphism databases
DMDM	2501208.
Proteomic databases
PaxDb	Q14554.
PRIDE	Q14554.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316218; ENSP00000323313; ENSG00000065485.
GeneID	10954.
KEGG	hsa:10954.
UCSC	uc003egc.2. human.
Organism-specific databases
CTD	10954.
GeneCards	GC03P122785.
HGNC	HGNC:24811. PDIA5.
HPA	HPA030353. HPA030354. HPA030355. HPA030356.
neXtProt	NX_Q14554.
PharmGKB	PA142671191.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0526.
HOGENOM	HOG000039967.
HOVERGEN	HBG053547.
InParanoid	Q14554.
KO	K09583.
OMA	LAGMNVY.
PhylomeDB	Q14554.
Enzyme and pathway databases
Reactome	REACT_116125. Disease.
Gene expression databases
ArrayExpress	Q14554.
Bgee	Q14554.
CleanEx	HS_PDIA5.
Genevestigator	Q14554.
GermOnline	ENSG00000065485. Homo sapiens.
Family and domain databases
Gene3D	3.40.30.10. 3 hits.
InterPro	IPR005746. Thioredoxin. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. [Graphical view]
Pfam	PF00085. Thioredoxin. 3 hits. [Graphical view]
PRINTS	PR00421. THIOREDOXIN.
SUPFAM	SSF52833. Thiordxn-like_fd. 4 hits.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00194. THIOREDOXIN_1. 2 hits. PS51352. THIOREDOXIN_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PDIA5. human.
GenomeRNAi	10954.
NextBio	41621.

Entry information

Entry name

PDIA5_HUMAN

Accession

Primary (citable) accession number: Q14554
Secondary accession number(s): D3DN95

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.