SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q14554

- PDIA5_HUMAN

UniProt

Q14554 - PDIA5_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Protein disulfide-isomerase A5
Gene
PDIA5, PDIR
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB
  2. protein disulfide isomerase activity Source: UniProtKB

GO - Biological processi

  1. activation of signaling protein activity involved in unfolded protein response Source: Reactome
  2. cell redox homeostasis Source: InterPro
  3. cellular protein metabolic process Source: Reactome
  4. endoplasmic reticulum unfolded protein response Source: Reactome
  5. oxidation-reduction process Source: UniProtKB
  6. protein folding Source: UniProtKB
  7. response to endoplasmic reticulum stress Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiREACT_18273. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase A5 (EC:5.3.4.1)
Alternative name(s):
Protein disulfide isomerase-related protein
Gene namesi
Name:PDIA5
Synonyms:PDIR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:24811. PDIA5.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
  2. endoplasmic reticulum lumen Source: UniProtKB
  3. endoplasmic reticulum membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671191.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 519498Protein disulfide-isomerase A5
PRO_0000034233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi182 ↔ 185Redox-active By similarity
Disulfide bondi305 ↔ 308Redox-active By similarity
Disulfide bondi426 ↔ 429Redox-active By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ14554.
PaxDbiQ14554.
PRIDEiQ14554.

PTM databases

PhosphoSiteiQ14554.

Expressioni

Gene expression databases

ArrayExpressiQ14554.
BgeeiQ14554.
CleanExiHS_PDIA5.
GenevestigatoriQ14554.

Organism-specific databases

HPAiHPA030353.
HPA030354.
HPA030355.
HPA030356.

Interactioni

Protein-protein interaction databases

BioGridi116154. 5 interactions.
IntActiQ14554. 12 interactions.
MINTiMINT-2868874.
STRINGi9606.ENSP00000323313.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi36 – 4510
Beta strandi47 – 5610
Helixi57 – 7317
Turni74 – 774
Beta strandi79 – 846
Helixi88 – 969
Beta strandi108 – 1147
Beta strandi117 – 1215
Helixi128 – 1369

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I6XX-ray1.50A29-150[»]
ProteinModelPortaliQ14554.
SMRiQ14554. Positions 29-502.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 261128Thioredoxin 1
Add
BLAST
Domaini270 – 384115Thioredoxin 2
Add
BLAST
Domaini378 – 506129Thioredoxin 3
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi516 – 5194Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Contains 3 thioredoxin domains.

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000039967.
HOVERGENiHBG053547.
InParanoidiQ14554.
KOiK09583.
OMAiYYHYGKF.
PhylomeDBiQ14554.
TreeFamiTF106379.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14554-1 [UniParc]FASTAAdd to Basket

« Hide

MARAGPAWLL LAIWVVLPSW LSSAKVSSLI ERISDPKDLK KLLRTRNNVL    50
VLYSKSEVAA ENHLRLLSTV AQAVKGQGTI CWVDCGDAES RKLCKKMKVD 100
LSPKDKKVEL FHYQDGAFHT EYNRAVTFKS IVAFLKDPKG PPLWEEDPGA 150
KDVVHLDSEK DFRRLLKKEE KPLLIMFYAP WCSMCKRMMP HFQKAATQLR 200
GHAVLAGMNV YSSEFENIKE EYSVRGFPTI CYFEKGRFLF QYDNYGSTAE 250
DIVEWLKNPQ PPQPQVPETP WADEGGSVYH LTDEDFDQFV KEHSSVLVMF 300
HAPWCGHCKK MKPEFEKAAE ALHGEADSSG VLAAVDATVN KALAERFHIS 350
EFPTLKYFKN GEKYAVPVLR TKKKFLEWMQ NPEAPPPPEP TWEEQQTSVL 400
HLVGDNFRET LKKKKHTLVM FYAPWCPHCK KVIPHFTATA DAFKDDRKIA 450
CAAVDCVKDK NQDLCQQEAV KGYPTFHYYH YGKFAEKYDS DRTELGFTNY 500
IRALREGDHE RLGKKKEEL 519
Length:519
Mass (Da):59,594
Last modified:November 1, 1997 - v1
Checksum:i6083FBEB8C019658
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti391 – 3911T → M.
Corresponds to variant rs2292661 [ dbSNP | Ensembl ].
VAR_052581

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49490 mRNA. Translation: BAA08451.1.
CH471052 Genomic DNA. Translation: EAW79452.1.
CH471052 Genomic DNA. Translation: EAW79454.1.
CCDSiCCDS3020.1.
PIRiS66673.
RefSeqiNP_006801.1. NM_006810.3.
UniGeneiHs.477352.

Genome annotation databases

EnsembliENST00000316218; ENSP00000323313; ENSG00000065485.
GeneIDi10954.
KEGGihsa:10954.
UCSCiuc003egc.2. human.

Polymorphism databases

DMDMi2501208.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49490 mRNA. Translation: BAA08451.1 .
CH471052 Genomic DNA. Translation: EAW79452.1 .
CH471052 Genomic DNA. Translation: EAW79454.1 .
CCDSi CCDS3020.1.
PIRi S66673.
RefSeqi NP_006801.1. NM_006810.3.
UniGenei Hs.477352.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I6X X-ray 1.50 A 29-150 [» ]
ProteinModelPortali Q14554.
SMRi Q14554. Positions 29-502.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116154. 5 interactions.
IntActi Q14554. 12 interactions.
MINTi MINT-2868874.
STRINGi 9606.ENSP00000323313.

PTM databases

PhosphoSitei Q14554.

Polymorphism databases

DMDMi 2501208.

Proteomic databases

MaxQBi Q14554.
PaxDbi Q14554.
PRIDEi Q14554.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316218 ; ENSP00000323313 ; ENSG00000065485 .
GeneIDi 10954.
KEGGi hsa:10954.
UCSCi uc003egc.2. human.

Organism-specific databases

CTDi 10954.
GeneCardsi GC03P122785.
HGNCi HGNC:24811. PDIA5.
HPAi HPA030353.
HPA030354.
HPA030355.
HPA030356.
neXtProti NX_Q14554.
PharmGKBi PA142671191.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000039967.
HOVERGENi HBG053547.
InParanoidi Q14554.
KOi K09583.
OMAi YYHYGKF.
PhylomeDBi Q14554.
TreeFami TF106379.

Enzyme and pathway databases

Reactomei REACT_18273. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSi PDIA5. human.
GenomeRNAii 10954.
NextBioi 41621.
PROi Q14554.

Gene expression databases

ArrayExpressi Q14554.
Bgeei Q14554.
CleanExi HS_PDIA5.
Genevestigatori Q14554.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 3 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the cDNA encoding a novel protein disulfide isomerase-related protein (PDIR)."
    Hayano T., Kikuchi M.
    FEBS Lett. 372:210-214(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPDIA5_HUMAN
AccessioniPrimary (citable) accession number: Q14554
Secondary accession number(s): D3DN95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi