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Q14549 (GBX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homeobox protein GBX-1
Alternative name(s):
Gastrulation and brain-specific homeobox protein 1
Gene names
Name:GBX1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Homeobox protein GBX-1
PRO_0000048878

Regions

DNA binding261 – 32060Homeobox
Compositional bias5 – 2218Gly-rich
Compositional bias33 – 179147Pro-rich
Compositional bias60 – 13374Ala-rich

Natural variations

Natural variant1941A → T.
Corresponds to variant rs11975799 [ dbSNP | Ensembl ].
VAR_049579

Secondary structure

......... 363
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q14549 [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: 738A37958DBD2E43

FASTA36337,629
        10         20         30         40         50         60 
MQRAGGGSAP GGNGGGGGGG PGTAFSIDSL IGPPPPRSGH LLYTGYPMFM PYRPLVLPQA 

        70         80         90        100        110        120 
LAPAPLPAGL PPLAPLASFA GRLTNTFCAG LGQAVPSMVA LTTALPSFAE PPDAFYGPQE 

       130        140        150        160        170        180 
LAAAAAAAAA TAARNNPEPG GRRPEGGLEA DELLPAREKV AEPPPPPPPH FSETFPSLPA 

       190        200        210        220        230        240 
EGKVYSSDEE KLEASAGDPA GSEQEEEGSG GDSEDDGFLD SSAGGPGALL GPKPKLKGSL 

       250        260        270        280        290        300 
GTGAEEGAPV TAGVTAPGGK SRRRRTAFTS EQLLELEKEF HCKKYLSLTE RSQIAHALKL 

       310        320        330        340        350        360 
SEVQVKIWFQ NRRAKWKRIK AGNVSSRSGE PVRNPKIVVP IPVHVNRFAV RSQHQQMEQG 


ARP 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Expression of a novel human homeobox-containing gene that maps to chromosome 7q36.1 in hematopoietic cells."
Matsui T., Hirai M., Wakita M., Hirano M., Kurosawa Y.
FEBS Lett. 322:181-185(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 225-363.
[3]"NMR structure of the homeodomain transcription factor GBX1 from Homo sapiens."
Joint center for structural genomics (JCSG)
Submitted (JAN-2013) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 256-325.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC010973 Genomic DNA. No translation available.
L11239 Genomic DNA. Translation: AAA36002.1.
CCDSCCDS43682.1.
PIRS32510.
RefSeqNP_001092304.1. NM_001098834.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2M34NMR-A256-325[»]
2ME0NMR-A256-325[»]
2ME6NMR-A256-325[»]
ProteinModelPortalQ14549.
SMRQ14549. Positions 255-325.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000297537.

PTM databases

PhosphoSiteQ14549.

Polymorphism databases

DMDM115502392.

Proteomic databases

PaxDbQ14549.
PRIDEQ14549.

Protocols and materials databases

DNASU2636.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297537; ENSP00000297537; ENSG00000164900.
GeneID2636.
KEGGhsa:2636.
UCSCuc011kvg.2. human.

Organism-specific databases

CTD2636.
GeneCardsGC07M150845.
HGNCHGNC:4185. GBX1.
HPAHPA055783.
MIM603354. gene.
neXtProtNX_Q14549.
PharmGKBPA28599.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG315879.
HOGENOMHOG000060099.
HOVERGENHBG003967.
InParanoidQ14549.
KOK09321.
OMARARSEPC.
OrthoDBEOG7D2FDK.
PhylomeDBQ14549.
TreeFamTF351530.

Gene expression databases

BgeeQ14549.
CleanExHS_GBX1.
GenevestigatorQ14549.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi2636.
NextBio10392.
PROQ14549.
SOURCESearch...

Entry information

Entry nameGBX1_HUMAN
AccessionPrimary (citable) accession number: Q14549
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM