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Q14542

- S29A2_HUMAN

UniProt

Q14542 - S29A2_HUMAN

Protein

Equilibrative nucleoside transporter 2

Gene

SLC29A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.1 Publication

    Kineticsi

    Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.

    1. KM=0.2 mM for uridine2 Publications
    2. KM=0.75 mM for adenosine2 Publications

    GO - Molecular functioni

    1. nucleoside transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. cell proliferation Source: ProtInc
    2. nucleobase-containing compound metabolic process Source: ProtInc
    3. nucleoside transmembrane transport Source: GOC
    4. nucleoside transport Source: UniProtKB
    5. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.57.1.8. the equilibrative nucleoside transporter (ent) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Equilibrative nucleoside transporter 2
    Alternative name(s):
    36 kDa nucleolar protein HNP36
    Delayed-early response protein 12
    Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter
    Short name:
    Equilibrative NBMPR-insensitive nucleoside transporter
    Hydrophobic nucleolar protein, 36 kDa
    Nucleoside transporter, ei-type
    Solute carrier family 29 member 2
    Gene namesi
    Name:SLC29A2
    Synonyms:DER12, ENT2, HNP36
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:11004. SLC29A2.

    Subcellular locationi

    Basolateral cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Nucleus membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Localized at the basolateral cell membrane in polarized MDCK cells.

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB
    2. integral component of plasma membrane Source: ProtInc
    3. nuclear membrane Source: UniProtKB-SubCell
    4. nucleolus Source: ProtInc
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi455 – 4551L → R: Reduces drastically localization at the cell surface. No effect on uptake of adenosine and thymidine. Reduces drastically localization at the cell surface and induces an significant reduction of adenosine or thymidine uptake; when associated with R-456. 1 Publication
    Mutagenesisi456 – 4561L → R: Reduces drastically localization at the cell surface and induces an significant reduction of adenosine or thymidine uptake; when associated with R-455. 1 Publication

    Organism-specific databases

    PharmGKBiPA191.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Equilibrative nucleoside transporter 2PRO_0000209340Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)1 Publication
    Glycosylationi57 – 571N-linked (GlcNAc...)1 Publication
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Modified residuei252 – 2521Phosphoserine2 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ14542.
    PaxDbiQ14542.
    PRIDEiQ14542.

    PTM databases

    PhosphoSiteiQ14542.

    Expressioni

    Tissue specificityi

    Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues.2 Publications

    Inductioni

    By PDGF/platelet derived growth factor and fibroblast growth factor (FGF).

    Gene expression databases

    ArrayExpressiQ14542.
    BgeeiQ14542.
    CleanExiHS_SLC29A2.
    GenevestigatoriQ14542.

    Organism-specific databases

    HPAiHPA018168.

    Interactioni

    Protein-protein interaction databases

    BioGridi109419. 1 interaction.
    IntActiQ14542. 1 interaction.
    STRINGi9606.ENSP00000350024.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14542.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei291 – 31121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei324 – 34421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei360 – 38021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei386 – 40621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249415.
    HOGENOMiHOG000007684.
    HOVERGENiHBG074626.
    InParanoidiQ14542.
    KOiK15014.
    OMAiPEKPSVF.
    PhylomeDBiQ14542.
    TreeFamiTF313950.

    Family and domain databases

    InterProiIPR002259. Eqnu_transpt.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PANTHERiPTHR10332. PTHR10332. 1 hit.
    PfamiPF01733. Nucleoside_tran. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016379. ENT. 1 hit.
    PRINTSiPR01130. DERENTRNSPRT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00939. 2a57. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14542-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARGDAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ ARLAGAGNST    50
    ARILSTNHTG PEDAFNFNNW VTLLSQLPLL LFTLLNSFLY QCVPETVRIL 100
    GSLLAILLLF ALTAALVKVD MSPGPFFSIT MASVCFINSF SAVLQGSLFG 150
    QLGTMPSTYS TLFLSGQGLA GIFAALAMLL SMASGVDAET SALGYFITPC 200
    VGILMSIVCY LSLPHLKFAR YYLANKSSQA QAQELETKAE LLQSDENGIP 250
    SSPQKVALTL DLDLEKEPES EPDEPQKPGK PSVFTVFQKI WLTALCLVLV 300
    FTVTLSVFPA ITAMVTSSTS PGKWSQFFNP ICCFLLFNIM DWLGRSLTSY 350
    FLWPDEDSRL LPLLVCLRFL FVPLFMLCHV PQRSRLPILF PQDAYFITFM 400
    LLFAVSNGYL VSLTMCLAPR QVLPHEREVA GALMTFFLAL GLSCGASLSF 450
    LFKALL 456
    Length:456
    Mass (Da):50,113
    Last modified:October 17, 2006 - v3
    Checksum:iABCBD244306708E1
    GO
    Isoform 2 (identifier: Q14542-2) [UniParc]FASTAAdd to Basket

    Also known as: Short, HNP36

    The sequence of this isoform differs from the canonical sequence as follows:
         93-202: VPETVRILGS...LGYFITPCVG → AGQGGHEPRT...PEVCPLLPGQ
         203-456: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:202
    Mass (Da):22,276
    Checksum:iE1E980B5CCC29586
    GO
    Isoform 3 (identifier: Q14542-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         290-301: IWLTALCLVLVF → SPCPSSPPSQPW
         302-456: Missing.

    Show »
    Length:301
    Mass (Da):32,507
    Checksum:i5DFD77C4226D4F15
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti200 – 2001C → Y in CAA60380. (PubMed:7639753)Curated
    Sequence conflicti200 – 2001C → Y in AAC39526. (PubMed:9396714)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51D → Y.1 Publication
    Corresponds to variant rs8187643 [ dbSNP | Ensembl ].
    VAR_029289
    Natural varianti68 – 681N → K.1 Publication
    Corresponds to variant rs8187644 [ dbSNP | Ensembl ].
    VAR_029290
    Natural varianti94 – 941P → L.1 Publication
    Corresponds to variant rs8187648 [ dbSNP | Ensembl ].
    VAR_029291
    Natural varianti184 – 1863SGV → M.
    VAR_036822

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei93 – 202110VPETV…TPCVG → AGQGGHEPRTLLLHHHGLRL LHQLLQCSPTGQPLRAAGHH ALHLQHPLPQRPGPGWDLCC PCHAPVHGQWRGRRDLCPGV LYHALCGHPHVHRVLPEPAS PEVCPLLPGQ in isoform 2. 1 PublicationVSP_040728Add
    BLAST
    Alternative sequencei203 – 456254Missing in isoform 2. 1 PublicationVSP_040729Add
    BLAST
    Alternative sequencei290 – 30112IWLTA…LVLVF → SPCPSSPPSQPW in isoform 3. 1 PublicationVSP_040730Add
    BLAST
    Alternative sequencei302 – 456155Missing in isoform 3. 1 PublicationVSP_040731Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86681 mRNA. Translation: CAA60380.1. Sequence problems.
    AF029358 mRNA. Translation: AAC39526.1.
    AF034102 mRNA. Translation: AAB97834.1.
    AK057041 mRNA. Translation: BAG51849.1.
    AF401235 mRNA. Translation: AAK92533.1.
    AP001107 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74521.1.
    CH471076 Genomic DNA. Translation: EAW74519.1.
    BC093634 mRNA. Translation: AAH93634.1.
    CCDSiCCDS8137.1. [Q14542-1]
    PIRiJC4196.
    RefSeqiNP_001523.2. NM_001532.2. [Q14542-1]
    XP_006718587.1. XM_006718524.1. [Q14542-1]
    XP_006718591.1. XM_006718528.1. [Q14542-3]
    UniGeneiHs.569017.

    Genome annotation databases

    EnsembliENST00000357440; ENSP00000350024; ENSG00000174669. [Q14542-1]
    ENST00000540386; ENSP00000444870; ENSG00000174669. [Q14542-3]
    ENST00000541567; ENSP00000442116; ENSG00000174669. [Q14542-2]
    ENST00000544554; ENSP00000439456; ENSG00000174669. [Q14542-1]
    ENST00000546034; ENSP00000440329; ENSG00000174669. [Q14542-1]
    GeneIDi3177.
    KEGGihsa:3177.
    UCSCiuc001oht.3. human. [Q14542-1]

    Polymorphism databases

    DMDMi116242781.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86681 mRNA. Translation: CAA60380.1 . Sequence problems.
    AF029358 mRNA. Translation: AAC39526.1 .
    AF034102 mRNA. Translation: AAB97834.1 .
    AK057041 mRNA. Translation: BAG51849.1 .
    AF401235 mRNA. Translation: AAK92533.1 .
    AP001107 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74521.1 .
    CH471076 Genomic DNA. Translation: EAW74519.1 .
    BC093634 mRNA. Translation: AAH93634.1 .
    CCDSi CCDS8137.1. [Q14542-1 ]
    PIRi JC4196.
    RefSeqi NP_001523.2. NM_001532.2. [Q14542-1 ]
    XP_006718587.1. XM_006718524.1. [Q14542-1 ]
    XP_006718591.1. XM_006718528.1. [Q14542-3 ]
    UniGenei Hs.569017.

    3D structure databases

    ProteinModelPortali Q14542.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109419. 1 interaction.
    IntActi Q14542. 1 interaction.
    STRINGi 9606.ENSP00000350024.

    Protein family/group databases

    TCDBi 2.A.57.1.8. the equilibrative nucleoside transporter (ent) family.

    PTM databases

    PhosphoSitei Q14542.

    Polymorphism databases

    DMDMi 116242781.

    Proteomic databases

    MaxQBi Q14542.
    PaxDbi Q14542.
    PRIDEi Q14542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357440 ; ENSP00000350024 ; ENSG00000174669 . [Q14542-1 ]
    ENST00000540386 ; ENSP00000444870 ; ENSG00000174669 . [Q14542-3 ]
    ENST00000541567 ; ENSP00000442116 ; ENSG00000174669 . [Q14542-2 ]
    ENST00000544554 ; ENSP00000439456 ; ENSG00000174669 . [Q14542-1 ]
    ENST00000546034 ; ENSP00000440329 ; ENSG00000174669 . [Q14542-1 ]
    GeneIDi 3177.
    KEGGi hsa:3177.
    UCSCi uc001oht.3. human. [Q14542-1 ]

    Organism-specific databases

    CTDi 3177.
    GeneCardsi GC11M066129.
    HGNCi HGNC:11004. SLC29A2.
    HPAi HPA018168.
    MIMi 602110. gene.
    neXtProti NX_Q14542.
    PharmGKBi PA191.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG249415.
    HOGENOMi HOG000007684.
    HOVERGENi HBG074626.
    InParanoidi Q14542.
    KOi K15014.
    OMAi PEKPSVF.
    PhylomeDBi Q14542.
    TreeFami TF313950.

    Enzyme and pathway databases

    Reactomei REACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

    Miscellaneous databases

    GeneWikii Equilibrative_nucleoside_transporter_2.
    GenomeRNAii 3177.
    NextBioi 12610.
    PROi Q14542.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14542.
    Bgeei Q14542.
    CleanExi HS_SLC29A2.
    Genevestigatori Q14542.

    Family and domain databases

    InterProi IPR002259. Eqnu_transpt.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    PANTHERi PTHR10332. PTHR10332. 1 hit.
    Pfami PF01733. Nucleoside_tran. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016379. ENT. 1 hit.
    PRINTSi PR01130. DERENTRNSPRT.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00939. 2a57. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein."
      Williams J.B., Lanahan A.A.
      Biochem. Biophys. Res. Commun. 213:325-333(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Heart.
    2. "Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta."
      Griffiths M., Yao S.Y., Abidi F., Phillips S.E., Cass C.E., Young J.D., Baldwin S.A.
      Biochem. J. 328:739-743(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
      Tissue: Placenta.
    3. "Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line."
      Crawford C.R., Patel D.H., Naeve C., Belt J.A.
      J. Biol. Chem. 273:5288-5293(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), RESPONSE TO NBMPR.
    4. "Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells."
      Mangravite L.M., Xiao G., Giacomini K.M.
      Am. J. Physiol. 284:F902-F910(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF LEU-455 AND LEU-456.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    9. "Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2."
      Ward J.L., Leung G.P., Toan S.V., Tse C.-M.
      Arch. Biochem. Biophys. 411:19-26(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-48 AND ASN-57.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2."
      Owen R.P., Lagpacan L.L., Taylor T.R., De La Cruz M., Huang C.C., Kawamoto M., Johns S.J., Stryke D., Ferrin T.E., Giacomini K.M.
      Drug Metab. Dispos. 34:12-15(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS TYR-5; LYS-68; LEU-94 AND 184-SER--VAL-186 DELINS MET.

    Entry informationi

    Entry nameiS29A2_HUMAN
    AccessioniPrimary (citable) accession number: Q14542
    Secondary accession number(s): B3KPY7
    , O43530, Q52M84, Q96R00, Q9UPE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3