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Q14542

- S29A2_HUMAN

UniProt

Q14542 - S29A2_HUMAN

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Protein

Equilibrative nucleoside transporter 2

Gene

SLC29A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.1 Publication

Kineticsi

Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2.

  1. KM=0.2 mM for uridine2 Publications
  2. KM=0.75 mM for adenosine2 Publications

GO - Molecular functioni

  1. nucleoside transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. cell proliferation Source: ProtInc
  2. nucleobase-containing compound metabolic process Source: ProtInc
  3. nucleoside transmembrane transport Source: GOC
  4. nucleoside transport Source: UniProtKB
  5. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Protein family/group databases

TCDBi2.A.57.1.8. the equilibrative nucleoside transporter (ent) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Equilibrative nucleoside transporter 2
Alternative name(s):
36 kDa nucleolar protein HNP36
Delayed-early response protein 12
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter
Short name:
Equilibrative NBMPR-insensitive nucleoside transporter
Hydrophobic nucleolar protein, 36 kDa
Nucleoside transporter, ei-type
Solute carrier family 29 member 2
Gene namesi
Name:SLC29A2
Synonyms:DER12, ENT2, HNP36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:11004. SLC29A2.

Subcellular locationi

Basolateral cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Nucleus membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Localized at the basolateral cell membrane in polarized MDCK cells.

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. nucleolus Source: ProtInc
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi455 – 4551L → R: Reduces drastically localization at the cell surface. No effect on uptake of adenosine and thymidine. Reduces drastically localization at the cell surface and induces an significant reduction of adenosine or thymidine uptake; when associated with R-456. 1 Publication
Mutagenesisi456 – 4561L → R: Reduces drastically localization at the cell surface and induces an significant reduction of adenosine or thymidine uptake; when associated with R-455. 1 Publication

Organism-specific databases

PharmGKBiPA191.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Equilibrative nucleoside transporter 2PRO_0000209340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)1 Publication
Glycosylationi57 – 571N-linked (GlcNAc...)1 Publication
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
Modified residuei252 – 2521Phosphoserine2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ14542.
PaxDbiQ14542.
PRIDEiQ14542.

PTM databases

PhosphoSiteiQ14542.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues.2 Publications

Inductioni

By PDGF/platelet derived growth factor and fibroblast growth factor (FGF).

Gene expression databases

BgeeiQ14542.
CleanExiHS_SLC29A2.
ExpressionAtlasiQ14542. baseline and differential.
GenevestigatoriQ14542.

Organism-specific databases

HPAiHPA018168.

Interactioni

Protein-protein interaction databases

BioGridi109419. 1 interaction.
IntActiQ14542. 1 interaction.
STRINGi9606.ENSP00000350024.

Structurei

3D structure databases

ProteinModelPortaliQ14542.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence AnalysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence AnalysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence AnalysisAdd
BLAST
Transmembranei324 – 34421HelicalSequence AnalysisAdd
BLAST
Transmembranei360 – 38021HelicalSequence AnalysisAdd
BLAST
Transmembranei386 – 40621HelicalSequence AnalysisAdd
BLAST
Transmembranei432 – 45221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249415.
GeneTreeiENSGT00390000002232.
HOGENOMiHOG000007684.
HOVERGENiHBG074626.
InParanoidiQ14542.
KOiK15014.
OMAiPEKPSVF.
PhylomeDBiQ14542.
TreeFamiTF313950.

Family and domain databases

InterProiIPR002259. Eqnu_transpt.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PANTHERiPTHR10332. PTHR10332. 1 hit.
PfamiPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF016379. ENT. 1 hit.
PRINTSiPR01130. DERENTRNSPRT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00939. 2a57. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14542) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARGDAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ ARLAGAGNST
60 70 80 90 100
ARILSTNHTG PEDAFNFNNW VTLLSQLPLL LFTLLNSFLY QCVPETVRIL
110 120 130 140 150
GSLLAILLLF ALTAALVKVD MSPGPFFSIT MASVCFINSF SAVLQGSLFG
160 170 180 190 200
QLGTMPSTYS TLFLSGQGLA GIFAALAMLL SMASGVDAET SALGYFITPC
210 220 230 240 250
VGILMSIVCY LSLPHLKFAR YYLANKSSQA QAQELETKAE LLQSDENGIP
260 270 280 290 300
SSPQKVALTL DLDLEKEPES EPDEPQKPGK PSVFTVFQKI WLTALCLVLV
310 320 330 340 350
FTVTLSVFPA ITAMVTSSTS PGKWSQFFNP ICCFLLFNIM DWLGRSLTSY
360 370 380 390 400
FLWPDEDSRL LPLLVCLRFL FVPLFMLCHV PQRSRLPILF PQDAYFITFM
410 420 430 440 450
LLFAVSNGYL VSLTMCLAPR QVLPHEREVA GALMTFFLAL GLSCGASLSF

LFKALL
Length:456
Mass (Da):50,113
Last modified:October 17, 2006 - v3
Checksum:iABCBD244306708E1
GO
Isoform 2 (identifier: Q14542-2) [UniParc]FASTAAdd to Basket

Also known as: Short, HNP36

The sequence of this isoform differs from the canonical sequence as follows:
     93-202: VPETVRILGS...LGYFITPCVG → AGQGGHEPRT...PEVCPLLPGQ
     203-456: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:202
Mass (Da):22,276
Checksum:iE1E980B5CCC29586
GO
Isoform 3 (identifier: Q14542-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     290-301: IWLTALCLVLVF → SPCPSSPPSQPW
     302-456: Missing.

Show »
Length:301
Mass (Da):32,507
Checksum:i5DFD77C4226D4F15
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti200 – 2001C → Y in CAA60380. (PubMed:7639753)Curated
Sequence conflicti200 – 2001C → Y in AAC39526. (PubMed:9396714)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51D → Y.1 Publication
Corresponds to variant rs8187643 [ dbSNP | Ensembl ].
VAR_029289
Natural varianti68 – 681N → K.1 Publication
Corresponds to variant rs8187644 [ dbSNP | Ensembl ].
VAR_029290
Natural varianti94 – 941P → L.1 Publication
Corresponds to variant rs8187648 [ dbSNP | Ensembl ].
VAR_029291
Natural varianti184 – 1863SGV → M.1 Publication
VAR_036822

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei93 – 202110VPETV…TPCVG → AGQGGHEPRTLLLHHHGLRL LHQLLQCSPTGQPLRAAGHH ALHLQHPLPQRPGPGWDLCC PCHAPVHGQWRGRRDLCPGV LYHALCGHPHVHRVLPEPAS PEVCPLLPGQ in isoform 2. 1 PublicationVSP_040728Add
BLAST
Alternative sequencei203 – 456254Missing in isoform 2. 1 PublicationVSP_040729Add
BLAST
Alternative sequencei290 – 30112IWLTA…LVLVF → SPCPSSPPSQPW in isoform 3. 1 PublicationVSP_040730Add
BLAST
Alternative sequencei302 – 456155Missing in isoform 3. 1 PublicationVSP_040731Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86681 mRNA. Translation: CAA60380.1. Sequence problems.
AF029358 mRNA. Translation: AAC39526.1.
AF034102 mRNA. Translation: AAB97834.1.
AK057041 mRNA. Translation: BAG51849.1.
AF401235 mRNA. Translation: AAK92533.1.
AP001107 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74521.1.
CH471076 Genomic DNA. Translation: EAW74519.1.
BC093634 mRNA. Translation: AAH93634.1.
CCDSiCCDS8137.1. [Q14542-1]
PIRiJC4196.
RefSeqiNP_001523.2. NM_001532.2. [Q14542-1]
XP_006718591.1. XM_006718528.1. [Q14542-3]
UniGeneiHs.569017.
Hs.736345.

Genome annotation databases

EnsembliENST00000357440; ENSP00000350024; ENSG00000174669. [Q14542-1]
ENST00000540386; ENSP00000444870; ENSG00000174669. [Q14542-3]
ENST00000541567; ENSP00000442116; ENSG00000174669. [Q14542-2]
ENST00000544554; ENSP00000439456; ENSG00000174669. [Q14542-1]
ENST00000546034; ENSP00000440329; ENSG00000174669. [Q14542-1]
GeneIDi3177.
KEGGihsa:3177.
UCSCiuc001oht.3. human. [Q14542-1]

Polymorphism databases

DMDMi116242781.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86681 mRNA. Translation: CAA60380.1 . Sequence problems.
AF029358 mRNA. Translation: AAC39526.1 .
AF034102 mRNA. Translation: AAB97834.1 .
AK057041 mRNA. Translation: BAG51849.1 .
AF401235 mRNA. Translation: AAK92533.1 .
AP001107 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74521.1 .
CH471076 Genomic DNA. Translation: EAW74519.1 .
BC093634 mRNA. Translation: AAH93634.1 .
CCDSi CCDS8137.1. [Q14542-1 ]
PIRi JC4196.
RefSeqi NP_001523.2. NM_001532.2. [Q14542-1 ]
XP_006718591.1. XM_006718528.1. [Q14542-3 ]
UniGenei Hs.569017.
Hs.736345.

3D structure databases

ProteinModelPortali Q14542.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109419. 1 interaction.
IntActi Q14542. 1 interaction.
STRINGi 9606.ENSP00000350024.

Chemistry

DrugBanki DB00900. Didanosine.
DB00441. Gemcitabine.
DB01033. Mercaptopurine.
DB00943. Zalcitabine.
DB00495. Zidovudine.

Protein family/group databases

TCDBi 2.A.57.1.8. the equilibrative nucleoside transporter (ent) family.

PTM databases

PhosphoSitei Q14542.

Polymorphism databases

DMDMi 116242781.

Proteomic databases

MaxQBi Q14542.
PaxDbi Q14542.
PRIDEi Q14542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357440 ; ENSP00000350024 ; ENSG00000174669 . [Q14542-1 ]
ENST00000540386 ; ENSP00000444870 ; ENSG00000174669 . [Q14542-3 ]
ENST00000541567 ; ENSP00000442116 ; ENSG00000174669 . [Q14542-2 ]
ENST00000544554 ; ENSP00000439456 ; ENSG00000174669 . [Q14542-1 ]
ENST00000546034 ; ENSP00000440329 ; ENSG00000174669 . [Q14542-1 ]
GeneIDi 3177.
KEGGi hsa:3177.
UCSCi uc001oht.3. human. [Q14542-1 ]

Organism-specific databases

CTDi 3177.
GeneCardsi GC11M066129.
HGNCi HGNC:11004. SLC29A2.
HPAi HPA018168.
MIMi 602110. gene.
neXtProti NX_Q14542.
PharmGKBi PA191.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG249415.
GeneTreei ENSGT00390000002232.
HOGENOMi HOG000007684.
HOVERGENi HBG074626.
InParanoidi Q14542.
KOi K15014.
OMAi PEKPSVF.
PhylomeDBi Q14542.
TreeFami TF313950.

Enzyme and pathway databases

Reactomei REACT_1206. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Miscellaneous databases

GeneWikii Equilibrative_nucleoside_transporter_2.
GenomeRNAii 3177.
NextBioi 12610.
PROi Q14542.
SOURCEi Search...

Gene expression databases

Bgeei Q14542.
CleanExi HS_SLC29A2.
ExpressionAtlasi Q14542. baseline and differential.
Genevestigatori Q14542.

Family and domain databases

InterProi IPR002259. Eqnu_transpt.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
PANTHERi PTHR10332. PTHR10332. 1 hit.
Pfami PF01733. Nucleoside_tran. 1 hit.
[Graphical view ]
PIRSFi PIRSF016379. ENT. 1 hit.
PRINTSi PR01130. DERENTRNSPRT.
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00939. 2a57. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein."
    Williams J.B., Lanahan A.A.
    Biochem. Biophys. Res. Commun. 213:325-333(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Heart.
  2. "Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta."
    Griffiths M., Yao S.Y., Abidi F., Phillips S.E., Cass C.E., Young J.D., Baldwin S.A.
    Biochem. J. 328:739-743(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
    Tissue: Placenta.
  3. "Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line."
    Crawford C.R., Patel D.H., Naeve C., Belt J.A.
    J. Biol. Chem. 273:5288-5293(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), RESPONSE TO NBMPR.
  4. "Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells."
    Mangravite L.M., Xiao G., Giacomini K.M.
    Am. J. Physiol. 284:F902-F910(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF LEU-455 AND LEU-456.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  9. "Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2."
    Ward J.L., Leung G.P., Toan S.V., Tse C.-M.
    Arch. Biochem. Biophys. 411:19-26(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-48 AND ASN-57.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2."
    Owen R.P., Lagpacan L.L., Taylor T.R., De La Cruz M., Huang C.C., Kawamoto M., Johns S.J., Stryke D., Ferrin T.E., Giacomini K.M.
    Drug Metab. Dispos. 34:12-15(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS TYR-5; LYS-68; LEU-94 AND 184-SER--VAL-186 DELINS MET.

Entry informationi

Entry nameiS29A2_HUMAN
AccessioniPrimary (citable) accession number: Q14542
Secondary accession number(s): B3KPY7
, O43530, Q52M84, Q96R00, Q9UPE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3