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Protein

Keratin, type I cuticular Ha2

Gene

KRT32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei345 – 3451Stutter

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. epidermis development Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha2
Alternative name(s):
Hair keratin, type I Ha2
Keratin-32
Short name:
K32
Gene namesi
Name:KRT32
Synonyms:HHA2, HKA2, KRTHA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6449. KRT32.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Keratin, type I cuticular Ha2PRO_0000063686Add
BLAST

Proteomic databases

MaxQBiQ14532.
PaxDbiQ14532.
PeptideAtlasiQ14532.
PRIDEiQ14532.

PTM databases

PhosphoSiteiQ14532.

Expressioni

Tissue specificityi

Restricted to the hair cuticle.

Gene expression databases

BgeeiQ14532.
CleanExiHS_KRT32.
GenevestigatoriQ14532.

Organism-specific databases

HPAiHPA040330.

Interactioni

Protein-protein interaction databases

BioGridi110080. 3 interactions.
IntActiQ14532. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ14532.
SMRiQ14532. Positions 150-245, 314-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9696HeadAdd
BLAST
Regioni97 – 403307RodAdd
BLAST
Regioni97 – 13135Coil 1AAdd
BLAST
Regioni132 – 14211Linker 1Add
BLAST
Regioni143 – 243101Coil 1BAdd
BLAST
Regioni244 – 25916Linker 12Add
BLAST
Regioni260 – 403144Coil 2Add
BLAST
Regioni404 – 44845TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG149251.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ14532.
KOiK07604.
OMAiEEWFNMQ.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ14532.
TreeFamiTF332742.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14532-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSCCVTNN LQASLKSCPR PASVCSSGVN CRPELCLGYV CQPMACLPSV
60 70 80 90 100
CLPTTFRPAS CLSKTYLSSS CQAASGISGS MGPGSWYSEG AFNGNEKETM
110 120 130 140 150
QFLNDRLASY LTRVRQLEQE NAELESRIQE ASHSQVLTMT PDYQSHFRTI
160 170 180 190 200
EELQQKILCT KAENARMVVN IDNAKLAADD FRAKYEAELA MRQLVEADIN
210 220 230 240 250
GLRRILDDLT LCKADLEAQV ESLKEELMCL KKNHEEEVGS LRCQLGDRLN
260 270 280 290 300
IEVDAAPPVD LTRVLEEMRC QYEAMVEANR RDVEEWFNMQ MEELNQQVAT
310 320 330 340 350
SSEQLQNYQS DIIDLRRTVN TLEIELQAQH SLRDSLENTL TESEARYSSQ
360 370 380 390 400
LAQMQCMITN VEAQLAEIRA DLERQNQEYQ VLLDVRARLE GEINTYRSLL
410 420 430 440
ENEDCKLPCN PCSTPSCTTC VPSPCVPRTV CVPRTVGMPC SPCPQGRY
Length:448
Mass (Da):50,343
Last modified:November 1, 2010 - v3
Checksum:iF223A4F828B7EACB
GO

Sequence cautioni

The sequence CAA57179.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521E → Q in CAA62284 (PubMed:8823373).Curated
Sequence conflicti152 – 1521E → Q in CAA57179 (PubMed:7556444).Curated
Sequence conflicti371 – 3711D → E in CAA62284 (PubMed:8823373).Curated
Sequence conflicti371 – 3711D → E in CAA57179 (PubMed:7556444).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721Q → R.
Corresponds to variant rs3744786 [ dbSNP | Ensembl ].
VAR_056011
Natural varianti89 – 891E → K.1 Publication
VAR_069391
Natural varianti151 – 1511E → D.2 Publications
Corresponds to variant rs1111168 [ dbSNP | Ensembl ].
VAR_060237
Natural varianti171 – 1711I → T.
Corresponds to variant rs2071560 [ dbSNP | Ensembl ].
VAR_056012
Natural varianti222 – 2221S → Y.
Corresponds to variant rs2071561 [ dbSNP | Ensembl ].
VAR_056013
Natural varianti280 – 2801R → H.
Corresponds to variant rs72830046 [ dbSNP | Ensembl ].
VAR_060238
Natural varianti339 – 3391T → M.
Corresponds to variant rs16966929 [ dbSNP | Ensembl ].
VAR_056014
Natural varianti395 – 3951T → M.
Corresponds to variant rs2071563 [ dbSNP | Ensembl ].
VAR_056015
Natural varianti402 – 4021N → S.2 Publications
Corresponds to variant rs2604955 [ dbSNP | Ensembl ].
VAR_060239
Natural varianti427 – 4271P → T.2 Publications
Corresponds to variant rs2604953 [ dbSNP | Ensembl ].
VAR_060240
Natural varianti428 – 4281R → C.
Corresponds to variant rs9893787 [ dbSNP | Ensembl ].
VAR_056016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90761 Genomic DNA. Translation: CAA62284.1.
AC019349 Genomic DNA. No translation available.
X81419 mRNA. Translation: CAA57179.1. Different initiation.
CCDSiCCDS11393.1.
RefSeqiNP_002269.3. NM_002278.3.
UniGeneiHs.41752.

Genome annotation databases

EnsembliENST00000225899; ENSP00000225899; ENSG00000108759.
GeneIDi3882.
KEGGihsa:3882.
UCSCiuc002hwr.3. human.

Polymorphism databases

DMDMi311033432.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90761 Genomic DNA. Translation: CAA62284.1.
AC019349 Genomic DNA. No translation available.
X81419 mRNA. Translation: CAA57179.1. Different initiation.
CCDSiCCDS11393.1.
RefSeqiNP_002269.3. NM_002278.3.
UniGeneiHs.41752.

3D structure databases

ProteinModelPortaliQ14532.
SMRiQ14532. Positions 150-245, 314-401.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110080. 3 interactions.
IntActiQ14532. 1 interaction.

PTM databases

PhosphoSiteiQ14532.

Polymorphism databases

DMDMi311033432.

Proteomic databases

MaxQBiQ14532.
PaxDbiQ14532.
PeptideAtlasiQ14532.
PRIDEiQ14532.

Protocols and materials databases

DNASUi3882.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225899; ENSP00000225899; ENSG00000108759.
GeneIDi3882.
KEGGihsa:3882.
UCSCiuc002hwr.3. human.

Organism-specific databases

CTDi3882.
GeneCardsiGC17M039615.
H-InvDBHIX0202544.
HGNCiHGNC:6449. KRT32.
HPAiHPA040330.
MIMi602760. gene.
neXtProtiNX_Q14532.
PharmGKBiPA30238.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG149251.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ14532.
KOiK07604.
OMAiEEWFNMQ.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ14532.
TreeFamiTF332742.

Miscellaneous databases

GeneWikiiKRT32.
GenomeRNAii3882.
NextBioi15239.
PROiQ14532.
SOURCEiSearch...

Gene expression databases

BgeeiQ14532.
CleanExiHS_KRT32.
GenevestigatoriQ14532.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5."
    Rogers M.A., Winter H., Langbein L., Krieg T., Schweizer J.
    J. Invest. Dermatol. 107:633-638(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASP-151; SER-402 AND THR-427.
    Tissue: Hair.
  2. Rogers M.A.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO N-TERMINUS.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Sequence data and chromosomal localization of human type I and type II hair keratin genes."
    Rogers M.A., Nischt R., Korge B., Krieg T., Fink T.M., Lichter P., Winter H., Schweizer J.
    Exp. Cell Res. 220:357-362(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-448, VARIANTS ASP-151; SER-402 AND THR-427.
    Tissue: Hair.
  5. Cited for: VARIANT LYS-89.

Entry informationi

Entry nameiK1H2_HUMAN
AccessioniPrimary (citable) accession number: Q14532
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1998
Last sequence update: November 1, 2010
Last modified: January 6, 2015
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.