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Protein

Keratin, type I cuticular Ha2

Gene

KRT32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei345Stutter1

GO - Molecular functioni

GO - Biological processi

  • cornification Source: Reactome
  • epidermis development Source: ProtInc
  • keratinization Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha2
Alternative name(s):
Hair keratin, type I Ha2
Keratin-32
Short name:
K32
Gene namesi
Name:KRT32
Synonyms:HHA2, HKA2, KRTHA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6449. KRT32.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • intermediate filament Source: UniProtKB-KW

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi3882.
OpenTargetsiENSG00000108759.
PharmGKBiPA30238.

Polymorphism and mutation databases

BioMutaiKRT32.
DMDMi311033432.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636861 – 448Keratin, type I cuticular Ha2Add BLAST448

Proteomic databases

PaxDbiQ14532.
PeptideAtlasiQ14532.
PRIDEiQ14532.

PTM databases

iPTMnetiQ14532.
PhosphoSitePlusiQ14532.

Expressioni

Tissue specificityi

Restricted to the hair cuticle.

Gene expression databases

BgeeiENSG00000108759.
CleanExiHS_KRT32.
GenevisibleiQ14532. HS.

Interactioni

Protein-protein interaction databases

BioGridi110080. 5 interactors.
IntActiQ14532. 10 interactors.
STRINGi9606.ENSP00000225899.

Structurei

3D structure databases

ProteinModelPortaliQ14532.
SMRiQ14532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 96HeadAdd BLAST96
Regioni97 – 403RodAdd BLAST307
Regioni97 – 131Coil 1AAdd BLAST35
Regioni132 – 142Linker 1Add BLAST11
Regioni143 – 243Coil 1BAdd BLAST101
Regioni244 – 259Linker 12Add BLAST16
Regioni260 – 403Coil 2Add BLAST144
Regioni404 – 448TailAdd BLAST45

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJCJ. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ14532.
KOiK07604.
OMAiNCRPELC.
OrthoDBiEOG091G087I.
PhylomeDBiQ14532.
TreeFamiTF332742.

Family and domain databases

InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_.
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PRINTSiPR01248. TYPE1KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS00226. IF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14532-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSCCVTNN LQASLKSCPR PASVCSSGVN CRPELCLGYV CQPMACLPSV
60 70 80 90 100
CLPTTFRPAS CLSKTYLSSS CQAASGISGS MGPGSWYSEG AFNGNEKETM
110 120 130 140 150
QFLNDRLASY LTRVRQLEQE NAELESRIQE ASHSQVLTMT PDYQSHFRTI
160 170 180 190 200
EELQQKILCT KAENARMVVN IDNAKLAADD FRAKYEAELA MRQLVEADIN
210 220 230 240 250
GLRRILDDLT LCKADLEAQV ESLKEELMCL KKNHEEEVGS LRCQLGDRLN
260 270 280 290 300
IEVDAAPPVD LTRVLEEMRC QYEAMVEANR RDVEEWFNMQ MEELNQQVAT
310 320 330 340 350
SSEQLQNYQS DIIDLRRTVN TLEIELQAQH SLRDSLENTL TESEARYSSQ
360 370 380 390 400
LAQMQCMITN VEAQLAEIRA DLERQNQEYQ VLLDVRARLE GEINTYRSLL
410 420 430 440
ENEDCKLPCN PCSTPSCTTC VPSPCVPRTV CVPRTVGMPC SPCPQGRY
Length:448
Mass (Da):50,343
Last modified:November 2, 2010 - v3
Checksum:iF223A4F828B7EACB
GO

Sequence cautioni

The sequence CAA57179 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152E → Q in CAA62284 (PubMed:8823373).Curated1
Sequence conflicti152E → Q in CAA57179 (PubMed:7556444).Curated1
Sequence conflicti371D → E in CAA62284 (PubMed:8823373).Curated1
Sequence conflicti371D → E in CAA57179 (PubMed:7556444).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05601172Q → R. Corresponds to variant dbSNP:rs3744786Ensembl.1
Natural variantiVAR_06939189E → K1 PublicationCorresponds to variant dbSNP:rs565998951Ensembl.1
Natural variantiVAR_060237151E → D2 PublicationsCorresponds to variant dbSNP:rs1111168Ensembl.1
Natural variantiVAR_056012171I → T. Corresponds to variant dbSNP:rs2071560Ensembl.1
Natural variantiVAR_056013222S → Y. Corresponds to variant dbSNP:rs2071561Ensembl.1
Natural variantiVAR_060238280R → H. Corresponds to variant dbSNP:rs72830046Ensembl.1
Natural variantiVAR_056014339T → M. Corresponds to variant dbSNP:rs16966929Ensembl.1
Natural variantiVAR_056015395T → M. Corresponds to variant dbSNP:rs2071563Ensembl.1
Natural variantiVAR_060239402N → S2 PublicationsCorresponds to variant dbSNP:rs2604955Ensembl.1
Natural variantiVAR_060240427P → T2 PublicationsCorresponds to variant dbSNP:rs2604953Ensembl.1
Natural variantiVAR_056016428R → C. Corresponds to variant dbSNP:rs9893787Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90761 Genomic DNA. Translation: CAA62284.1.
AC019349 Genomic DNA. No translation available.
X81419 mRNA. Translation: CAA57179.1. Different initiation.
CCDSiCCDS11393.1.
RefSeqiNP_002269.3. NM_002278.3.
UniGeneiHs.41752.

Genome annotation databases

EnsembliENST00000225899; ENSP00000225899; ENSG00000108759.
GeneIDi3882.
KEGGihsa:3882.
UCSCiuc002hwr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90761 Genomic DNA. Translation: CAA62284.1.
AC019349 Genomic DNA. No translation available.
X81419 mRNA. Translation: CAA57179.1. Different initiation.
CCDSiCCDS11393.1.
RefSeqiNP_002269.3. NM_002278.3.
UniGeneiHs.41752.

3D structure databases

ProteinModelPortaliQ14532.
SMRiQ14532.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110080. 5 interactors.
IntActiQ14532. 10 interactors.
STRINGi9606.ENSP00000225899.

PTM databases

iPTMnetiQ14532.
PhosphoSitePlusiQ14532.

Polymorphism and mutation databases

BioMutaiKRT32.
DMDMi311033432.

Proteomic databases

PaxDbiQ14532.
PeptideAtlasiQ14532.
PRIDEiQ14532.

Protocols and materials databases

DNASUi3882.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225899; ENSP00000225899; ENSG00000108759.
GeneIDi3882.
KEGGihsa:3882.
UCSCiuc002hwr.4. human.

Organism-specific databases

CTDi3882.
DisGeNETi3882.
GeneCardsiKRT32.
H-InvDBHIX0202544.
HGNCiHGNC:6449. KRT32.
MIMi602760. gene.
neXtProtiNX_Q14532.
OpenTargetsiENSG00000108759.
PharmGKBiPA30238.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJCJ. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ14532.
KOiK07604.
OMAiNCRPELC.
OrthoDBiEOG091G087I.
PhylomeDBiQ14532.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GeneWikiiKRT32.
GenomeRNAii3882.
PROiQ14532.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108759.
CleanExiHS_KRT32.
GenevisibleiQ14532. HS.

Family and domain databases

InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_.
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PRINTSiPR01248. TYPE1KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS00226. IF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiK1H2_HUMAN
AccessioniPrimary (citable) accession number: Q14532
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 2, 2010
Last modified: March 15, 2017
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.