Reviewed, UniProtKB/Swiss-Prot Q14532 (K1H2_HUMAN)

Names and origin

Protein names

Recommended name:
    Keratin, type I cuticular Ha2
Alternative name(s):
    Hair keratin, type I Ha2
    Keratin-32
      Short name=K32

Gene names

Name:	KRT32
Synonyms:	HHA2, HKA2, KRTHA2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Restricted to the hair cuticle.
Miscellaneous	There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	epidermis development Ref.1 Traceable author statement. Source: ProtInc
Cellular component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC20	Q12834	1	EBI-1044146,EBI-367462

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Keratin, type I cuticular Ha2		PRO_0000063686
Regions
	Region	1 – 96	96	Head
	Region	97 – 403	307	Rod
	Region	97 – 131	35	Coil 1A
	Region	132 – 142	11	Linker 1
	Region	143 – 243	101	Coil 1B
	Region	244 – 259	16	Linker 12
	Region	260 – 403	144	Coil 2
	Region	404 – 448	45	Tail
Sites
	Site	345	1	Stutter
Natural variations
	Natural variant	72	1	Q → R: dbSNP rs3744786.		VAR_056011
	Natural variant	171	1	I → T: dbSNP rs2071560.		VAR_056012
	Natural variant	222	1	S → Y: dbSNP rs2071561.		VAR_056013
	Natural variant	339	1	T → M: dbSNP rs16966929.		VAR_056014
	Natural variant	395	1	T → M: dbSNP rs2071563.		VAR_056015
	Natural variant	428	1	R → C: dbSNP rs9893787.		VAR_056016

Sequences

	Sequence		Length	Mass (Da)
	Q14532-1 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 35B42ADD2397D128	FASTA	448	50,319
	10 20 30 40 50 60 MTSSCCVTNN LQASLKSCPR PASVCSSGVN CRPELCLGYV CQPMACLPSV CLPTTFRPAS 70 80 90 100 110 120 CLSKTYLSSS CQAASGISGS MGPGSWYSEG AFNGNEKETM QFLNDRLASY LTRVRQLEQE 130 140 150 160 170 180 NAELESRIQE ASHSQVLTMT PDYQSHFRTI DQLQQKILCT KAENARMVVN IDNAKLAADD 190 200 210 220 230 240 FRAKYEAELA MRQLVEADIN GLRRILDDLT LCKADLEAQV ESLKEELMCL KKNHEEEVGS 250 260 270 280 290 300 LRCQLGDRLN IEVDAAPPVD LTRVLEEMRC QYEAMVEANR RDVEEWFNMQ MEELNQQVAT 310 320 330 340 350 360 SSEQLQNYQS DIIDLRRTVN TLEIELQAQH SLRDSLENTL TESEARYSSQ LAQMQCMITN 370 380 390 400 410 420 VEAQLAEIRA ELERQNQEYQ VLLDVRARLE GEINTYRSLL ESEDCKLPCN PCSTPSCTTC 430 440 VPSPCVTRTV CVPRTVGMPC SPCPQGRY

References

[1]	"Sequence data and chromosomal localization of human type I and type II hair keratin genes." Rogers M.A., Nischt R., Korge B., Krieg T., Fink T.M., Lichter P., Winter H., Schweizer J. Exp. Cell Res. 220:357-362(1995) [PubMed: 7556444] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hair.
[2]	"Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5." Rogers M.A., Winter H., Langbein L., Krieg T., Schweizer J. J. Invest. Dermatol. 107:633-638(1996) [PubMed: 8823373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Hair.
[3]	Rogers M.A. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO N-TERMINUS.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X81419 mRNA. Translation: CAA57179.1. Different initiation. X90761 Genomic DNA. Translation: CAA62284.1.
IPI	IPI00291540.
RefSeq	NP_002269.3.
UniGene	Hs.41752
3D structure databases
HSSP	HSSP built from PDB template 1GK7 based on UniProtKB P08670.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14532. 3 interactions.
PTM databases
PhosphoSite	Q14532.
Proteomic databases
PeptideAtlas	Q14532.
PRIDE	Q14532.
Genome annotation databases
Ensembl	ENSG00000108759. Homo sapiens. [Contig view]
GeneID	3882.
KEGG	hsa:3882.
UCSC	uc002hwr.1. human.
Organism-specific databases
GeneCards	GC17M036870.
H-InvDB	HIX0039247.
HGNC	HGNC:6449. KRT32.
MIM	602760. gene.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q14532.
HOVERGEN	Q14532.
Gene expression databases
ArrayExpress	Q14532.
Bgee	Q14532.
CleanEx	HS_KRT32.
GermOnline	ENSG00000108759. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. IF. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	15239.
SOURCE	Search...

Entry information

Entry name

K1H2_HUMAN

Accession

Primary (citable) accession number: Q14532

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1999
Last modified:	July 7, 2009
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)