ID   KT33B_HUMAN             Reviewed;         404 AA.
AC   Q14525; O76010;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 3.
DT   27-MAR-2024, entry version 184.
DE   RecName: Full=Keratin, type I cuticular Ha3-II;
DE   AltName: Full=Hair keratin, type I Ha3-II;
DE   AltName: Full=Keratin-33B;
DE            Short=K33B;
GN   Name=KRT33B; Synonyms=HHA3-II, HKA3B, KRTHA3B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9756910; DOI=10.1074/jbc.273.41.26683;
RA   Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.;
RT   "Characterization of a 190-kilobase pair domain of human type I hair
RT   keratin genes.";
RL   J. Biol. Chem. 273:26683-26691(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 44-404.
RC   TISSUE=Hair;
RX   PubMed=7565656; DOI=10.1007/bf00990548;
RA   Rogers M.A., Schweizer J., Kreig T., Winter H.;
RT   "A novel human type I hair keratin gene: evidence for two keratin hHa3
RT   isoforms.";
RL   Mol. Biol. Rep. 20:155-161(1994).
RN   [4]
RP   SEQUENCE REVISION.
RA   Rogers M.A.;
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- INTERACTION:
CC       Q14525; Q9NYB9: ABI2; NbExp=3; IntAct=EBI-1049638, EBI-743598;
CC       Q14525; Q13155: AIMP2; NbExp=3; IntAct=EBI-1049638, EBI-745226;
CC       Q14525; P29972: AQP1; NbExp=3; IntAct=EBI-1049638, EBI-745213;
CC       Q14525; P53367: ARFIP1; NbExp=3; IntAct=EBI-1049638, EBI-2808808;
CC       Q14525; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-1049638, EBI-12006308;
CC       Q14525; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-1049638, EBI-747505;
CC       Q14525; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-1049638, EBI-1104933;
CC       Q14525; P48643: CCT5; NbExp=3; IntAct=EBI-1049638, EBI-355710;
CC       Q14525; P28329-3: CHAT; NbExp=3; IntAct=EBI-1049638, EBI-25837549;
CC       Q14525; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-1049638, EBI-741032;
CC       Q14525; P10606: COX5B; NbExp=3; IntAct=EBI-1049638, EBI-1053725;
CC       Q14525; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-1049638, EBI-3867333;
CC       Q14525; P17661: DES; NbExp=3; IntAct=EBI-1049638, EBI-1055572;
CC       Q14525; G5E9A7: DMWD; NbExp=3; IntAct=EBI-1049638, EBI-10976677;
CC       Q14525; O60941-5: DTNB; NbExp=3; IntAct=EBI-1049638, EBI-11984733;
CC       Q14525; Q9H596: DUSP21; NbExp=3; IntAct=EBI-1049638, EBI-7357329;
CC       Q14525; P48023: FASLG; NbExp=3; IntAct=EBI-1049638, EBI-495538;
CC       Q14525; P22607: FGFR3; NbExp=3; IntAct=EBI-1049638, EBI-348399;
CC       Q14525; O43559: FRS3; NbExp=3; IntAct=EBI-1049638, EBI-725515;
CC       Q14525; P14136: GFAP; NbExp=3; IntAct=EBI-1049638, EBI-744302;
CC       Q14525; Q8N9W4-2: GOLGA6L2; NbExp=3; IntAct=EBI-1049638, EBI-10268729;
CC       Q14525; P06396: GSN; NbExp=3; IntAct=EBI-1049638, EBI-351506;
CC       Q14525; P09211: GSTP1; NbExp=3; IntAct=EBI-1049638, EBI-353467;
CC       Q14525; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-1049638, EBI-11956675;
CC       Q14525; P56524-2: HDAC4; NbExp=3; IntAct=EBI-1049638, EBI-11953488;
CC       Q14525; O14964: HGS; NbExp=6; IntAct=EBI-1049638, EBI-740220;
CC       Q14525; P49639: HOXA1; NbExp=3; IntAct=EBI-1049638, EBI-740785;
CC       Q14525; P01112: HRAS; NbExp=3; IntAct=EBI-1049638, EBI-350145;
CC       Q14525; O43464: HTRA2; NbExp=3; IntAct=EBI-1049638, EBI-517086;
CC       Q14525; P42858: HTT; NbExp=12; IntAct=EBI-1049638, EBI-466029;
CC       Q14525; Q0VD86: INCA1; NbExp=3; IntAct=EBI-1049638, EBI-6509505;
CC       Q14525; O60341: KDM1A; NbExp=4; IntAct=EBI-1049638, EBI-710124;
CC       Q14525; O60333-2: KIF1B; NbExp=3; IntAct=EBI-1049638, EBI-10975473;
CC       Q14525; Q9NSK0: KLC4; NbExp=3; IntAct=EBI-1049638, EBI-949319;
CC       Q14525; O14901: KLF11; NbExp=3; IntAct=EBI-1049638, EBI-948266;
CC       Q14525; P04264: KRT1; NbExp=7; IntAct=EBI-1049638, EBI-298429;
CC       Q14525; P35908: KRT2; NbExp=3; IntAct=EBI-1049638, EBI-1247312;
CC       Q14525; P12035: KRT3; NbExp=3; IntAct=EBI-1049638, EBI-2430095;
CC       Q14525; P19013: KRT4; NbExp=7; IntAct=EBI-1049638, EBI-2371606;
CC       Q14525; P04259: KRT6B; NbExp=5; IntAct=EBI-1049638, EBI-740907;
CC       Q14525; P48668: KRT6C; NbExp=3; IntAct=EBI-1049638, EBI-2564105;
CC       Q14525; Q3SY84: KRT71; NbExp=3; IntAct=EBI-1049638, EBI-2952676;
CC       Q14525; Q14CN4: KRT72; NbExp=3; IntAct=EBI-1049638, EBI-1221280;
CC       Q14525; O95678: KRT75; NbExp=3; IntAct=EBI-1049638, EBI-2949715;
CC       Q14525; Q8N1N4: KRT78; NbExp=5; IntAct=EBI-1049638, EBI-1056564;
CC       Q14525; Q5XKE5: KRT79; NbExp=8; IntAct=EBI-1049638, EBI-2514135;
CC       Q14525; P05787: KRT8; NbExp=5; IntAct=EBI-1049638, EBI-297852;
CC       Q14525; Q6KB66-2: KRT80; NbExp=3; IntAct=EBI-1049638, EBI-11999246;
CC       Q14525; Q9NSB4: KRT82; NbExp=3; IntAct=EBI-1049638, EBI-1045341;
CC       Q14525; P78385: KRT83; NbExp=3; IntAct=EBI-1049638, EBI-10221390;
CC       Q14525; P78386: KRT85; NbExp=3; IntAct=EBI-1049638, EBI-1049371;
CC       Q14525; O43790: KRT86; NbExp=3; IntAct=EBI-1049638, EBI-9996498;
CC       Q14525; P61968: LMO4; NbExp=3; IntAct=EBI-1049638, EBI-2798728;
CC       Q14525; P00540: MOS; NbExp=3; IntAct=EBI-1049638, EBI-1757866;
CC       Q14525; P19404: NDUFV2; NbExp=3; IntAct=EBI-1049638, EBI-713665;
CC       Q14525; P07196: NEFL; NbExp=3; IntAct=EBI-1049638, EBI-475646;
CC       Q14525; P35240: NF2; NbExp=3; IntAct=EBI-1049638, EBI-1014472;
CC       Q14525; P29474: NOS3; NbExp=3; IntAct=EBI-1049638, EBI-1391623;
CC       Q14525; Q7Z3B4: NUP54; NbExp=3; IntAct=EBI-1049638, EBI-741048;
CC       Q14525; Q9BVL2: NUP58; NbExp=6; IntAct=EBI-1049638, EBI-2811583;
CC       Q14525; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-1049638, EBI-11022007;
CC       Q14525; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-1049638, EBI-2557469;
CC       Q14525; P41219: PRPH; NbExp=3; IntAct=EBI-1049638, EBI-752074;
CC       Q14525; P60891: PRPS1; NbExp=3; IntAct=EBI-1049638, EBI-749195;
CC       Q14525; Q9ULW5: RAB26; NbExp=3; IntAct=EBI-1049638, EBI-958239;
CC       Q14525; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-1049638, EBI-744023;
CC       Q14525; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-1049638, EBI-396669;
CC       Q14525; Q14D33: RTP5; NbExp=3; IntAct=EBI-1049638, EBI-10217913;
CC       Q14525; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-1049638, EBI-11984663;
CC       Q14525; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-1049638, EBI-748391;
CC       Q14525; Q96ES7: SGF29; NbExp=3; IntAct=EBI-1049638, EBI-743117;
CC       Q14525; Q92529: SHC3; NbExp=3; IntAct=EBI-1049638, EBI-79084;
CC       Q14525; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-1049638, EBI-5235340;
CC       Q14525; O75604: USP2; NbExp=3; IntAct=EBI-1049638, EBI-743272;
CC       Q14525; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-1049638, EBI-2559305;
CC       Q14525; O76024: WFS1; NbExp=3; IntAct=EBI-1049638, EBI-720609;
CC       Q14525; Q9Y649; NbExp=3; IntAct=EBI-1049638, EBI-25900580;
CC   -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I
CC       (acidic) and II (neutral to basic).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; Y16789; CAA76385.1; -; Genomic_DNA.
DR   EMBL; BC009971; AAH09971.1; -; mRNA.
DR   EMBL; X82634; CAA57956.1; -; mRNA.
DR   CCDS; CCDS11389.1; -.
DR   PIR; I37459; I37459.
DR   RefSeq; NP_002270.1; NM_002279.4.
DR   AlphaFoldDB; Q14525; -.
DR   SMR; Q14525; -.
DR   BioGRID; 110082; 91.
DR   IntAct; Q14525; 89.
DR   MINT; Q14525; -.
DR   STRING; 9606.ENSP00000251646; -.
DR   GlyGen; Q14525; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q14525; -.
DR   PhosphoSitePlus; Q14525; -.
DR   SwissPalm; Q14525; -.
DR   BioMuta; KRT33B; -.
DR   DMDM; 6686299; -.
DR   jPOST; Q14525; -.
DR   MassIVE; Q14525; -.
DR   PaxDb; 9606-ENSP00000251646; -.
DR   PeptideAtlas; Q14525; -.
DR   PRIDE; Q14525; -.
DR   ProteomicsDB; 60027; -.
DR   Antibodypedia; 28829; 178 antibodies from 28 providers.
DR   DNASU; 3884; -.
DR   Ensembl; ENST00000251646.8; ENSP00000251646.3; ENSG00000131738.11.
DR   Ensembl; ENST00000570596.1; ENSP00000459509.1; ENSG00000263012.1.
DR   Ensembl; ENST00000709591.1; ENSP00000517783.1; ENSG00000292028.1.
DR   GeneID; 3884; -.
DR   KEGG; hsa:3884; -.
DR   MANE-Select; ENST00000251646.8; ENSP00000251646.3; NM_002279.5; NP_002270.1.
DR   UCSC; uc002hwl.4; human.
DR   AGR; HGNC:6451; -.
DR   CTD; 3884; -.
DR   GeneCards; KRT33B; -.
DR   HGNC; HGNC:6451; KRT33B.
DR   HPA; ENSG00000131738; Tissue enriched (skin).
DR   MIM; 602762; gene.
DR   neXtProt; NX_Q14525; -.
DR   OpenTargets; ENSG00000131738; -.
DR   PharmGKB; PA30240; -.
DR   VEuPathDB; HostDB:ENSG00000131738; -.
DR   eggNOG; ENOG502SNBF; Eukaryota.
DR   GeneTree; ENSGT00940000163841; -.
DR   InParanoid; Q14525; -.
DR   OMA; QHNLVYS; -.
DR   OrthoDB; 4640531at2759; -.
DR   PhylomeDB; Q14525; -.
DR   TreeFam; TF332742; -.
DR   PathwayCommons; Q14525; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR   SignaLink; Q14525; -.
DR   BioGRID-ORCS; 3884; 8 hits in 1145 CRISPR screens.
DR   ChiTaRS; KRT33B; human.
DR   GeneWiki; KRT33B; -.
DR   GenomeRNAi; 3884; -.
DR   Pharos; Q14525; Tbio.
DR   PRO; PR:Q14525; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q14525; Protein.
DR   Bgee; ENSG00000131738; Expressed in prefrontal cortex and 46 other cell types or tissues.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR   GO; GO:0042633; P:hair cycle; IDA:UniProtKB.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR   PANTHER; PTHR23239:SF99; KERATIN, TYPE I CUTICULAR HA3-II; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
DR   Genevisible; Q14525; HS.
PE   1: Evidence at protein level;
KW   Coiled coil; Intermediate filament; Keratin; Reference proteome.
FT   CHAIN           1..404
FT                   /note="Keratin, type I cuticular Ha3-II"
FT                   /id="PRO_0000063689"
FT   DOMAIN          56..367
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..56
FT                   /note="Head"
FT   REGION          57..91
FT                   /note="Coil 1A"
FT   REGION          92..102
FT                   /note="Linker 1"
FT   REGION          103..203
FT                   /note="Coil 1B"
FT   REGION          204..219
FT                   /note="Linker 12"
FT   REGION          220..363
FT                   /note="Coil 2"
FT   REGION          364..404
FT                   /note="Tail"
FT   SITE            305
FT                   /note="Stutter"
FT   CONFLICT        76..77
FT                   /note="QL -> HV (in Ref. 3; CAA57956)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   404 AA;  46214 MW;  54B5F7BEDC34619F CRC64;
     MPYNFCLPSL SCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG SFNGSEKETM
     QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC PSYQSYFKTI EELQQKILCS
     KSENARLVVQ IDNAKLAADD FRTKYQTEQS LRQLVESDIN SLRRILDELT LCRSDLEAQM
     ESLKEELLSL KQNHEQEVNT LRCQLGDRLN VEVDAAPAVD LNQVLNETRN QYEALVETNR
     REVEQWFATQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRYSLENTL
     TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL
     ESEDCKLPSN PCATTNACEK PIGSCVTNPC GPRSRCGPCN TFGY
//