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Protein

Keratin, type I cuticular Ha3-II

Gene

KRT33B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei305 – 3051Stutter

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. aging Source: UniProtKB
  2. hair cycle Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-II
Alternative name(s):
Hair keratin, type I Ha3-II
Keratin-33B
Short name:
K33B
Gene namesi
Name:KRT33B
Synonyms:HHA3-II, HKA3B, KRTHA3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 17, Unplaced

Organism-specific databases

HGNCiHGNC:6451. KRT33B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProtKB
  3. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30240.

Polymorphism and mutation databases

BioMutaiKRT33B.
DMDMi6686299.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Keratin, type I cuticular Ha3-IIPRO_0000063689Add
BLAST

Proteomic databases

MaxQBiQ14525.
PRIDEiQ14525.

PTM databases

PhosphoSiteiQ14525.

Expressioni

Gene expression databases

BgeeiQ14525.
CleanExiHS_KRT33B.
GenevestigatoriQ14525.

Organism-specific databases

HPAiHPA055194.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-1049638,EBI-743598
AQP1P299723EBI-1049638,EBI-745213
KRT4P190133EBI-1049638,EBI-2371606
KRT79Q5XKE53EBI-1049638,EBI-2514135

Protein-protein interaction databases

BioGridi110082. 18 interactions.
IntActiQ14525. 13 interactions.
MINTiMINT-8417685.
STRINGi9606.ENSP00000251646.

Structurei

3D structure databases

ProteinModelPortaliQ14525.
SMRiQ14525. Positions 106-204, 274-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5656HeadAdd
BLAST
Regioni57 – 363307RodAdd
BLAST
Regioni57 – 9135Coil 1AAdd
BLAST
Regioni92 – 10211Linker 1Add
BLAST
Regioni103 – 203101Coil 1BAdd
BLAST
Regioni204 – 21916Linker 12Add
BLAST
Regioni220 – 363144Coil 2Add
BLAST
Regioni364 – 40441TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ14525.
KOiK07604.
OMAiNKAENAR.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ14525.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNFCLPSL SCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG
60 70 80 90 100
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC
110 120 130 140 150
PSYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLAADD FRTKYQTEQS
160 170 180 190 200
LRQLVESDIN SLRRILDELT LCRSDLEAQM ESLKEELLSL KQNHEQEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPAVD LNQVLNETRN QYEALVETNR REVEQWFATQ
260 270 280 290 300
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRYSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE
360 370 380 390 400
CEINTYRSLL ESEDCKLPSN PCATTNACEK PIGSCVTNPC GPRSRCGPCN

TFGY
Length:404
Mass (Da):46,214
Last modified:May 30, 2000 - v3
Checksum:i54B5F7BEDC34619F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti76 – 772QL → HV in CAA57956 (PubMed:7565656).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16789 Genomic DNA. Translation: CAA76385.1.
BC009971 mRNA. Translation: AAH09971.1.
X82634 mRNA. Translation: CAA57956.1.
CCDSiCCDS11389.1.
PIRiI37459.
RefSeqiNP_002270.1. NM_002279.4.
UniGeneiHs.32950.

Genome annotation databases

EnsembliENST00000251646; ENSP00000251646; ENSG00000131738.
ENST00000570596; ENSP00000459509; ENSG00000263012.
GeneIDi3884.
KEGGihsa:3884.
UCSCiuc002hwl.4. human.

Polymorphism and mutation databases

BioMutaiKRT33B.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16789 Genomic DNA. Translation: CAA76385.1.
BC009971 mRNA. Translation: AAH09971.1.
X82634 mRNA. Translation: CAA57956.1.
CCDSiCCDS11389.1.
PIRiI37459.
RefSeqiNP_002270.1. NM_002279.4.
UniGeneiHs.32950.

3D structure databases

ProteinModelPortaliQ14525.
SMRiQ14525. Positions 106-204, 274-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110082. 18 interactions.
IntActiQ14525. 13 interactions.
MINTiMINT-8417685.
STRINGi9606.ENSP00000251646.

PTM databases

PhosphoSiteiQ14525.

Polymorphism and mutation databases

BioMutaiKRT33B.
DMDMi6686299.

Proteomic databases

MaxQBiQ14525.
PRIDEiQ14525.

Protocols and materials databases

DNASUi3884.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251646; ENSP00000251646; ENSG00000131738.
ENST00000570596; ENSP00000459509; ENSG00000263012.
GeneIDi3884.
KEGGihsa:3884.
UCSCiuc002hwl.4. human.

Organism-specific databases

CTDi3884.
GeneCardsiGC17M039519.
HGNCiHGNC:6451. KRT33B.
HPAiHPA055194.
MIMi602762. gene.
neXtProtiNX_Q14525.
PharmGKBiPA30240.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ14525.
KOiK07604.
OMAiNKAENAR.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ14525.
TreeFamiTF332742.

Miscellaneous databases

GeneWikiiKRT33B.
GenomeRNAii3884.
NextBioi15247.
PROiQ14525.
SOURCEiSearch...

Gene expression databases

BgeeiQ14525.
CleanExiHS_KRT33B.
GenevestigatoriQ14525.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
    Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
    J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms."
    Rogers M.A., Schweizer J., Kreig T., Winter H.
    Mol. Biol. Rep. 20:155-161(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-404.
    Tissue: Hair.
  4. Rogers M.A.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiKT33B_HUMAN
AccessioniPrimary (citable) accession number: Q14525
Secondary accession number(s): O76010
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: April 29, 2015
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.