Reviewed, UniProtKB/Swiss-Prot Q14525 (KT33B_HUMAN)

Names and origin

Protein names

Recommended name:
    Keratin, type I cuticular Ha3-II
Alternative name(s):
    Hair keratin, type I Ha3-II
    Keratin-33B
      Short name=K33B

Gene names

Name:	KRT33B
Synonyms:	HHA3-II, HKA3B, KRTHA3B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Miscellaneous	There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Domain	Coiled coil
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BCL10	O95999	1	EBI-1049638,EBI-958922
ICA1	Q05084	1	EBI-1049638,EBI-1046751
PLEKHJ1	Q9NW61	1	EBI-1049638,EBI-1057560
YWHAG	P61981	1	EBI-1049638,EBI-359832

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Keratin, type I cuticular Ha3-II		PRO_0000063689
Regions
	Region	1 – 56	56	Head
	Region	57 – 363	307	Rod
	Region	57 – 91	35	Coil 1A
	Region	92 – 102	11	Linker 1
	Region	103 – 203	101	Coil 1B
	Region	204 – 219	16	Linker 12
	Region	220 – 363	144	Coil 2
	Region	364 – 404	41	Tail
Sites
	Site	305	1	Stutter
Experimental info
	Sequence conflict	76 – 77	2	QL → HV in CAA57956. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q14525-1 [UniParc]. Last modified May 30, 2000. Version 3. Checksum: 54B5F7BEDC34619F	FASTA	404	46,214
	10 20 30 40 50 60 MPYNFCLPSL SCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG SFNGSEKETM 70 80 90 100 110 120 QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC PSYQSYFKTI EELQQKILCS 130 140 150 160 170 180 KSENARLVVQ IDNAKLAADD FRTKYQTEQS LRQLVESDIN SLRRILDELT LCRSDLEAQM 190 200 210 220 230 240 ESLKEELLSL KQNHEQEVNT LRCQLGDRLN VEVDAAPAVD LNQVLNETRN QYEALVETNR 250 260 270 280 290 300 REVEQWFATQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRYSLENTL 310 320 330 340 350 360 TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL 370 380 390 400 ESEDCKLPSN PCATTNACEK PIGSCVTNPC GPRSRCGPCN TFGY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a 190-kilobase pair domain of human type I hair keratin genes." Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J. J. Biol. Chem. 273:26683-26691(1998) [PubMed: 9756910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[3]	"A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms." Rogers M.A., Schweizer J., Kreig T., Winter H. Mol. Biol. Rep. 20:155-161(1994) [PubMed: 7565656] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-404. Tissue: Hair.
[4]	Rogers M.A. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y16789 Genomic DNA. Translation: CAA76385.1. BC009971 mRNA. Translation: AAH09971.1. X82634 mRNA. Translation: CAA57956.1.
IPI	IPI00031423.
PIR	I37459.
RefSeq	NP_002270.1.
UniGene	Hs.32950
3D structure databases
HSSP	HSSP built from PDB template 1GK7 based on UniProtKB P08670.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14525. 7 interactions.
Proteomic databases
PRIDE	Q14525.
Genome annotation databases
Ensembl	ENSG00000131738. Homo sapiens. [Contig view]
GeneID	3884.
KEGG	hsa:3884.
UCSC	uc002hwl.1. human.
Organism-specific databases
GeneCards	GC17M036774.
H-InvDB	HIX0013810.
HGNC	HGNC:6451. KRT33B.
MIM	602762. gene.
PharmGKB	PA30240.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q14525.
HOVERGEN	Q14525.
OMA	Q14525. GSCVTNP.
Gene expression databases
ArrayExpress	Q14525.
Bgee	Q14525.
CleanEx	HS_KRT33B.
GermOnline	ENSG00000131738. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. IF. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	15247.
SOURCE	Search...

Entry information

Entry name

KT33B_HUMAN

Accession

Primary (citable) accession number: Q14525
Secondary accession number(s): O76010

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 30, 2000
Last modified:	July 7, 2009
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)