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Protein

Keratin, type I cuticular Ha3-II

Gene

KRT33B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei305Stutter1

GO - Molecular functioni

GO - Biological processi

  • aging Source: UniProtKB
  • hair cycle Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131738-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-II
Alternative name(s):
Hair keratin, type I Ha3-II
Keratin-33B
Short name:
K33B
Gene namesi
Name:KRT33B
Synonyms:HHA3-II, HKA3B, KRTHA3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6451. KRT33B.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131738.
ENSG00000263012.
PharmGKBiPA30240.

Polymorphism and mutation databases

BioMutaiKRT33B.
DMDMi6686299.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636891 – 404Keratin, type I cuticular Ha3-IIAdd BLAST404

Proteomic databases

PaxDbiQ14525.
PeptideAtlasiQ14525.
PRIDEiQ14525.

PTM databases

iPTMnetiQ14525.
PhosphoSitePlusiQ14525.
SwissPalmiQ14525.

Expressioni

Gene expression databases

BgeeiENSG00000131738.
CleanExiHS_KRT33B.
GenevisibleiQ14525. HS.

Organism-specific databases

HPAiHPA055194.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-1049638,EBI-743598
AQP1P299723EBI-1049638,EBI-745213
KRT4P190135EBI-1049638,EBI-2371606
KRT79Q5XKE53EBI-1049638,EBI-2514135

Protein-protein interaction databases

BioGridi110082. 17 interactors.
IntActiQ14525. 26 interactors.
MINTiMINT-8417685.
STRINGi9606.ENSP00000251646.

Structurei

3D structure databases

ProteinModelPortaliQ14525.
SMRiQ14525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 56HeadAdd BLAST56
Regioni57 – 363RodAdd BLAST307
Regioni57 – 91Coil 1AAdd BLAST35
Regioni92 – 102Linker 1Add BLAST11
Regioni103 – 203Coil 1BAdd BLAST101
Regioni204 – 219Linker 12Add BLAST16
Regioni220 – 363Coil 2Add BLAST144
Regioni364 – 404TailAdd BLAST41

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ14525.
KOiK07604.
OMAiCGPRSRF.
OrthoDBiEOG091G087I.
PhylomeDBiQ14525.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNFCLPSL SCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG
60 70 80 90 100
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC
110 120 130 140 150
PSYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLAADD FRTKYQTEQS
160 170 180 190 200
LRQLVESDIN SLRRILDELT LCRSDLEAQM ESLKEELLSL KQNHEQEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPAVD LNQVLNETRN QYEALVETNR REVEQWFATQ
260 270 280 290 300
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRYSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE
360 370 380 390 400
CEINTYRSLL ESEDCKLPSN PCATTNACEK PIGSCVTNPC GPRSRCGPCN

TFGY
Length:404
Mass (Da):46,214
Last modified:May 30, 2000 - v3
Checksum:i54B5F7BEDC34619F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76 – 77QL → HV in CAA57956 (PubMed:7565656).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16789 Genomic DNA. Translation: CAA76385.1.
BC009971 mRNA. Translation: AAH09971.1.
X82634 mRNA. Translation: CAA57956.1.
CCDSiCCDS11389.1.
PIRiI37459.
RefSeqiNP_002270.1. NM_002279.4.
UniGeneiHs.32950.

Genome annotation databases

EnsembliENST00000251646; ENSP00000251646; ENSG00000131738.
ENST00000570596; ENSP00000459509; ENSG00000263012.
GeneIDi3884.
KEGGihsa:3884.
UCSCiuc002hwl.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16789 Genomic DNA. Translation: CAA76385.1.
BC009971 mRNA. Translation: AAH09971.1.
X82634 mRNA. Translation: CAA57956.1.
CCDSiCCDS11389.1.
PIRiI37459.
RefSeqiNP_002270.1. NM_002279.4.
UniGeneiHs.32950.

3D structure databases

ProteinModelPortaliQ14525.
SMRiQ14525.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110082. 17 interactors.
IntActiQ14525. 26 interactors.
MINTiMINT-8417685.
STRINGi9606.ENSP00000251646.

PTM databases

iPTMnetiQ14525.
PhosphoSitePlusiQ14525.
SwissPalmiQ14525.

Polymorphism and mutation databases

BioMutaiKRT33B.
DMDMi6686299.

Proteomic databases

PaxDbiQ14525.
PeptideAtlasiQ14525.
PRIDEiQ14525.

Protocols and materials databases

DNASUi3884.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251646; ENSP00000251646; ENSG00000131738.
ENST00000570596; ENSP00000459509; ENSG00000263012.
GeneIDi3884.
KEGGihsa:3884.
UCSCiuc002hwl.4. human.

Organism-specific databases

CTDi3884.
GeneCardsiKRT33B.
HGNCiHGNC:6451. KRT33B.
HPAiHPA055194.
MIMi602762. gene.
neXtProtiNX_Q14525.
OpenTargetsiENSG00000131738.
ENSG00000263012.
PharmGKBiPA30240.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ14525.
KOiK07604.
OMAiCGPRSRF.
OrthoDBiEOG091G087I.
PhylomeDBiQ14525.
TreeFamiTF332742.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131738-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GeneWikiiKRT33B.
GenomeRNAii3884.
PROiQ14525.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131738.
CleanExiHS_KRT33B.
GenevisibleiQ14525. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKT33B_HUMAN
AccessioniPrimary (citable) accession number: Q14525
Secondary accession number(s): O76010
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.