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Q14525

- KT33B_HUMAN

UniProt

Q14525 - KT33B_HUMAN

Protein

Keratin, type I cuticular Ha3-II

Gene

KRT33B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 3 (30 May 2000)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei305 – 3051Stutter

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. aging Source: UniProt
    2. hair cycle Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cuticular Ha3-II
    Alternative name(s):
    Hair keratin, type I Ha3-II
    Keratin-33B
    Short name:
    K33B
    Gene namesi
    Name:KRT33B
    Synonyms:HHA3-II, HKA3B, KRTHA3B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6451. KRT33B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30240.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Keratin, type I cuticular Ha3-IIPRO_0000063689Add
    BLAST

    Proteomic databases

    MaxQBiQ14525.
    PRIDEiQ14525.

    PTM databases

    PhosphoSiteiQ14525.

    Expressioni

    Gene expression databases

    BgeeiQ14525.
    CleanExiHS_KRT33B.
    GenevestigatoriQ14525.

    Interactioni

    Protein-protein interaction databases

    BioGridi110082. 13 interactions.
    IntActiQ14525. 8 interactions.
    MINTiMINT-8417685.
    STRINGi9606.ENSP00000251646.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14525.
    SMRiQ14525. Positions 106-204, 274-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5656HeadAdd
    BLAST
    Regioni57 – 363307RodAdd
    BLAST
    Regioni57 – 9135Coil 1AAdd
    BLAST
    Regioni92 – 10211Linker 1Add
    BLAST
    Regioni103 – 203101Coil 1BAdd
    BLAST
    Regioni204 – 21916Linker 12Add
    BLAST
    Regioni220 – 363144Coil 2Add
    BLAST
    Regioni364 – 40441TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiQ14525.
    KOiK07604.
    OMAiACNISAN.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiQ14525.
    TreeFamiTF332742.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14525-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPYNFCLPSL SCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG    50
    SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC 100
    PSYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLAADD FRTKYQTEQS 150
    LRQLVESDIN SLRRILDELT LCRSDLEAQM ESLKEELLSL KQNHEQEVNT 200
    LRCQLGDRLN VEVDAAPAVD LNQVLNETRN QYEALVETNR REVEQWFATQ 250
    TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRYSLENTL 300
    TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE 350
    CEINTYRSLL ESEDCKLPSN PCATTNACEK PIGSCVTNPC GPRSRCGPCN 400
    TFGY 404
    Length:404
    Mass (Da):46,214
    Last modified:May 30, 2000 - v3
    Checksum:i54B5F7BEDC34619F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti76 – 772QL → HV in CAA57956. (PubMed:7565656)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16789 Genomic DNA. Translation: CAA76385.1.
    BC009971 mRNA. Translation: AAH09971.1.
    X82634 mRNA. Translation: CAA57956.1.
    CCDSiCCDS11389.1.
    PIRiI37459.
    RefSeqiNP_002270.1. NM_002279.4.
    UniGeneiHs.32950.

    Genome annotation databases

    EnsembliENST00000251646; ENSP00000251646; ENSG00000131738.
    ENST00000570596; ENSP00000459509; ENSG00000263012.
    GeneIDi3884.
    KEGGihsa:3884.
    UCSCiuc002hwl.4. human.

    Polymorphism databases

    DMDMi6686299.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16789 Genomic DNA. Translation: CAA76385.1 .
    BC009971 mRNA. Translation: AAH09971.1 .
    X82634 mRNA. Translation: CAA57956.1 .
    CCDSi CCDS11389.1.
    PIRi I37459.
    RefSeqi NP_002270.1. NM_002279.4.
    UniGenei Hs.32950.

    3D structure databases

    ProteinModelPortali Q14525.
    SMRi Q14525. Positions 106-204, 274-361.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110082. 13 interactions.
    IntActi Q14525. 8 interactions.
    MINTi MINT-8417685.
    STRINGi 9606.ENSP00000251646.

    PTM databases

    PhosphoSitei Q14525.

    Polymorphism databases

    DMDMi 6686299.

    Proteomic databases

    MaxQBi Q14525.
    PRIDEi Q14525.

    Protocols and materials databases

    DNASUi 3884.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000251646 ; ENSP00000251646 ; ENSG00000131738 .
    ENST00000570596 ; ENSP00000459509 ; ENSG00000263012 .
    GeneIDi 3884.
    KEGGi hsa:3884.
    UCSCi uc002hwl.4. human.

    Organism-specific databases

    CTDi 3884.
    GeneCardsi GC17M039519.
    HGNCi HGNC:6451. KRT33B.
    MIMi 602762. gene.
    neXtProti NX_Q14525.
    PharmGKBi PA30240.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi Q14525.
    KOi K07604.
    OMAi ACNISAN.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi Q14525.
    TreeFami TF332742.

    Miscellaneous databases

    GeneWikii KRT33B.
    GenomeRNAii 3884.
    NextBioi 15247.
    PROi Q14525.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q14525.
    CleanExi HS_KRT33B.
    Genevestigatori Q14525.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
      Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
      J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. "A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms."
      Rogers M.A., Schweizer J., Kreig T., Winter H.
      Mol. Biol. Rep. 20:155-161(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-404.
      Tissue: Hair.
    4. Rogers M.A.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiKT33B_HUMAN
    AccessioniPrimary (citable) accession number: Q14525
    Secondary accession number(s): O76010
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3