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Q14525 (KT33B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cuticular Ha3-II
Alternative name(s):
Hair keratin, type I Ha3-II
Keratin-33B
Short name=K33B
Gene names
Name:KRT33B
Synonyms:HHA3-II, HKA3B, KRTHA3B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404Keratin, type I cuticular Ha3-II
PRO_0000063689

Regions

Region1 – 5656Head
Region57 – 363307Rod
Region57 – 9135Coil 1A
Region92 – 10211Linker 1
Region103 – 203101Coil 1B
Region204 – 21916Linker 12
Region220 – 363144Coil 2
Region364 – 40441Tail

Sites

Site3051Stutter

Experimental info

Sequence conflict76 – 772QL → HV in CAA57956. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q14525 [UniParc].

Last modified May 30, 2000. Version 3.
Checksum: 54B5F7BEDC34619F

FASTA40446,214
        10         20         30         40         50         60 
MPYNFCLPSL SCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG SFNGSEKETM 

        70         80         90        100        110        120 
QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC PSYQSYFKTI EELQQKILCS 

       130        140        150        160        170        180 
KSENARLVVQ IDNAKLAADD FRTKYQTEQS LRQLVESDIN SLRRILDELT LCRSDLEAQM 

       190        200        210        220        230        240 
ESLKEELLSL KQNHEQEVNT LRCQLGDRLN VEVDAAPAVD LNQVLNETRN QYEALVETNR 

       250        260        270        280        290        300 
REVEQWFATQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRYSLENTL 

       310        320        330        340        350        360 
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL 

       370        380        390        400 
ESEDCKLPSN PCATTNACEK PIGSCVTNPC GPRSRCGPCN TFGY 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]"A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms."
Rogers M.A., Schweizer J., Kreig T., Winter H.
Mol. Biol. Rep. 20:155-161(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-404.
Tissue: Hair.
[4]Rogers M.A.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y16789 Genomic DNA. Translation: CAA76385.1.
BC009971 mRNA. Translation: AAH09971.1.
X82634 mRNA. Translation: CAA57956.1.
CCDSCCDS11389.1.
PIRI37459.
RefSeqNP_002270.1. NM_002279.4.
UniGeneHs.32950.

3D structure databases

ProteinModelPortalQ14525.
SMRQ14525. Positions 106-204, 274-361.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110082. 13 interactions.
IntActQ14525. 8 interactions.
MINTMINT-8417685.
STRING9606.ENSP00000251646.

PTM databases

PhosphoSiteQ14525.

Polymorphism databases

DMDM6686299.

Proteomic databases

MaxQBQ14525.
PRIDEQ14525.

Protocols and materials databases

DNASU3884.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000251646; ENSP00000251646; ENSG00000131738.
ENST00000570596; ENSP00000459509; ENSG00000263012.
GeneID3884.
KEGGhsa:3884.
UCSCuc002hwl.4. human.

Organism-specific databases

CTD3884.
GeneCardsGC17M039519.
HGNCHGNC:6451. KRT33B.
MIM602762. gene.
neXtProtNX_Q14525.
PharmGKBPA30240.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000230975.
HOVERGENHBG013015.
InParanoidQ14525.
KOK07604.
OMAACNISAN.
OrthoDBEOG7FV3Q8.
PhylomeDBQ14525.
TreeFamTF332742.

Gene expression databases

BgeeQ14525.
CleanExHS_KRT33B.
GenevestigatorQ14525.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKRT33B.
GenomeRNAi3884.
NextBio15247.
PROQ14525.
SOURCESearch...

Entry information

Entry nameKT33B_HUMAN
AccessionPrimary (citable) accession number: Q14525
Secondary accession number(s): O76010
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM