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Q14525

- KT33B_HUMAN

UniProt

Q14525 - KT33B_HUMAN

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Protein
Keratin, type I cuticular Ha3-II
Gene
KRT33B, HHA3-II, HKA3B, KRTHA3B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei305 – 3051Stutter

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. aging Source: UniProt
  2. hair cycle Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-II
Alternative name(s):
Hair keratin, type I Ha3-II
Keratin-33B
Short name:
K33B
Gene namesi
Name:KRT33B
Synonyms:HHA3-II, HKA3B, KRTHA3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6451. KRT33B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30240.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Keratin, type I cuticular Ha3-II
PRO_0000063689Add
BLAST

Proteomic databases

MaxQBiQ14525.
PRIDEiQ14525.

PTM databases

PhosphoSiteiQ14525.

Expressioni

Gene expression databases

BgeeiQ14525.
CleanExiHS_KRT33B.
GenevestigatoriQ14525.

Interactioni

Protein-protein interaction databases

BioGridi110082. 13 interactions.
IntActiQ14525. 8 interactions.
MINTiMINT-8417685.
STRINGi9606.ENSP00000251646.

Structurei

3D structure databases

ProteinModelPortaliQ14525.
SMRiQ14525. Positions 106-204, 274-361.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5656Head
Add
BLAST
Regioni57 – 363307Rod
Add
BLAST
Regioni57 – 9135Coil 1A
Add
BLAST
Regioni92 – 10211Linker 1
Add
BLAST
Regioni103 – 203101Coil 1B
Add
BLAST
Regioni204 – 21916Linker 12
Add
BLAST
Regioni220 – 363144Coil 2
Add
BLAST
Regioni364 – 40441Tail
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ14525.
KOiK07604.
OMAiACNISAN.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ14525.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14525-1 [UniParc]FASTAAdd to Basket

« Hide

MPYNFCLPSL SCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG    50
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC 100
PSYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLAADD FRTKYQTEQS 150
LRQLVESDIN SLRRILDELT LCRSDLEAQM ESLKEELLSL KQNHEQEVNT 200
LRCQLGDRLN VEVDAAPAVD LNQVLNETRN QYEALVETNR REVEQWFATQ 250
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRYSLENTL 300
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE 350
CEINTYRSLL ESEDCKLPSN PCATTNACEK PIGSCVTNPC GPRSRCGPCN 400
TFGY 404
Length:404
Mass (Da):46,214
Last modified:May 30, 2000 - v3
Checksum:i54B5F7BEDC34619F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti76 – 772QL → HV in CAA57956. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16789 Genomic DNA. Translation: CAA76385.1.
BC009971 mRNA. Translation: AAH09971.1.
X82634 mRNA. Translation: CAA57956.1.
CCDSiCCDS11389.1.
PIRiI37459.
RefSeqiNP_002270.1. NM_002279.4.
UniGeneiHs.32950.

Genome annotation databases

EnsembliENST00000251646; ENSP00000251646; ENSG00000131738.
ENST00000570596; ENSP00000459509; ENSG00000263012.
GeneIDi3884.
KEGGihsa:3884.
UCSCiuc002hwl.4. human.

Polymorphism databases

DMDMi6686299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y16789 Genomic DNA. Translation: CAA76385.1 .
BC009971 mRNA. Translation: AAH09971.1 .
X82634 mRNA. Translation: CAA57956.1 .
CCDSi CCDS11389.1.
PIRi I37459.
RefSeqi NP_002270.1. NM_002279.4.
UniGenei Hs.32950.

3D structure databases

ProteinModelPortali Q14525.
SMRi Q14525. Positions 106-204, 274-361.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110082. 13 interactions.
IntActi Q14525. 8 interactions.
MINTi MINT-8417685.
STRINGi 9606.ENSP00000251646.

PTM databases

PhosphoSitei Q14525.

Polymorphism databases

DMDMi 6686299.

Proteomic databases

MaxQBi Q14525.
PRIDEi Q14525.

Protocols and materials databases

DNASUi 3884.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000251646 ; ENSP00000251646 ; ENSG00000131738 .
ENST00000570596 ; ENSP00000459509 ; ENSG00000263012 .
GeneIDi 3884.
KEGGi hsa:3884.
UCSCi uc002hwl.4. human.

Organism-specific databases

CTDi 3884.
GeneCardsi GC17M039519.
HGNCi HGNC:6451. KRT33B.
MIMi 602762. gene.
neXtProti NX_Q14525.
PharmGKBi PA30240.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi Q14525.
KOi K07604.
OMAi ACNISAN.
OrthoDBi EOG7FV3Q8.
PhylomeDBi Q14525.
TreeFami TF332742.

Miscellaneous databases

GeneWikii KRT33B.
GenomeRNAii 3884.
NextBioi 15247.
PROi Q14525.
SOURCEi Search...

Gene expression databases

Bgeei Q14525.
CleanExi HS_KRT33B.
Genevestigatori Q14525.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
    Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
    J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms."
    Rogers M.A., Schweizer J., Kreig T., Winter H.
    Mol. Biol. Rep. 20:155-161(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-404.
    Tissue: Hair.
  4. Rogers M.A.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiKT33B_HUMAN
AccessioniPrimary (citable) accession number: Q14525
Secondary accession number(s): O76010
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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