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Protein

Keratin, type I cuticular Ha3-II

Gene

KRT33B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei305Stutter1

GO - Molecular functioni

GO - Biological processi

  • aging Source: UniProtKB
  • cornification Source: Reactome
  • hair cycle Source: UniProtKB
  • keratinization Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha3-II
Alternative name(s):
Hair keratin, type I Ha3-II
Keratin-33B
Short name:
K33B
Gene namesi
Name:KRT33B
Synonyms:HHA3-II, HKA3B, KRTHA3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6451. KRT33B.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • intermediate filament Source: UniProtKB-KW

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131738.
PharmGKBiPA30240.

Polymorphism and mutation databases

BioMutaiKRT33B.
DMDMi6686299.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636891 – 404Keratin, type I cuticular Ha3-IIAdd BLAST404

Proteomic databases

PaxDbiQ14525.
PeptideAtlasiQ14525.
PRIDEiQ14525.

PTM databases

iPTMnetiQ14525.
PhosphoSitePlusiQ14525.
SwissPalmiQ14525.

Expressioni

Gene expression databases

BgeeiENSG00000131738.
CleanExiHS_KRT33B.
GenevisibleiQ14525. HS.

Organism-specific databases

HPAiHPA055194.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110082. 17 interactors.
IntActiQ14525. 66 interactors.
MINTiMINT-8417685.
STRINGi9606.ENSP00000251646.

Structurei

3D structure databases

ProteinModelPortaliQ14525.
SMRiQ14525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 56HeadAdd BLAST56
Regioni57 – 363RodAdd BLAST307
Regioni57 – 91Coil 1AAdd BLAST35
Regioni92 – 102Linker 1Add BLAST11
Regioni103 – 203Coil 1BAdd BLAST101
Regioni204 – 219Linker 12Add BLAST16
Regioni220 – 363Coil 2Add BLAST144
Regioni364 – 404TailAdd BLAST41

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ14525.
KOiK07604.
OMAiQCEINTY.
OrthoDBiEOG091G087I.
PhylomeDBiQ14525.
TreeFamiTF332742.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PRINTSiPR01248. TYPE1KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNFCLPSL SCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG
60 70 80 90 100
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC
110 120 130 140 150
PSYQSYFKTI EELQQKILCS KSENARLVVQ IDNAKLAADD FRTKYQTEQS
160 170 180 190 200
LRQLVESDIN SLRRILDELT LCRSDLEAQM ESLKEELLSL KQNHEQEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPAVD LNQVLNETRN QYEALVETNR REVEQWFATQ
260 270 280 290 300
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRYSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE
360 370 380 390 400
CEINTYRSLL ESEDCKLPSN PCATTNACEK PIGSCVTNPC GPRSRCGPCN

TFGY
Length:404
Mass (Da):46,214
Last modified:May 30, 2000 - v3
Checksum:i54B5F7BEDC34619F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76 – 77QL → HV in CAA57956 (PubMed:7565656).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16789 Genomic DNA. Translation: CAA76385.1.
BC009971 mRNA. Translation: AAH09971.1.
X82634 mRNA. Translation: CAA57956.1.
CCDSiCCDS11389.1.
PIRiI37459.
RefSeqiNP_002270.1. NM_002279.4.
UniGeneiHs.32950.

Genome annotation databases

EnsembliENST00000251646; ENSP00000251646; ENSG00000131738.
ENST00000570596; ENSP00000459509; ENSG00000263012.
GeneIDi3884.
KEGGihsa:3884.
UCSCiuc002hwl.4. human.

Similar proteinsi

Entry informationi

Entry nameiKT33B_HUMAN
AccessioniPrimary (citable) accession number: Q14525
Secondary accession number(s): O76010
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: August 30, 2017
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families