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Q14517 (FAT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin Fat 1
Alternative name(s):
Cadherin family member 7
Cadherin-related tumor suppressor homolog
Protein fat homolog

Cleaved into the following chain:

  1. Protocadherin Fat 1, nuclear form
Gene names
Name:FAT1
Synonyms:CDHF7, FAT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length4588 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact By similarity.

Subunit structure

Interacts (via the C-terminus 4300-4400 AA) with ATN1. Interacts with RERE. Interacts (via EVH1 domains) with ENAH By similarity. Interacts (via cytoplasmic domain) with CTNNB1 By similarity. Ref.5

Subcellular location

Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasmperinuclear region Ref.3.

Tissue specificity

Expressed in many epithelial and some endothelial and smooth muscle cells.

Domain

A PTB-like motif (DNXYH sequence) is required for the targeting to the leading edge. This motif represents a minimal protein-protein interaction core motif that is not regulated by tyrosine phosphorylation By similarity.

Post-translational modification

Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus. Ref.3

Sequence similarities

Contains 33 cadherin domains.

Contains 5 EGF-like domains.

Contains 1 laminin G-like domain.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Cytoplasm
Membrane
Nucleus
   Coding sequence diversityPolymorphism
   DomainEGF-like domain
Repeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin filament organization

Inferred from sequence or structural similarity. Source: UniProtKB

anatomical structure morphogenesis

Traceable author statement Ref.1. Source: ProtInc

cell adhesion

Traceable author statement Ref.1. Source: ProtInc

cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

cell-cell adhesion

Inferred from sequence or structural similarity. Source: UniProtKB

cell-cell signaling

Traceable author statement Ref.1. Source: ProtInc

establishment or maintenance of cell polarity

Inferred from sequence or structural similarity. Source: UniProtKB

homophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcell-cell junction

Inferred from direct assay PubMed 15148305. Source: UniProtKB

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867. Source: UniProt

filopodium

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

lamellipodium

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay Ref.3. Source: UniProtKB

perinuclear region of cytoplasm

Inferred from direct assay Ref.3. Source: UniProtKB

plasma membrane

Inferred from direct assay Ref.3. Source: UniProtKB

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ENAHQ8N8S72EBI-1171918,EBI-2834410
HOMER3Q9NSC54EBI-1171918,EBI-748420
Homer3Q99JP62EBI-1171918,EBI-6272061From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 45884567Protocadherin Fat 1
PRO_0000004017
Chain? – 4588Protocadherin Fat 1, nuclear formPRO_0000408559

Regions

Topological domain22 – 41814160Extracellular Potential
Transmembrane4182 – 420221Helical; Potential
Topological domain4203 – 4588386Cytoplasmic Potential
Domain35 – 149115Cadherin 1
Domain150 – 257108Cadherin 2
Domain368 – 46396Cadherin 3
Domain464 – 569106Cadherin 4
Domain570 – 673104Cadherin 5
Domain718 – 822105Cadherin 6
Domain823 – 927105Cadherin 7
Domain928 – 1034107Cadherin 8
Domain1035 – 1139105Cadherin 9
Domain1140 – 1245106Cadherin 10
Domain1246 – 1357112Cadherin 11
Domain1359 – 145698Cadherin 12
Domain1457 – 1562106Cadherin 13
Domain1563 – 1667105Cadherin 14
Domain1668 – 176598Cadherin 15
Domain1766 – 1879114Cadherin 16
Domain1880 – 1979100Cadherin 17
Domain1980 – 2081102Cadherin 18
Domain2082 – 2182101Cadherin 19
Domain2183 – 2283101Cadherin 20
Domain2284 – 2390107Cadherin 21
Domain2391 – 2492102Cadherin 22
Domain2493 – 2596104Cadherin 23
Domain2597 – 2703107Cadherin 24
Domain2704 – 2809106Cadherin 25
Domain2810 – 2918109Cadherin 26
Domain2919 – 3023105Cadherin 27
Domain3024 – 3125102Cadherin 28
Domain3126 – 3230105Cadherin 29
Domain3231 – 3335105Cadherin 30
Domain3336 – 3440105Cadherin 31
Domain3441 – 3545105Cadherin 32
Domain3546 – 3647102Cadherin 33
Domain3790 – 382738EGF-like 1
Domain3829 – 4009181Laminin G-like
Domain4013 – 405038EGF-like 2
Domain4052 – 408837EGF-like 3
Domain4089 – 412537EGF-like 4
Domain4127 – 416337EGF-like 5; calcium-binding Potential
Motif4204 – 421411Nuclear localization signal Potential
Motif4378 – 43825PTB-like motif By similarity

Amino acid modifications

Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation3331N-linked (GlcNAc...) Potential
Glycosylation6601N-linked (GlcNAc...) Potential
Glycosylation7401N-linked (GlcNAc...) Potential
Glycosylation7911N-linked (GlcNAc...) Potential
Glycosylation9981N-linked (GlcNAc...) Potential
Glycosylation14261N-linked (GlcNAc...) Potential
Glycosylation15511N-linked (GlcNAc...) Potential
Glycosylation17481N-linked (GlcNAc...) Potential
Glycosylation18641N-linked (GlcNAc...) Potential
Glycosylation19021N-linked (GlcNAc...) Potential
Glycosylation19401N-linked (GlcNAc...) Potential
Glycosylation19911N-linked (GlcNAc...) Potential
Glycosylation23251N-linked (GlcNAc...) Potential
Glycosylation24641N-linked (GlcNAc...) Potential
Glycosylation33241N-linked (GlcNAc...) Potential
Glycosylation34151N-linked (GlcNAc...) Ref.6
Glycosylation34221N-linked (GlcNAc...) Ref.6
Glycosylation34441N-linked (GlcNAc...) Potential
Glycosylation36131N-linked (GlcNAc...) Potential
Glycosylation36401N-linked (GlcNAc...) Potential
Glycosylation37161N-linked (GlcNAc...) Ref.6 Ref.7
Glycosylation41521N-linked (GlcNAc...) Potential
Disulfide bond3794 ↔ 3805 By similarity
Disulfide bond3799 ↔ 3816 By similarity
Disulfide bond3818 ↔ 3826 By similarity
Disulfide bond3976 ↔ 4009 By similarity
Disulfide bond4017 ↔ 4028 By similarity
Disulfide bond4022 ↔ 4038 By similarity
Disulfide bond4040 ↔ 4049 By similarity
Disulfide bond4056 ↔ 4067 By similarity
Disulfide bond4061 ↔ 4076 By similarity
Disulfide bond4078 ↔ 4087 By similarity
Disulfide bond4093 ↔ 4104 By similarity
Disulfide bond4098 ↔ 4113 By similarity
Disulfide bond4115 ↔ 4124 By similarity
Disulfide bond4131 ↔ 4142 By similarity
Disulfide bond4136 ↔ 4151 By similarity
Disulfide bond4153 ↔ 4162 By similarity

Natural variations

Natural variant1311A → V.
Corresponds to variant rs3733415 [ dbSNP | Ensembl ].
VAR_055590
Natural variant13301N → S.
Corresponds to variant rs874111 [ dbSNP | Ensembl ].
VAR_055591
Natural variant15641A → T.
Corresponds to variant rs2304867 [ dbSNP | Ensembl ].
VAR_055592
Natural variant16051N → D.
Corresponds to variant rs6836935 [ dbSNP | Ensembl ].
VAR_055593
Natural variant38001P → H.
Corresponds to variant rs11731738 [ dbSNP | Ensembl ].
VAR_055594

Experimental info

Sequence conflict3221G → D in CAA60685. Ref.1
Sequence conflict4041S → R in CAA60685. Ref.1
Sequence conflict4821V → I in CAA60685. Ref.1
Sequence conflict6141F → L in CAA60685. Ref.1
Sequence conflict8621V → L in CAA60685. Ref.1
Sequence conflict10641R → G in CAA60685. Ref.1
Sequence conflict12731H → R in CAA60685. Ref.1
Sequence conflict13511P → Q in CAA60685. Ref.1
Sequence conflict1526 – 15294HQHT → SPAH in CAA60685. Ref.1
Sequence conflict16041G → GNIG in CAA60685. Ref.1
Sequence conflict20061N → S in CAA60685. Ref.1
Sequence conflict20541T → I in CAA60685. Ref.1
Sequence conflict23851D → G in CAA60685. Ref.1
Sequence conflict2618 – 26192VL → S in CAA60685. Ref.1
Sequence conflict27181I → V in CAA60685. Ref.1
Sequence conflict31131L → V in CAA60685. Ref.1
Sequence conflict40591K → N in CAA60685. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q14517 [UniParc].

Last modified May 31, 2011. Version 2.
Checksum: 1896223E46E3B892

FASTA4,588506,273
        10         20         30         40         50         60 
MGRHLALLLL LLLLFQHFGD SDGSQRLEQT PLQFTHLEYN VTVQENSAAK TYVGHPVKMG 

        70         80         90        100        110        120 
VYITHPAWEV RYKIVSGDSE NLFKAEEYIL GDFCFLRIRT KGGNTAILNR EVKDHYTLIV 

       130        140        150        160        170        180 
KALEKNTNVE ARTKVRVQVL DTNDLRPLFS PTSYSVSLPE NTAIRTSIAR VSATDADIGT 

       190        200        210        220        230        240 
NGEFYYSFKD RTDMFAIHPT SGVIVLTGRL DYLETKLYEM EILAADRGMK LYGSSGISSM 

       250        260        270        280        290        300 
AKLTVHIEQA NECAPVITAV TLSPSELDRD PAYAIVTVDD CDQGANGDIA SLSIVAGDLL 

       310        320        330        340        350        360 
QQFRTVRSFP GSKEYKVKAI GGIDWDSHPF GYNLTLQAKD KGTPPQFSSV KVIHVTSPQF 

       370        380        390        400        410        420 
KAGPVKFEKD VYRAEISEFA PPNTPVVMVK AIPAYSHLRY VFKSTPGKAK FSLNYNTGLI 

       430        440        450        460        470        480 
SILEPVKRQQ AAHFELEVTT SDRKASTKVL VKVLGANSNP PEFTQTAYKA AFDENVPIGT 

       490        500        510        520        530        540 
TVMSLSAVDP DEGENGYVTY SIANLNHVPF AIDHFTGAVS TSENLDYELM PRVYTLRIRA 

       550        560        570        580        590        600 
SDWGLPYRRE VEVLATITLN NLNDNTPLFE KINCEGTIPR DLGVGEQITT VSAIDADELQ 

       610        620        630        640        650        660 
LVQYQIEAGN ELDFFSLNPN SGVLSLKRSL MDGLGAKVSF HSLRITATDG ENFATPLYIN 

       670        680        690        700        710        720 
ITVAASHKLV NLQCEETGVA KMLAEKLLQA NKLHNQGEVE DIFFDSHSVN AHIPQFRSTL 

       730        740        750        760        770        780 
PTGIQVKENQ PVGSSVIFMN STDLDTGFNG KLVYAVSGGN EDSCFMIDME TGMLKILSPL 

       790        800        810        820        830        840 
DRETTDKYTL NITVYDLGIP QKAAWRLLHV VVVDANDNPP EFLQESYFVE VSEDKEVHSE 

       850        860        870        880        890        900 
IIQVEATDKD LGPNGHVTYS IVTDTDTFSI DSVTGVVNIA RPLDRELQHE HSLKIEARDQ 

       910        920        930        940        950        960 
AREEPQLFST VVVKVSLEDV NDNPPTFIPP NYRVKVREDL PEGTVIMWLE AHDPDLGQSG 

       970        980        990       1000       1010       1020 
QVRYSLLDHG EGNFDVDKLS GAVRIVQQLD FEKKQVYNLT VRAKDKGKPV SLSSTCYVEV 

      1030       1040       1050       1060       1070       1080 
EVVDVNENLH PPVFSSFVEK GTVKEDAPVG SLVMTVSAHD EDARRDGEIR YSIRDGSGVG 

      1090       1100       1110       1120       1130       1140 
VFKIGEETGV IETSDRLDRE STSHYWLTVF ATDQGVVPLS SFIEIYIEVE DVNDNAPQTS 

      1150       1160       1170       1180       1190       1200 
EPVYYPEIME NSPKDVSVVQ IEAFDPDSSS NDKLMYKITS GNPQGFFSIH PKTGLITTTS 

      1210       1220       1230       1240       1250       1260 
RKLDREQQDE HILEVTVTDN GSPPKSTIAR VIVKILDEND NKPQFLQKFY KIRLPEREKP 

      1270       1280       1290       1300       1310       1320 
DRERNARREP LYHVIATDKD EGPNAEISYS IEDGNEHGKF FIEPKTGVVS SKRFSAAGEY 

      1330       1340       1350       1360       1370       1380 
DILSIKAVDN GRPQKSSTTR LHIEWISKPK PSLEPISFEE SFFTFTVMES DPVAHMIGVI 

      1390       1400       1410       1420       1430       1440 
SVEPPGIPLW FDITGGNYDS HFDVDKGTGT IIVAKPLDAE QKSNYNLTVE ATDGTTTILT 

      1450       1460       1470       1480       1490       1500 
QVFIKVIDTN DHRPQFSTSK YEVVIPEDTA PETEILQISA VDQDEKNKLI YTLQSSRDPL 

      1510       1520       1530       1540       1550       1560 
SLKKFRLDPA TGSLYTSEKL DHEAVHQHTL TVMVRDQDVP VKRNFARIVV NVSDTNDHAP 

      1570       1580       1590       1600       1610       1620 
WFTASSYKGR VYESAAVGSV VLQVTALDKD KGKNAEVLYS IESGNIGNSF MIDPVLGSIK 

      1630       1640       1650       1660       1670       1680 
TAKELDRSNQ AEYDLMVKAT DKGSPPMSEI TSVRIFVTIA DNASPKFTSK EYSVELSETV 

      1690       1700       1710       1720       1730       1740 
SIGSFVGMVT AHSQSSVVYE IKDGNTGDAF DINPHSGTII TQKALDFETL PIYTLIIQGT 

      1750       1760       1770       1780       1790       1800 
NMAGLSTNTT VLVHLQDEND NAPVFMQAEY TGLISESASI NSVVLTDRNV PLVIRAADAD 

      1810       1820       1830       1840       1850       1860 
KDSNALLVYH IVEPSVHTYF AIDSSTGAIH TVLSLDYEET SIFHFTVQVH DMGTPRLFAE 

      1870       1880       1890       1900       1910       1920 
YAANVTVHVI DINDCPPVFA KPLYEASLLL PTYKGVKVIT VNATDADSSA FSQLIYSITE 

      1930       1940       1950       1960       1970       1980 
GNIGEKFSMD YKTGALTVQN TTQLRSRYEL TVRASDGRFA GLTSVKINVK ESKESHLKFT 

      1990       2000       2010       2020       2030       2040 
QDVYSAVVKE NSTEAETLAV ITAIGNPINE PLFYHILNPD RRFKISRTSG VLSTTGTPFD 

      2050       2060       2070       2080       2090       2100 
REQQEAFDVV VEVTEEHKPS AVAHVVVKVI VEDQNDNAPV FVNLPYYAVV KVDTEVGHVI 

      2110       2120       2130       2140       2150       2160 
RYVTAVDRDS GRNGEVHYYL KEHHEHFQIG PLGEISLKKQ FELDTLNKEY LVTVVAKDGG 

      2170       2180       2190       2200       2210       2220 
NPAFSAEVIV PITVMNKAMP VFEKPFYSAE IAESIQVHSP VVHVQANSPE GLKVFYSITD 

      2230       2240       2250       2260       2270       2280 
GDPFSQFTIN FNTGVINVIA PLDFEAHPAY KLSIRATDSL TGAHAEVFVD IIVDDINDNP 

      2290       2300       2310       2320       2330       2340 
PVFAQQSYAV TLSEASVIGT SVVQVRATDS DSEPNRGISY QMFGNHSKSH DHFHVDSSTG 

      2350       2360       2370       2380       2390       2400 
LISLLRTLDY EQSRQHTIFV RAVDGGMPTL SSDVIVTVDV TDLNDNPPLF EQQIYEARIS 

      2410       2420       2430       2440       2450       2460 
EHAPHGHFVT CVKAYDADSS DIDKLQYSIL SGNDHKHFVI DSATGIITLS NLHRHALKPF 

      2470       2480       2490       2500       2510       2520 
YSLNLSVSDG VFRSSTQVHV TVIGGNLHSP AFLQNEYEVE LAENAPLHTL VMEVKTTDGD 

      2530       2540       2550       2560       2570       2580 
SGIYGHVTYH IVNDFAKDRF YINERGQIFT LEKLDRETPA EKVISVRLMA KDAGGKVAFC 

      2590       2600       2610       2620       2630       2640 
TVNVILTDDN DNAPQFRATK YEVNIGSSAA KGTSVVKVLA SDADEGSNAD ITYAIEADSE 

      2650       2660       2670       2680       2690       2700 
SVKENLEINK LSGVITTKES LIGLENEFFT FFVRAVDNGS PSKESVVLVY VKILPPEMQL 

      2710       2720       2730       2740       2750       2760 
PKFSEPFYTF TVSEDVPIGT EIDLIRAEHS GTVLYSLVKG NTPESNRDES FVIDRQSGRL 

      2770       2780       2790       2800       2810       2820 
KLEKSLDHET TKWYQFSILA RCTQDDHEMV ASVDVSIQVK DANDNSPVFE SSPYEAFIVE 

      2830       2840       2850       2860       2870       2880 
NLPGGSRVIQ IRASDADSGT NGQVMYSLDQ SQSVEVIESF AINMETGWIT TLKELDHEKR 

      2890       2900       2910       2920       2930       2940 
DNYQIKVVAS DHGEKIQLSS TAIVDVTVTD VNDSPPRFTA EIYKGTVSED DPQGGVIAIL 

      2950       2960       2970       2980       2990       3000 
STTDADSEEI NRQVTYFITG GDPLGQFAVE TIQNEWKVYV KKPLDREKRD NYLLTITATD 

      3010       3020       3030       3040       3050       3060 
GTFSSKAIVE VKVLDANDNS PVCEKTLYSD TIPEDVLPGK LIMQISATDA DIRSNAEITY 

      3070       3080       3090       3100       3110       3120 
TLLGSGAEKF KLNPDTGELK TSTPLDREEQ AVYHLLVRAT DGGGRFCQAS IVLTLEDVND 

      3130       3140       3150       3160       3170       3180 
NAPEFSADPY AITVFENTEP GTLLTRVQAT DADAGLNRKI LYSLIDSADG QFSINELSGI 

      3190       3200       3210       3220       3230       3240 
IQLEKPLDRE LQAVYTLSLK AVDQGLPRRL TATGTVIVSV LDINDNPPVF EYREYGATVS 

      3250       3260       3270       3280       3290       3300 
EDILVGTEVL QVYAASRDIE ANAEITYSII SGNEHGKFSI DSKTGAVFII ENLDYESSHE 

      3310       3320       3330       3340       3350       3360 
YYLTVEATDG GTPSLSDVAT VNVNVTDIND NTPVFSQDTY TTVISEDAVL EQSVITVMAD 

      3370       3380       3390       3400       3410       3420 
DADGPSNSHI HYSIIDGNQG SSFTIDPVRG EVKVTKLLDR ETISGYTLTV QASDNGSPPR 

      3430       3440       3450       3460       3470       3480 
VNTTTVNIDV SDVNDNAPVF SRGNYSVIIQ ENKPVGFSVL QLVVTDEDSS HNGPPFFFTI 

      3490       3500       3510       3520       3530       3540 
VTGNDEKAFE VNPQGVLLTS SAIKRKEKDH YLLQVKVADN GKPQLSSLTY IDIRVIEESI 

      3550       3560       3570       3580       3590       3600 
YPPAILPLEI FITSSGEEYS GGVIGKIHAT DQDVYDTLTY SLDPQMDNLF SVSSTGGKLI 

      3610       3620       3630       3640       3650       3660 
AHKKLDIGQY LLNVSVTDGK FTTVADITVH IRQVTQEMLN HTIAIRFANL TPEEFVGDYW 

      3670       3680       3690       3700       3710       3720 
RNFQRALRNI LGVRRNDIQI VSLQSSEPHP HLDVLLFVEK PGSAQISTKQ LLHKINSSVT 

      3730       3740       3750       3760       3770       3780 
DIEEIIGVRI LNVFQKLCAG LDCPWKFCDE KVSVDESVMS THSTARLSFV TPRHHRAAVC 

      3790       3800       3810       3820       3830       3840 
LCKEGRCPPV HHGCEDDPCP EGSECVSDPW EEKHTCVCPS GRFGQCPGSS SMTLTGNSYV 

      3850       3860       3870       3880       3890       3900 
KYRLTENENK LEMKLTMRLR TYSTHAVVMY ARGTDYSILE IHHGRLQYKF DCGSGPGIVS 

      3910       3920       3930       3940       3950       3960 
VQSIQVNDGQ WHAVALEVNG NYARLVLDQV HTASGTAPGT LKTLNLDNYV FFGGHIRQQG 

      3970       3980       3990       4000       4010       4020 
TRHGRSPQVG NGFRGCMDSI YLNGQELPLN SKPRSYAHIE ESVDVSPGCF LTATEDCASN 

      4030       4040       4050       4060       4070       4080 
PCQNGGVCNP SPAGGYYCKC SALYIGTHCE ISVNPCSSKP CLYGGTCVVD NGGFVCQCRG 

      4090       4100       4110       4120       4130       4140 
LYTGQRCQLS PYCKDEPCKN GGTCFDSLDG AVCQCDSGFR GERCQSDIDE CSGNPCLHGA 

      4150       4160       4170       4180       4190       4200 
LCENTHGSYH CNCSHEYRGR HCEDAAPNQY VSTPWNIGLA EGIGIVVFVA GIFLLVVVFV 

      4210       4220       4230       4240       4250       4260 
LCRKMISRKK KHQAEPKDKH LGPATAFLQR PYFDSKLNKN IYSDIPPQVP VRPISYTPSI 

      4270       4280       4290       4300       4310       4320 
PSDSRNNLDR NSFEGSAIPE HPEFSTFNPE SVHGHRKAVA VCSVAPNLPP PPPSNSPSDS 

      4330       4340       4350       4360       4370       4380 
DSIQKPSWDF DYDTKVVDLD PCLSKKPLEE KPSQPYSARE SLSEVQSLSS FQSESCDDNG 

      4390       4400       4410       4420       4430       4440 
YHWDTSDWMP SVPLPDIQEF PNYEVIDEQT PLYSADPNAI DTDYYPGGYD IESDFPPPPE 

      4450       4460       4470       4480       4490       4500 
DFPAADELPP LPPEFSNQFE SIHPPRDMPA AGSLGSSSRN RQRFNLNQYL PNFYPLDMSE 

      4510       4520       4530       4540       4550       4560 
PQTKGTGENS TCREPHAPYP PGYQRHFEAP AVESMPMSVY ASTASCSDVS ACCEVESEVM 

      4570       4580 
MSDYESGDDG HFEEVTIPPL DSQQHTEV 

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References

« Hide 'large scale' references
[1]"Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule."
Dunne J., Hanby A.M., Poulsom R., Jones T.A., Sheer D., Chin W.G., Da S.M., Zhao Q., Beverley P.C.L., Owen M.J.
Genomics 30:207-223(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lymphocyte.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus."
Magg T., Schreiner D., Solis G.P., Bade E.G., Hofer H.W.
Exp. Cell Res. 307:100-108(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, PROTEOLYTIC CLEAVAGE.
[4]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells."
Hou R., Sibinga N.E.
J. Biol. Chem. 284:6955-6965(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ATN1 AND RERE.
[6]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-3415; ASN-3422 AND ASN-3716.
Tissue: Liver.
[7]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-3716.
Tissue: Leukemic T-cell.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X87241 mRNA. Translation: CAA60685.1.
AC107050 Genomic DNA. No translation available.
AC110761 Genomic DNA. No translation available.
RefSeqNP_005236.2. NM_005245.3.
UniGeneHs.481371.

3D structure databases

ProteinModelPortalQ14517.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108489. 5 interactions.
IntActQ14517. 10 interactions.
MINTMINT-2806731.
STRING9606.ENSP00000406229.

PTM databases

PhosphoSiteQ14517.

Polymorphism databases

DMDM334302792.

Proteomic databases

PaxDbQ14517.
PRIDEQ14517.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000441802; ENSP00000406229; ENSG00000083857.
GeneID2195.
KEGGhsa:2195.
UCSCuc003izf.3. human.

Organism-specific databases

CTD2195.
GeneCardsGC04M187508.
HGNCHGNC:3595. FAT1.
HPAHPA001869.
HPA023882.
MIM600976. gene.
neXtProtNX_Q14517.
PharmGKBPA164719952.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000046499.
HOVERGENHBG005641.
InParanoidQ14517.
KOK16506.
OMAPYEAFIV.
OrthoDBEOG7WMCHJ.
TreeFamTF316403.

Gene expression databases

ArrayExpressQ14517.
BgeeQ14517.
CleanExHS_FAT1.
GenevestigatorQ14517.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
2.60.40.60. 33 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view]
PfamPF00028. Cadherin. 29 hits.
PF00008. EGF. 2 hits.
PF07645. EGF_CA. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 34 hits.
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMSSF49313. SSF49313. 33 hits.
SSF49899. SSF49899. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 17 hits.
PS50268. CADHERIN_2. 33 hits.
PS00022. EGF_1. 4 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 1 hit.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFAT1. human.
GeneWikiFAT_(gene).
GenomeRNAi2195.
NextBio8873.
PROQ14517.
SOURCESearch...

Entry information

Entry nameFAT1_HUMAN
AccessionPrimary (citable) accession number: Q14517
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 31, 2011
Last modified: April 16, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM