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Q14517

- FAT1_HUMAN

UniProt

Q14517 - FAT1_HUMAN

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Protein

Protocadherin Fat 1

Gene
FAT1, CDHF7, FAT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. actin filament organization Source: UniProtKB
  2. anatomical structure morphogenesis Source: ProtInc
  3. cell adhesion Source: ProtInc
  4. cell-cell signaling Source: ProtInc
  5. cell migration Source: UniProtKB
  6. establishment or maintenance of cell polarity Source: UniProtKB
  7. homophilic cell adhesion Source: InterPro
  8. single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin Fat 1
Alternative name(s):
Cadherin family member 7
Cadherin-related tumor suppressor homolog
Protein fat homolog
Cleaved into the following chain:
Gene namesi
Name:FAT1
Synonyms:CDHF7, FAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:3595. FAT1.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasmperinuclear region 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 41814160Extracellular Reviewed predictionAdd
BLAST
Transmembranei4182 – 420221Helical; Reviewed predictionAdd
BLAST
Topological domaini4203 – 4588386Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell-cell junction Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
  3. filopodium Source: Ensembl
  4. integral component of plasma membrane Source: ProtInc
  5. lamellipodium Source: Ensembl
  6. nucleus Source: UniProtKB
  7. perinuclear region of cytoplasm Source: UniProtKB
  8. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164719952.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 4588Protocadherin Fat 1, nuclear formPRO_0000408559
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 45884567Protocadherin Fat 1PRO_0000004017Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi333 – 3331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi660 – 6601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi740 – 7401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi791 – 7911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi998 – 9981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1426 – 14261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1551 – 15511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1748 – 17481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1864 – 18641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1902 – 19021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1940 – 19401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1991 – 19911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2325 – 23251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2464 – 24641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3324 – 33241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3415 – 34151N-linked (GlcNAc...)1 Publication
Glycosylationi3422 – 34221N-linked (GlcNAc...)1 Publication
Glycosylationi3444 – 34441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3613 – 36131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3640 – 36401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3716 – 37161N-linked (GlcNAc...)2 Publications
Disulfide bondi3794 ↔ 3805 By similarity
Disulfide bondi3799 ↔ 3816 By similarity
Disulfide bondi3818 ↔ 3826 By similarity
Disulfide bondi3976 ↔ 4009 By similarity
Disulfide bondi4017 ↔ 4028 By similarity
Disulfide bondi4022 ↔ 4038 By similarity
Disulfide bondi4040 ↔ 4049 By similarity
Disulfide bondi4056 ↔ 4067 By similarity
Disulfide bondi4061 ↔ 4076 By similarity
Disulfide bondi4078 ↔ 4087 By similarity
Disulfide bondi4093 ↔ 4104 By similarity
Disulfide bondi4098 ↔ 4113 By similarity
Disulfide bondi4115 ↔ 4124 By similarity
Disulfide bondi4131 ↔ 4142 By similarity
Disulfide bondi4136 ↔ 4151 By similarity
Glycosylationi4152 – 41521N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4153 ↔ 4162 By similarity

Post-translational modificationi

Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ14517.
PaxDbiQ14517.
PRIDEiQ14517.

PTM databases

PhosphoSiteiQ14517.

Expressioni

Tissue specificityi

Expressed in many epithelial and some endothelial and smooth muscle cells.

Gene expression databases

ArrayExpressiQ14517.
BgeeiQ14517.
CleanExiHS_FAT1.
GenevestigatoriQ14517.

Organism-specific databases

HPAiHPA001869.
HPA023882.

Interactioni

Subunit structurei

Interacts (via the C-terminus 4300-4400 AA) with ATN1. Interacts with RERE. Interacts (via EVH1 domains) with ENAH By similarity. Interacts (via cytoplasmic domain) with CTNNB1 By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ENAHQ8N8S72EBI-1171918,EBI-2834410
HOMER3Q9NSC54EBI-1171918,EBI-748420
Homer3Q99JP62EBI-1171918,EBI-6272061From a different organism.

Protein-protein interaction databases

BioGridi108489. 5 interactions.
IntActiQ14517. 10 interactions.
MINTiMINT-2806731.
STRINGi9606.ENSP00000406229.

Structurei

3D structure databases

ProteinModelPortaliQ14517.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 149115Cadherin 1Add
BLAST
Domaini150 – 257108Cadherin 2Add
BLAST
Domaini368 – 46396Cadherin 3Add
BLAST
Domaini464 – 569106Cadherin 4Add
BLAST
Domaini570 – 673104Cadherin 5Add
BLAST
Domaini718 – 822105Cadherin 6Add
BLAST
Domaini823 – 927105Cadherin 7Add
BLAST
Domaini928 – 1034107Cadherin 8Add
BLAST
Domaini1035 – 1139105Cadherin 9Add
BLAST
Domaini1140 – 1245106Cadherin 10Add
BLAST
Domaini1246 – 1357112Cadherin 11Add
BLAST
Domaini1359 – 145698Cadherin 12Add
BLAST
Domaini1457 – 1562106Cadherin 13Add
BLAST
Domaini1563 – 1667105Cadherin 14Add
BLAST
Domaini1668 – 176598Cadherin 15Add
BLAST
Domaini1766 – 1879114Cadherin 16Add
BLAST
Domaini1880 – 1979100Cadherin 17Add
BLAST
Domaini1980 – 2081102Cadherin 18Add
BLAST
Domaini2082 – 2182101Cadherin 19Add
BLAST
Domaini2183 – 2283101Cadherin 20Add
BLAST
Domaini2284 – 2390107Cadherin 21Add
BLAST
Domaini2391 – 2492102Cadherin 22Add
BLAST
Domaini2493 – 2596104Cadherin 23Add
BLAST
Domaini2597 – 2703107Cadherin 24Add
BLAST
Domaini2704 – 2809106Cadherin 25Add
BLAST
Domaini2810 – 2918109Cadherin 26Add
BLAST
Domaini2919 – 3023105Cadherin 27Add
BLAST
Domaini3024 – 3125102Cadherin 28Add
BLAST
Domaini3126 – 3230105Cadherin 29Add
BLAST
Domaini3231 – 3335105Cadherin 30Add
BLAST
Domaini3336 – 3440105Cadherin 31Add
BLAST
Domaini3441 – 3545105Cadherin 32Add
BLAST
Domaini3546 – 3647102Cadherin 33Add
BLAST
Domaini3790 – 382738EGF-like 1Add
BLAST
Domaini3829 – 4009181Laminin G-likeAdd
BLAST
Domaini4013 – 405038EGF-like 2Add
BLAST
Domaini4052 – 408837EGF-like 3Add
BLAST
Domaini4089 – 412537EGF-like 4Add
BLAST
Domaini4127 – 416337EGF-like 5; calcium-binding Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi4204 – 421411Nuclear localization signal Reviewed predictionAdd
BLAST
Motifi4378 – 43825PTB-like motif By similarity

Domaini

A PTB-like motif (DNXYH sequence) is required for the targeting to the leading edge. This motif represents a minimal protein-protein interaction core motif that is not regulated by tyrosine phosphorylation By similarity.

Sequence similaritiesi

Contains 33 cadherin domains.
Contains 5 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000046499.
HOVERGENiHBG005641.
InParanoidiQ14517.
KOiK16506.
OMAiPYEAFIV.
OrthoDBiEOG7WMCHJ.
TreeFamiTF316403.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 33 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 29 hits.
PF00008. EGF. 2 hits.
PF07645. EGF_CA. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 34 hits.
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 33 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 17 hits.
PS50268. CADHERIN_2. 33 hits.
PS00022. EGF_1. 4 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 1 hit.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14517-1 [UniParc]FASTAAdd to Basket

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MGRHLALLLL LLLLFQHFGD SDGSQRLEQT PLQFTHLEYN VTVQENSAAK     50
TYVGHPVKMG VYITHPAWEV RYKIVSGDSE NLFKAEEYIL GDFCFLRIRT 100
KGGNTAILNR EVKDHYTLIV KALEKNTNVE ARTKVRVQVL DTNDLRPLFS 150
PTSYSVSLPE NTAIRTSIAR VSATDADIGT NGEFYYSFKD RTDMFAIHPT 200
SGVIVLTGRL DYLETKLYEM EILAADRGMK LYGSSGISSM AKLTVHIEQA 250
NECAPVITAV TLSPSELDRD PAYAIVTVDD CDQGANGDIA SLSIVAGDLL 300
QQFRTVRSFP GSKEYKVKAI GGIDWDSHPF GYNLTLQAKD KGTPPQFSSV 350
KVIHVTSPQF KAGPVKFEKD VYRAEISEFA PPNTPVVMVK AIPAYSHLRY 400
VFKSTPGKAK FSLNYNTGLI SILEPVKRQQ AAHFELEVTT SDRKASTKVL 450
VKVLGANSNP PEFTQTAYKA AFDENVPIGT TVMSLSAVDP DEGENGYVTY 500
SIANLNHVPF AIDHFTGAVS TSENLDYELM PRVYTLRIRA SDWGLPYRRE 550
VEVLATITLN NLNDNTPLFE KINCEGTIPR DLGVGEQITT VSAIDADELQ 600
LVQYQIEAGN ELDFFSLNPN SGVLSLKRSL MDGLGAKVSF HSLRITATDG 650
ENFATPLYIN ITVAASHKLV NLQCEETGVA KMLAEKLLQA NKLHNQGEVE 700
DIFFDSHSVN AHIPQFRSTL PTGIQVKENQ PVGSSVIFMN STDLDTGFNG 750
KLVYAVSGGN EDSCFMIDME TGMLKILSPL DRETTDKYTL NITVYDLGIP 800
QKAAWRLLHV VVVDANDNPP EFLQESYFVE VSEDKEVHSE IIQVEATDKD 850
LGPNGHVTYS IVTDTDTFSI DSVTGVVNIA RPLDRELQHE HSLKIEARDQ 900
AREEPQLFST VVVKVSLEDV NDNPPTFIPP NYRVKVREDL PEGTVIMWLE 950
AHDPDLGQSG QVRYSLLDHG EGNFDVDKLS GAVRIVQQLD FEKKQVYNLT 1000
VRAKDKGKPV SLSSTCYVEV EVVDVNENLH PPVFSSFVEK GTVKEDAPVG 1050
SLVMTVSAHD EDARRDGEIR YSIRDGSGVG VFKIGEETGV IETSDRLDRE 1100
STSHYWLTVF ATDQGVVPLS SFIEIYIEVE DVNDNAPQTS EPVYYPEIME 1150
NSPKDVSVVQ IEAFDPDSSS NDKLMYKITS GNPQGFFSIH PKTGLITTTS 1200
RKLDREQQDE HILEVTVTDN GSPPKSTIAR VIVKILDEND NKPQFLQKFY 1250
KIRLPEREKP DRERNARREP LYHVIATDKD EGPNAEISYS IEDGNEHGKF 1300
FIEPKTGVVS SKRFSAAGEY DILSIKAVDN GRPQKSSTTR LHIEWISKPK 1350
PSLEPISFEE SFFTFTVMES DPVAHMIGVI SVEPPGIPLW FDITGGNYDS 1400
HFDVDKGTGT IIVAKPLDAE QKSNYNLTVE ATDGTTTILT QVFIKVIDTN 1450
DHRPQFSTSK YEVVIPEDTA PETEILQISA VDQDEKNKLI YTLQSSRDPL 1500
SLKKFRLDPA TGSLYTSEKL DHEAVHQHTL TVMVRDQDVP VKRNFARIVV 1550
NVSDTNDHAP WFTASSYKGR VYESAAVGSV VLQVTALDKD KGKNAEVLYS 1600
IESGNIGNSF MIDPVLGSIK TAKELDRSNQ AEYDLMVKAT DKGSPPMSEI 1650
TSVRIFVTIA DNASPKFTSK EYSVELSETV SIGSFVGMVT AHSQSSVVYE 1700
IKDGNTGDAF DINPHSGTII TQKALDFETL PIYTLIIQGT NMAGLSTNTT 1750
VLVHLQDEND NAPVFMQAEY TGLISESASI NSVVLTDRNV PLVIRAADAD 1800
KDSNALLVYH IVEPSVHTYF AIDSSTGAIH TVLSLDYEET SIFHFTVQVH 1850
DMGTPRLFAE YAANVTVHVI DINDCPPVFA KPLYEASLLL PTYKGVKVIT 1900
VNATDADSSA FSQLIYSITE GNIGEKFSMD YKTGALTVQN TTQLRSRYEL 1950
TVRASDGRFA GLTSVKINVK ESKESHLKFT QDVYSAVVKE NSTEAETLAV 2000
ITAIGNPINE PLFYHILNPD RRFKISRTSG VLSTTGTPFD REQQEAFDVV 2050
VEVTEEHKPS AVAHVVVKVI VEDQNDNAPV FVNLPYYAVV KVDTEVGHVI 2100
RYVTAVDRDS GRNGEVHYYL KEHHEHFQIG PLGEISLKKQ FELDTLNKEY 2150
LVTVVAKDGG NPAFSAEVIV PITVMNKAMP VFEKPFYSAE IAESIQVHSP 2200
VVHVQANSPE GLKVFYSITD GDPFSQFTIN FNTGVINVIA PLDFEAHPAY 2250
KLSIRATDSL TGAHAEVFVD IIVDDINDNP PVFAQQSYAV TLSEASVIGT 2300
SVVQVRATDS DSEPNRGISY QMFGNHSKSH DHFHVDSSTG LISLLRTLDY 2350
EQSRQHTIFV RAVDGGMPTL SSDVIVTVDV TDLNDNPPLF EQQIYEARIS 2400
EHAPHGHFVT CVKAYDADSS DIDKLQYSIL SGNDHKHFVI DSATGIITLS 2450
NLHRHALKPF YSLNLSVSDG VFRSSTQVHV TVIGGNLHSP AFLQNEYEVE 2500
LAENAPLHTL VMEVKTTDGD SGIYGHVTYH IVNDFAKDRF YINERGQIFT 2550
LEKLDRETPA EKVISVRLMA KDAGGKVAFC TVNVILTDDN DNAPQFRATK 2600
YEVNIGSSAA KGTSVVKVLA SDADEGSNAD ITYAIEADSE SVKENLEINK 2650
LSGVITTKES LIGLENEFFT FFVRAVDNGS PSKESVVLVY VKILPPEMQL 2700
PKFSEPFYTF TVSEDVPIGT EIDLIRAEHS GTVLYSLVKG NTPESNRDES 2750
FVIDRQSGRL KLEKSLDHET TKWYQFSILA RCTQDDHEMV ASVDVSIQVK 2800
DANDNSPVFE SSPYEAFIVE NLPGGSRVIQ IRASDADSGT NGQVMYSLDQ 2850
SQSVEVIESF AINMETGWIT TLKELDHEKR DNYQIKVVAS DHGEKIQLSS 2900
TAIVDVTVTD VNDSPPRFTA EIYKGTVSED DPQGGVIAIL STTDADSEEI 2950
NRQVTYFITG GDPLGQFAVE TIQNEWKVYV KKPLDREKRD NYLLTITATD 3000
GTFSSKAIVE VKVLDANDNS PVCEKTLYSD TIPEDVLPGK LIMQISATDA 3050
DIRSNAEITY TLLGSGAEKF KLNPDTGELK TSTPLDREEQ AVYHLLVRAT 3100
DGGGRFCQAS IVLTLEDVND NAPEFSADPY AITVFENTEP GTLLTRVQAT 3150
DADAGLNRKI LYSLIDSADG QFSINELSGI IQLEKPLDRE LQAVYTLSLK 3200
AVDQGLPRRL TATGTVIVSV LDINDNPPVF EYREYGATVS EDILVGTEVL 3250
QVYAASRDIE ANAEITYSII SGNEHGKFSI DSKTGAVFII ENLDYESSHE 3300
YYLTVEATDG GTPSLSDVAT VNVNVTDIND NTPVFSQDTY TTVISEDAVL 3350
EQSVITVMAD DADGPSNSHI HYSIIDGNQG SSFTIDPVRG EVKVTKLLDR 3400
ETISGYTLTV QASDNGSPPR VNTTTVNIDV SDVNDNAPVF SRGNYSVIIQ 3450
ENKPVGFSVL QLVVTDEDSS HNGPPFFFTI VTGNDEKAFE VNPQGVLLTS 3500
SAIKRKEKDH YLLQVKVADN GKPQLSSLTY IDIRVIEESI YPPAILPLEI 3550
FITSSGEEYS GGVIGKIHAT DQDVYDTLTY SLDPQMDNLF SVSSTGGKLI 3600
AHKKLDIGQY LLNVSVTDGK FTTVADITVH IRQVTQEMLN HTIAIRFANL 3650
TPEEFVGDYW RNFQRALRNI LGVRRNDIQI VSLQSSEPHP HLDVLLFVEK 3700
PGSAQISTKQ LLHKINSSVT DIEEIIGVRI LNVFQKLCAG LDCPWKFCDE 3750
KVSVDESVMS THSTARLSFV TPRHHRAAVC LCKEGRCPPV HHGCEDDPCP 3800
EGSECVSDPW EEKHTCVCPS GRFGQCPGSS SMTLTGNSYV KYRLTENENK 3850
LEMKLTMRLR TYSTHAVVMY ARGTDYSILE IHHGRLQYKF DCGSGPGIVS 3900
VQSIQVNDGQ WHAVALEVNG NYARLVLDQV HTASGTAPGT LKTLNLDNYV 3950
FFGGHIRQQG TRHGRSPQVG NGFRGCMDSI YLNGQELPLN SKPRSYAHIE 4000
ESVDVSPGCF LTATEDCASN PCQNGGVCNP SPAGGYYCKC SALYIGTHCE 4050
ISVNPCSSKP CLYGGTCVVD NGGFVCQCRG LYTGQRCQLS PYCKDEPCKN 4100
GGTCFDSLDG AVCQCDSGFR GERCQSDIDE CSGNPCLHGA LCENTHGSYH 4150
CNCSHEYRGR HCEDAAPNQY VSTPWNIGLA EGIGIVVFVA GIFLLVVVFV 4200
LCRKMISRKK KHQAEPKDKH LGPATAFLQR PYFDSKLNKN IYSDIPPQVP 4250
VRPISYTPSI PSDSRNNLDR NSFEGSAIPE HPEFSTFNPE SVHGHRKAVA 4300
VCSVAPNLPP PPPSNSPSDS DSIQKPSWDF DYDTKVVDLD PCLSKKPLEE 4350
KPSQPYSARE SLSEVQSLSS FQSESCDDNG YHWDTSDWMP SVPLPDIQEF 4400
PNYEVIDEQT PLYSADPNAI DTDYYPGGYD IESDFPPPPE DFPAADELPP 4450
LPPEFSNQFE SIHPPRDMPA AGSLGSSSRN RQRFNLNQYL PNFYPLDMSE 4500
PQTKGTGENS TCREPHAPYP PGYQRHFEAP AVESMPMSVY ASTASCSDVS 4550
ACCEVESEVM MSDYESGDDG HFEEVTIPPL DSQQHTEV 4588
Length:4,588
Mass (Da):506,273
Last modified:May 31, 2011 - v2
Checksum:i1896223E46E3B892
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti131 – 1311A → V.
Corresponds to variant rs3733415 [ dbSNP | Ensembl ].
VAR_055590
Natural varianti1330 – 13301N → S.
Corresponds to variant rs874111 [ dbSNP | Ensembl ].
VAR_055591
Natural varianti1564 – 15641A → T.
Corresponds to variant rs2304867 [ dbSNP | Ensembl ].
VAR_055592
Natural varianti1605 – 16051N → D.
Corresponds to variant rs6836935 [ dbSNP | Ensembl ].
VAR_055593
Natural varianti3800 – 38001P → H.
Corresponds to variant rs11731738 [ dbSNP | Ensembl ].
VAR_055594

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti322 – 3221G → D in CAA60685. 1 Publication
Sequence conflicti404 – 4041S → R in CAA60685. 1 Publication
Sequence conflicti482 – 4821V → I in CAA60685. 1 Publication
Sequence conflicti614 – 6141F → L in CAA60685. 1 Publication
Sequence conflicti862 – 8621V → L in CAA60685. 1 Publication
Sequence conflicti1064 – 10641R → G in CAA60685. 1 Publication
Sequence conflicti1273 – 12731H → R in CAA60685. 1 Publication
Sequence conflicti1351 – 13511P → Q in CAA60685. 1 Publication
Sequence conflicti1526 – 15294HQHT → SPAH in CAA60685. 1 Publication
Sequence conflicti1604 – 16041G → GNIG in CAA60685. 1 Publication
Sequence conflicti2006 – 20061N → S in CAA60685. 1 Publication
Sequence conflicti2054 – 20541T → I in CAA60685. 1 Publication
Sequence conflicti2385 – 23851D → G in CAA60685. 1 Publication
Sequence conflicti2618 – 26192VL → S in CAA60685. 1 Publication
Sequence conflicti2718 – 27181I → V in CAA60685. 1 Publication
Sequence conflicti3113 – 31131L → V in CAA60685. 1 Publication
Sequence conflicti4059 – 40591K → N in CAA60685. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87241 mRNA. Translation: CAA60685.1.
AC107050 Genomic DNA. No translation available.
AC110761 Genomic DNA. No translation available.
CCDSiCCDS47177.1.
RefSeqiNP_005236.2. NM_005245.3.
XP_006714202.1. XM_006714139.1.
UniGeneiHs.481371.

Genome annotation databases

EnsembliENST00000441802; ENSP00000406229; ENSG00000083857.
GeneIDi2195.
KEGGihsa:2195.
UCSCiuc003izf.3. human.

Polymorphism databases

DMDMi334302792.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87241 mRNA. Translation: CAA60685.1 .
AC107050 Genomic DNA. No translation available.
AC110761 Genomic DNA. No translation available.
CCDSi CCDS47177.1.
RefSeqi NP_005236.2. NM_005245.3.
XP_006714202.1. XM_006714139.1.
UniGenei Hs.481371.

3D structure databases

ProteinModelPortali Q14517.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108489. 5 interactions.
IntActi Q14517. 10 interactions.
MINTi MINT-2806731.
STRINGi 9606.ENSP00000406229.

PTM databases

PhosphoSitei Q14517.

Polymorphism databases

DMDMi 334302792.

Proteomic databases

MaxQBi Q14517.
PaxDbi Q14517.
PRIDEi Q14517.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000441802 ; ENSP00000406229 ; ENSG00000083857 .
GeneIDi 2195.
KEGGi hsa:2195.
UCSCi uc003izf.3. human.

Organism-specific databases

CTDi 2195.
GeneCardsi GC04M187508.
HGNCi HGNC:3595. FAT1.
HPAi HPA001869.
HPA023882.
MIMi 600976. gene.
neXtProti NX_Q14517.
PharmGKBi PA164719952.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000046499.
HOVERGENi HBG005641.
InParanoidi Q14517.
KOi K16506.
OMAi PYEAFIV.
OrthoDBi EOG7WMCHJ.
TreeFami TF316403.

Miscellaneous databases

ChiTaRSi FAT1. human.
GeneWikii FAT_(gene).
GenomeRNAii 2195.
NextBioi 8873.
PROi Q14517.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q14517.
Bgeei Q14517.
CleanExi HS_FAT1.
Genevestigatori Q14517.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
2.60.40.60. 33 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF00028. Cadherin. 29 hits.
PF00008. EGF. 2 hits.
PF07645. EGF_CA. 1 hit.
PF02210. Laminin_G_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 34 hits.
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 33 hits.
SSF49899. SSF49899. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 17 hits.
PS50268. CADHERIN_2. 33 hits.
PS00022. EGF_1. 4 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 1 hit.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule."
    Dunne J., Hanby A.M., Poulsom R., Jones T.A., Sheer D., Chin W.G., Da S.M., Zhao Q., Beverley P.C.L., Owen M.J.
    Genomics 30:207-223(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lymphocyte.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus."
    Magg T., Schreiner D., Solis G.P., Bade E.G., Hofer H.W.
    Exp. Cell Res. 307:100-108(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, PROTEOLYTIC CLEAVAGE.
  4. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells."
    Hou R., Sibinga N.E.
    J. Biol. Chem. 284:6955-6965(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATN1 AND RERE.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-3415; ASN-3422 AND ASN-3716.
    Tissue: Liver.
  7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-3716.
    Tissue: Leukemic T-cell.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFAT1_HUMAN
AccessioniPrimary (citable) accession number: Q14517
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 31, 2011
Last modified: July 9, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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