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Protein

Fibroblast growth factor-binding protein 1

Gene

FGFBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.4 Publications

Miscellaneous

Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell carcinomas, some colon cancer cell lines and tumors.

GO - Molecular functioni

  • fibroblast growth factor binding Source: Ensembl
  • heparin binding Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • fibroblast growth factor receptor signaling pathway Source: Reactome
  • negative regulation of cell proliferation Source: ProtInc
  • positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
  • positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
  • positive regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-HSA-190377 FGFR2b ligand binding and activation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor-binding protein 1
Short name:
FGF-BP
Short name:
FGF-BP1
Short name:
FGF-binding protein 1
Short name:
FGFBP-1
Alternative name(s):
17 kDa heparin-binding growth factor-binding protein
Short name:
17 kDa HBGF-binding protein
Short name:
HBp17
Gene namesi
Name:FGFBP1
Synonyms:FGFBP, HBP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000137440.4
HGNCiHGNC:19695 FGFBP1
MIMi607737 gene
neXtProtiNX_Q14512

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi214C → A: Strongly reduces interaction with FGF2. 1 Publication1

Organism-specific databases

DisGeNETi9982
OpenTargetsiENSG00000137440
PharmGKBiPA134880558

Polymorphism and mutation databases

BioMutaiFGFBP1
DMDMi74739840

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000024551224 – 234Fibroblast growth factor-binding protein 1Add BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 85By similarity
Disulfide bondi94 ↔ 127By similarity
Disulfide bondi103 ↔ 139By similarity
Glycosylationi169O-linked (GalNAc...) serineBy similarity1
Disulfide bondi197 ↔ 234By similarity
Disulfide bondi214 ↔ 222By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ14512
PaxDbiQ14512
PeptideAtlasiQ14512
PRIDEiQ14512

PTM databases

iPTMnetiQ14512
PhosphoSitePlusiQ14512

Expressioni

Tissue specificityi

Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas.3 Publications

Inductioni

Up-regulated in epithelial cells after skin injury. Keratinocyte mitogens.1 Publication

Gene expression databases

BgeeiENSG00000137440
CleanExiHS_FGFBP1
GenevisibleiQ14512 HS

Organism-specific databases

HPAiHPA004332

Interactioni

Subunit structurei

Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FGF2P090383EBI-953742,EBI-977447

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115304, 73 interactors
IntActiQ14512, 2 interactors
STRINGi9606.ENSP00000259988

Structurei

3D structure databases

ProteinModelPortaliQ14512
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni193 – 234Sufficient for interaction with FGF2 and FGF2-induced effectsAdd BLAST42

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZBN Eukaryota
ENOG4111SHY LUCA
GeneTreeiENSGT00730000111278
HOGENOMiHOG000013097
HOVERGENiHBG053095
InParanoidiQ14512
OMAiLKVECTR
OrthoDBiEOG091G0Q03
PhylomeDBiQ14512
TreeFamiTF335877

Family and domain databases

InterProiView protein in InterPro
IPR010510 FGF1-bd
PANTHERiPTHR15258 PTHR15258, 1 hit
PfamiView protein in Pfam
PF06473 FGF-BP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKICSLTLLS FLLLAAQVLL VEGKKKVKNG LHSKVVSEQK DTLGNTQIKQ
60 70 80 90 100
KSRPGNKGKF VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNP
110 120 130 140 150
TSCLKLKDER VYWKQVARNL RSQKDICRYS KTAVKTRVCR KDFPESSLKL
160 170 180 190 200
VSSTLFGNTK PRKEKTEMSP REHIKGKETT PSSLAVTQTM ATKAPECVED
210 220 230
PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC
Length:234
Mass (Da):26,264
Last modified:November 1, 1996 - v1
Checksum:iAAF4209F29F2D058
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60047 mRNA Translation: AAA58636.1
AF149412 Genomic DNA Translation: AAD39216.1
AK291307 mRNA Translation: BAF83996.1
CH471069 Genomic DNA Translation: EAW92748.1
BC003628 mRNA Translation: AAH03628.1
BC008910 mRNA Translation: AAH08910.1
CCDSiCCDS3418.1
PIRiA41178
RefSeqiNP_005121.1, NM_005130.4
UniGeneiHs.1690

Genome annotation databases

EnsembliENST00000382333; ENSP00000371770; ENSG00000137440
GeneIDi9982
KEGGihsa:9982
UCSCiuc003gom.4 human

Similar proteinsi

Entry informationi

Entry nameiFGFP1_HUMAN
AccessioniPrimary (citable) accession number: Q14512
Secondary accession number(s): A8K5J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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