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Q14512 (FGFP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor-binding protein 1

Short name=FGF-BP
Short name=FGF-BP1
Short name=FGF-binding protein 1
Short name=FGFBP-1
Alternative name(s):
17 kDa heparin-binding growth factor-binding protein
Short name=17 kDa HBGF-binding protein
Short name=HBp17
Gene names
Name:FGFBP1
Synonyms:FGFBP, HBP17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. Ref.1 Ref.6 Ref.8 Ref.9

Subunit structure

Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2. Ref.1 Ref.7 Ref.8 Ref.9 Ref.10

Subcellular location

Secretedextracellular space. Cell membrane; Peripheral membrane protein. Note: Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas. Ref.7 Ref.9

Tissue specificity

Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas. Ref.1 Ref.7 Ref.9

Induction

Up-regulated in epithelial cells after skin injury. Keratinocyte mitogens. Ref.9

Miscellaneous

Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell carcinomas, some colon cancer cell lines and tumors.

Sequence similarities

Belongs to the fibroblast growth factor-binding protein family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FGF2P090383EBI-953742,EBI-977447

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 234211Fibroblast growth factor-binding protein 1
PRO_0000245512

Regions

Region193 – 23442Sufficient for interaction with FGF2 and FGF2-induced effects

Amino acid modifications

Glycosylation1691O-linked (GalNAc...) By similarity
Disulfide bond68 ↔ 85 By similarity
Disulfide bond94 ↔ 127 By similarity
Disulfide bond103 ↔ 139 By similarity
Disulfide bond197 ↔ 234 By similarity
Disulfide bond214 ↔ 222 By similarity

Experimental info

Mutagenesis2141C → A: Strongly reduces interaction with FGF2. Ref.10

Sequences

Sequence LengthMass (Da)Tools
Q14512 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: AAF4209F29F2D058

FASTA23426,264
        10         20         30         40         50         60 
MKICSLTLLS FLLLAAQVLL VEGKKKVKNG LHSKVVSEQK DTLGNTQIKQ KSRPGNKGKF 

        70         80         90        100        110        120 
VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNP TSCLKLKDER VYWKQVARNL 

       130        140        150        160        170        180 
RSQKDICRYS KTAVKTRVCR KDFPESSLKL VSSTLFGNTK PRKEKTEMSP REHIKGKETT 

       190        200        210        220        230 
PSSLAVTQTM ATKAPECVED PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC 

« Hide

References

« Hide 'large scale' references
[1]"Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors."
Wu D.Q., Kan M.K., Sato G.H., Okamoto T., Sato J.D.
J. Biol. Chem. 266:16778-16785(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROTEIN SEQUENCE OF 34-67; 92-118 AND 146-158, IDENTIFICATION IN A COMPLEX WITH FGF1 AND FGF2, INTERACTION WITH FGF1, TISSUE SPECIFICITY.
Tissue: Epidermal carcinoma.
[2]"Gene sequence for the human FGF-binding protein HBp17."
Shi S., Sato J.D.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tongue.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary and Pancreas.
[6]"A secreted FGF-binding protein can serve as the angiogenic switch in human cancer."
Czubayko F., Liaudet-Coopman E.D., Aigner A., Tuveson A.T., Berchem G.J., Wellstein A.
Nat. Med. 3:1137-1140(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Fibroblast growth factor-binding protein is a novel partner for perlecan protein core."
Mongiat M., Otto J., Oldershaw R., Ferrer F., Sato J.D., Iozzo R.V.
J. Biol. Chem. 276:10263-10271(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HSPG2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]"Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein."
Tassi E., Al-Attar A., Aigner A., Swift M.R., McDonnell K., Karavanov A., Wellstein A.
J. Biol. Chem. 276:40247-40253(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH FGF2.
[9]"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH FGF7; FGF10 AND FGF22, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[10]"Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display."
Xie B., Tassi E., Swift M.R., McDonnell K., Bowden E.T., Wang S., Ueda Y., Tomita Y., Riegel A.T., Wellstein A.
J. Biol. Chem. 281:1137-1144(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGF2, MUTAGENESIS OF CYS-214.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M60047 mRNA. Translation: AAA58636.1.
AF149412 Genomic DNA. Translation: AAD39216.1.
AK291307 mRNA. Translation: BAF83996.1.
CH471069 Genomic DNA. Translation: EAW92748.1.
BC003628 mRNA. Translation: AAH03628.1.
BC008910 mRNA. Translation: AAH08910.1.
PIRA41178.
RefSeqNP_005121.1. NM_005130.4.
UniGeneHs.1690.

3D structure databases

ProteinModelPortalQ14512.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115304. 5 interactions.
IntActQ14512. 2 interactions.
MINTMINT-2867884.
STRING9606.ENSP00000259988.

PTM databases

PhosphoSiteQ14512.

Polymorphism databases

DMDM74739840.

Proteomic databases

PaxDbQ14512.
PRIDEQ14512.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000259988; ENSP00000259988; ENSG00000137440.
ENST00000382333; ENSP00000371770; ENSG00000137440.
GeneID9982.
KEGGhsa:9982.
UCSCuc003gom.3. human.

Organism-specific databases

CTD9982.
GeneCardsGC04M015937.
HGNCHGNC:19695. FGFBP1.
HPAHPA004332.
MIM607737. gene.
neXtProtNX_Q14512.
PharmGKBPA134880558.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42715.
HOGENOMHOG000013097.
HOVERGENHBG053095.
InParanoidQ14512.
OMALKVECTR.
OrthoDBEOG7S4X70.
PhylomeDBQ14512.
TreeFamTF335877.

Gene expression databases

BgeeQ14512.
CleanExHS_FGFBP1.
GenevestigatorQ14512.

Family and domain databases

InterProIPR010510. FGF1-bd.
[Graphical view]
PANTHERPTHR15258. PTHR15258. 1 hit.
PfamPF06473. FGF-BP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFGFBP1.
GenomeRNAi9982.
NextBio37692.
PROQ14512.
SOURCESearch...

Entry information

Entry nameFGFP1_HUMAN
AccessionPrimary (citable) accession number: Q14512
Secondary accession number(s): A8K5J2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM