Reviewed, UniProtKB/Swiss-Prot Q14512 (FGFP1_HUMAN)

Names and origin

Protein names

Recommended name:
    Fibroblast growth factor-binding protein 1
      Short name=FGF-binding protein 1
      Short name=FGF-BP1
      Short name=FGFBP-1
      Short name=FGF-BP
Alternative name(s):
    17 kDa heparin-binding growth factor-binding protein
      Short name=17 kDa HBGF-binding protein
    HBp17

Gene names

Name:	FGFBP1
Synonyms:	FGFBP, HBP17

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
Subunit structure	Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2.
Subcellular location	Secreted › extracellular space. Cell membrane; Peripheral membrane protein. Note= Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas.
Tissue specificity	Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas.
Induction	Up-regulated in epithelial cells after skin injury. Keratinocyte mitogens.
Miscellaneous	Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell carcinomas, some colon cancer cell lines and tumors.
Sequence similarities	Belongs to the fibroblast growth factor-binding protein family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Domain	Signal
Ligand	Growth factor binding
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc negative regulation of cell proliferation Ref.1 Traceable author statement. Source: ProtInc signal transduction Ref.1 Non-traceable author statement. Source: ProtInc
Cellular component	extracellular space Ref.1 Traceable author statement. Source: ProtInc plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	growth factor binding Inferred from electronic annotation. Source: UniProtKB-KW heparin binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FGF2	P09038	3	EBI-953742,EBI-977447

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 234	211	Fibroblast growth factor-binding protein 1		PRO_0000245512
Regions
	Region	193 – 234	42	Sufficient for interaction with FGF2 and FGF2-induced effects
Amino acid modifications
	Glycosylation	169	1	O-linked (GalNAc...) By similarity
	Disulfide bond	68 ↔ 85		By similarity
	Disulfide bond	94 ↔ 127		By similarity
	Disulfide bond	103 ↔ 139		By similarity
	Disulfide bond	197 ↔ 234		By similarity
	Disulfide bond	214 ↔ 222		By similarity
Experimental info
	Mutagenesis	214	1	C → A: Strongly reduces interaction with FGF2

Sequences

	Sequence		Length	Mass (Da)
	Q14512-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: AAF4209F29F2D058	FASTA	234	26,264
	10 20 30 40 50 60 MKICSLTLLS FLLLAAQVLL VEGKKKVKNG LHSKVVSEQK DTLGNTQIKQ KSRPGNKGKF 70 80 90 100 110 120 VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNP TSCLKLKDER VYWKQVARNL 130 140 150 160 170 180 RSQKDICRYS KTAVKTRVCR KDFPESSLKL VSSTLFGNTK PRKEKTEMSP REHIKGKETT 190 200 210 220 230 PSSLAVTQTM ATKAPECVED PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors." Wu D.Q., Kan M.K., Sato G.H., Okamoto T., Sato J.D. J. Biol. Chem. 266:16778-16785(1991) [PubMed: 1885605] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROTEIN SEQUENCE OF 34-67; 92-118 AND 146-158, IDENTIFICATION IN A COMPLEX WITH FGF1 AND FGF2, INTERACTION WITH FGF1, TISSUE SPECIFICITY. Tissue: Epidermal carcinoma.
[2]	"Gene sequence for the human FGF-binding protein HBp17." Shi S., Sato J.D. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Pancreas.
[4]	"A secreted FGF-binding protein can serve as the angiogenic switch in human cancer." Czubayko F., Liaudet-Coopman E.D., Aigner A., Tuveson A.T., Berchem G.J., Wellstein A. Nat. Med. 3:1137-1140(1997) [PubMed: 9334727] [Abstract] Cited for: FUNCTION.
[5]	"Fibroblast growth factor-binding protein is a novel partner for perlecan protein core." Mongiat M., Otto J., Oldershaw R., Ferrer F., Sato J.D., Iozzo R.V. J. Biol. Chem. 276:10263-10271(2001) [PubMed: 11148217] [Abstract] Cited for: INTERACTION WITH HSPG2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[6]	"Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein." Tassi E., Al-Attar A., Aigner A., Swift M.R., McDonnell K., Karavanov A., Wellstein A. J. Biol. Chem. 276:40247-40253(2001) [PubMed: 11509569] [Abstract] Cited for: FUNCTION, INTERACTION WITH FGF2.
[7]	"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair." Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S. Oncogene 24:5269-5277(2005) [PubMed: 15806171] [Abstract] Cited for: FUNCTION, INTERACTION WITH FGF7; FGF10 AND FGF22, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]	"Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display." Xie B., Tassi E., Swift M.R., McDonnell K., Bowden E.T., Wang S., Ueda Y., Tomita Y., Riegel A.T., Wellstein A. J. Biol. Chem. 281:1137-1144(2006) [PubMed: 16257968] [Abstract] Cited for: INTERACTION WITH FGF2, MUTAGENESIS OF CYS-214.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M60047 mRNA. Translation: AAA58636.1. AF149412 Genomic DNA. Translation: AAD39216.1. BC003628 mRNA. Translation: AAH03628.1. BC008910 mRNA. Translation: AAH08910.1.
PIR	A41178.
RefSeq	NP_005121.1.
UniGene	Hs.1690
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14512.
PTM databases
PhosphoSite	Q14512.
Genome annotation databases
Ensembl	ENSG00000137440. Homo sapiens. [Contig view]
GeneID	9982.
KEGG	hsa:9982.
Organism-specific databases
H-InvDB	HIX0004114.
HGNC	HGNC:19695. FGFBP1.
HPA	HPA004332.
MIM	607737. gene.
PharmGKB	PA134880558.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q14512.
HOVERGEN	Q14512.
Gene expression databases
ArrayExpress	Q14512.
CleanEx	HS_FGFBP1.
GermOnline	ENSG00000137440. Homo sapiens.
Family and domain databases
InterPro	IPR010510. FGF1_bd. [Graphical view]
PANTHER	PTHR15258. FGF1_bd. 1 hit.
Pfam	PF06473. FGF-BP1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	37692.
SOURCE	Search...

Entry information

Entry name

FGFP1_HUMAN

Accession

Primary (citable) accession number: Q14512

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)