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Q14512

- FGFP1_HUMAN

UniProt

Q14512 - FGFP1_HUMAN

Protein

Fibroblast growth factor-binding protein 1

Gene

FGFBP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.4 Publications

    GO - Molecular functioni

    1. heparin binding Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. negative regulation of cell proliferation Source: ProtInc
    3. positive regulation of cell proliferation Source: Ensembl
    4. positive regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
    5. signal transduction Source: ProtInc

    Keywords - Ligandi

    Growth factor binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor-binding protein 1
    Short name:
    FGF-BP
    Short name:
    FGF-BP1
    Short name:
    FGF-binding protein 1
    Short name:
    FGFBP-1
    Alternative name(s):
    17 kDa heparin-binding growth factor-binding protein
    Short name:
    17 kDa HBGF-binding protein
    Short name:
    HBp17
    Gene namesi
    Name:FGFBP1
    Synonyms:FGFBP, HBP17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:19695. FGFBP1.

    Subcellular locationi

    Secretedextracellular space. Cell membrane; Peripheral membrane protein
    Note: Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas.

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular space Source: ProtInc
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi214 – 2141C → A: Strongly reduces interaction with FGF2. 1 Publication

    Organism-specific databases

    PharmGKBiPA134880558.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 234211Fibroblast growth factor-binding protein 1PRO_0000245512Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi68 ↔ 85By similarity
    Disulfide bondi94 ↔ 127By similarity
    Disulfide bondi103 ↔ 139By similarity
    Glycosylationi169 – 1691O-linked (GalNAc...)By similarity
    Disulfide bondi197 ↔ 234By similarity
    Disulfide bondi214 ↔ 222By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ14512.
    PaxDbiQ14512.
    PRIDEiQ14512.

    PTM databases

    PhosphoSiteiQ14512.

    Expressioni

    Tissue specificityi

    Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas.3 Publications

    Inductioni

    Up-regulated in epithelial cells after skin injury. Keratinocyte mitogens.1 Publication

    Gene expression databases

    BgeeiQ14512.
    CleanExiHS_FGFBP1.
    GenevestigatoriQ14512.

    Organism-specific databases

    HPAiHPA004332.

    Interactioni

    Subunit structurei

    Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FGF2P090383EBI-953742,EBI-977447

    Protein-protein interaction databases

    BioGridi115304. 5 interactions.
    IntActiQ14512. 2 interactions.
    MINTiMINT-2867884.
    STRINGi9606.ENSP00000259988.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14512.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni193 – 23442Sufficient for interaction with FGF2 and FGF2-induced effectsAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42715.
    HOGENOMiHOG000013097.
    HOVERGENiHBG053095.
    InParanoidiQ14512.
    OMAiCGESWSS.
    OrthoDBiEOG7S4X70.
    PhylomeDBiQ14512.
    TreeFamiTF335877.

    Family and domain databases

    InterProiIPR010510. FGF1-bd.
    [Graphical view]
    PANTHERiPTHR15258. PTHR15258. 1 hit.
    PfamiPF06473. FGF-BP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q14512-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKICSLTLLS FLLLAAQVLL VEGKKKVKNG LHSKVVSEQK DTLGNTQIKQ    50
    KSRPGNKGKF VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNP 100
    TSCLKLKDER VYWKQVARNL RSQKDICRYS KTAVKTRVCR KDFPESSLKL 150
    VSSTLFGNTK PRKEKTEMSP REHIKGKETT PSSLAVTQTM ATKAPECVED 200
    PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC 234
    Length:234
    Mass (Da):26,264
    Last modified:November 1, 1996 - v1
    Checksum:iAAF4209F29F2D058
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60047 mRNA. Translation: AAA58636.1.
    AF149412 Genomic DNA. Translation: AAD39216.1.
    AK291307 mRNA. Translation: BAF83996.1.
    CH471069 Genomic DNA. Translation: EAW92748.1.
    BC003628 mRNA. Translation: AAH03628.1.
    BC008910 mRNA. Translation: AAH08910.1.
    CCDSiCCDS3418.1.
    PIRiA41178.
    RefSeqiNP_005121.1. NM_005130.4.
    UniGeneiHs.1690.

    Genome annotation databases

    EnsembliENST00000382333; ENSP00000371770; ENSG00000137440.
    GeneIDi9982.
    KEGGihsa:9982.
    UCSCiuc003gom.3. human.

    Polymorphism databases

    DMDMi74739840.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60047 mRNA. Translation: AAA58636.1 .
    AF149412 Genomic DNA. Translation: AAD39216.1 .
    AK291307 mRNA. Translation: BAF83996.1 .
    CH471069 Genomic DNA. Translation: EAW92748.1 .
    BC003628 mRNA. Translation: AAH03628.1 .
    BC008910 mRNA. Translation: AAH08910.1 .
    CCDSi CCDS3418.1.
    PIRi A41178.
    RefSeqi NP_005121.1. NM_005130.4.
    UniGenei Hs.1690.

    3D structure databases

    ProteinModelPortali Q14512.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115304. 5 interactions.
    IntActi Q14512. 2 interactions.
    MINTi MINT-2867884.
    STRINGi 9606.ENSP00000259988.

    PTM databases

    PhosphoSitei Q14512.

    Polymorphism databases

    DMDMi 74739840.

    Proteomic databases

    MaxQBi Q14512.
    PaxDbi Q14512.
    PRIDEi Q14512.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382333 ; ENSP00000371770 ; ENSG00000137440 .
    GeneIDi 9982.
    KEGGi hsa:9982.
    UCSCi uc003gom.3. human.

    Organism-specific databases

    CTDi 9982.
    GeneCardsi GC04M015937.
    HGNCi HGNC:19695. FGFBP1.
    HPAi HPA004332.
    MIMi 607737. gene.
    neXtProti NX_Q14512.
    PharmGKBi PA134880558.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42715.
    HOGENOMi HOG000013097.
    HOVERGENi HBG053095.
    InParanoidi Q14512.
    OMAi CGESWSS.
    OrthoDBi EOG7S4X70.
    PhylomeDBi Q14512.
    TreeFami TF335877.

    Miscellaneous databases

    GeneWikii FGFBP1.
    GenomeRNAii 9982.
    NextBioi 37692.
    PROi Q14512.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q14512.
    CleanExi HS_FGFBP1.
    Genevestigatori Q14512.

    Family and domain databases

    InterProi IPR010510. FGF1-bd.
    [Graphical view ]
    PANTHERi PTHR15258. PTHR15258. 1 hit.
    Pfami PF06473. FGF-BP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors."
      Wu D.Q., Kan M.K., Sato G.H., Okamoto T., Sato J.D.
      J. Biol. Chem. 266:16778-16785(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROTEIN SEQUENCE OF 34-67; 92-118 AND 146-158, IDENTIFICATION IN A COMPLEX WITH FGF1 AND FGF2, INTERACTION WITH FGF1, TISSUE SPECIFICITY.
      Tissue: Epidermal carcinoma.
    2. "Gene sequence for the human FGF-binding protein HBp17."
      Shi S., Sato J.D.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary and Pancreas.
    6. "A secreted FGF-binding protein can serve as the angiogenic switch in human cancer."
      Czubayko F., Liaudet-Coopman E.D., Aigner A., Tuveson A.T., Berchem G.J., Wellstein A.
      Nat. Med. 3:1137-1140(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core."
      Mongiat M., Otto J., Oldershaw R., Ferrer F., Sato J.D., Iozzo R.V.
      J. Biol. Chem. 276:10263-10271(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HSPG2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    8. "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein."
      Tassi E., Al-Attar A., Aigner A., Swift M.R., McDonnell K., Karavanov A., Wellstein A.
      J. Biol. Chem. 276:40247-40253(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH FGF2.
    9. "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
      Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
      Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH FGF7; FGF10 AND FGF22, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    10. "Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display."
      Xie B., Tassi E., Swift M.R., McDonnell K., Bowden E.T., Wang S., Ueda Y., Tomita Y., Riegel A.T., Wellstein A.
      J. Biol. Chem. 281:1137-1144(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGF2, MUTAGENESIS OF CYS-214.

    Entry informationi

    Entry nameiFGFP1_HUMAN
    AccessioniPrimary (citable) accession number: Q14512
    Secondary accession number(s): A8K5J2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell carcinomas, some colon cancer cell lines and tumors.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3