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Q14512

- FGFP1_HUMAN

UniProt

Q14512 - FGFP1_HUMAN

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Protein
Fibroblast growth factor-binding protein 1
Gene
FGFBP1, FGFBP, HBP17
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.4 Publications

GO - Molecular functioni

  1. heparin binding Source: ProtInc
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. negative regulation of cell proliferation Source: ProtInc
  3. positive regulation of cell proliferation Source: Ensembl
  4. positive regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
  5. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor-binding protein 1
Short name:
FGF-BP
Short name:
FGF-BP1
Short name:
FGF-binding protein 1
Short name:
FGFBP-1
Alternative name(s):
17 kDa heparin-binding growth factor-binding protein
Short name:
17 kDa HBGF-binding protein
Short name:
HBp17
Gene namesi
Name:FGFBP1
Synonyms:FGFBP, HBP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:19695. FGFBP1.

Subcellular locationi

Secretedextracellular space. Cell membrane; Peripheral membrane protein
Note: Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas.2 Publications

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular space Source: ProtInc
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi214 – 2141C → A: Strongly reduces interaction with FGF2. 1 Publication

Organism-specific databases

PharmGKBiPA134880558.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 234211Fibroblast growth factor-binding protein 1
PRO_0000245512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 85 By similarity
Disulfide bondi94 ↔ 127 By similarity
Disulfide bondi103 ↔ 139 By similarity
Glycosylationi169 – 1691O-linked (GalNAc...) By similarity
Disulfide bondi197 ↔ 234 By similarity
Disulfide bondi214 ↔ 222 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ14512.
PaxDbiQ14512.
PRIDEiQ14512.

PTM databases

PhosphoSiteiQ14512.

Expressioni

Tissue specificityi

Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas.3 Publications

Inductioni

Up-regulated in epithelial cells after skin injury. Keratinocyte mitogens.1 Publication

Gene expression databases

BgeeiQ14512.
CleanExiHS_FGFBP1.
GenevestigatoriQ14512.

Organism-specific databases

HPAiHPA004332.

Interactioni

Subunit structurei

Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FGF2P090383EBI-953742,EBI-977447

Protein-protein interaction databases

BioGridi115304. 5 interactions.
IntActiQ14512. 2 interactions.
MINTiMINT-2867884.
STRINGi9606.ENSP00000259988.

Structurei

3D structure databases

ProteinModelPortaliQ14512.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni193 – 23442Sufficient for interaction with FGF2 and FGF2-induced effects
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42715.
HOGENOMiHOG000013097.
HOVERGENiHBG053095.
InParanoidiQ14512.
OMAiCGESWSS.
OrthoDBiEOG7S4X70.
PhylomeDBiQ14512.
TreeFamiTF335877.

Family and domain databases

InterProiIPR010510. FGF1-bd.
[Graphical view]
PANTHERiPTHR15258. PTHR15258. 1 hit.
PfamiPF06473. FGF-BP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14512-1 [UniParc]FASTAAdd to Basket

« Hide

MKICSLTLLS FLLLAAQVLL VEGKKKVKNG LHSKVVSEQK DTLGNTQIKQ    50
KSRPGNKGKF VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNP 100
TSCLKLKDER VYWKQVARNL RSQKDICRYS KTAVKTRVCR KDFPESSLKL 150
VSSTLFGNTK PRKEKTEMSP REHIKGKETT PSSLAVTQTM ATKAPECVED 200
PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC 234
Length:234
Mass (Da):26,264
Last modified:November 1, 1996 - v1
Checksum:iAAF4209F29F2D058
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60047 mRNA. Translation: AAA58636.1.
AF149412 Genomic DNA. Translation: AAD39216.1.
AK291307 mRNA. Translation: BAF83996.1.
CH471069 Genomic DNA. Translation: EAW92748.1.
BC003628 mRNA. Translation: AAH03628.1.
BC008910 mRNA. Translation: AAH08910.1.
CCDSiCCDS3418.1.
PIRiA41178.
RefSeqiNP_005121.1. NM_005130.4.
UniGeneiHs.1690.

Genome annotation databases

EnsembliENST00000259988; ENSP00000259988; ENSG00000137440.
ENST00000382333; ENSP00000371770; ENSG00000137440.
GeneIDi9982.
KEGGihsa:9982.
UCSCiuc003gom.3. human.

Polymorphism databases

DMDMi74739840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60047 mRNA. Translation: AAA58636.1 .
AF149412 Genomic DNA. Translation: AAD39216.1 .
AK291307 mRNA. Translation: BAF83996.1 .
CH471069 Genomic DNA. Translation: EAW92748.1 .
BC003628 mRNA. Translation: AAH03628.1 .
BC008910 mRNA. Translation: AAH08910.1 .
CCDSi CCDS3418.1.
PIRi A41178.
RefSeqi NP_005121.1. NM_005130.4.
UniGenei Hs.1690.

3D structure databases

ProteinModelPortali Q14512.
ModBasei Search...

Protein-protein interaction databases

BioGridi 115304. 5 interactions.
IntActi Q14512. 2 interactions.
MINTi MINT-2867884.
STRINGi 9606.ENSP00000259988.

PTM databases

PhosphoSitei Q14512.

Polymorphism databases

DMDMi 74739840.

Proteomic databases

MaxQBi Q14512.
PaxDbi Q14512.
PRIDEi Q14512.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259988 ; ENSP00000259988 ; ENSG00000137440 .
ENST00000382333 ; ENSP00000371770 ; ENSG00000137440 .
GeneIDi 9982.
KEGGi hsa:9982.
UCSCi uc003gom.3. human.

Organism-specific databases

CTDi 9982.
GeneCardsi GC04M015937.
HGNCi HGNC:19695. FGFBP1.
HPAi HPA004332.
MIMi 607737. gene.
neXtProti NX_Q14512.
PharmGKBi PA134880558.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42715.
HOGENOMi HOG000013097.
HOVERGENi HBG053095.
InParanoidi Q14512.
OMAi CGESWSS.
OrthoDBi EOG7S4X70.
PhylomeDBi Q14512.
TreeFami TF335877.

Miscellaneous databases

GeneWikii FGFBP1.
GenomeRNAii 9982.
NextBioi 37692.
PROi Q14512.
SOURCEi Search...

Gene expression databases

Bgeei Q14512.
CleanExi HS_FGFBP1.
Genevestigatori Q14512.

Family and domain databases

InterProi IPR010510. FGF1-bd.
[Graphical view ]
PANTHERi PTHR15258. PTHR15258. 1 hit.
Pfami PF06473. FGF-BP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors."
    Wu D.Q., Kan M.K., Sato G.H., Okamoto T., Sato J.D.
    J. Biol. Chem. 266:16778-16785(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROTEIN SEQUENCE OF 34-67; 92-118 AND 146-158, IDENTIFICATION IN A COMPLEX WITH FGF1 AND FGF2, INTERACTION WITH FGF1, TISSUE SPECIFICITY.
    Tissue: Epidermal carcinoma.
  2. "Gene sequence for the human FGF-binding protein HBp17."
    Shi S., Sato J.D.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary and Pancreas.
  6. "A secreted FGF-binding protein can serve as the angiogenic switch in human cancer."
    Czubayko F., Liaudet-Coopman E.D., Aigner A., Tuveson A.T., Berchem G.J., Wellstein A.
    Nat. Med. 3:1137-1140(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core."
    Mongiat M., Otto J., Oldershaw R., Ferrer F., Sato J.D., Iozzo R.V.
    J. Biol. Chem. 276:10263-10271(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HSPG2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein."
    Tassi E., Al-Attar A., Aigner A., Swift M.R., McDonnell K., Karavanov A., Wellstein A.
    J. Biol. Chem. 276:40247-40253(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FGF2.
  9. "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
    Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
    Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FGF7; FGF10 AND FGF22, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  10. "Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display."
    Xie B., Tassi E., Swift M.R., McDonnell K., Bowden E.T., Wang S., Ueda Y., Tomita Y., Riegel A.T., Wellstein A.
    J. Biol. Chem. 281:1137-1144(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGF2, MUTAGENESIS OF CYS-214.

Entry informationi

Entry nameiFGFP1_HUMAN
AccessioniPrimary (citable) accession number: Q14512
Secondary accession number(s): A8K5J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell carcinomas, some colon cancer cell lines and tumors.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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