Q14512 (FGFP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor-binding protein 1
Short name=FGF-BP
Short name=FGF-BP1
Short name=FGF-binding protein 1
Short name=FGFBP-1

Alternative name(s):
17 kDa heparin-binding growth factor-binding protein
Short name=17 kDa HBGF-binding protein
Short name=HBp17

Gene names

Name:	FGFBP1
Synonyms:	FGFBP, HBP17

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. Ref.1 Ref.6 Ref.8 Ref.9
Subunit structure	Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2. Ref.1 Ref.7 Ref.8 Ref.9 Ref.10
Subcellular location	Secreted › extracellular space. Cell membrane; Peripheral membrane protein. Note: Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas. Ref.7 Ref.9
Tissue specificity	Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas. Ref.1 Ref.7 Ref.9
Induction	Up-regulated in epithelial cells after skin injury. Keratinocyte mitogens. Ref.9
Miscellaneous	Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell carcinomas, some colon cancer cell lines and tumors.
Sequence similarities	Belongs to the fibroblast growth factor-binding protein family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Domain	Signal
Ligand	Growth factor binding
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell signaling Traceable author statement Ref.1. Source: ProtInc negative regulation of cell proliferation Traceable author statement Ref.1. Source: ProtInc positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of fibroblast growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara signal transduction Non-traceable author statement Ref.1. Source: ProtInc
Cellular_component	cell surface Inferred from electronic annotation. Source: Compara extracellular space Traceable author statement Ref.1. Source: ProtInc plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	heparin binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FGF2	P09038	3	EBI-953742,EBI-977447

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 234	211	Fibroblast growth factor-binding protein 1		PRO_0000245512
Regions
	Region	193 – 234	42	Sufficient for interaction with FGF2 and FGF2-induced effects
Amino acid modifications
	Glycosylation	169	1	O-linked (GalNAc...) By similarity
	Disulfide bond	68 ↔ 85		By similarity
	Disulfide bond	94 ↔ 127		By similarity
	Disulfide bond	103 ↔ 139		By similarity
	Disulfide bond	197 ↔ 234		By similarity
	Disulfide bond	214 ↔ 222		By similarity
Experimental info
	Mutagenesis	214	1	C → A: Strongly reduces interaction with FGF2. Ref.10

Sequences

	Sequence		Length	Mass (Da)
	Q14512 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: AAF4209F29F2D058	FASTA	234	26,264
	10 20 30 40 50 60 MKICSLTLLS FLLLAAQVLL VEGKKKVKNG LHSKVVSEQK DTLGNTQIKQ KSRPGNKGKF 70 80 90 100 110 120 VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNP TSCLKLKDER VYWKQVARNL 130 140 150 160 170 180 RSQKDICRYS KTAVKTRVCR KDFPESSLKL VSSTLFGNTK PRKEKTEMSP REHIKGKETT 190 200 210 220 230 PSSLAVTQTM ATKAPECVED PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors." Wu D.Q., Kan M.K., Sato G.H., Okamoto T., Sato J.D. J. Biol. Chem. 266:16778-16785(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROTEIN SEQUENCE OF 34-67; 92-118 AND 146-158, IDENTIFICATION IN A COMPLEX WITH FGF1 AND FGF2, INTERACTION WITH FGF1, TISSUE SPECIFICITY. Tissue: Epidermal carcinoma.
[2]	"Gene sequence for the human FGF-binding protein HBp17." Shi S., Sato J.D. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tongue.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Pancreas.
[6]	"A secreted FGF-binding protein can serve as the angiogenic switch in human cancer." Czubayko F., Liaudet-Coopman E.D., Aigner A., Tuveson A.T., Berchem G.J., Wellstein A. Nat. Med. 3:1137-1140(1997) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Fibroblast growth factor-binding protein is a novel partner for perlecan protein core." Mongiat M., Otto J., Oldershaw R., Ferrer F., Sato J.D., Iozzo R.V. J. Biol. Chem. 276:10263-10271(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HSPG2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]	"Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein." Tassi E., Al-Attar A., Aigner A., Swift M.R., McDonnell K., Karavanov A., Wellstein A. J. Biol. Chem. 276:40247-40253(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH FGF2.
[9]	"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair." Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S. Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH FGF7; FGF10 AND FGF22, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[10]	"Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display." Xie B., Tassi E., Swift M.R., McDonnell K., Bowden E.T., Wang S., Ueda Y., Tomita Y., Riegel A.T., Wellstein A. J. Biol. Chem. 281:1137-1144(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGF2, MUTAGENESIS OF CYS-214.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M60047 mRNA. Translation: AAA58636.1. AF149412 Genomic DNA. Translation: AAD39216.1. AK291307 mRNA. Translation: BAF83996.1. CH471069 Genomic DNA. Translation: EAW92748.1. BC003628 mRNA. Translation: AAH03628.1. BC008910 mRNA. Translation: AAH08910.1.
IPI	IPI00021399.
PIR	A41178.
RefSeq	NP_005121.1. NM_005130.4.
UniGene	Hs.1690.
3D structure databases
ProteinModelPortal	Q14512.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14512. 2 interactions.
MINT	MINT-2867884.
STRING	9606.ENSP00000259988.
PTM databases
PhosphoSite	Q14512.
Polymorphism databases
DMDM	74739840.
Proteomic databases
PaxDb	Q14512.
PRIDE	Q14512.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259988; ENSP00000259988; ENSG00000137440. ENST00000382333; ENSP00000371770; ENSG00000137440.
GeneID	9982.
KEGG	hsa:9982.
UCSC	uc003gom.3. human.
Organism-specific databases
CTD	9982.
GeneCards	GC04M015937.
HGNC	HGNC:19695. FGFBP1.
HPA	HPA004332.
MIM	607737. gene.
neXtProt	NX_Q14512.
PharmGKB	PA134880558.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42715.
HOGENOM	HOG000013097.
HOVERGEN	HBG053095.
InParanoid	Q14512.
OMA	LKVECTR.
OrthoDB	EOG49KFRN.
PhylomeDB	Q14512.
Gene expression databases
Bgee	Q14512.
CleanEx	HS_FGFBP1.
Genevestigator	Q14512.
GermOnline	ENSG00000137440. Homo sapiens.
Family and domain databases
InterPro	IPR010510. FGF1-bd. [Graphical view]
PANTHER	PTHR15258. PTHR15258. 1 hit.
Pfam	PF06473. FGF-BP1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9982.
NextBio	37692.
SOURCE	Search...

Entry information

Entry name

FGFP1_HUMAN

Accession

Primary (citable) accession number: Q14512
Secondary accession number(s): A8K5J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.