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Reviewed, UniProtKB/Swiss-Prot Q14512 (FGFP1_HUMAN)

Last modified November 25, 2008. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Fibroblast growth factor-binding protein 1
      Short name=FGF-binding protein 1
      Short name=FGF-BP1
      Short name=FGFBP-1
      Short name=FGF-BP
Alternative name(s):
    17 kDa heparin-binding growth factor-binding protein
      Short name=17 kDa HBGF-binding protein
    HBp17
Gene names
Name: FGFBP1
Synonyms: FGFBP, HBP17
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.

Subunit structure

Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2.

Subcellular location

Secretedextracellular space. Cell membrane; Peripheral membrane protein. Note= Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas.

Tissue specificity

Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas.

Induction

Up-regulated in epithelial cells after skin injury. Keratinocyte mitogens.

Miscellaneous

Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell carcinomas, some colon cancer cell lines and tumors.

Sequence similarities

Belongs to the fibroblast growth factor-binding protein family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FGF2P090383EBI-953742,EBI-977447

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 234211Fibroblast growth factor-binding protein 1
PRO_0000245512

Regions

Region193 – 23442Sufficient for interaction with FGF2 and FGF2-induced effects

Amino acid modifications

Glycosylation1691O-linked (GalNAc...) By similarity
Disulfide bond68 ↔ 85 By similarity
Disulfide bond94 ↔ 127 By similarity
Disulfide bond103 ↔ 139 By similarity
Disulfide bond197 ↔ 234 By similarity
Disulfide bond214 ↔ 222 By similarity

Experimental info

Mutagenesis2141C → A: Strongly reduces interaction with FGF2

Sequences

Sequence LengthMass (Da)Tools
Q14512-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: AAF4209F29F2D058

FASTA23426,264
        10         20         30         40         50         60 
MKICSLTLLS FLLLAAQVLL VEGKKKVKNG LHSKVVSEQK DTLGNTQIKQ KSRPGNKGKF 

        70         80         90        100        110        120 
VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNP TSCLKLKDER VYWKQVARNL 

       130        140        150        160        170        180 
RSQKDICRYS KTAVKTRVCR KDFPESSLKL VSSTLFGNTK PRKEKTEMSP REHIKGKETT 

       190        200        210        220        230 
PSSLAVTQTM ATKAPECVED PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC 

« Hide

References

« Hide 'large scale' references
[1]"Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors."
Wu D.Q., Kan M.K., Sato G.H., Okamoto T., Sato J.D.
J. Biol. Chem. 266:16778-16785(1991) [PubMed: 1885605] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROTEIN SEQUENCE OF 34-67; 92-118 AND 146-158, IDENTIFICATION IN A COMPLEX WITH FGF1 AND FGF2, INTERACTION WITH FGF1, TISSUE SPECIFICITY.
Tissue: Epidermal carcinoma.
[2]"Gene sequence for the human FGF-binding protein HBp17."
Shi S., Sato J.D.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary and Pancreas.
[4]"A secreted FGF-binding protein can serve as the angiogenic switch in human cancer."
Czubayko F., Liaudet-Coopman E.D., Aigner A., Tuveson A.T., Berchem G.J., Wellstein A.
Nat. Med. 3:1137-1140(1997) [PubMed: 9334727] [Abstract]
Cited for: FUNCTION.
[5]"Fibroblast growth factor-binding protein is a novel partner for perlecan protein core."
Mongiat M., Otto J., Oldershaw R., Ferrer F., Sato J.D., Iozzo R.V.
J. Biol. Chem. 276:10263-10271(2001) [PubMed: 11148217] [Abstract]
Cited for: INTERACTION WITH HSPG2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[6]"Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein."
Tassi E., Al-Attar A., Aigner A., Swift M.R., McDonnell K., Karavanov A., Wellstein A.
J. Biol. Chem. 276:40247-40253(2001) [PubMed: 11509569] [Abstract]
Cited for: FUNCTION, INTERACTION WITH FGF2.
[7]"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
Oncogene 24:5269-5277(2005) [PubMed: 15806171] [Abstract]
Cited for: FUNCTION, INTERACTION WITH FGF7; FGF10 AND FGF22, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]"Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display."
Xie B., Tassi E., Swift M.R., McDonnell K., Bowden E.T., Wang S., Ueda Y., Tomita Y., Riegel A.T., Wellstein A.
J. Biol. Chem. 281:1137-1144(2006) [PubMed: 16257968] [Abstract]
Cited for: INTERACTION WITH FGF2, MUTAGENESIS OF CYS-214.
+Additional computationally mapped references.

Cross-references

Sequence databases

M60047 mRNA. Translation: AAA58636.1.
AF149412 Genomic DNA. Translation: AAD39216.1.
BC003628 mRNA. Translation: AAH03628.1.
BC008910 mRNA. Translation: AAH08910.1.
PIRA41178.
RefSeqNP_005121.1.
UniGeneHs.1690

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ14512.

PTM databases

PhosphoSiteQ14512.

Genome annotation databases

EnsemblENSG00000137440. Homo sapiens. [Contig view]
GeneID9982.
KEGGhsa:9982.

Organism-specific databases

H-InvDBHIX0004114.
HGNCHGNC:19695. FGFBP1.
HPAHPA004332.
MIM607737. gene.
PharmGKBPA134880558.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ14512.
HOVERGENQ14512.

Gene expression databases

ArrayExpressQ14512.
CleanExHS_FGFBP1.
GermOnlineENSG00000137440. Homo sapiens.

Family and domain databases

InterProIPR010510. FGF1_bd.
[Graphical view]
PANTHERPTHR15258. FGF1_bd. 1 hit.
PfamPF06473. FGF-BP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio37692.
SOURCESearch...

Entry information

Entry nameFGFP1_HUMAN
AccessionPrimary (citable) accession number: Q14512
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1996
Last modified: November 25, 2008
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents