ID   EP4_HUMAN      STANDARD;      PRT;   125 AA.
AC   Q14508;
DT   15-JUL-1998 (Rel. 36, Created)
DT   15-JUL-1998 (Rel. 36, Last sequence update)
DT   30-MAY-2000 (Rel. 39, Last annotation update)
DE   MAJOR EPIDIDYMIS-SPECIFIC PROTEIN E4 PRECURSOR (HE4) (EPIDIDYMAL
DE   SECRETORY PROTEIN E4).
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Epididymis;
RX   MEDLINE=92153963; PubMed=1686187;
RA   Kirchhoff C., Habben L., Ivell R., Krull N.;
RT   "A major human epididymis-specific cDNA encodes a protein with
RT   sequence homology to extracellular proteinase inhibitors.";
RL   Biol. Reprod. 45:350-357(1991).
CC   -!- FUNCTION: POSSIBLE FUNCTION IN SPERM MATURATION.
CC   -!- SUBCELLULAR LOCATION: SECRETED (POTENTIAL).
CC   -!- TISSUE SPECIFICITY: EPITHELIAL CELLS OF THE EPIDIDYMAL DUCT,
CC       PREDOMINANTLY WITHIN THE DISTAL SECTIONS.
CC   -!- SIMILARITY: BELONGS TO THE WAP-TYPE 'FOUR-DISULFIDE CORE' FAMILY.
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DR   EMBL; X63187; CAA44869.1; -.
DR   EMBL; A18924; CAA01433.1; -.
DR   HSSP; P19957; 1FLE.
DR   InterPro; IPR002221; -.
DR   Pfam; PF00095; wap; 2.
DR   PROSITE; PS00317; 4_DISULFIDE_CORE; 2.
KW   Signal; Glycoprotein.
FT   SIGNAL        1     21       POTENTIAL.
FT   CHAIN        22    125       MAJOR EPIDIDYMIS-SPECIFIC PROTEIN E4.
FT   DOMAIN       27     75       WAP 1.
FT   DOMAIN       76    125       WAP 2.
FT   CARBOHYD     44     44       N-LINKED (GLCNAC...) (POTENTIAL).
SQ   SEQUENCE   125 AA;  13136 MW;  B5BF5C08FF70E245 CRC64;
     MPACRLGPLA AALLLSLLLF GFTLVSGTGA EKTGVCPELQ ADQNCTQECV SDSECADNLK
     CCSAGCATFC LLCPNDKEGS CPQVNINFPQ LGLCRDQCQV DTQCPGQMKC CRNGCGKVSC
     VTPNF
//