ID   WFD2_HUMAN     STANDARD;      PRT;   124 AA.
AC   Q14508; Q96KJ1;
DT   15-JUL-1998 (Rel. 36, Created)
DT   15-JUN-2002 (Rel. 41, Last sequence update)
DT   15-JUN-2002 (Rel. 41, Last annotation update)
DE   Major epididymis-specific protein E4 precursor (HE4) (Epididymal
DE   secretory protein E4) (WAP four-disulfide core domain protein 2).
GN   WFDC2 OR HE4.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Epididymis;
RX   MEDLINE=92153963; PubMed=1686187;
RA   Kirchhoff C., Habben L., Ivell R., Krull N.;
RT   "A major human epididymis-specific cDNA encodes a protein with
RT   sequence homology to extracellular proteinase inhibitors.";
RL   Biol. Reprod. 45:350-357(1991).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=21638749; PubMed=11780052;
RA   Deloukas P., Matthews L.H., Ashurst J., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaslaiho M.H., Leversha M., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
CC   -!- FUNCTION: POSSIBLE FUNCTION IN SPERM MATURATION.
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- TISSUE SPECIFICITY: EPITHELIAL CELLS OF THE EPIDIDYMAL DUCT,
CC       PREDOMINANTLY WITHIN THE DISTAL SECTIONS.
CC   -!- SIMILARITY: CONTAINS 2 WAP-TYPE DOMAINS.
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DR   EMBL; X63187; CAA44869.1; -.
DR   EMBL; A18924; CAA01433.1; -.
DR   EMBL; AL031663; CAB37641.1; -.
DR   HSSP; Q9N0L8; 1TWP.
DR   InterPro; IPR002221; WAP.
DR   Pfam; PF00095; wap; 3.
DR   SMART; SM00217; WAP; 1.
DR   PROSITE; PS00317; 4_DISULFIDE_CORE; 2.
KW   Repeat; Signal; Glycoprotein.
FT   SIGNAL        1     21       POTENTIAL.
FT   CHAIN        22    124       MAJOR EPIDIDYMIS-SPECIFIC PROTEIN E4.
FT   DOMAIN       32     73       WAP 1.
FT   DOMAIN       76    124       WAP 2.
FT   DISULFID     36     62       BY SIMILARITY.
FT   DISULFID     45     66       BY SIMILARITY.
FT   DISULFID     49     61       BY SIMILARITY.
FT   DISULFID     55     70       BY SIMILARITY.
FT   DISULFID     80    110       BY SIMILARITY.
FT   DISULFID     93    114       BY SIMILARITY.
FT   DISULFID     97    109       BY SIMILARITY.
FT   DISULFID    103    119       BY SIMILARITY.
FT   CARBOHYD     44     44       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CONFLICT     71     72       SL -> LLC (IN REF. 1).
FT   CONFLICT    101    101       S -> T (IN REF. 1).
SQ   SEQUENCE   124 AA;  12993 MW;  9536B00B385259AD CRC64;
     MPACRLGPLA AALLLSLLLF GFTLVSGTGA EKTGVCPELQ ADQNCTQECV SDSECADNLK
     CCSAGCATFC SLPNDKEGSC PQVNINFPQL GLCRDQCQVD SQCPGQMKCC RNGCGKVSCV
     TPNF
//