ID   EP4_HUMAN      STANDARD;      PRT;   125 AA.
AC   Q14508;
DT   15-JUL-1998 (Rel. 36, Created)
DT   15-JUL-1998 (Rel. 36, Last sequence update)
DT   16-OCT-2001 (Rel. 40, Last annotation update)
DE   Major epididymis-specific protein E4 precursor (HE4) (Epididymal
DE   secretory protein E4).
GN   HE4.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Epididymis;
RX   MEDLINE=92153963; PubMed=1686187;
RA   Kirchhoff C., Habben L., Ivell R., Krull N.;
RT   "A major human epididymis-specific cDNA encodes a protein with
RT   sequence homology to extracellular proteinase inhibitors.";
RL   Biol. Reprod. 45:350-357(1991).
CC   -!- FUNCTION: POSSIBLE FUNCTION IN SPERM MATURATION.
CC   -!- SUBCELLULAR LOCATION: SECRETED (POTENTIAL).
CC   -!- TISSUE SPECIFICITY: EPITHELIAL CELLS OF THE EPIDIDYMAL DUCT,
CC       PREDOMINANTLY WITHIN THE DISTAL SECTIONS.
CC   -!- SIMILARITY: CONTAINS 2 WAP-TYPE DOMAINS.
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DR   EMBL; X63187; CAA44869.1; -.
DR   EMBL; A18924; CAA01433.1; -.
DR   HSSP; P19957; 1FLE.
DR   InterPro; IPR002221; WAP.
DR   Pfam; PF00095; wap; 2.
DR   ProDom; PD001224; WAP; 1.
DR   SMART; SM00217; WAP; 2.
DR   PROSITE; PS00317; 4_DISULFIDE_CORE; 2.
KW   Signal; Glycoprotein.
FT   SIGNAL        1     21       POTENTIAL.
FT   CHAIN        22    125       MAJOR EPIDIDYMIS-SPECIFIC PROTEIN E4.
FT   DOMAIN       32     74       WAP 1.
FT   DOMAIN       77    125       WAP 2.
FT   DISULFID     36     62       BY SIMILARITY.
FT   DISULFID     45     66       BY SIMILARITY.
FT   DISULFID     49     61       BY SIMILARITY.
FT   DISULFID     55     70       BY SIMILARITY.
FT   DISULFID     81    111       BY SIMILARITY.
FT   DISULFID     94    115       BY SIMILARITY.
FT   DISULFID     98    110       BY SIMILARITY.
FT   DISULFID    104    120       BY SIMILARITY.
FT   CARBOHYD     44     44       N-LINKED (GLCNAC...) (POTENTIAL).
SQ   SEQUENCE   125 AA;  13136 MW;  B5BF5C08FF70E245 CRC64;
     MPACRLGPLA AALLLSLLLF GFTLVSGTGA EKTGVCPELQ ADQNCTQECV SDSECADNLK
     CCSAGCATFC LLCPNDKEGS CPQVNINFPQ LGLCRDQCQV DTQCPGQMKC CRNGCGKVSC
     VTPNF
//