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Protein

Epididymal secretory protein E3-alpha

Gene

EDDM3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Possible function in sperm maturation.

GO - Biological processi

  • sperm displacement Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal secretory protein E3-alpha
Alternative name(s):
Human epididymis-specific protein 3-alpha
Short name:
HE3-alpha
Gene namesi
Name:EDDM3A
Synonyms:FAM12A, HE3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:16978. EDDM3A.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: ProtInc

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181562.
PharmGKBiPA165478869.

Polymorphism and mutation databases

BioMutaiEDDM3A.
DMDMi14916983.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002118826 – 147Epididymal secretory protein E3-alphaAdd BLAST122

Proteomic databases

PaxDbiQ14507.
PeptideAtlasiQ14507.
PRIDEiQ14507.

PTM databases

iPTMnetiQ14507.
PhosphoSitePlusiQ14507.

Expressioni

Tissue specificityi

Epididymis, with predominant expression in the corpus region. Moderately expressed in the vas deferens; only low levels are detectable in the caput and cauda regions.

Gene expression databases

BgeeiENSG00000181562.
CleanExiHS_FAM12A.
ExpressionAtlasiQ14507. baseline and differential.
GenevisibleiQ14507. HS.

Organism-specific databases

HPAiHPA049952.

Interactioni

Protein-protein interaction databases

BioGridi116084. 25 interactors.
STRINGi9606.ENSP00000315098.

Structurei

3D structure databases

ProteinModelPortaliQ14507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0SW. Eukaryota.
ENOG41115Q7. LUCA.
GeneTreeiENSGT00390000004706.
HOGENOMiHOG000112382.
HOVERGENiHBG018983.
InParanoidiQ14507.
PhylomeDBiQ14507.
TreeFamiTF314795.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiView protein in InterPro
IPR029747. EDDM3A.
IPR023412. RNaseA_domain.
PANTHERiPTHR16788:SF4. PTHR16788:SF4. 1 hit.
PfamiView protein in Pfam
PF00074. RnaseA. 1 hit.
SUPFAMiSSF54076. SSF54076. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSLKIWGI LLALLCILCR LCVYSNNIYW REFIKLHYLS PSREFKEYKC
60 70 80 90 100
DVLMREKEAL KGKSFHMFIY SLWFKIQRAC INEKGSDRYR NAYVWAPGAL
110 120 130 140
KVLECHWEKY NNRYTESRSF SYIEFHCGVD GYVDNIEDLR IIEPISN
Length:147
Mass (Da):17,646
Last modified:July 11, 2001 - v2
Checksum:i3C700AEB01793A44
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05096862G → C. Corresponds to variant dbSNP:rs34552133Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76383 mRNA. Translation: CAA53971.2.
X76385 Genomic DNA. No translation available.
BC069407 mRNA. Translation: AAH69407.1.
BC096698 mRNA. Translation: AAH96698.1.
BC096731 mRNA. Translation: AAH96731.1.
BC098164 mRNA. Translation: AAH98164.1.
BC098356 mRNA. Translation: AAH98356.1.
BC106711 mRNA. Translation: AAI06712.1.
BC106712 mRNA. Translation: AAI06713.1.
CCDSiCCDS9556.1.
PIRiI37455. S42795.
RefSeqiNP_006674.2. NM_006683.4.
XP_016876423.1. XM_017020934.1.
UniGeneiHs.304757.

Genome annotation databases

EnsembliENST00000326842; ENSP00000315098; ENSG00000181562.
GeneIDi10876.
KEGGihsa:10876.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEP3A_HUMAN
AccessioniPrimary (citable) accession number: Q14507
Secondary accession number(s): Q4KN33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 11, 2001
Last modified: August 30, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot