##gff-version 3 Q14500 UniProtKB Chain 1 433 . . . ID=PRO_0000154962;Note=ATP-sensitive inward rectifier potassium channel 12 Q14500 UniProtKB Topological domain 1 82 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Transmembrane 83 107 . . . Note=Helical%3B Name%3DM1;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Topological domain 108 123 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Intramembrane 124 128 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Intramembrane 129 141 . . . Note=Helical%3B Pore-forming%3B Name%3DH5;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Intramembrane 142 151 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Topological domain 152 156 . . . Note=Extracellular;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Transmembrane 157 181 . . . Note=Helical%3B Name%3DM2;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Topological domain 182 433 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Region 387 433 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q14500 UniProtKB Motif 79 81 . . . Note=Interaction with phosphatidylinositides;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Motif 143 148 . . . Note=Selectivity filter;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Motif 183 190 . . . Note=Interaction with phosphatidylinositides;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Motif 431 433 . . . Note=PDZ-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q14500 UniProtKB Site 173 173 . . . Note=Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Modified residue 75 75 . . . Note=S-nitrosocysteine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P63252 Q14500 UniProtKB Disulfide bond 155 155 . . . Note=Interchain;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q14500 UniProtKB Natural variant 6 6 . . . ID=VAR_024509;Note=R->Q;Dbxref=dbSNP:rs3752032 Q14500 UniProtKB Natural variant 15 15 . . . ID=VAR_049671;Note=S->L;Dbxref=dbSNP:rs1657738 Q14500 UniProtKB Natural variant 100 100 . . . ID=VAR_059365;Note=I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8647284;Dbxref=dbSNP:rs8076599,PMID:8647284 Q14500 UniProtKB Natural variant 118 118 . . . ID=VAR_059366;Note=R->Q;Dbxref=dbSNP:rs1657740 Q14500 UniProtKB Natural variant 156 156 . . . ID=VAR_049672;Note=P->L;Dbxref=dbSNP:rs1714864 Q14500 UniProtKB Natural variant 192 192 . . . ID=VAR_059367;Note=Q->H;Dbxref=dbSNP:rs1657742 Q14500 UniProtKB Natural variant 249 249 . . . ID=VAR_049673;Note=I->V;Dbxref=dbSNP:rs4985866 Q14500 UniProtKB Natural variant 430 430 . . . ID=VAR_059368;Note=E->G;Dbxref=dbSNP:rs5021699 Q14500 UniProtKB Sequence conflict 43 43 . . . Note=R->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 71 71 . . . Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 139 139 . . . Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 142 142 . . . Note=T->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 145 145 . . . Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 173 173 . . . Note=D->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 184 184 . . . Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 185 185 . . . Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 211 211 . . . Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 239 239 . . . Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 261 262 . . . Note=RI->HS;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 285 285 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 289 290 . . . Note=ET->QM;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 297 297 . . . Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 302 302 . . . Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 334 334 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 335 335 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 343 343 . . . Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 371 371 . . . Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 378 378 . . . Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 402 402 . . . Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q14500 UniProtKB Sequence conflict 405 405 . . . Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305