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Q14457

- BECN1_HUMAN

UniProt

Q14457 - BECN1_HUMAN

Protein

Beclin-1

Gene

BECN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (21 Feb 2001)
      Previous versions | rss
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    Functioni

    Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. autophagic vacuole assembly Source: Ensembl
    2. beta-amyloid metabolic process Source: Ensembl
    3. cellular defense response Source: ProtInc
    4. cellular response to aluminum ion Source: Ensembl
    5. cellular response to epidermal growth factor stimulus Source: Ensembl
    6. cytokinesis Source: UniProtKB
    7. defense response to virus Source: UniProtKB-KW
    8. lysosome organization Source: Ensembl
    9. negative regulation of apoptotic process Source: ProtInc
    10. negative regulation of cell proliferation Source: Ensembl
    11. neuron development Source: Ensembl
    12. positive regulation of macroautophagy Source: Ensembl
    13. response to drug Source: Ensembl
    14. response to hypoxia Source: Ensembl
    15. response to vitamin E Source: Ensembl
    16. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Antiviral defense, Autophagy, Cell cycle, Cell division, Host-virus interaction

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beclin-1
    Alternative name(s):
    Coiled-coil myosin-like BCL2-interacting protein
    Protein GT197
    Gene namesi
    Name:BECN1
    Synonyms:GT197
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:1034. BECN1.

    Subcellular locationi

    Golgi apparatustrans-Golgi network membrane 1 Publication; Peripheral membrane protein 1 Publication
    Note: Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: Ensembl
    2. dendrite Source: Ensembl
    3. membrane Source: UniProtKB-KW
    4. nucleus Source: Ensembl
    5. protein complex Source: Ensembl
    6. trans-Golgi network Source: Ensembl

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi352 – 3521Y → A: Significantly reduces ubiquitination. 1 Publication

    Organism-specific databases

    PharmGKBiPA25337.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Beclin-1PRO_0000218555Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei119 – 1191Phosphothreonine; by DAPK11 Publication

    Post-translational modificationi

    Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy.1 Publication
    polyubiquitinated by NEDD4, both with 'Lys11'- and 'Lys63'-linkages. 'Lys'-11-linked poyubiquitination leads to degradation and is enhanced when the stabilizing interaction partner VPS34 is depleted. Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes.2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ14457.
    PaxDbiQ14457.
    PRIDEiQ14457.

    PTM databases

    PhosphoSiteiQ14457.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ14457.
    BgeeiQ14457.
    CleanExiHS_BECN1.
    GenevestigatoriQ14457.

    Organism-specific databases

    HPAiCAB010143.

    Interactioni

    Subunit structurei

    Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy By similarity. Interacts with BCL2 and BCL2L1. Interacts with VMP1. Interacts with PIK3CB By similarity. Interacts with DAPK1. Interacts with human cytomegalovirus/HHV-5 protein TRS1.By similarity10 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AMBRA1Q9C0C76EBI-949378,EBI-2512975
    ATG14Q6ZNE511EBI-949378,EBI-2690371
    BCL2P1041516EBI-949378,EBI-77694
    BCL2L1Q07817-14EBI-949378,EBI-287195
    BIRC5O153923EBI-949378,EBI-518823
    DAPK1P533554EBI-949378,EBI-358616
    EGFRP005337EBI-949378,EBI-297353
    EXOC8Q8IYI64EBI-949378,EBI-742102
    MCL1Q078202EBI-949378,EBI-1003422
    PIK3C3Q8NEB914EBI-949378,EBI-1056470
    TAB2Q9NYJ811EBI-949378,EBI-358708
    TAB3Q8N5C89EBI-949378,EBI-359964
    UVRAGQ9P2Y515EBI-949378,EBI-2952704
    v-bcl-2P898842EBI-949378,EBI-8849581From a different organism.
    ZWINTO952296EBI-949378,EBI-1001132

    Protein-protein interaction databases

    BioGridi114226. 48 interactions.
    DIPiDIP-44611N.
    IntActiQ14457. 73 interactions.
    MINTiMINT-2865445.
    STRINGi9606.ENSP00000355231.

    Structurei

    Secondary structure

    1
    450
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi109 – 12315
    Turni124 – 1263
    Helixi250 – 26213
    Beta strandi276 – 2794
    Beta strandi282 – 2854
    Helixi300 – 32122
    Beta strandi326 – 3316
    Helixi334 – 3363
    Beta strandi338 – 3436
    Beta strandi349 – 3513
    Helixi358 – 3603
    Helixi364 – 38421
    Turni398 – 4014
    Beta strandi402 – 4043
    Turni406 – 4094
    Beta strandi412 – 4154
    Helixi422 – 44625

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2P1LX-ray2.50B/D/F/H107-135[»]
    2PONNMR-A106-128[»]
    3DVUX-ray2.50C/D105-130[»]
    4DDPX-ray1.55A241-450[»]
    4MI8X-ray2.10C/D107-130[»]
    ProteinModelPortaliQ14457.
    SMRiQ14457. Positions 176-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ14457.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili142 – 270129Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi108 – 12720BH3Add
    BLAST

    Sequence similaritiesi

    Belongs to the beclin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG285533.
    HOGENOMiHOG000158093.
    HOVERGENiHBG003181.
    InParanoidiQ14457.
    KOiK08334.
    OMAiYIPPARM.
    OrthoDBiEOG7D2FDG.
    PhylomeDBiQ14457.
    TreeFamiTF314282.

    Family and domain databases

    InterProiIPR007243. Atg6/Beclin.
    IPR029318. BH3_dom.
    [Graphical view]
    PANTHERiPTHR12768. PTHR12768. 1 hit.
    PfamiPF04111. APG6. 1 hit.
    PF15285. BH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14457-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA    50
    QAKPGETQEE ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI 100
    GEASDGGTME NLSRRLKVTG DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT 150
    QLNVTENECQ NYKRCLEILE QMNEDDSEQL QMELKELALE EERLIQELED 200
    VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ LELDDELKSV 250
    ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG QFGTINNFRL GRLPSVPVEW 300
    NEINAAWGQT VLLLHALANK MGLKFQRYRL VPYGNHSYLE SLTDKSKELP 350
    LYCSGGLRFF WDNKFDHAMV AFLDCVQQFK EEVEKGETRF CLPYRMDVEK 400
    GKIEDTGGSG GSYSIKTQFN SEEQWTKALK FMLTNLKWGL AWVSSQFYNK 450
    Length:450
    Mass (Da):51,896
    Last modified:February 21, 2001 - v2
    Checksum:iABF0C2DD7087473C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti150 – 1501T → A in AAB59573. (PubMed:7490091)Curated
    Sequence conflicti161 – 1611N → S in BAG35534. (PubMed:14702039)Curated
    Sequence conflicti314 – 3141L → H in BAG35534. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti103 – 1031A → V.
    VAR_010384
    Natural varianti403 – 4031I → T.
    VAR_005236

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077301 mRNA. Translation: AAC68653.1.
    AF139131 mRNA. Translation: AAD27650.1.
    AK312651 mRNA. Translation: BAG35534.1.
    BC010276 mRNA. Translation: AAH10276.1.
    L38932 mRNA. Translation: AAB59573.1.
    CCDSiCCDS11441.1.
    PIRiI54209.
    RefSeqiNP_003757.1. NM_003766.3.
    XP_005257815.1. XM_005257758.1.
    UniGeneiHs.716464.

    Genome annotation databases

    EnsembliENST00000361523; ENSP00000355231; ENSG00000126581.
    ENST00000590099; ENSP00000465364; ENSG00000126581.
    GeneIDi8678.
    KEGGihsa:8678.
    UCSCiuc002ibn.2. human.

    Polymorphism databases

    DMDMi13124704.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077301 mRNA. Translation: AAC68653.1 .
    AF139131 mRNA. Translation: AAD27650.1 .
    AK312651 mRNA. Translation: BAG35534.1 .
    BC010276 mRNA. Translation: AAH10276.1 .
    L38932 mRNA. Translation: AAB59573.1 .
    CCDSi CCDS11441.1.
    PIRi I54209.
    RefSeqi NP_003757.1. NM_003766.3.
    XP_005257815.1. XM_005257758.1.
    UniGenei Hs.716464.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2P1L X-ray 2.50 B/D/F/H 107-135 [» ]
    2PON NMR - A 106-128 [» ]
    3DVU X-ray 2.50 C/D 105-130 [» ]
    4DDP X-ray 1.55 A 241-450 [» ]
    4MI8 X-ray 2.10 C/D 107-130 [» ]
    ProteinModelPortali Q14457.
    SMRi Q14457. Positions 176-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114226. 48 interactions.
    DIPi DIP-44611N.
    IntActi Q14457. 73 interactions.
    MINTi MINT-2865445.
    STRINGi 9606.ENSP00000355231.

    PTM databases

    PhosphoSitei Q14457.

    Polymorphism databases

    DMDMi 13124704.

    Proteomic databases

    MaxQBi Q14457.
    PaxDbi Q14457.
    PRIDEi Q14457.

    Protocols and materials databases

    DNASUi 8678.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361523 ; ENSP00000355231 ; ENSG00000126581 .
    ENST00000590099 ; ENSP00000465364 ; ENSG00000126581 .
    GeneIDi 8678.
    KEGGi hsa:8678.
    UCSCi uc002ibn.2. human.

    Organism-specific databases

    CTDi 8678.
    GeneCardsi GC17M040963.
    HGNCi HGNC:1034. BECN1.
    HPAi CAB010143.
    MIMi 604378. gene.
    neXtProti NX_Q14457.
    PharmGKBi PA25337.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285533.
    HOGENOMi HOG000158093.
    HOVERGENi HBG003181.
    InParanoidi Q14457.
    KOi K08334.
    OMAi YIPPARM.
    OrthoDBi EOG7D2FDG.
    PhylomeDBi Q14457.
    TreeFami TF314282.

    Miscellaneous databases

    ChiTaRSi BECN1. human.
    EvolutionaryTracei Q14457.
    GeneWikii BECN1.
    GenomeRNAii 8678.
    NextBioi 32555.
    PROi Q14457.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14457.
    Bgeei Q14457.
    CleanExi HS_BECN1.
    Genevestigatori Q14457.

    Family and domain databases

    InterProi IPR007243. Atg6/Beclin.
    IPR029318. BH3_dom.
    [Graphical view ]
    PANTHERi PTHR12768. PTHR12768. 1 hit.
    Pfami PF04111. APG6. 1 hit.
    PF15285. BH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein."
      Liang X.H., Kleeman L.K., Jiang H.H., Gordon G., Goldman J.E., Berry G., Herman B., Levine B.
      J. Virol. 72:8586-8596(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH BCL-2.
      Tissue: Brain.
    2. "Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21."
      Aita V.M., Liang X.H., Murty V.V.V.S., Pincus D.L., Yu W., Cayanis E., Kalachikov S., Gilliam T.C., Levine B.
      Genomics 59:59-65(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.
    5. "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21."
      Rommens J.M., Durocher F., McArthur J., Tonin P., Leblanc J.-F., Allen T., Samson C., Ferri L., Narod S., Morgan K., Simard J.
      Genomics 28:530-542(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 150-450.
      Tissue: Mammary gland.
    6. "Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG."
      Itakura E., Kishi C., Inoue K., Mizushima N.
      Mol. Biol. Cell 19:5360-5372(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATG14; PIK3C3; PIK3R4 AND UVRAG.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells."
      Sauermann M., Sahin O., Sultmann H., Hahne F., Blaszkiewicz S., Majety M., Zatloukal K., Fuzesi L., Poustka A., Wiemann S., Arlt D.
      Oncogene 27:1320-1326(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH VMP1.
    9. "Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase."
      Sun Q., Fan W., Chen K., Ding X., Chen S., Zhong Q.
      Proc. Natl. Acad. Sci. U.S.A. 105:19211-19216(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATG14; PIK3C3 AND UVRAG, SUBCELLULAR LOCATION.
    10. "DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy."
      Zalckvar E., Berissi H., Mizrachy L., Idelchuk Y., Koren I., Eisenstein M., Sabanay H., Pinkas-Kramarski R., Kimchi A.
      EMBO Rep. 10:285-292(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-119, INTERACTION WITH DAPK1.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages."
      Matsunaga K., Saitoh T., Tabata K., Omori H., Satoh T., Kurotori N., Maejima I., Shirahama-Noda K., Ichimura T., Isobe T., Akira S., Noda T., Yoshimori T.
      Nat. Cell Biol. 11:385-396(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATG14; KIAA0226; PIK3C3; PIK3R4 AND UVRAG.
    13. "PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody."
      Sagona A.P., Nezis I.P., Pedersen N.M., Liestol K., Poulton J., Rusten T.E., Skotheim R.I., Raiborg C., Stenmark H.
      Nat. Cell Biol. 12:362-371(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13."
      Liu J., Xia H., Kim M., Xu L., Li Y., Zhang L., Cai Y., Norberg H.V., Zhang T., Furuya T., Jin M., Zhu Z., Wang H., Yu J., Li Y., Hao Y., Choi A., Ke H., Ma D., Yuan J.
      Cell 147:223-234(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION, INTERACTION WITH USP10 AND USP13.
    15. "Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1."
      Platta H.W., Abrahamsen H., Thoresen S.B., Stenmark H.
      Biochem. J. 441:399-406(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION BY NEDD4, MUTAGENESIS OF TYR-352.
    16. "The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1."
      Chaumorcel M., Lussignol M., Mouna L., Cavignac Y., Fahie K., Cotte-Laffitte J., Geballe A., Brune W., Beau I., Codogno P., Esclatine A.
      J. Virol. 86:2571-2584(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HHV-5 PROTEIN TRS1.
    17. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein."
      Oberstein A., Jeffrey P.D., Shi Y.
      J. Biol. Chem. 282:13123-13132(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 107-135 IN COMPLEX WITH BCL2L1, DOMAIN BH3 MOTIF.
    19. "Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of beclin-1."
      Feng W., Huang S., Wu H., Zhang M.
      J. Mol. Biol. 372:223-235(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 106-128 IN COMPLEX WITH BCL2L1.

    Entry informationi

    Entry nameiBECN1_HUMAN
    AccessioniPrimary (citable) accession number: Q14457
    Secondary accession number(s): B2R6N7, O75595, Q9UNA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 21, 2001
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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