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Protein

Probable G-protein coupled receptor 176

Gene

GPR176

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc
  • synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 176
Alternative name(s):
HB-954
Gene namesi
Name:GPR176
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:32370. GPR176.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242ExtracellularSequence analysisAdd
BLAST
Transmembranei43 – 6321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 8219CytoplasmicSequence analysisAdd
BLAST
Transmembranei83 – 10321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini104 – 11815ExtracellularSequence analysisAdd
BLAST
Transmembranei119 – 13921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini140 – 16021CytoplasmicSequence analysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini182 – 20726ExtracellularSequence analysisAdd
BLAST
Transmembranei208 – 22821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini229 – 26739CytoplasmicSequence analysisAdd
BLAST
Transmembranei268 – 28821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini289 – 29911ExtracellularSequence analysisAdd
BLAST
Transmembranei300 – 32021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini321 – 515195CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671712.

Polymorphism and mutation databases

DMDMi74754475.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Probable G-protein coupled receptor 176PRO_0000069656Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ14439.
PaxDbiQ14439.
PeptideAtlasiQ14439.
PRIDEiQ14439.

PTM databases

iPTMnetiQ14439.
PhosphoSiteiQ14439.

Expressioni

Gene expression databases

BgeeiQ14439.
CleanExiHS_GPR176.
ExpressionAtlasiQ14439. baseline and differential.
GenevisibleiQ14439. HS.

Organism-specific databases

HPAiHPA039943.
HPA039979.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000453076.

Structurei

3D structure databases

ProteinModelPortaliQ14439.
SMRiQ14439. Positions 49-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000231854.
HOVERGENiHBG080463.
InParanoidiQ14439.
KOiK08442.
OMAiIWAHAVV.
PhylomeDBiQ14439.
TreeFamiTF331506.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14439-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHNGSWISP NASEPHNASG AEAAGVNRSA LGEFGEAQLY RQFTTTVQVV
60 70 80 90 100
IFIGSLLGNF MVLWSTCRTT VFKSVTNRFI KNLACSGICA SLVCVPFDII
110 120 130 140 150
LSTSPHCCWW IYTMLFCKVV KFLHKVFCSV TILSFPAIAL DRYYSVLYPL
160 170 180 190 200
ERKISDAKSR ELVMYIWAHA VVASVPVFAV TNVADIYATS TCTEVWSNSL
210 220 230 240 250
GHLVYVLVYN ITTVIVPVVV VFLFLILIRR ALSASQKKKV IIAALRTPQN
260 270 280 290 300
TISIPYASQR EAELHATLLS MVMVFILCSV PYATLVVYQT VLNVPDTSVF
310 320 330 340 350
LLLTAVWLPK VSLLANPVLF LTVNKSVRKC LIGTLVQLHH RYSRRNVVST
360 370 380 390 400
GSGMAEASLE PSIRSGSQLL EMFHIGQQQI FKPTEDEEES EAKYIGSADF
410 420 430 440 450
QAKEIFSTCL EGEQGPQFAP SAPPLSTVDS VSQVAPAAPV EPETFPDKYS
460 470 480 490 500
LQFGFGPFEL PPQWLSETRN SKKRLLPPLG NTPEELIQTK VPKVGRVERK
510
MSRNNKVSIF PKVDS
Length:515
Mass (Da):56,998
Last modified:November 1, 1996 - v1
Checksum:iDE21C57952BB6D12
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 7720GNFMV…KSVTN → EFGNMEVTRKLDKSRLPGI (PubMed:15489334).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38449 mRNA. Translation: BAA07481.1.
BC067106 mRNA. Translation: AAH67106.1.
CCDSiCCDS10051.1.
PIRiS53525.
RefSeqiNP_001258783.1. NM_001271854.1.
NP_001258784.1. NM_001271855.1.
NP_009154.1. NM_007223.2.
UniGeneiHs.37196.

Genome annotation databases

EnsembliENST00000561100; ENSP00000453076; ENSG00000166073.
GeneIDi11245.
KEGGihsa:11245.
UCSCiuc001zkj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38449 mRNA. Translation: BAA07481.1.
BC067106 mRNA. Translation: AAH67106.1.
CCDSiCCDS10051.1.
PIRiS53525.
RefSeqiNP_001258783.1. NM_001271854.1.
NP_001258784.1. NM_001271855.1.
NP_009154.1. NM_007223.2.
UniGeneiHs.37196.

3D structure databases

ProteinModelPortaliQ14439.
SMRiQ14439. Positions 49-320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000453076.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ14439.
PhosphoSiteiQ14439.

Polymorphism and mutation databases

DMDMi74754475.

Proteomic databases

EPDiQ14439.
PaxDbiQ14439.
PeptideAtlasiQ14439.
PRIDEiQ14439.

Protocols and materials databases

DNASUi11245.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000561100; ENSP00000453076; ENSG00000166073.
GeneIDi11245.
KEGGihsa:11245.
UCSCiuc001zkj.3. human.

Organism-specific databases

CTDi11245.
GeneCardsiGPR176.
HGNCiHGNC:32370. GPR176.
HPAiHPA039943.
HPA039979.
MIMi612183. gene.
neXtProtiNX_Q14439.
PharmGKBiPA142671712.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000231854.
HOVERGENiHBG080463.
InParanoidiQ14439.
KOiK08442.
OMAiIWAHAVV.
PhylomeDBiQ14439.
TreeFamiTF331506.

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiGPR176.
GenomeRNAii11245.
PROiQ14439.
SOURCEiSearch...

Gene expression databases

BgeeiQ14439.
CleanExiHS_GPR176.
ExpressionAtlasiQ14439. baseline and differential.
GenevisibleiQ14439. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a putative G protein-coupled receptor from brain."
    Hata S., Emi Y., Iyanagi T., Osumi T.
    Biochim. Biophys. Acta 1261:121-125(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiGP176_HUMAN
AccessioniPrimary (citable) accession number: Q14439
Secondary accession number(s): Q6NXF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.