Q14416 (GRM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Metabotropic glutamate receptor 2
Short name=mGluR2

Gene names

Name:	GRM2
Synonyms:	GPRC1B, MGLUR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	872 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Subunit structure	Interacts with GRASP By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Widely expressed in different regions of the adult brain as well as in fetal brain.
Sequence similarities	Belongs to the G-protein coupled receptor 3 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutamate secretion Inferred from electronic annotation. Source: Compara negative regulation of adenylate cyclase activity Traceable author statement Ref.1. Source: ProtInc synaptic transmission Traceable author statement Ref.1. Source: ProtInc
Cellular_component	axon Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc intracellular Inferred from electronic annotation. Source: Compara presynaptic membrane Inferred from electronic annotation. Source: Compara
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: UniProtKB calcium channel regulator activity Inferred from electronic annotation. Source: Compara glutamate receptor activity Traceable author statement Ref.1. Source: UniProtKB group II metabotropic glutamate receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 872	854	Metabotropic glutamate receptor 2		PRO_0000012925
Regions
	Topological domain	19 – 567	549	Extracellular Potential
	Transmembrane	568 – 590	23	Helical; Name=1; Potential
	Topological domain	591 – 604	14	Cytoplasmic Potential
	Transmembrane	605 – 625	21	Helical; Name=2; Potential
	Topological domain	626 – 636	11	Extracellular Potential
	Transmembrane	637 – 655	19	Helical; Name=3; Potential
	Topological domain	656 – 679	24	Cytoplasmic Potential
	Transmembrane	680 – 700	21	Helical; Name=4; Potential
	Topological domain	701 – 725	25	Extracellular Potential
	Transmembrane	726 – 747	22	Helical; Name=5; Potential
	Topological domain	748 – 760	13	Cytoplasmic Potential
	Transmembrane	761 – 783	23	Helical; Name=6; Potential
	Topological domain	784 – 793	10	Extracellular Potential
	Transmembrane	794 – 819	26	Helical; Name=7; Potential
	Topological domain	820 – 872	53	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	203	1	N-linked (GlcNAc...) Potential
	Glycosylation	286	1	N-linked (GlcNAc...) Potential
	Glycosylation	338	1	N-linked (GlcNAc...) Potential
	Glycosylation	402	1	N-linked (GlcNAc...) Potential
	Glycosylation	547	1	N-linked (GlcNAc...) Potential
	Disulfide bond	50 ↔ 92		By similarity
	Disulfide bond	234 ↔ 518		By similarity
	Disulfide bond	355 ↔ 362		By similarity
	Disulfide bond	400 ↔ 407		By similarity
	Disulfide bond	500 ↔ 519		By similarity
	Disulfide bond	504 ↔ 522		By similarity
	Disulfide bond	525 ↔ 537		By similarity
	Disulfide bond	540 ↔ 553		By similarity
Experimental info
	Sequence conflict	12	1	L → P in AAA76855. Ref.1
	Sequence conflict	210	1	V → E in AAA76855. Ref.1
	Sequence conflict	496	1	P → A in AAA76855. Ref.1
	Sequence conflict	748	1	K → N in AAA76855. Ref.1
	Sequence conflict	776	1	F → L in AAA76855. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q14416 [UniParc]. Last modified September 27, 2005. Version 2. Checksum: 801976D034AA8100	FASTA	872	95,568
	10 20 30 40 50 60 MGSLLALLAL LLLWGAVAEG PAKKVLTLEG DLVLGGLFPV HQKGGPAEDC GPVNEHRGIQ 70 80 90 100 110 120 RLEAMLFALD RINRDPHLLP GVRLGAHILD SCSKDTHALE QALDFVRASL SRGADGSRHI 130 140 150 160 170 180 CPDGSYATHG DAPTAITGVI GGSYSDVSIQ VANLLRLFQI PQISYASTSA KLSDKSRYDY 190 200 210 220 230 240 FARTVPPDFF QAKAMAEILR FFNWTYVSTV ASEGDYGETG IEAFELEARA RNICVATSEK 250 260 270 280 290 300 VGRAMSRAAF EGVVRALLQK PSARVAVLFT RSEDARELLA ASQRLNASFT WVASDGWGAL 310 320 330 340 350 360 ESVVAGSEGA AEGAITIELA SYPISDFASY FQSLDPWNNS RNPWFREFWE QRFRCSFRQR 370 380 390 400 410 420 DCAAHSLRAV PFEQESKIMF VVNAVYAMAH ALHNMHRALC PNTTRLCDAM RPVNGRRLYK 430 440 450 460 470 480 DFVLNVKFDA PFRPADTHNE VRFDRFGDGI GRYNIFTYLR AGSGRYRYQK VGYWAEGLTL 490 500 510 520 530 540 DTSLIPWASP SAGPLPASRC SEPCLQNEVK SVQPGEVCCW LCIPCQPYEY RLDEFTCADC 550 560 570 580 590 600 GLGYWPNASL TGCFELPQEY IRWGDAWAVG PVTIACLGAL ATLFVLGVFV RHNATPVVKA 610 620 630 640 650 660 SGRELCYILL GGVFLCYCMT FIFIAKPSTA VCTLRRLGLG TAFSVCYSAL LTKTNRIARI 670 680 690 700 710 720 FGGAREGAQR PRFISPASQV AICLALISGQ LLIVVAWLVV EAPGTGKETA PERREVVTLR 730 740 750 760 770 780 CNHRDASMLG SLAYNVLLIA LCTLYAFKTR KCPENFNEAK FIGFTMYTTC IIWLAFLPIF 790 800 810 820 830 840 YVTSSDYRVQ TTTMCVSVSL SGSVVLGCLF APKLHIILFQ PQKNVVSHRA PTSRFGSAAA 850 860 870 RASSSLGQGS GSQFVPTVCN GREVVDSTTS SL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2." Flor P.J., Lindauer K., Puttner I., Ruegg D., Lukic S., Knopfel T., Kuhn R. Eur. J. Neurosci. 7:622-629(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure and polymorphisms of the human metabotropic glutamate receptor type 2 (hmGluR2) gene: analysis of association with schizophrenia." Yasuyuki F., Akiko J. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete coding sequence of human metabotropic glutamate receptor 2." Bonner T.I., Kauffman D., Nagle J.W. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[4]	Kaighin V.A., Martin A.L., Aronstam R.S. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L35318 mRNA. Translation: AAA76855.1. AB045011 Genomic DNA. Translation: BAB19817.1. AY999299 mRNA. Translation: AAY14640.1. EU432122 mRNA. Translation: ABY87921.1. CH471055 Genomic DNA. Translation: EAW65150.1. BC113615 mRNA. Translation: AAI13616.1. BC113619 mRNA. Translation: AAI13620.1.
IPI	IPI00030834.
RefSeq	NP_000830.2. NM_000839.3. NP_001123535.1. NM_001130063.1.
UniGene	Hs.121510.
3D structure databases
ProteinModelPortal	Q14416.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-59826N.
STRING	9606.ENSP00000378492.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q14416.
Polymorphism databases
DMDM	76803802.
Proteomic databases
PaxDb	Q14416.
PRIDE	Q14416.
Protocols and materials databases
DNASU	2912.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000395052; ENSP00000378492; ENSG00000164082.
GeneID	2912.
KEGG	hsa:2912.
UCSC	uc010hlv.3. human.
Organism-specific databases
CTD	2912.
GeneCards	GC03P051716.
HGNC	HGNC:4594. GRM2.
MIM	604099. gene.
neXtProt	NX_Q14416.
PharmGKB	PA28991.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG295200.
HOGENOM	HOG000218635.
HOVERGEN	HBG107965.
KO	K04605.
OMA	IPCQPYE.
OrthoDB	EOG461439.
PhylomeDB	Q14416.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q14416.
Bgee	Q14416.
CleanEx	HS_GRM2.
Genevestigator	Q14416.
GermOnline	ENSG00000164082. Homo sapiens.
Family and domain databases
InterPro	IPR001828. ANF_lig-bd_rcpt. IPR000337. GPCR_3. IPR011500. GPCR_3_9-Cys_dom. IPR017978. GPCR_3_C. IPR017979. GPCR_3_CS. IPR000162. GPCR_3_mtglu_rcpt. IPR001458. GPCR_3_mtglu_rcpt_2. [Graphical view]
Pfam	PF00003. 7tm_3. 1 hit. PF01094. ANF_receptor. 1 hit. PF07562. NCD3G. 1 hit. [Graphical view]
PRINTS	PR00248. GPCRMGR. PR01052. MTABOTROPC2R. PR00593. MTABOTROPICR.
PROSITE	PS00979. G_PROTEIN_RECEP_F3_1. 1 hit. PS00980. G_PROTEIN_RECEP_F3_2. 1 hit. PS00981. G_PROTEIN_RECEP_F3_3. 1 hit. PS50259. G_PROTEIN_RECEP_F3_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q14416.
ChEMBL	CHEMBL5137.
DrugBank	DB00659. Acamprosate. DB00184. Nicotine.
GenomeRNAi	2912.
NextBio	11543.
SOURCE	Search...

Entry information

Entry name

GRM2_HUMAN

Accession

Primary (citable) accession number: Q14416
Secondary accession number(s): B0M0K7 , Q14CU5, Q52MC6, Q9H3N6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	September 27, 2005
Last modified:	May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.