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Q14410

- GLPK2_HUMAN

UniProt

Q14410 - GLPK2_HUMAN

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Protein
Glycerol kinase 2
Gene
GK2, GKP2, GKTA
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism By similarity.

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Substrate By similarity
Binding sitei24 – 241ATP By similarity
Binding sitei94 – 941Substrate By similarity
Binding sitei148 – 1481Substrate By similarity
Binding sitei259 – 2591Substrate By similarity
Binding sitei281 – 2811ATP By similarity
Binding sitei326 – 3261ATP; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi427 – 4315ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glycerol kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glycerol catabolic process Source: UniProtKB-UniPathway
  2. glycerol-3-phosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_1190. Triglyceride Biosynthesis.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase 2 (EC:2.7.1.30)
Short name:
GK 2
Short name:
Glycerokinase 2
Alternative name(s):
ATP:glycerol 3-phosphotransferase 2
Glycerol kinase, testis specific 2
Gene namesi
Name:GK2
Synonyms:GKP2, GKTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:4291. GK2.

Subcellular locationi

Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity
Note: In sperm the majority of the enzyme is bound to mitochondria By similarity.

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28702.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Glycerol kinase 2
PRO_0000059536Add
BLAST

Proteomic databases

MaxQBiQ14410.
PaxDbiQ14410.
PRIDEiQ14410.

PTM databases

PhosphoSiteiQ14410.

Expressioni

Gene expression databases

BgeeiQ14410.
GenevestigatoriQ14410.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351706.

Structurei

3D structure databases

ProteinModelPortaliQ14410.
SMRiQ14410. Positions 13-514.

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG0554.
HOGENOMiHOG000222134.
HOVERGENiHBG002451.
InParanoidiQ14410.
KOiK00864.
OMAiCCFEPGS.
OrthoDBiEOG7VTDMZ.
PhylomeDBiQ14410.
TreeFamiTF321504.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14410-1 [UniParc]FASTAAdd to Basket

« Hide

MAAPKTAAVG PLVGAVVQGT NSTRFLVFNS KTAELLSHHK VELTQEFPKE    50
GWVEQDPKEI LQSVYECIAR TCEKLDELNI DISNIKAVGV SNQRETTVIW 100
DKLTGEPLYN AVVWLDLRTQ TTVEDLSKKI PGNSNFVKSK TGLPLSTYFS 150
AVKLRWMLDN VRNVQKAVEE GRALFGTIDS WLIWSLTGGV NGGVHCTDVT 200
NASRTMLFNI HSLEWDKELC DFFEIPMDLL PNVFSSSEIY GLIKTGALEG 250
VPISGCLGDQ CAALVGQMCF QEGQAKNTYG TGCFLLCNTG RKCVFSEHGL 300
LTTVAYKLGR EKPAYYALEG SVAIAGAVIR WLRDNLGIIE TSGDIERLAK 350
EVGTSYGCYF VPAFSGLYAP YWEPSARGIL CGLTQFTNKC HIAFAALEAV 400
CFQTREILEA MNRDCGIPLR HLQVDGGMTN NKVLMQLQAD ILHIPVIKPF 450
MPETTALGAA MAAGAAEGVS VWSLEPQALS VLRMERFEPQ IQATESEIRY 500
ATWKKAVMKS MGWVTSQSPE GGDPSIFSSL PLGFFIVSSM VMLIGARYIS 550
GVP 553
Length:553
Mass (Da):60,594
Last modified:July 22, 2008 - v2
Checksum:i8CE43A0686BC4AD6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381E → G in BAF84930. 1 Publication
Sequence conflicti369 – 3691A → T in BAF84930. 1 Publication
Sequence conflicti499 – 4991R → C in BAF84930. 1 Publication
Sequence conflicti528 – 5281S → C in CAA55365. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78712 mRNA. Translation: CAA55365.1.
AK292241 mRNA. Translation: BAF84930.1.
CH471057 Genomic DNA. Translation: EAX05842.1.
BC029820 mRNA. Translation: AAH29820.1.
BC048274 mRNA. Translation: AAH48274.2.
BC058888 mRNA. Translation: AAH58888.1.
CCDSiCCDS3585.1.
PIRiI37417.
RefSeqiNP_149991.2. NM_033214.2.
UniGeneiHs.98008.

Genome annotation databases

EnsembliENST00000358842; ENSP00000351706; ENSG00000196475.
GeneIDi2712.
KEGGihsa:2712.
UCSCiuc003hlu.3. human.

Polymorphism databases

DMDMi212286188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78712 mRNA. Translation: CAA55365.1 .
AK292241 mRNA. Translation: BAF84930.1 .
CH471057 Genomic DNA. Translation: EAX05842.1 .
BC029820 mRNA. Translation: AAH29820.1 .
BC048274 mRNA. Translation: AAH48274.2 .
BC058888 mRNA. Translation: AAH58888.1 .
CCDSi CCDS3585.1.
PIRi I37417.
RefSeqi NP_149991.2. NM_033214.2.
UniGenei Hs.98008.

3D structure databases

ProteinModelPortali Q14410.
SMRi Q14410. Positions 13-514.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000351706.

PTM databases

PhosphoSitei Q14410.

Polymorphism databases

DMDMi 212286188.

Proteomic databases

MaxQBi Q14410.
PaxDbi Q14410.
PRIDEi Q14410.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358842 ; ENSP00000351706 ; ENSG00000196475 .
GeneIDi 2712.
KEGGi hsa:2712.
UCSCi uc003hlu.3. human.

Organism-specific databases

CTDi 2712.
GeneCardsi GC04M080255.
H-InvDB HIX0004328.
HGNCi HGNC:4291. GK2.
MIMi 600148. gene.
neXtProti NX_Q14410.
PharmGKBi PA28702.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0554.
HOGENOMi HOG000222134.
HOVERGENi HBG002451.
InParanoidi Q14410.
KOi K00864.
OMAi CCFEPGS.
OrthoDBi EOG7VTDMZ.
PhylomeDBi Q14410.
TreeFami TF321504.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
Reactomei REACT_1190. Triglyceride Biosynthesis.

Miscellaneous databases

GenomeRNAii 2712.
NextBioi 10720.
PROi Q14410.
SOURCEi Search...

Gene expression databases

Bgeei Q14410.
Genevestigatori Q14410.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons."
    Sargent C.A., Young C., Marsh S., Ferguson-Smith M.A., Affara N.A.
    Hum. Mol. Genet. 3:1317-1324(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGLPK2_HUMAN
AccessioniPrimary (citable) accession number: Q14410
Secondary accession number(s): A8K876, Q6PD73, Q86XV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 22, 2008
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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