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Q14410

- GLPK2_HUMAN

UniProt

Q14410 - GLPK2_HUMAN

Protein

Glycerol kinase 2

Gene

GK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Key enzyme in the regulation of glycerol uptake and metabolism.By similarity

    Catalytic activityi

    ATP + glycerol = ADP + sn-glycerol 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei20 – 201SubstrateBy similarity
    Binding sitei24 – 241ATPBy similarity
    Binding sitei94 – 941SubstrateBy similarity
    Binding sitei148 – 1481SubstrateBy similarity
    Binding sitei259 – 2591SubstrateBy similarity
    Binding sitei281 – 2811ATPBy similarity
    Binding sitei326 – 3261ATP; via carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi427 – 4315ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glycerol kinase activity Source: UniProtKB

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: InterPro
    2. glycerol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycerol metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_1190. Triglyceride Biosynthesis.
    UniPathwayiUPA00618; UER00672.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol kinase 2 (EC:2.7.1.30)
    Short name:
    GK 2
    Short name:
    Glycerokinase 2
    Alternative name(s):
    ATP:glycerol 3-phosphotransferase 2
    Glycerol kinase, testis specific 2
    Gene namesi
    Name:GK2
    Synonyms:GKP2, GKTA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:4291. GK2.

    Subcellular locationi

    Mitochondrion outer membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasm By similarity
    Note: In sperm the majority of the enzyme is bound to mitochondria.By similarity

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28702.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Glycerol kinase 2PRO_0000059536Add
    BLAST

    Proteomic databases

    MaxQBiQ14410.
    PaxDbiQ14410.
    PRIDEiQ14410.

    PTM databases

    PhosphoSiteiQ14410.

    Expressioni

    Gene expression databases

    BgeeiQ14410.
    GenevestigatoriQ14410.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000351706.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14410.
    SMRiQ14410. Positions 13-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FGGY kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0554.
    HOGENOMiHOG000222134.
    HOVERGENiHBG002451.
    InParanoidiQ14410.
    KOiK00864.
    OMAiCCFEPGS.
    OrthoDBiEOG7VTDMZ.
    PhylomeDBiQ14410.
    TreeFamiTF321504.

    Family and domain databases

    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
    PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14410-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPKTAAVG PLVGAVVQGT NSTRFLVFNS KTAELLSHHK VELTQEFPKE    50
    GWVEQDPKEI LQSVYECIAR TCEKLDELNI DISNIKAVGV SNQRETTVIW 100
    DKLTGEPLYN AVVWLDLRTQ TTVEDLSKKI PGNSNFVKSK TGLPLSTYFS 150
    AVKLRWMLDN VRNVQKAVEE GRALFGTIDS WLIWSLTGGV NGGVHCTDVT 200
    NASRTMLFNI HSLEWDKELC DFFEIPMDLL PNVFSSSEIY GLIKTGALEG 250
    VPISGCLGDQ CAALVGQMCF QEGQAKNTYG TGCFLLCNTG RKCVFSEHGL 300
    LTTVAYKLGR EKPAYYALEG SVAIAGAVIR WLRDNLGIIE TSGDIERLAK 350
    EVGTSYGCYF VPAFSGLYAP YWEPSARGIL CGLTQFTNKC HIAFAALEAV 400
    CFQTREILEA MNRDCGIPLR HLQVDGGMTN NKVLMQLQAD ILHIPVIKPF 450
    MPETTALGAA MAAGAAEGVS VWSLEPQALS VLRMERFEPQ IQATESEIRY 500
    ATWKKAVMKS MGWVTSQSPE GGDPSIFSSL PLGFFIVSSM VMLIGARYIS 550
    GVP 553
    Length:553
    Mass (Da):60,594
    Last modified:July 22, 2008 - v2
    Checksum:i8CE43A0686BC4AD6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti238 – 2381E → G in BAF84930. (PubMed:14702039)Curated
    Sequence conflicti369 – 3691A → T in BAF84930. (PubMed:14702039)Curated
    Sequence conflicti499 – 4991R → C in BAF84930. (PubMed:14702039)Curated
    Sequence conflicti528 – 5281S → C in CAA55365. (PubMed:7987308)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78712 mRNA. Translation: CAA55365.1.
    AK292241 mRNA. Translation: BAF84930.1.
    CH471057 Genomic DNA. Translation: EAX05842.1.
    BC029820 mRNA. Translation: AAH29820.1.
    BC048274 mRNA. Translation: AAH48274.2.
    BC058888 mRNA. Translation: AAH58888.1.
    CCDSiCCDS3585.1.
    PIRiI37417.
    RefSeqiNP_149991.2. NM_033214.2.
    UniGeneiHs.98008.

    Genome annotation databases

    EnsembliENST00000358842; ENSP00000351706; ENSG00000196475.
    GeneIDi2712.
    KEGGihsa:2712.
    UCSCiuc003hlu.3. human.

    Polymorphism databases

    DMDMi212286188.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78712 mRNA. Translation: CAA55365.1 .
    AK292241 mRNA. Translation: BAF84930.1 .
    CH471057 Genomic DNA. Translation: EAX05842.1 .
    BC029820 mRNA. Translation: AAH29820.1 .
    BC048274 mRNA. Translation: AAH48274.2 .
    BC058888 mRNA. Translation: AAH58888.1 .
    CCDSi CCDS3585.1.
    PIRi I37417.
    RefSeqi NP_149991.2. NM_033214.2.
    UniGenei Hs.98008.

    3D structure databases

    ProteinModelPortali Q14410.
    SMRi Q14410. Positions 13-514.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000351706.

    PTM databases

    PhosphoSitei Q14410.

    Polymorphism databases

    DMDMi 212286188.

    Proteomic databases

    MaxQBi Q14410.
    PaxDbi Q14410.
    PRIDEi Q14410.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358842 ; ENSP00000351706 ; ENSG00000196475 .
    GeneIDi 2712.
    KEGGi hsa:2712.
    UCSCi uc003hlu.3. human.

    Organism-specific databases

    CTDi 2712.
    GeneCardsi GC04M080255.
    H-InvDB HIX0004328.
    HGNCi HGNC:4291. GK2.
    MIMi 600148. gene.
    neXtProti NX_Q14410.
    PharmGKBi PA28702.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0554.
    HOGENOMi HOG000222134.
    HOVERGENi HBG002451.
    InParanoidi Q14410.
    KOi K00864.
    OMAi CCFEPGS.
    OrthoDBi EOG7VTDMZ.
    PhylomeDBi Q14410.
    TreeFami TF321504.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00672 .
    Reactomei REACT_1190. Triglyceride Biosynthesis.

    Miscellaneous databases

    GenomeRNAii 2712.
    NextBioi 10720.
    PROi Q14410.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q14410.
    Genevestigatori Q14410.

    Family and domain databases

    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
    PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons."
      Sargent C.A., Young C., Marsh S., Ferguson-Smith M.A., Affara N.A.
      Hum. Mol. Genet. 3:1317-1324(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGLPK2_HUMAN
    AccessioniPrimary (citable) accession number: Q14410
    Secondary accession number(s): A8K876, Q6PD73, Q86XV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3