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Protein

Glycerol kinase 2

Gene

GK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism.By similarity

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201SubstrateBy similarity
Binding sitei24 – 241ATPBy similarity
Binding sitei94 – 941SubstrateBy similarity
Binding sitei148 – 1481SubstrateBy similarity
Binding sitei259 – 2591SubstrateBy similarity
Binding sitei281 – 2811ATPBy similarity
Binding sitei326 – 3261ATP; via carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi427 – 4315ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glycerol kinase activity Source: UniProtKB

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: InterPro
  2. glycerol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_1190. Triglyceride Biosynthesis.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase 2 (EC:2.7.1.30)
Short name:
GK 2
Short name:
Glycerokinase 2
Alternative name(s):
ATP:glycerol 3-phosphotransferase 2
Glycerol kinase, testis specific 2
Gene namesi
Name:GK2
Synonyms:GKP2, GKTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4291. GK2.

Subcellular locationi

Mitochondrion outer membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasm By similarity
Note: In sperm the majority of the enzyme is bound to mitochondria.By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28702.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Glycerol kinase 2PRO_0000059536Add
BLAST

Proteomic databases

MaxQBiQ14410.
PaxDbiQ14410.
PRIDEiQ14410.

PTM databases

PhosphoSiteiQ14410.

Expressioni

Gene expression databases

BgeeiQ14410.
GenevestigatoriQ14410.

Organism-specific databases

HPAiHPA060687.

Interactioni

Protein-protein interaction databases

BioGridi108977. 1 interaction.
STRINGi9606.ENSP00000351706.

Structurei

3D structure databases

ProteinModelPortaliQ14410.
SMRiQ14410. Positions 13-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiCOG0554.
GeneTreeiENSGT00530000063143.
HOGENOMiHOG000222134.
HOVERGENiHBG002451.
InParanoidiQ14410.
KOiK00864.
OMAiRMERFEP.
OrthoDBiEOG7VTDMZ.
PhylomeDBiQ14410.
TreeFamiTF321504.

Family and domain databases

InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPKTAAVG PLVGAVVQGT NSTRFLVFNS KTAELLSHHK VELTQEFPKE
60 70 80 90 100
GWVEQDPKEI LQSVYECIAR TCEKLDELNI DISNIKAVGV SNQRETTVIW
110 120 130 140 150
DKLTGEPLYN AVVWLDLRTQ TTVEDLSKKI PGNSNFVKSK TGLPLSTYFS
160 170 180 190 200
AVKLRWMLDN VRNVQKAVEE GRALFGTIDS WLIWSLTGGV NGGVHCTDVT
210 220 230 240 250
NASRTMLFNI HSLEWDKELC DFFEIPMDLL PNVFSSSEIY GLIKTGALEG
260 270 280 290 300
VPISGCLGDQ CAALVGQMCF QEGQAKNTYG TGCFLLCNTG RKCVFSEHGL
310 320 330 340 350
LTTVAYKLGR EKPAYYALEG SVAIAGAVIR WLRDNLGIIE TSGDIERLAK
360 370 380 390 400
EVGTSYGCYF VPAFSGLYAP YWEPSARGIL CGLTQFTNKC HIAFAALEAV
410 420 430 440 450
CFQTREILEA MNRDCGIPLR HLQVDGGMTN NKVLMQLQAD ILHIPVIKPF
460 470 480 490 500
MPETTALGAA MAAGAAEGVS VWSLEPQALS VLRMERFEPQ IQATESEIRY
510 520 530 540 550
ATWKKAVMKS MGWVTSQSPE GGDPSIFSSL PLGFFIVSSM VMLIGARYIS

GVP
Length:553
Mass (Da):60,594
Last modified:July 22, 2008 - v2
Checksum:i8CE43A0686BC4AD6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381E → G in BAF84930 (PubMed:14702039).Curated
Sequence conflicti369 – 3691A → T in BAF84930 (PubMed:14702039).Curated
Sequence conflicti499 – 4991R → C in BAF84930 (PubMed:14702039).Curated
Sequence conflicti528 – 5281S → C in CAA55365 (PubMed:7987308).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78712 mRNA. Translation: CAA55365.1.
AK292241 mRNA. Translation: BAF84930.1.
CH471057 Genomic DNA. Translation: EAX05842.1.
BC029820 mRNA. Translation: AAH29820.1.
BC048274 mRNA. Translation: AAH48274.2.
BC058888 mRNA. Translation: AAH58888.1.
CCDSiCCDS3585.1.
PIRiI37417.
RefSeqiNP_149991.2. NM_033214.2.
UniGeneiHs.98008.

Genome annotation databases

EnsembliENST00000358842; ENSP00000351706; ENSG00000196475.
GeneIDi2712.
KEGGihsa:2712.
UCSCiuc003hlu.3. human.

Polymorphism databases

DMDMi212286188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78712 mRNA. Translation: CAA55365.1.
AK292241 mRNA. Translation: BAF84930.1.
CH471057 Genomic DNA. Translation: EAX05842.1.
BC029820 mRNA. Translation: AAH29820.1.
BC048274 mRNA. Translation: AAH48274.2.
BC058888 mRNA. Translation: AAH58888.1.
CCDSiCCDS3585.1.
PIRiI37417.
RefSeqiNP_149991.2. NM_033214.2.
UniGeneiHs.98008.

3D structure databases

ProteinModelPortaliQ14410.
SMRiQ14410. Positions 13-514.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108977. 1 interaction.
STRINGi9606.ENSP00000351706.

PTM databases

PhosphoSiteiQ14410.

Polymorphism databases

DMDMi212286188.

Proteomic databases

MaxQBiQ14410.
PaxDbiQ14410.
PRIDEiQ14410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358842; ENSP00000351706; ENSG00000196475.
GeneIDi2712.
KEGGihsa:2712.
UCSCiuc003hlu.3. human.

Organism-specific databases

CTDi2712.
GeneCardsiGC04M080255.
H-InvDBHIX0004328.
HGNCiHGNC:4291. GK2.
HPAiHPA060687.
MIMi600148. gene.
neXtProtiNX_Q14410.
PharmGKBiPA28702.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0554.
GeneTreeiENSGT00530000063143.
HOGENOMiHOG000222134.
HOVERGENiHBG002451.
InParanoidiQ14410.
KOiK00864.
OMAiRMERFEP.
OrthoDBiEOG7VTDMZ.
PhylomeDBiQ14410.
TreeFamiTF321504.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.
ReactomeiREACT_1190. Triglyceride Biosynthesis.

Miscellaneous databases

GenomeRNAii2712.
NextBioi10720.
PROiQ14410.
SOURCEiSearch...

Gene expression databases

BgeeiQ14410.
GenevestigatoriQ14410.

Family and domain databases

InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons."
    Sargent C.A., Young C., Marsh S., Ferguson-Smith M.A., Affara N.A.
    Hum. Mol. Genet. 3:1317-1324(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGLPK2_HUMAN
AccessioniPrimary (citable) accession number: Q14410
Secondary accession number(s): A8K876, Q6PD73, Q86XV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 22, 2008
Last modified: April 1, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.