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Protein

Glycerol kinase 2

Gene

GK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism.By similarity

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.
Proteins known to be involved in this subpathway in this organism are:
  1. Putative glycerol kinase 5 (GK5), Glycerol kinase (GK), Glycerol kinase 3 (GK3P), Glycerol kinase 2 (GK2)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20SubstrateBy similarity1
Binding sitei24ATPBy similarity1
Binding sitei94SubstrateBy similarity1
Binding sitei148SubstrateBy similarity1
Binding sitei259SubstrateBy similarity1
Binding sitei281ATPBy similarity1
Binding sitei326ATP; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi427 – 431ATPBy similarity5

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • glycerol kinase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS08823-MONOMER.
ReactomeiR-HSA-75109. Triglyceride Biosynthesis.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase 2 (EC:2.7.1.30)
Short name:
GK 2
Short name:
Glycerokinase 2
Alternative name(s):
ATP:glycerol 3-phosphotransferase 2
Glycerol kinase, testis specific 2
Gene namesi
Name:GK2
Synonyms:GKP2, GKTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4291. GK2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196475.
PharmGKBiPA28702.

Polymorphism and mutation databases

BioMutaiGK2.
DMDMi212286188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000595361 – 553Glycerol kinase 2Add BLAST553

Proteomic databases

EPDiQ14410.
MaxQBiQ14410.
PaxDbiQ14410.
PeptideAtlasiQ14410.
PRIDEiQ14410.

PTM databases

iPTMnetiQ14410.
PhosphoSitePlusiQ14410.

Expressioni

Gene expression databases

BgeeiENSG00000196475.
ExpressionAtlasiQ14410. baseline and differential.
GenevisibleiQ14410. HS.

Organism-specific databases

HPAiHPA060687.

Interactioni

Protein-protein interaction databases

BioGridi108977. 4 interactors.
STRINGi9606.ENSP00000351706.

Structurei

3D structure databases

ProteinModelPortaliQ14410.
SMRiQ14410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiKOG2517. Eukaryota.
COG0554. LUCA.
GeneTreeiENSGT00530000063143.
HOGENOMiHOG000222134.
HOVERGENiHBG002451.
InParanoidiQ14410.
KOiK00864.
OMAiNVRNVQK.
OrthoDBiEOG091G04EJ.
PhylomeDBiQ14410.
TreeFamiTF321504.

Family and domain databases

InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPKTAAVG PLVGAVVQGT NSTRFLVFNS KTAELLSHHK VELTQEFPKE
60 70 80 90 100
GWVEQDPKEI LQSVYECIAR TCEKLDELNI DISNIKAVGV SNQRETTVIW
110 120 130 140 150
DKLTGEPLYN AVVWLDLRTQ TTVEDLSKKI PGNSNFVKSK TGLPLSTYFS
160 170 180 190 200
AVKLRWMLDN VRNVQKAVEE GRALFGTIDS WLIWSLTGGV NGGVHCTDVT
210 220 230 240 250
NASRTMLFNI HSLEWDKELC DFFEIPMDLL PNVFSSSEIY GLIKTGALEG
260 270 280 290 300
VPISGCLGDQ CAALVGQMCF QEGQAKNTYG TGCFLLCNTG RKCVFSEHGL
310 320 330 340 350
LTTVAYKLGR EKPAYYALEG SVAIAGAVIR WLRDNLGIIE TSGDIERLAK
360 370 380 390 400
EVGTSYGCYF VPAFSGLYAP YWEPSARGIL CGLTQFTNKC HIAFAALEAV
410 420 430 440 450
CFQTREILEA MNRDCGIPLR HLQVDGGMTN NKVLMQLQAD ILHIPVIKPF
460 470 480 490 500
MPETTALGAA MAAGAAEGVS VWSLEPQALS VLRMERFEPQ IQATESEIRY
510 520 530 540 550
ATWKKAVMKS MGWVTSQSPE GGDPSIFSSL PLGFFIVSSM VMLIGARYIS

GVP
Length:553
Mass (Da):60,594
Last modified:July 22, 2008 - v2
Checksum:i8CE43A0686BC4AD6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238E → G in BAF84930 (PubMed:14702039).Curated1
Sequence conflicti369A → T in BAF84930 (PubMed:14702039).Curated1
Sequence conflicti499R → C in BAF84930 (PubMed:14702039).Curated1
Sequence conflicti528S → C in CAA55365 (PubMed:7987308).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78712 mRNA. Translation: CAA55365.1.
AK292241 mRNA. Translation: BAF84930.1.
CH471057 Genomic DNA. Translation: EAX05842.1.
BC029820 mRNA. Translation: AAH29820.1.
BC048274 mRNA. Translation: AAH48274.2.
BC058888 mRNA. Translation: AAH58888.1.
CCDSiCCDS3585.1.
PIRiI37417.
RefSeqiNP_149991.2. NM_033214.2.
UniGeneiHs.98008.

Genome annotation databases

EnsembliENST00000358842; ENSP00000351706; ENSG00000196475.
GeneIDi2712.
KEGGihsa:2712.
UCSCiuc003hlu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78712 mRNA. Translation: CAA55365.1.
AK292241 mRNA. Translation: BAF84930.1.
CH471057 Genomic DNA. Translation: EAX05842.1.
BC029820 mRNA. Translation: AAH29820.1.
BC048274 mRNA. Translation: AAH48274.2.
BC058888 mRNA. Translation: AAH58888.1.
CCDSiCCDS3585.1.
PIRiI37417.
RefSeqiNP_149991.2. NM_033214.2.
UniGeneiHs.98008.

3D structure databases

ProteinModelPortaliQ14410.
SMRiQ14410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108977. 4 interactors.
STRINGi9606.ENSP00000351706.

PTM databases

iPTMnetiQ14410.
PhosphoSitePlusiQ14410.

Polymorphism and mutation databases

BioMutaiGK2.
DMDMi212286188.

Proteomic databases

EPDiQ14410.
MaxQBiQ14410.
PaxDbiQ14410.
PeptideAtlasiQ14410.
PRIDEiQ14410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358842; ENSP00000351706; ENSG00000196475.
GeneIDi2712.
KEGGihsa:2712.
UCSCiuc003hlu.4. human.

Organism-specific databases

CTDi2712.
GeneCardsiGK2.
H-InvDBHIX0004328.
HGNCiHGNC:4291. GK2.
HPAiHPA060687.
MIMi600148. gene.
neXtProtiNX_Q14410.
OpenTargetsiENSG00000196475.
PharmGKBiPA28702.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2517. Eukaryota.
COG0554. LUCA.
GeneTreeiENSGT00530000063143.
HOGENOMiHOG000222134.
HOVERGENiHBG002451.
InParanoidiQ14410.
KOiK00864.
OMAiNVRNVQK.
OrthoDBiEOG091G04EJ.
PhylomeDBiQ14410.
TreeFamiTF321504.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.
BioCyciZFISH:HS08823-MONOMER.
ReactomeiR-HSA-75109. Triglyceride Biosynthesis.

Miscellaneous databases

GenomeRNAii2712.
PROiQ14410.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196475.
ExpressionAtlasiQ14410. baseline and differential.
GenevisibleiQ14410. HS.

Family and domain databases

InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLPK2_HUMAN
AccessioniPrimary (citable) accession number: Q14410
Secondary accession number(s): A8K876, Q6PD73, Q86XV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 22, 2008
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.