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Q14409 (GLPK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative glycerol kinase 3

Short name=GK 3
Short name=Glycerokinase 3
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase 3
Glycerol kinase, testis specific 1
Gene names
Name:GK3P
Synonyms:GKP3, GKTB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism.

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.

Subcellular location

Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity. Note: In sperm the majority of the enzyme is bound to mitochondria By similarity.

Sequence similarities

Belongs to the FGGY kinase family.

Caution

Could be the product of a pseudogene.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Putative glycerol kinase 3
PRO_0000059537

Regions

Nucleotide binding427 – 4315ATP By similarity

Sites

Binding site201Substrate By similarity
Binding site241ATP By similarity
Binding site941Substrate By similarity
Binding site1481Substrate By similarity
Binding site2591Substrate By similarity
Binding site2811ATP By similarity
Binding site3261ATP; via carbonyl oxygen By similarity

Experimental info

Sequence conflict991V → A in CAA55364. Ref.1
Sequence conflict4851E → K in BC066960. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q14409 [UniParc].

Last modified July 22, 2008. Version 2.
Checksum: 1D6A197F32A921FB

FASTA55360,598
        10         20         30         40         50         60 
MAASKKAVLG PLVGAVDQGT SSTRFLVFNS RTAELLSHHQ VEIKQEFPRE GWVEQDPKEI 

        70         80         90        100        110        120 
LHSVYECIEK TCEKLGQLNI GISNIKAIGV SNQRETTVVW DKITGEPLYN AVVWLDLRTQ 

       130        140        150        160        170        180 
STVESLSKRI PGNNNFVKSK TGLPLSTYFS AVKLRWLLDN VRKVQKAVEE KRALFGTIDS 

       190        200        210        220        230        240 
WLIWSLTGGV NGGVHCTDVT NASRTMLFNI HSLEWDKQLC EFFGIPMEIL PHVRSSSEIY 

       250        260        270        280        290        300 
GLMKAGALEG VPISGCLGDQ SAALVGQMCF QIGQAKNTYG TGCFLLCNTG HKCVFSDHGL 

       310        320        330        340        350        360 
LTTVAYKLGR DKPVYYALEG SVAIAGAVIR WLRDNLGIIK TSEEIEKLAK EVGTSYGCYF 

       370        380        390        400        410        420 
VPAFSGLYAP YWEPSARGII CGLTQFTNKC HIAFAALEAV CFQTREILDA MNRDCGIPLS 

       430        440        450        460        470        480 
HLQVDGGMTS NKILMQLQAD ILYIPVVKPL MPETTALGAA MAAGAAEGVD VWSLEPEDLS 

       490        500        510        520        530        540 
AVTMERFEPQ INAEESEIRY STWKKAVMKS MGWVTTQSPE GGDPSVFCSL PLGFFIVSSM 

       550 
AMLIGARYIS GIP 

« Hide

References

« Hide 'large scale' references
[1]"The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons."
Sargent C.A., Young C., Marsh S., Ferguson-Smith M.A., Affara N.A.
Hum. Mol. Genet. 3:1317-1324(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78711 mRNA. Translation: CAA55364.1.
AC107059 Genomic DNA. No translation available.
BC066960 mRNA. No translation available.

3D structure databases

ProteinModelPortalQ14409.
SMRQ14409. Positions 13-514.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4825691.
STRING9606.ENSP00000401574.

Polymorphism databases

DMDM215277039.

Proteomic databases

PaxDbQ14409.
PRIDEQ14409.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc003ird.3. human.

Organism-specific databases

GeneCardsGC04M166198.
HGNCHGNC:4292. GK3P.
MIM600149. gene.
neXtProtNX_Q14409.
PharmGKBPA28703.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0554.
HOVERGENHBG002451.
PhylomeDBQ14409.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
UniPathwayUPA00618; UER00672.

Gene expression databases

GenevestigatorQ14409.

Family and domain databases

InterProIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ14409.
SOURCESearch...

Entry information

Entry nameGLPK3_HUMAN
AccessionPrimary (citable) accession number: Q14409
Secondary accession number(s): Q6NXP9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 22, 2008
Last modified: March 19, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM