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Protein

Glycerol kinase 3

Gene

GK3P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism.

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.
Proteins known to be involved in this subpathway in this organism are:
  1. Putative glycerol kinase 5 (GK5), Glycerol kinase (GK), Glycerol kinase 3 (GK3P), Glycerol kinase 2 (GK2)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20SubstrateBy similarity1
Binding sitei24ATPBy similarity1
Binding sitei94SubstrateBy similarity1
Binding sitei148SubstrateBy similarity1
Binding sitei259SubstrateBy similarity1
Binding sitei281ATPBy similarity1
Binding sitei326ATP; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi427 – 431ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycerol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-75109 Triglyceride biosynthesis
UniPathwayiUPA00618; UER00672

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase 3Curated (EC:2.7.1.30)
Short name:
GK 3
Short name:
Glycerokinase 3
Alternative name(s):
ATP:glycerol 3-phosphotransferase 3
Glycerol kinase 3 pseudogeneImported
Glycerol kinase, testis specific 1
Gene namesi
Name:GK3PImported
Synonyms:GKP3, GKTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4292 GK3P
MIMi600149 gene
neXtProtiNX_Q14409

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000229894
PharmGKBiPA28703

Polymorphism and mutation databases

DMDMi215277039

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000595371 – 553Glycerol kinase 3Add BLAST553

Proteomic databases

MaxQBiQ14409
PaxDbiQ14409
PeptideAtlasiQ14409
PRIDEiQ14409

Expressioni

Organism-specific databases

HPAiHPA060687

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368226

Structurei

3D structure databases

ProteinModelPortaliQ14409
SMRiQ14409
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiKOG2517 Eukaryota
COG0554 LUCA
GeneTreeiENSGT00530000063143
HOVERGENiHBG002451
InParanoidiQ14409
OMAiATRWNPD
PhylomeDBiQ14409

Family and domain databases

InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q14409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASKKAVLG PLVGAVDQGT SSTRFLVFNS RTAELLSHHQ VEIKQEFPRE
60 70 80 90 100
GWVEQDPKEI LHSVYECIEK TCEKLGQLNI GISNIKAIGV SNQRETTVVW
110 120 130 140 150
DKITGEPLYN AVVWLDLRTQ STVESLSKRI PGNNNFVKSK TGLPLSTYFS
160 170 180 190 200
AVKLRWLLDN VRKVQKAVEE KRALFGTIDS WLIWSLTGGV NGGVHCTDVT
210 220 230 240 250
NASRTMLFNI HSLEWDKQLC EFFGIPMEIL PHVRSSSEIY GLMKAGALEG
260 270 280 290 300
VPISGCLGDQ SAALVGQMCF QIGQAKNTYG TGCFLLCNTG HKCVFSDHGL
310 320 330 340 350
LTTVAYKLGR DKPVYYALEG SVAIAGAVIR WLRDNLGIIK TSEEIEKLAK
360 370 380 390 400
EVGTSYGCYF VPAFSGLYAP YWEPSARGII CGLTQFTNKC HIAFAALEAV
410 420 430 440 450
CFQTREILDA MNRDCGIPLS HLQVDGGMTS NKILMQLQAD ILYIPVVKPL
460 470 480 490 500
MPETTALGAA MAAGAAEGVD VWSLEPEDLS AVTMERFEPQ INAEESEIRY
510 520 530 540 550
STWKKAVMKS MGWVTTQSPE GGDPSVFCSL PLGFFIVSSM AMLIGARYIS

GIP
Length:553
Mass (Da):60,598
Last modified:July 22, 2008 - v2
Checksum:i1D6A197F32A921FB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99V → A in CAA55364 (PubMed:7987308).Curated1
Sequence conflicti485E → K in BC066960 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78711 mRNA Translation: CAA55364.1
AC107059 Genomic DNA No translation available.
BC066960 mRNA No translation available.

Genome annotation databases

EnsembliENST00000505354; ENSP00000489687; ENSG00000229894

Similar proteinsi

Entry informationi

Entry nameiGLPK3_HUMAN
AccessioniPrimary (citable) accession number: Q14409
Secondary accession number(s): Q6NXP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 22, 2008
Last modified: March 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health