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Q14409

- GLPK3_HUMAN

UniProt

Q14409 - GLPK3_HUMAN

Protein

Putative glycerol kinase 3

Gene

GK3P

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Protein uncertaini
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Key enzyme in the regulation of glycerol uptake and metabolism.

    Catalytic activityi

    ATP + glycerol = ADP + sn-glycerol 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei20 – 201SubstrateBy similarity
    Binding sitei24 – 241ATPBy similarity
    Binding sitei94 – 941SubstrateBy similarity
    Binding sitei148 – 1481SubstrateBy similarity
    Binding sitei259 – 2591SubstrateBy similarity
    Binding sitei281 – 2811ATPBy similarity
    Binding sitei326 – 3261ATP; via carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi427 – 4315ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glycerol kinase activity Source: UniProtKB

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: InterPro
    2. glycerol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycerol metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_1190. Triglyceride Biosynthesis.
    UniPathwayiUPA00618; UER00672.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative glycerol kinase 3 (EC:2.7.1.30)
    Short name:
    GK 3
    Short name:
    Glycerokinase 3
    Alternative name(s):
    ATP:glycerol 3-phosphotransferase 3
    Glycerol kinase, testis specific 1
    Gene namesi
    Name:GK3P
    Synonyms:GKP3, GKTB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4292. GK3P.

    Subcellular locationi

    Mitochondrion outer membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasm By similarity
    Note: In sperm the majority of the enzyme is bound to mitochondria.By similarity

    GO - Cellular componenti

    1. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28703.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Putative glycerol kinase 3PRO_0000059537Add
    BLAST

    Proteomic databases

    MaxQBiQ14409.
    PaxDbiQ14409.
    PRIDEiQ14409.

    Expressioni

    Gene expression databases

    GenevestigatoriQ14409.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4825691.
    STRINGi9606.ENSP00000401574.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14409.
    SMRiQ14409. Positions 13-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FGGY kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0554.
    HOVERGENiHBG002451.
    PhylomeDBiQ14409.

    Family and domain databases

    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
    PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14409-1 [UniParc]FASTAAdd to Basket

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    MAASKKAVLG PLVGAVDQGT SSTRFLVFNS RTAELLSHHQ VEIKQEFPRE    50
    GWVEQDPKEI LHSVYECIEK TCEKLGQLNI GISNIKAIGV SNQRETTVVW 100
    DKITGEPLYN AVVWLDLRTQ STVESLSKRI PGNNNFVKSK TGLPLSTYFS 150
    AVKLRWLLDN VRKVQKAVEE KRALFGTIDS WLIWSLTGGV NGGVHCTDVT 200
    NASRTMLFNI HSLEWDKQLC EFFGIPMEIL PHVRSSSEIY GLMKAGALEG 250
    VPISGCLGDQ SAALVGQMCF QIGQAKNTYG TGCFLLCNTG HKCVFSDHGL 300
    LTTVAYKLGR DKPVYYALEG SVAIAGAVIR WLRDNLGIIK TSEEIEKLAK 350
    EVGTSYGCYF VPAFSGLYAP YWEPSARGII CGLTQFTNKC HIAFAALEAV 400
    CFQTREILDA MNRDCGIPLS HLQVDGGMTS NKILMQLQAD ILYIPVVKPL 450
    MPETTALGAA MAAGAAEGVD VWSLEPEDLS AVTMERFEPQ INAEESEIRY 500
    STWKKAVMKS MGWVTTQSPE GGDPSVFCSL PLGFFIVSSM AMLIGARYIS 550
    GIP 553
    Length:553
    Mass (Da):60,598
    Last modified:July 22, 2008 - v2
    Checksum:i1D6A197F32A921FB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti99 – 991V → A in CAA55364. (PubMed:7987308)Curated
    Sequence conflicti485 – 4851E → K in BC066960. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78711 mRNA. Translation: CAA55364.1.
    AC107059 Genomic DNA. No translation available.
    BC066960 mRNA. No translation available.

    Genome annotation databases

    UCSCiuc003ird.3. human.

    Polymorphism databases

    DMDMi215277039.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78711 mRNA. Translation: CAA55364.1 .
    AC107059 Genomic DNA. No translation available.
    BC066960 mRNA. No translation available.

    3D structure databases

    ProteinModelPortali Q14409.
    SMRi Q14409. Positions 13-514.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4825691.
    STRINGi 9606.ENSP00000401574.

    Polymorphism databases

    DMDMi 215277039.

    Proteomic databases

    MaxQBi Q14409.
    PaxDbi Q14409.
    PRIDEi Q14409.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc003ird.3. human.

    Organism-specific databases

    GeneCardsi GC04M166198.
    HGNCi HGNC:4292. GK3P.
    MIMi 600149. gene.
    neXtProti NX_Q14409.
    PharmGKBi PA28703.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0554.
    HOVERGENi HBG002451.
    PhylomeDBi Q14409.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00672 .
    Reactomei REACT_1190. Triglyceride Biosynthesis.

    Miscellaneous databases

    PROi Q14409.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q14409.

    Family and domain databases

    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
    PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons."
      Sargent C.A., Young C., Marsh S., Ferguson-Smith M.A., Affara N.A.
      Hum. Mol. Genet. 3:1317-1324(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGLPK3_HUMAN
    AccessioniPrimary (citable) accession number: Q14409
    Secondary accession number(s): Q6NXP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3