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Q14409

- GLPK3_HUMAN

UniProt

Q14409 - GLPK3_HUMAN

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Protein

Putative glycerol kinase 3

Gene

GK3P

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Protein uncertaini

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism.

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201SubstrateBy similarity
Binding sitei24 – 241ATPBy similarity
Binding sitei94 – 941SubstrateBy similarity
Binding sitei148 – 1481SubstrateBy similarity
Binding sitei259 – 2591SubstrateBy similarity
Binding sitei281 – 2811ATPBy similarity
Binding sitei326 – 3261ATP; via carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi427 – 4315ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glycerol kinase activity Source: UniProtKB

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: InterPro
  2. glycerol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_1190. Triglyceride Biosynthesis.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glycerol kinase 3 (EC:2.7.1.30)
Short name:
GK 3
Short name:
Glycerokinase 3
Alternative name(s):
ATP:glycerol 3-phosphotransferase 3
Glycerol kinase, testis specific 1
Gene namesi
Name:GK3P
Synonyms:GKP3, GKTB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4292. GK3P.

Subcellular locationi

Mitochondrion outer membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasm By similarity
Note: In sperm the majority of the enzyme is bound to mitochondria.By similarity

GO - Cellular componenti

  1. mitochondrial outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28703.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Putative glycerol kinase 3PRO_0000059537Add
BLAST

Proteomic databases

MaxQBiQ14409.
PaxDbiQ14409.
PRIDEiQ14409.

Expressioni

Gene expression databases

GenevestigatoriQ14409.

Interactioni

Protein-protein interaction databases

MINTiMINT-4825691.
STRINGi9606.ENSP00000401574.

Structurei

3D structure databases

ProteinModelPortaliQ14409.
SMRiQ14409. Positions 13-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiCOG0554.
HOVERGENiHBG002451.
InParanoidiQ14409.
PhylomeDBiQ14409.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14409-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASKKAVLG PLVGAVDQGT SSTRFLVFNS RTAELLSHHQ VEIKQEFPRE
60 70 80 90 100
GWVEQDPKEI LHSVYECIEK TCEKLGQLNI GISNIKAIGV SNQRETTVVW
110 120 130 140 150
DKITGEPLYN AVVWLDLRTQ STVESLSKRI PGNNNFVKSK TGLPLSTYFS
160 170 180 190 200
AVKLRWLLDN VRKVQKAVEE KRALFGTIDS WLIWSLTGGV NGGVHCTDVT
210 220 230 240 250
NASRTMLFNI HSLEWDKQLC EFFGIPMEIL PHVRSSSEIY GLMKAGALEG
260 270 280 290 300
VPISGCLGDQ SAALVGQMCF QIGQAKNTYG TGCFLLCNTG HKCVFSDHGL
310 320 330 340 350
LTTVAYKLGR DKPVYYALEG SVAIAGAVIR WLRDNLGIIK TSEEIEKLAK
360 370 380 390 400
EVGTSYGCYF VPAFSGLYAP YWEPSARGII CGLTQFTNKC HIAFAALEAV
410 420 430 440 450
CFQTREILDA MNRDCGIPLS HLQVDGGMTS NKILMQLQAD ILYIPVVKPL
460 470 480 490 500
MPETTALGAA MAAGAAEGVD VWSLEPEDLS AVTMERFEPQ INAEESEIRY
510 520 530 540 550
STWKKAVMKS MGWVTTQSPE GGDPSVFCSL PLGFFIVSSM AMLIGARYIS

GIP
Length:553
Mass (Da):60,598
Last modified:July 22, 2008 - v2
Checksum:i1D6A197F32A921FB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991V → A in CAA55364. (PubMed:7987308)Curated
Sequence conflicti485 – 4851E → K in BC066960. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78711 mRNA. Translation: CAA55364.1.
AC107059 Genomic DNA. No translation available.
BC066960 mRNA. No translation available.

Genome annotation databases

UCSCiuc003ird.3. human.

Polymorphism databases

DMDMi215277039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78711 mRNA. Translation: CAA55364.1 .
AC107059 Genomic DNA. No translation available.
BC066960 mRNA. No translation available.

3D structure databases

ProteinModelPortali Q14409.
SMRi Q14409. Positions 13-514.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4825691.
STRINGi 9606.ENSP00000401574.

Polymorphism databases

DMDMi 215277039.

Proteomic databases

MaxQBi Q14409.
PaxDbi Q14409.
PRIDEi Q14409.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc003ird.3. human.

Organism-specific databases

GeneCardsi GC04M166198.
HGNCi HGNC:4292. GK3P.
MIMi 600149. gene.
neXtProti NX_Q14409.
PharmGKBi PA28703.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0554.
HOVERGENi HBG002451.
InParanoidi Q14409.
PhylomeDBi Q14409.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
Reactomei REACT_1190. Triglyceride Biosynthesis.

Miscellaneous databases

PROi Q14409.
SOURCEi Search...

Gene expression databases

Genevestigatori Q14409.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons."
    Sargent C.A., Young C., Marsh S., Ferguson-Smith M.A., Affara N.A.
    Hum. Mol. Genet. 3:1317-1324(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGLPK3_HUMAN
AccessioniPrimary (citable) accession number: Q14409
Secondary accession number(s): Q6NXP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 22, 2008
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3