Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chorionic somatomammotropin hormone-like 1

Gene

CSHL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44ZincBy similarity1
Metal bindingi205ZincBy similarity1

GO - Molecular functioni

  • hormone activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136488-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chorionic somatomammotropin hormone-like 1
Short name:
Chorionic somatomammotropin-like
Alternative name(s):
Lactogen-like
Gene namesi
Name:CSHL1
Synonyms:CSHP1, CSL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:2442. CSHL1.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1444.
OpenTargetsiENSG00000204414.
PharmGKBiPA26945.

Polymorphism and mutation databases

BioMutaiCSHL1.
DMDMi313104096.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003295927 – 222Chorionic somatomammotropin hormone-like 1Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi213 ↔ 220By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ14406.
PeptideAtlasiQ14406.
PRIDEiQ14406.

Expressioni

Gene expression databases

BgeeiENSG00000204414.
CleanExiHS_CSHL1.
ExpressionAtlasiQ14406. baseline and differential.
GenevisibleiQ14406. HS.

Organism-specific databases

HPAiCAB025646.
HPA043715.

Interactioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB

Protein-protein interaction databases

BioGridi107831. 1 interactor.
STRINGi9606.ENSP00000309524.

Structurei

3D structure databases

ProteinModelPortaliQ14406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.
InParanoidiQ14406.
OMAiRSIFAND.
OrthoDBiEOG091G0KPU.
PhylomeDBiQ14406.
TreeFamiTF332592.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14406-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA
60 70 80 90 100
IDTYQEFISS WGMEAYITKE QKYSFLHDSQ TSFCFSDSIP TSSNMEETQQ
110 120 130 140 150
KSNLELLHIS LLLIESRLEP VRFLRSTFTN NLVYDTSDSD DYHLLKDLEE
160 170 180 190 200
GIQMLMGRLE DGSHLTGQTL KQTYSKFDTN SHNHDALLKN YGLLHCFRKD
210 220
MDKVETFLRM VQCRSVEGSC GF
Length:222
Mass (Da):25,391
Last modified:November 30, 2010 - v2
Checksum:iE450E16D4731813A
GO
Isoform 2 (identifier: Q14406-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-86: Missing.

Show »
Length:199
Mass (Da):22,649
Checksum:i119656E87AFD55C3
GO
Isoform 3 (identifier: Q14406-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-86: Missing.

Show »
Length:139
Mass (Da):15,950
Checksum:i1F7CB63B6C869E84
GO
Isoform 4 (identifier: Q14406-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Show »
Length:128
Mass (Da):14,875
Checksum:i3EA9C8B73EBF67D5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059807141D → E.1 PublicationCorresponds to variant rs2727307dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0401141 – 94Missing in isoform 4. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_0401154 – 86Missing in isoform 3. CuratedAdd BLAST83
Alternative sequenceiVSP_04011664 – 86Missing in isoform 2. CuratedAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03071 Genomic DNA. Translation: AAA52550.1.
AC127029 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94245.1.
CH471109 Genomic DNA. Translation: EAW94246.1.
CH471109 Genomic DNA. Translation: EAW94253.1.
CH471109 Genomic DNA. Translation: EAW94264.1.
BC119747 mRNA. Translation: AAI19748.1.
CCDSiCCDS11652.1. [Q14406-1]
CCDS42370.1. [Q14406-4]
CCDS45759.1. [Q14406-3]
PIRiB32435.
RefSeqiNP_072101.1. NM_022579.2. [Q14406-1]
NP_072102.1. NM_022580.2. [Q14406-3]
NP_072103.1. NM_022581.2. [Q14406-2]
UniGeneiHs.654390.
Hs.655225.

Genome annotation databases

EnsembliENST00000309894; ENSP00000309524; ENSG00000204414. [Q14406-1]
ENST00000346606; ENSP00000316360; ENSG00000204414. [Q14406-4]
ENST00000438387; ENSP00000402632; ENSG00000204414. [Q14406-3]
GeneIDi1444.
KEGGihsa:1444.
UCSCiuc002jda.2. human. [Q14406-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03071 Genomic DNA. Translation: AAA52550.1.
AC127029 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94245.1.
CH471109 Genomic DNA. Translation: EAW94246.1.
CH471109 Genomic DNA. Translation: EAW94253.1.
CH471109 Genomic DNA. Translation: EAW94264.1.
BC119747 mRNA. Translation: AAI19748.1.
CCDSiCCDS11652.1. [Q14406-1]
CCDS42370.1. [Q14406-4]
CCDS45759.1. [Q14406-3]
PIRiB32435.
RefSeqiNP_072101.1. NM_022579.2. [Q14406-1]
NP_072102.1. NM_022580.2. [Q14406-3]
NP_072103.1. NM_022581.2. [Q14406-2]
UniGeneiHs.654390.
Hs.655225.

3D structure databases

ProteinModelPortaliQ14406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107831. 1 interactor.
STRINGi9606.ENSP00000309524.

Polymorphism and mutation databases

BioMutaiCSHL1.
DMDMi313104096.

Proteomic databases

PaxDbiQ14406.
PeptideAtlasiQ14406.
PRIDEiQ14406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309894; ENSP00000309524; ENSG00000204414. [Q14406-1]
ENST00000346606; ENSP00000316360; ENSG00000204414. [Q14406-4]
ENST00000438387; ENSP00000402632; ENSG00000204414. [Q14406-3]
GeneIDi1444.
KEGGihsa:1444.
UCSCiuc002jda.2. human. [Q14406-1]

Organism-specific databases

CTDi1444.
DisGeNETi1444.
GeneCardsiCSHL1.
HGNCiHGNC:2442. CSHL1.
HPAiCAB025646.
HPA043715.
MIMi603515. gene.
neXtProtiNX_Q14406.
OpenTargetsiENSG00000204414.
PharmGKBiPA26945.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.
InParanoidiQ14406.
OMAiRSIFAND.
OrthoDBiEOG091G0KPU.
PhylomeDBiQ14406.
TreeFamiTF332592.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136488-MONOMER.

Miscellaneous databases

ChiTaRSiCSHL1. human.
GenomeRNAii1444.
PROiQ14406.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204414.
CleanExiHS_CSHL1.
ExpressionAtlasiQ14406. baseline and differential.
GenevisibleiQ14406. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSHL_HUMAN
AccessioniPrimary (citable) accession number: Q14406
Secondary accession number(s): D3DU26, D3DU27, Q0VDB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.