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Q14406

- CSHL_HUMAN

UniProt

Q14406 - CSHL_HUMAN

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Protein

Chorionic somatomammotropin hormone-like 1

Gene

CSHL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441ZincBy similarity
Metal bindingi205 – 2051ZincBy similarity

GO - Molecular functioni

  1. hormone activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Chorionic somatomammotropin hormone-like 1
Short name:
Chorionic somatomammotropin-like
Alternative name(s):
Lactogen-like
Gene namesi
Name:CSHL1
Synonyms:CSHP1, CSL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:2442. CSHL1.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26945.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 222196Chorionic somatomammotropin hormone-like 1PRO_0000032959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi213 ↔ 220By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ14406.
PRIDEiQ14406.

Expressioni

Gene expression databases

BgeeiQ14406.
CleanExiHS_CSHL1.
ExpressionAtlasiQ14406. baseline.
GenevestigatoriQ14406.

Organism-specific databases

HPAiCAB025646.
HPA043715.

Interactioni

Protein-protein interaction databases

BioGridi107831. 3 interactions.
STRINGi9606.ENSP00000309524.

Structurei

3D structure databases

ProteinModelPortaliQ14406.
SMRiQ14406. Positions 29-221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG26152.
GeneTreeiENSGT00730000111012.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.
InParanoidiQ14406.
OMAiGMEAYIT.
PhylomeDBiQ14406.
TreeFamiTF332592.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14406-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA
60 70 80 90 100
IDTYQEFISS WGMEAYITKE QKYSFLHDSQ TSFCFSDSIP TSSNMEETQQ
110 120 130 140 150
KSNLELLHIS LLLIESRLEP VRFLRSTFTN NLVYDTSDSD DYHLLKDLEE
160 170 180 190 200
GIQMLMGRLE DGSHLTGQTL KQTYSKFDTN SHNHDALLKN YGLLHCFRKD
210 220
MDKVETFLRM VQCRSVEGSC GF
Length:222
Mass (Da):25,391
Last modified:November 30, 2010 - v2
Checksum:iE450E16D4731813A
GO
Isoform 2 (identifier: Q14406-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-86: Missing.

Show »
Length:199
Mass (Da):22,649
Checksum:i119656E87AFD55C3
GO
Isoform 3 (identifier: Q14406-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-86: Missing.

Show »
Length:139
Mass (Da):15,950
Checksum:i1F7CB63B6C869E84
GO
Isoform 4 (identifier: Q14406-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Show »
Length:128
Mass (Da):14,875
Checksum:i3EA9C8B73EBF67D5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti141 – 1411D → E.1 Publication
Corresponds to variant rs2727307 [ dbSNP | Ensembl ].
VAR_059807

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9494Missing in isoform 4. 1 PublicationVSP_040114Add
BLAST
Alternative sequencei4 – 8683Missing in isoform 3. CuratedVSP_040115Add
BLAST
Alternative sequencei64 – 8623Missing in isoform 2. CuratedVSP_040116Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03071 Genomic DNA. Translation: AAA52550.1.
AC127029 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94245.1.
CH471109 Genomic DNA. Translation: EAW94246.1.
CH471109 Genomic DNA. Translation: EAW94253.1.
CH471109 Genomic DNA. Translation: EAW94264.1.
BC119747 mRNA. Translation: AAI19748.1.
CCDSiCCDS11652.1. [Q14406-1]
CCDS42370.1. [Q14406-4]
CCDS45759.1. [Q14406-3]
PIRiB32435.
RefSeqiNP_072101.1. NM_022579.1. [Q14406-1]
NP_072102.1. NM_022580.1. [Q14406-3]
NP_072103.1. NM_022581.1. [Q14406-2]
UniGeneiHs.655225.

Genome annotation databases

EnsembliENST00000309894; ENSP00000309524; ENSG00000204414. [Q14406-1]
ENST00000346606; ENSP00000316360; ENSG00000204414. [Q14406-4]
ENST00000438387; ENSP00000402632; ENSG00000204414. [Q14406-3]
GeneIDi1444.
KEGGihsa:1444.
UCSCiuc002jcz.1. human. [Q14406-2]
uc002jda.1. human. [Q14406-1]
uc002jdc.1. human. [Q14406-3]

Polymorphism databases

DMDMi313104096.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03071 Genomic DNA. Translation: AAA52550.1 .
AC127029 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94245.1 .
CH471109 Genomic DNA. Translation: EAW94246.1 .
CH471109 Genomic DNA. Translation: EAW94253.1 .
CH471109 Genomic DNA. Translation: EAW94264.1 .
BC119747 mRNA. Translation: AAI19748.1 .
CCDSi CCDS11652.1. [Q14406-1 ]
CCDS42370.1. [Q14406-4 ]
CCDS45759.1. [Q14406-3 ]
PIRi B32435.
RefSeqi NP_072101.1. NM_022579.1. [Q14406-1 ]
NP_072102.1. NM_022580.1. [Q14406-3 ]
NP_072103.1. NM_022581.1. [Q14406-2 ]
UniGenei Hs.655225.

3D structure databases

ProteinModelPortali Q14406.
SMRi Q14406. Positions 29-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107831. 3 interactions.
STRINGi 9606.ENSP00000309524.

Polymorphism databases

DMDMi 313104096.

Proteomic databases

PaxDbi Q14406.
PRIDEi Q14406.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309894 ; ENSP00000309524 ; ENSG00000204414 . [Q14406-1 ]
ENST00000346606 ; ENSP00000316360 ; ENSG00000204414 . [Q14406-4 ]
ENST00000438387 ; ENSP00000402632 ; ENSG00000204414 . [Q14406-3 ]
GeneIDi 1444.
KEGGi hsa:1444.
UCSCi uc002jcz.1. human. [Q14406-2 ]
uc002jda.1. human. [Q14406-1 ]
uc002jdc.1. human. [Q14406-3 ]

Organism-specific databases

CTDi 1444.
GeneCardsi GC17M061986.
HGNCi HGNC:2442. CSHL1.
HPAi CAB025646.
HPA043715.
MIMi 603515. gene.
neXtProti NX_Q14406.
PharmGKBi PA26945.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26152.
GeneTreei ENSGT00730000111012.
HOGENOMi HOG000068443.
HOVERGENi HBG011318.
InParanoidi Q14406.
OMAi GMEAYIT.
PhylomeDBi Q14406.
TreeFami TF332592.

Miscellaneous databases

ChiTaRSi CSHL1. human.
GenomeRNAii 1444.
NextBioi 5927.
PROi Q14406.
SOURCEi Search...

Gene expression databases

Bgeei Q14406.
CleanExi HS_CSHL1.
ExpressionAtlasi Q14406. baseline.
Genevestigatori Q14406.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view ]
PANTHERi PTHR11417. PTHR11417. 1 hit.
Pfami PF00103. Hormone_1. 1 hit.
[Graphical view ]
PRINTSi PR00836. SOMATOTROPIN.
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human growth hormone locus: nucleotide sequence, biology, and evolution."
    Chen E.Y., Liao Y.C., Smith D.H., Barrera-Saldana H.A., Gelinas R.E., Seeburg P.H.
    Genomics 4:479-497(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  2. "Complex alternative splicing partially inactivates the human chorionic somatomammotropin-like (hCS-L) gene."
    Misra-Press A., Cooke N.E., Liebhaber S.A.
    J. Biol. Chem. 269:23220-23229(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3), FUNCTION, SUBCELLULAR LOCATION.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLU-141.

Entry informationi

Entry nameiCSHL_HUMAN
AccessioniPrimary (citable) accession number: Q14406
Secondary accession number(s): D3DU26, D3DU27, Q0VDB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 30, 2010
Last modified: November 26, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3