Q14406 (CSHL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorionic somatomammotropin hormone-like 1
Short name=Chorionic somatomammotropin-like

Alternative name(s):
Lactogen-like

Gene names

Name:	CSHL1
Synonyms:	CSHP1, CSL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation. Ref.2
Subcellular location	Secreted Ref.2.
Sequence similarities	Belongs to the somatotropin/prolactin family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Hormone
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	hormone activity Non-traceable author statement Ref.1. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14406-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14406-2)

The sequence of this isoform differs from the canonical sequence as follows:
     64-86: Missing.

Isoform 3 (identifier: Q14406-3)

The sequence of this isoform differs from the canonical sequence as follows:
     4-86: Missing.

Isoform 4 (identifier: Q14406-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 222	196	Chorionic somatomammotropin hormone-like 1		PRO_0000032959
Sites
	Metal binding	44	1	Zinc By similarity
	Metal binding	205	1	Zinc By similarity
Amino acid modifications
	Disulfide bond	213 ↔ 220		By similarity
Natural variations
	Alternative sequence	1 – 94	94	Missing in isoform 4.		VSP_040114
	Alternative sequence	4 – 86	83	Missing in isoform 3.		VSP_040115
	Alternative sequence	64 – 86	23	Missing in isoform 2.		VSP_040116
	Natural variant	141	1	D → E. Ref.5 Corresponds to variant rs2727307 [ dbSNP | Ensembl ].		VAR_059807

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: E450E16D4731813A	FASTA	222	25,391
	10 20 30 40 50 60 MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA IDTYQEFISS 70 80 90 100 110 120 WGMEAYITKE QKYSFLHDSQ TSFCFSDSIP TSSNMEETQQ KSNLELLHIS LLLIESRLEP 130 140 150 160 170 180 VRFLRSTFTN NLVYDTSDSD DYHLLKDLEE GIQMLMGRLE DGSHLTGQTL KQTYSKFDTN 190 200 210 220 SHNHDALLKN YGLLHCFRKD MDKVETFLRM VQCRSVEGSC GF
	Isoform 2 [UniParc]. Checksum: 119656E87AFD55C3	FASTA	199	22,649
	10 20 30 40 50 60 MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA IDTYQEFISS 70 80 90 100 110 120 WGMDSIPTSS NMEETQQKSN LELLHISLLL IESRLEPVRF LRSTFTNNLV YDTSDSDDYH 130 140 150 160 170 180 LLKDLEEGIQ MLMGRLEDGS HLTGQTLKQT YSKFDTNSHN HDALLKNYGL LHCFRKDMDK 190 VETFLRMVQC RSVEGSCGF
	Isoform 3 [UniParc]. Checksum: 1F7CB63B6C869E84	FASTA	139	15,950
	10 20 30 40 50 60 MAADSIPTSS NMEETQQKSN LELLHISLLL IESRLEPVRF LRSTFTNNLV YDTSDSDDYH 70 80 90 100 110 120 LLKDLEEGIQ MLMGRLEDGS HLTGQTLKQT YSKFDTNSHN HDALLKNYGL LHCFRKDMDK 130 VETFLRMVQC RSVEGSCGF
	Isoform 4 [UniParc]. Checksum: 3EA9C8B73EBF67D5	FASTA	128	14,875
	10 20 30 40 50 60 MEETQQKSNL ELLHISLLLI ESRLEPVRFL RSTFTNNLVY DTSDSDDYHL LKDLEEGIQM 70 80 90 100 110 120 LMGRLEDGSH LTGQTLKQTY SKFDTNSHNH DALLKNYGLL HCFRKDMDKV ETFLRMVQCR SVEGSCGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human growth hormone locus: nucleotide sequence, biology, and evolution." Chen E.Y., Liao Y.C., Smith D.H., Barrera-Saldana H.A., Gelinas R.E., Seeburg P.H. Genomics 4:479-497(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[2]	"Complex alternative splicing partially inactivates the human chorionic somatomammotropin-like (hCS-L) gene." Misra-Press A., Cooke N.E., Liebhaber S.A. J. Biol. Chem. 269:23220-23229(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3), FUNCTION, SUBCELLULAR LOCATION.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLU-141.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J03071 Genomic DNA. Translation: AAA52550.1. AC127029 Genomic DNA. No translation available. CH471109 Genomic DNA. Translation: EAW94245.1. CH471109 Genomic DNA. Translation: EAW94246.1. CH471109 Genomic DNA. Translation: EAW94253.1. CH471109 Genomic DNA. Translation: EAW94264.1. BC119747 mRNA. Translation: AAI19748.1.
IPI	IPI00022108. IPI00022110. IPI00374571. IPI00386440.
PIR	B32435.
RefSeq	NP_072101.1. NM_022579.1. NP_072102.1. NM_022580.1. NP_072103.1. NM_022581.1.
UniGene	Hs.655225.
3D structure databases
ProteinModelPortal	Q14406.
SMR	Q14406. Positions 29-221.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000309524.
Proteomic databases
PaxDb	Q14406.
PRIDE	Q14406.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309894; ENSP00000309524; ENSG00000204414. ENST00000346606; ENSP00000316360; ENSG00000204414. ENST00000438387; ENSP00000402632; ENSG00000204414.
GeneID	1444.
KEGG	hsa:1444.
UCSC	uc002jcz.1. human. uc002jda.1. human. uc002jdc.1. human.
Organism-specific databases
CTD	1444.
GeneCards	GC17M061986.
HGNC	HGNC:2442. CSHL1.
HPA	CAB025646. HPA043715.
MIM	603515. gene.
neXtProt	NX_Q14406.
PharmGKB	PA26945.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG26152.
HOGENOM	HOG000068443.
HOVERGEN	HBG011318.
InParanoid	Q14406.
Gene expression databases
ArrayExpress	Q14406.
Bgee	Q14406.
CleanEx	HS_CSHL1.
Genevestigator	Q14406.
GermOnline	ENSG00000204414. Homo sapiens.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR001400. Somatotropin. IPR018116. Somatotropin_CS. [Graphical view]
PANTHER	PTHR11417. PTHR11417. 1 hit.
Pfam	PF00103. Hormone_1. 1 hit. [Graphical view]
PRINTS	PR00836. SOMATOTROPIN.
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00266. SOMATOTROPIN_1. False negative. PS00338. SOMATOTROPIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1444.
NextBio	5927.
SOURCE	Search...

Entry information

Entry name

CSHL_HUMAN

Accession

Primary (citable) accession number: Q14406
Secondary accession number(s): D3DU26, D3DU27, Q0VDB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	November 30, 2010
Last modified:	April 3, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.