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Q14406 (CSHL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chorionic somatomammotropin hormone-like 1

Short name=Chorionic somatomammotropin-like
Alternative name(s):
Lactogen-like
Gene names
Name:CSHL1
Synonyms:CSHP1, CSL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation. Ref.2

Subcellular location

Secreted Ref.2.

Sequence similarities

Belongs to the somatotropin/prolactin family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   LigandMetal-binding
Zinc
   Molecular functionHormone
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhormone activity

Non-traceable author statement Ref.1. Source: UniProtKB

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q14406-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q14406-2)

The sequence of this isoform differs from the canonical sequence as follows:
     64-86: Missing.
Isoform 3 (identifier: Q14406-3)

The sequence of this isoform differs from the canonical sequence as follows:
     4-86: Missing.
Isoform 4 (identifier: Q14406-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 222196Chorionic somatomammotropin hormone-like 1
PRO_0000032959

Sites

Metal binding441Zinc By similarity
Metal binding2051Zinc By similarity

Amino acid modifications

Disulfide bond213 ↔ 220 By similarity

Natural variations

Alternative sequence1 – 9494Missing in isoform 4.
VSP_040114
Alternative sequence4 – 8683Missing in isoform 3.
VSP_040115
Alternative sequence64 – 8623Missing in isoform 2.
VSP_040116
Natural variant1411D → E. Ref.5
Corresponds to variant rs2727307 [ dbSNP | Ensembl ].
VAR_059807

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: E450E16D4731813A

FASTA22225,391
        10         20         30         40         50         60 
MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA IDTYQEFISS 

        70         80         90        100        110        120 
WGMEAYITKE QKYSFLHDSQ TSFCFSDSIP TSSNMEETQQ KSNLELLHIS LLLIESRLEP 

       130        140        150        160        170        180 
VRFLRSTFTN NLVYDTSDSD DYHLLKDLEE GIQMLMGRLE DGSHLTGQTL KQTYSKFDTN 

       190        200        210        220 
SHNHDALLKN YGLLHCFRKD MDKVETFLRM VQCRSVEGSC GF 

« Hide

Isoform 2 [UniParc].

Checksum: 119656E87AFD55C3
Show »

FASTA19922,649
Isoform 3 [UniParc].

Checksum: 1F7CB63B6C869E84
Show »

FASTA13915,950
Isoform 4 [UniParc].

Checksum: 3EA9C8B73EBF67D5
Show »

FASTA12814,875

References

« Hide 'large scale' references
[1]"The human growth hormone locus: nucleotide sequence, biology, and evolution."
Chen E.Y., Liao Y.C., Smith D.H., Barrera-Saldana H.A., Gelinas R.E., Seeburg P.H.
Genomics 4:479-497(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[2]"Complex alternative splicing partially inactivates the human chorionic somatomammotropin-like (hCS-L) gene."
Misra-Press A., Cooke N.E., Liebhaber S.A.
J. Biol. Chem. 269:23220-23229(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3), FUNCTION, SUBCELLULAR LOCATION.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLU-141.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J03071 Genomic DNA. Translation: AAA52550.1.
AC127029 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94245.1.
CH471109 Genomic DNA. Translation: EAW94246.1.
CH471109 Genomic DNA. Translation: EAW94253.1.
CH471109 Genomic DNA. Translation: EAW94264.1.
BC119747 mRNA. Translation: AAI19748.1.
PIRB32435.
RefSeqNP_072101.1. NM_022579.1.
NP_072102.1. NM_022580.1.
NP_072103.1. NM_022581.1.
UniGeneHs.655225.

3D structure databases

ProteinModelPortalQ14406.
SMRQ14406. Positions 29-221.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107831. 2 interactions.
STRING9606.ENSP00000309524.

Polymorphism databases

DMDM313104096.

Proteomic databases

PaxDbQ14406.
PRIDEQ14406.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309894; ENSP00000309524; ENSG00000204414. [Q14406-1]
ENST00000346606; ENSP00000316360; ENSG00000204414. [Q14406-4]
ENST00000438387; ENSP00000402632; ENSG00000204414. [Q14406-3]
GeneID1444.
KEGGhsa:1444.
UCSCuc002jcz.1. human. [Q14406-2]
uc002jda.1. human. [Q14406-1]
uc002jdc.1. human. [Q14406-3]

Organism-specific databases

CTD1444.
GeneCardsGC17M061986.
HGNCHGNC:2442. CSHL1.
HPACAB025646.
HPA043715.
MIM603515. gene.
neXtProtNX_Q14406.
PharmGKBPA26945.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG26152.
HOGENOMHOG000068443.
HOVERGENHBG011318.
InParanoidQ14406.
OMAIRANQDE.
PhylomeDBQ14406.
TreeFamTF332592.

Gene expression databases

BgeeQ14406.
CleanExHS_CSHL1.
GenevestigatorQ14406.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERPTHR11417. PTHR11417. 1 hit.
PfamPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSPR00836. SOMATOTROPIN.
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi1444.
NextBio5927.
PROQ14406.
SOURCESearch...

Entry information

Entry nameCSHL_HUMAN
AccessionPrimary (citable) accession number: Q14406
Secondary accession number(s): D3DU26, D3DU27, Q0VDB2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM