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Q14406

- CSHL_HUMAN

UniProt

Q14406 - CSHL_HUMAN

Protein

Chorionic somatomammotropin hormone-like 1

Gene

CSHL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi44 – 441ZincBy similarity
    Metal bindingi205 – 2051ZincBy similarity

    GO - Molecular functioni

    1. hormone activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hormone

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chorionic somatomammotropin hormone-like 1
    Short name:
    Chorionic somatomammotropin-like
    Alternative name(s):
    Lactogen-like
    Gene namesi
    Name:CSHL1
    Synonyms:CSHP1, CSL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:2442. CSHL1.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26945.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 222196Chorionic somatomammotropin hormone-like 1PRO_0000032959Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi213 ↔ 220By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ14406.
    PRIDEiQ14406.

    Expressioni

    Gene expression databases

    BgeeiQ14406.
    CleanExiHS_CSHL1.
    GenevestigatoriQ14406.

    Organism-specific databases

    HPAiCAB025646.
    HPA043715.

    Interactioni

    Protein-protein interaction databases

    BioGridi107831. 2 interactions.
    STRINGi9606.ENSP00000309524.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14406.
    SMRiQ14406. Positions 29-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the somatotropin/prolactin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG26152.
    HOGENOMiHOG000068443.
    HOVERGENiHBG011318.
    InParanoidiQ14406.
    OMAiGMEAYIT.
    PhylomeDBiQ14406.
    TreeFamiTF332592.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR001400. Somatotropin.
    IPR018116. Somatotropin_CS.
    [Graphical view]
    PANTHERiPTHR11417. PTHR11417. 1 hit.
    PfamiPF00103. Hormone_1. 1 hit.
    [Graphical view]
    PRINTSiPR00836. SOMATOTROPIN.
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14406-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA    50
    IDTYQEFISS WGMEAYITKE QKYSFLHDSQ TSFCFSDSIP TSSNMEETQQ 100
    KSNLELLHIS LLLIESRLEP VRFLRSTFTN NLVYDTSDSD DYHLLKDLEE 150
    GIQMLMGRLE DGSHLTGQTL KQTYSKFDTN SHNHDALLKN YGLLHCFRKD 200
    MDKVETFLRM VQCRSVEGSC GF 222
    Length:222
    Mass (Da):25,391
    Last modified:November 30, 2010 - v2
    Checksum:iE450E16D4731813A
    GO
    Isoform 2 (identifier: Q14406-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         64-86: Missing.

    Show »
    Length:199
    Mass (Da):22,649
    Checksum:i119656E87AFD55C3
    GO
    Isoform 3 (identifier: Q14406-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         4-86: Missing.

    Show »
    Length:139
    Mass (Da):15,950
    Checksum:i1F7CB63B6C869E84
    GO
    Isoform 4 (identifier: Q14406-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-94: Missing.

    Show »
    Length:128
    Mass (Da):14,875
    Checksum:i3EA9C8B73EBF67D5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti141 – 1411D → E.1 Publication
    Corresponds to variant rs2727307 [ dbSNP | Ensembl ].
    VAR_059807

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9494Missing in isoform 4. 1 PublicationVSP_040114Add
    BLAST
    Alternative sequencei4 – 8683Missing in isoform 3. CuratedVSP_040115Add
    BLAST
    Alternative sequencei64 – 8623Missing in isoform 2. CuratedVSP_040116Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03071 Genomic DNA. Translation: AAA52550.1.
    AC127029 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94245.1.
    CH471109 Genomic DNA. Translation: EAW94246.1.
    CH471109 Genomic DNA. Translation: EAW94253.1.
    CH471109 Genomic DNA. Translation: EAW94264.1.
    BC119747 mRNA. Translation: AAI19748.1.
    CCDSiCCDS11652.1. [Q14406-1]
    CCDS42370.1. [Q14406-4]
    CCDS45759.1. [Q14406-3]
    PIRiB32435.
    RefSeqiNP_072101.1. NM_022579.1. [Q14406-1]
    NP_072102.1. NM_022580.1. [Q14406-3]
    NP_072103.1. NM_022581.1. [Q14406-2]
    UniGeneiHs.655225.

    Genome annotation databases

    EnsembliENST00000309894; ENSP00000309524; ENSG00000204414. [Q14406-1]
    ENST00000346606; ENSP00000316360; ENSG00000204414. [Q14406-4]
    ENST00000438387; ENSP00000402632; ENSG00000204414. [Q14406-3]
    GeneIDi1444.
    KEGGihsa:1444.
    UCSCiuc002jcz.1. human. [Q14406-2]
    uc002jda.1. human. [Q14406-1]
    uc002jdc.1. human. [Q14406-3]

    Polymorphism databases

    DMDMi313104096.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03071 Genomic DNA. Translation: AAA52550.1 .
    AC127029 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94245.1 .
    CH471109 Genomic DNA. Translation: EAW94246.1 .
    CH471109 Genomic DNA. Translation: EAW94253.1 .
    CH471109 Genomic DNA. Translation: EAW94264.1 .
    BC119747 mRNA. Translation: AAI19748.1 .
    CCDSi CCDS11652.1. [Q14406-1 ]
    CCDS42370.1. [Q14406-4 ]
    CCDS45759.1. [Q14406-3 ]
    PIRi B32435.
    RefSeqi NP_072101.1. NM_022579.1. [Q14406-1 ]
    NP_072102.1. NM_022580.1. [Q14406-3 ]
    NP_072103.1. NM_022581.1. [Q14406-2 ]
    UniGenei Hs.655225.

    3D structure databases

    ProteinModelPortali Q14406.
    SMRi Q14406. Positions 29-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107831. 2 interactions.
    STRINGi 9606.ENSP00000309524.

    Polymorphism databases

    DMDMi 313104096.

    Proteomic databases

    PaxDbi Q14406.
    PRIDEi Q14406.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309894 ; ENSP00000309524 ; ENSG00000204414 . [Q14406-1 ]
    ENST00000346606 ; ENSP00000316360 ; ENSG00000204414 . [Q14406-4 ]
    ENST00000438387 ; ENSP00000402632 ; ENSG00000204414 . [Q14406-3 ]
    GeneIDi 1444.
    KEGGi hsa:1444.
    UCSCi uc002jcz.1. human. [Q14406-2 ]
    uc002jda.1. human. [Q14406-1 ]
    uc002jdc.1. human. [Q14406-3 ]

    Organism-specific databases

    CTDi 1444.
    GeneCardsi GC17M061986.
    HGNCi HGNC:2442. CSHL1.
    HPAi CAB025646.
    HPA043715.
    MIMi 603515. gene.
    neXtProti NX_Q14406.
    PharmGKBi PA26945.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26152.
    HOGENOMi HOG000068443.
    HOVERGENi HBG011318.
    InParanoidi Q14406.
    OMAi GMEAYIT.
    PhylomeDBi Q14406.
    TreeFami TF332592.

    Miscellaneous databases

    GenomeRNAii 1444.
    NextBioi 5927.
    PROi Q14406.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q14406.
    CleanExi HS_CSHL1.
    Genevestigatori Q14406.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR001400. Somatotropin.
    IPR018116. Somatotropin_CS.
    [Graphical view ]
    PANTHERi PTHR11417. PTHR11417. 1 hit.
    Pfami PF00103. Hormone_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00836. SOMATOTROPIN.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00338. SOMATOTROPIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human growth hormone locus: nucleotide sequence, biology, and evolution."
      Chen E.Y., Liao Y.C., Smith D.H., Barrera-Saldana H.A., Gelinas R.E., Seeburg P.H.
      Genomics 4:479-497(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    2. "Complex alternative splicing partially inactivates the human chorionic somatomammotropin-like (hCS-L) gene."
      Misra-Press A., Cooke N.E., Liebhaber S.A.
      J. Biol. Chem. 269:23220-23229(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3), FUNCTION, SUBCELLULAR LOCATION.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLU-141.

    Entry informationi

    Entry nameiCSHL_HUMAN
    AccessioniPrimary (citable) accession number: Q14406
    Secondary accession number(s): D3DU26, D3DU27, Q0VDB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3