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Q143P8

- ACDH1_BURXL

UniProt

Q143P8 - ACDH1_BURXL

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Protein
Acetaldehyde dehydrogenase 1
Gene
Bxeno_A0903, Bxe_A3547
Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331Acyl-thioester intermediate By similarity
Binding sitei291 – 2911NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 184NAD By similarity
Nucleotide bindingi164 – 1729NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBXEN266265:GJII-924-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1
Gene namesi
Ordered Locus Names:Bxeno_A0903
ORF Names:Bxe_A3547
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Acetaldehyde dehydrogenase 1UniRule annotation
PRO_0000387644Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_A3547.

Structurei

3D structure databases

ProteinModelPortaliQ143P8.
SMRiQ143P8. Positions 5-307.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiHARHEQL.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q143P8-1 [UniParc]FASTAAdd to Basket

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MSSNDEKHAV AIIGSGNIGT DLMVKILRHG KHLKMGAFVG IDPESDGLKR    50
AERMGVPTVT TGIDGLLAHP DFGSIRYVFD ATSAGAHARH EQLLRPHGVR 100
VIDLTPAAIG PFVVPAVNID QHLDSPNVNM VTCGGQATIP MVAAVSRVVP 150
VEYAEIVASI SSRSAGPGTR ANIDEFTETT SNAIVQVGGA KAGKAIIVLN 200
PAEPPLIMRD TVYCLVPGDA SQSAIVESVE QMVDSVRTYV PGYRLKQAVQ 250
FDEFKGRMPQ ELATVRAPRL KVSVFLEVEG AGHYLPSYAG NLDIMTSAAL 300
ATAERIAARQ PVTA 314
Length:314
Mass (Da):33,253
Last modified:August 22, 2006 - v1
Checksum:i395C5B6A8F309DA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000270 Genomic DNA. Translation: ABE29441.1.
RefSeqiYP_557493.1. NC_007951.1.

Genome annotation databases

EnsemblBacteriaiABE29441; ABE29441; Bxe_A3547.
GeneIDi4004910.
KEGGibxe:Bxe_A3547.
PATRICi19327157. VBIBurXen52548_0917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000270 Genomic DNA. Translation: ABE29441.1 .
RefSeqi YP_557493.1. NC_007951.1.

3D structure databases

ProteinModelPortali Q143P8.
SMRi Q143P8. Positions 5-307.
ModBasei Search...

Protein-protein interaction databases

STRINGi 266265.Bxe_A3547.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE29441 ; ABE29441 ; Bxe_A3547 .
GeneIDi 4004910.
KEGGi bxe:Bxe_A3547.
PATRICi 19327157. VBIBurXen52548_0917.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi HARHEQL.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci BXEN266265:GJII-924-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiACDH1_BURXL
AccessioniPrimary (citable) accession number: Q143P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: August 22, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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