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Protein

Bifunctional protein glk

Gene

glk

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 296ATPSequence Analysis
DNA bindingi378 – 39720H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBXEN266265:GJII-1017-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein glk
Including the following 2 domains:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Putative HTH-type transcriptional regulator
Gene namesi
Name:glk
Ordered Locus Names:Bxeno_A0993
ORF Names:Bxe_A3454
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Bifunctional protein glkPRO_0000268802Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_A3454.

Structurei

3D structure databases

ProteinModelPortaliQ143F8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini342 – 41877HTH rpiR-typeAdd
BLAST
Domaini462 – 601140SISAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 341341GlucokinaseAdd
BLAST
Regioni342 – 638297Putative HTH-type transcriptional regulatorAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the bacterial glucokinase family.Curated
Contains 1 SIS domain.Curated

Phylogenomic databases

eggNOGiCOG1737.
HOGENOMiHOG000257466.
KOiK00845.
OMAiQYARKKW.
OrthoDBiEOG64BQ47.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00524. Glucokinase.
InterProiIPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR00749. glk. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q143F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGVQTKAA PGAGQHADGP RLLADIGGTN ARFALETSPG EIGSVKVYPC
60 70 80 90 100
ADYPGVAEVI KRYLKDTKIG RVNHAAIAIA NPVDGDQVSM TNHDWSFSIE
110 120 130 140 150
ATRRALGFDT LLVVNDFTAL AMALPGLTDA QRVQVGGGTR RPNSVIGLLG
160 170 180 190 200
PGTGMGVSGL IPADDRWIAL GSEGGHATFA PADEREDIVL QYARKKWSHV
210 220 230 240 250
SFERVAAGPG IEVIYRALAG RDKKRVAANV DTIEIVKRAM EGEPLAAESV
260 270 280 290 300
DVFCGILGTF AGNIAVTLGA LGGIYIGGGV VPRLGELFAR SSFRKRFEAK
310 320 330 340 350
GRFEAYLQNV PTYVITAEYP AFLGVSAILA EQLSNRAGGS SSAVFERIRQ
360 370 380 390 400
MRDALTPAER RVADLALNHP RSIINDPIVD IARKADVSQP TVIRFCRSLG
410 420 430 440 450
CQGLSDFKLK LATGLTGTIP VSHSQVHLGD TATDFGAKVL DNTVSAILQL
460 470 480 490 500
REHLNFEHVE RAIDLLNGAR RIEFYGLGNS NIVAQDAHYK FFRFGIPTIA
510 520 530 540 550
YGDLYMQAAS AALLGKGDVI VAVSKSGRAP ELLRVLDVAM QAGAKVIAIT
560 570 580 590 600
SSNTPLAKRA TVALETDHIE IRESQLSMIS RILHLVMIDI LAVGVAIRRA
610 620 630
VPSADVAETV AKARQGADDD ATAVLDWLSH GAASSARD
Length:638
Mass (Da):67,858
Last modified:August 22, 2006 - v1
Checksum:i6C68510E194AA57F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE29531.1.
RefSeqiWP_007175889.1. NC_007951.1.
YP_557583.1. NC_007951.1.

Genome annotation databases

EnsemblBacteriaiABE29531; ABE29531; Bxe_A3454.
GeneIDi4001984.
KEGGibxe:Bxe_A3454.
PATRICi19327352. VBIBurXen52548_1014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE29531.1.
RefSeqiWP_007175889.1. NC_007951.1.
YP_557583.1. NC_007951.1.

3D structure databases

ProteinModelPortaliQ143F8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266265.Bxe_A3454.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE29531; ABE29531; Bxe_A3454.
GeneIDi4001984.
KEGGibxe:Bxe_A3454.
PATRICi19327352. VBIBurXen52548_1014.

Phylogenomic databases

eggNOGiCOG1737.
HOGENOMiHOG000257466.
KOiK00845.
OMAiQYARKKW.
OrthoDBiEOG64BQ47.

Enzyme and pathway databases

BioCyciBXEN266265:GJII-1017-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00524. Glucokinase.
InterProiIPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR00749. glk. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiGLK_BURXL
AccessioniPrimary (citable) accession number: Q143F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 22, 2006
Last modified: May 27, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.