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Q143F8

- GLK_BURXL

UniProt

Q143F8 - GLK_BURXL

Protein

Bifunctional protein glk

Gene

glk

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + D-glucose = ADP + D-glucose 6-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 296ATPSequence Analysis
    DNA bindingi378 – 39720H-T-H motifBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. carbohydrate binding Source: InterPro
    3. DNA binding Source: UniProtKB-KW
    4. glucokinase activity Source: UniProtKB-EC
    5. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis, Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBXEN266265:GJII-1017-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein glk
    Including the following 2 domains:
    Glucokinase (EC:2.7.1.2)
    Alternative name(s):
    Glucose kinase
    Putative HTH-type transcriptional regulator
    Gene namesi
    Name:glk
    Ordered Locus Names:Bxeno_A0993
    ORF Names:Bxe_A3454
    OrganismiBurkholderia xenovorans (strain LB400)
    Taxonomic identifieri266265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001817: Chromosome 1

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 638638Bifunctional protein glkPRO_0000268802Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266265.Bxe_A3454.

    Structurei

    3D structure databases

    ProteinModelPortaliQ143F8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini342 – 41877HTH rpiR-typeAdd
    BLAST
    Domaini462 – 601140SISAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 341341GlucokinaseAdd
    BLAST
    Regioni342 – 638297Putative HTH-type transcriptional regulatorAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the bacterial glucokinase family.Curated
    Contains 1 SIS domain.Curated

    Phylogenomic databases

    eggNOGiCOG1737.
    HOGENOMiHOG000257466.
    KOiK00845.
    OMAiQYARKKW.
    OrthoDBiEOG64BQ47.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    HAMAPiMF_00524. Glucokinase.
    InterProiIPR003836. Glucokinase.
    IPR009057. Homeodomain-like.
    IPR000281. HTH_RpiR.
    IPR001347. SIS.
    IPR000843. Tscrpt_reg_HTH_LacI.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF02685. Glucokinase. 1 hit.
    PF01418. HTH_6. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    TIGRFAMsiTIGR00749. glk. 1 hit.
    PROSITEiPS00356. HTH_LACI_1. 1 hit.
    PS51071. HTH_RPIR. 1 hit.
    PS51464. SIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q143F8-1 [UniParc]FASTAAdd to Basket

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    MSTGVQTKAA PGAGQHADGP RLLADIGGTN ARFALETSPG EIGSVKVYPC    50
    ADYPGVAEVI KRYLKDTKIG RVNHAAIAIA NPVDGDQVSM TNHDWSFSIE 100
    ATRRALGFDT LLVVNDFTAL AMALPGLTDA QRVQVGGGTR RPNSVIGLLG 150
    PGTGMGVSGL IPADDRWIAL GSEGGHATFA PADEREDIVL QYARKKWSHV 200
    SFERVAAGPG IEVIYRALAG RDKKRVAANV DTIEIVKRAM EGEPLAAESV 250
    DVFCGILGTF AGNIAVTLGA LGGIYIGGGV VPRLGELFAR SSFRKRFEAK 300
    GRFEAYLQNV PTYVITAEYP AFLGVSAILA EQLSNRAGGS SSAVFERIRQ 350
    MRDALTPAER RVADLALNHP RSIINDPIVD IARKADVSQP TVIRFCRSLG 400
    CQGLSDFKLK LATGLTGTIP VSHSQVHLGD TATDFGAKVL DNTVSAILQL 450
    REHLNFEHVE RAIDLLNGAR RIEFYGLGNS NIVAQDAHYK FFRFGIPTIA 500
    YGDLYMQAAS AALLGKGDVI VAVSKSGRAP ELLRVLDVAM QAGAKVIAIT 550
    SSNTPLAKRA TVALETDHIE IRESQLSMIS RILHLVMIDI LAVGVAIRRA 600
    VPSADVAETV AKARQGADDD ATAVLDWLSH GAASSARD 638
    Length:638
    Mass (Da):67,858
    Last modified:August 22, 2006 - v1
    Checksum:i6C68510E194AA57F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000270 Genomic DNA. Translation: ABE29531.1.
    RefSeqiYP_557583.1. NC_007951.1.

    Genome annotation databases

    EnsemblBacteriaiABE29531; ABE29531; Bxe_A3454.
    GeneIDi4001984.
    KEGGibxe:Bxe_A3454.
    PATRICi19327352. VBIBurXen52548_1014.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000270 Genomic DNA. Translation: ABE29531.1 .
    RefSeqi YP_557583.1. NC_007951.1.

    3D structure databases

    ProteinModelPortali Q143F8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266265.Bxe_A3454.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE29531 ; ABE29531 ; Bxe_A3454 .
    GeneIDi 4001984.
    KEGGi bxe:Bxe_A3454.
    PATRICi 19327352. VBIBurXen52548_1014.

    Phylogenomic databases

    eggNOGi COG1737.
    HOGENOMi HOG000257466.
    KOi K00845.
    OMAi QYARKKW.
    OrthoDBi EOG64BQ47.

    Enzyme and pathway databases

    BioCyci BXEN266265:GJII-1017-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    HAMAPi MF_00524. Glucokinase.
    InterProi IPR003836. Glucokinase.
    IPR009057. Homeodomain-like.
    IPR000281. HTH_RpiR.
    IPR001347. SIS.
    IPR000843. Tscrpt_reg_HTH_LacI.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF02685. Glucokinase. 1 hit.
    PF01418. HTH_6. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    TIGRFAMsi TIGR00749. glk. 1 hit.
    PROSITEi PS00356. HTH_LACI_1. 1 hit.
    PS51071. HTH_RPIR. 1 hit.
    PS51464. SIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LB400.

    Entry informationi

    Entry nameiGLK_BURXL
    AccessioniPrimary (citable) accession number: Q143F8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3