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Q143F8 (GLK_BURXL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein glk

Including the following 2 domains:

  1. Glucokinase
    EC=2.7.1.2
    Alternative name(s):
    Glucose kinase
  2. Putative HTH-type transcriptional regulator
Gene names
Name:glk
Ordered Locus Names:Bxeno_A0993
ORF Names:Bxe_A3454
OrganismBurkholderia xenovorans (strain LB400) [Complete proteome] [HAMAP]
Taxonomic identifier266265 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP-Rule MF_00524

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00524.

Sequence similarities

In the N-terminal section; belongs to the bacterial glucokinase family.

Contains 1 HTH rpiR-type DNA-binding domain.

Contains 1 SIS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 638638Bifunctional protein glk HAMAP-Rule MF_00524
PRO_0000268802

Regions

Domain342 – 41877HTH rpiR-type
Domain462 – 601140SIS
Nucleotide binding24 – 296ATP Potential
DNA binding378 – 39720H-T-H motif By similarity
Region1 – 341341Glucokinase HAMAP-Rule MF_00524
Region342 – 638297Putative HTH-type transcriptional regulator HAMAP-Rule MF_00524

Sequences

Sequence LengthMass (Da)Tools
Q143F8 [UniParc].

Last modified August 22, 2006. Version 1.
Checksum: 6C68510E194AA57F

FASTA63867,858
        10         20         30         40         50         60 
MSTGVQTKAA PGAGQHADGP RLLADIGGTN ARFALETSPG EIGSVKVYPC ADYPGVAEVI 

        70         80         90        100        110        120 
KRYLKDTKIG RVNHAAIAIA NPVDGDQVSM TNHDWSFSIE ATRRALGFDT LLVVNDFTAL 

       130        140        150        160        170        180 
AMALPGLTDA QRVQVGGGTR RPNSVIGLLG PGTGMGVSGL IPADDRWIAL GSEGGHATFA 

       190        200        210        220        230        240 
PADEREDIVL QYARKKWSHV SFERVAAGPG IEVIYRALAG RDKKRVAANV DTIEIVKRAM 

       250        260        270        280        290        300 
EGEPLAAESV DVFCGILGTF AGNIAVTLGA LGGIYIGGGV VPRLGELFAR SSFRKRFEAK 

       310        320        330        340        350        360 
GRFEAYLQNV PTYVITAEYP AFLGVSAILA EQLSNRAGGS SSAVFERIRQ MRDALTPAER 

       370        380        390        400        410        420 
RVADLALNHP RSIINDPIVD IARKADVSQP TVIRFCRSLG CQGLSDFKLK LATGLTGTIP 

       430        440        450        460        470        480 
VSHSQVHLGD TATDFGAKVL DNTVSAILQL REHLNFEHVE RAIDLLNGAR RIEFYGLGNS 

       490        500        510        520        530        540 
NIVAQDAHYK FFRFGIPTIA YGDLYMQAAS AALLGKGDVI VAVSKSGRAP ELLRVLDVAM 

       550        560        570        580        590        600 
QAGAKVIAIT SSNTPLAKRA TVALETDHIE IRESQLSMIS RILHLVMIDI LAVGVAIRRA 

       610        620        630 
VPSADVAETV AKARQGADDD ATAVLDWLSH GAASSARD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000270 Genomic DNA. Translation: ABE29531.1.
RefSeqYP_557583.1. NC_007951.1.

3D structure databases

ProteinModelPortalQ143F8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266265.Bxe_A3454.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABE29531; ABE29531; Bxe_A3454.
GeneID4001984.
KEGGbxe:Bxe_A3454.
PATRIC19327352. VBIBurXen52548_1014.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1737.
HOGENOMHOG000257466.
KOK00845.
OMAQYARKKW.
OrthoDBEOG64BQ47.
ProtClustDBPRK14101.

Enzyme and pathway databases

BioCycBXEN266265:GJII-1017-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
HAMAPMF_00524. Glucokinase.
InterProIPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
TIGRFAMsTIGR00749. glk. 1 hit.
PROSITEPS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLK_BURXL
AccessionPrimary (citable) accession number: Q143F8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 22, 2006
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families