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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei204 – 2041UniRule annotation
Active sitei646 – 6461UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciBXEN266265:GJII-1061-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:Bxeno_A1035
ORF Names:Bxe_A3412
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 994994Phosphoenolpyruvate carboxylasePRO_1000025554Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266265.Bxe_A3412.

Structurei

3D structure databases

ProteinModelPortaliQ143B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q143B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVRSDKTT QAATTAQAQK PAKAGSSKIK IVTAAPQAAN ASARQPASAQ
60 70 80 90 100
APAPKANGRT REDKDHPLFQ DIRYLGRLLG DVLREQEGDA VFDVVETIRQ
110 120 130 140 150
TAVRFRREDD SAAAQTLDKK LRSLSPEQTV SVVRAFSYFS HLANIAEDRH
160 170 180 190 200
RNRRHRIHEL AGSTSQPGTI AHSLERLVEA GAAATPVLQE FFNNALIVPV
210 220 230 240 250
LTAHPTEVQR KSILDAQHDV ARLLAERDQQ LTDRERAHNE AMLRARVTSL
260 270 280 290 300
WQTRMLRDSR LSVADEIENA LSYYRATFLE EIPALYADIE EALAEHGLEA
310 320 330 340 350
RLPPFFQMGS WIGGDRDGNP NVTAETLENA ITRQAAVIFE HYMEQVHKLG
360 370 380 390 400
AELSVSNLLA GASDALKELA AVSPDQSPHR TDEPYRRALI GMYTRLAASA
410 420 430 440 450
RVRLGEGSVP VRSAGRGAAP VRAKPYADSA EFVRDLHVLI DSLAEHHGAP
460 470 480 490 500
LAAPRLSPLA RAAEVFGFHL ASIDLRQSSD VHEAVITELL RRAGVEENYA
510 520 530 540 550
ELPEADKLNV LLSELAQPRP LRLPFAEYSD LVKSELGVLE EARVTREKFG
560 570 580 590 600
ARAVRNYIIS HTETVSDLVE VMLLQKETGL LRGCLGNAND PAQAGLMVIP
610 620 630 640 650
LFETIPDLRN APHIMRDLIA LPGVDALIEH QGNEQEVMLG YSDSNKDGGF
660 670 680 690 700
LTSNWELYRA ELALVSLFNE RGVTLRLFHG RGGTVGRGGG PTYQAILSQP
710 720 730 740 750
PGTVDGQIRL TEQGEVIASK FGNPEIGRRN LETVVAATLE ASLLPHGIAP
760 770 780 790 800
AQLPAFEETM QQLSDAAMAS YRALVYETPG FKEYFFESTP ISEIAELNIG
810 820 830 840 850
SRPASRKLQD PKQRKIEDLR AIPWGFSWGQ CRLLLTGWYG FGSAVAAHLD
860 870 880 890 900
SAPSDAERTR RLALLKKMHK TWPFFANLLS NMDMVLAKTD LAVASRYAAL
910 920 930 940 950
VSDKKLRKHV FERIVAEWER TSKVLSEITG KSERLAENPL LARSIKNRFP
960 970 980 990
YLDPLNHLQV ELLKRHRAGD TNARVRRGIH LSINGIAAGL RNTG
Length:994
Mass (Da):109,655
Last modified:August 22, 2006 - v1
Checksum:i018ADC914C1D9199
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE29573.1.
RefSeqiWP_011487316.1. NC_007951.1.
YP_557625.1. NC_007951.1.

Genome annotation databases

EnsemblBacteriaiABE29573; ABE29573; Bxe_A3412.
GeneIDi4002452.
KEGGibxe:Bxe_A3412.
PATRICi19327450. VBIBurXen52548_1062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE29573.1.
RefSeqiWP_011487316.1. NC_007951.1.
YP_557625.1. NC_007951.1.

3D structure databases

ProteinModelPortaliQ143B6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266265.Bxe_A3412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE29573; ABE29573; Bxe_A3412.
GeneIDi4002452.
KEGGibxe:Bxe_A3412.
PATRICi19327450. VBIBurXen52548_1062.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciBXEN266265:GJII-1061-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiCAPP_BURXL
AccessioniPrimary (citable) accession number: Q143B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.