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Reviewed, UniProtKB/Swiss-Prot Q14397 (GCKR_HUMAN)

Last modified November 25, 2008. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glucokinase regulatory protein
      Short name=Glucokinase regulator
Gene names
Name: GCKR
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length625 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Inhibits glucokinase by forming an inactive complex with this enzyme.

Tissue specificity

Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.

Sequence similarities

Belongs to the GCKR family.

Contains 1 SIS domain.

Ontologies

Keywords

   Coding sequence diversityPolymorphism

Gene Ontology (GO)

   Cellular componentcytosol

Inferred from Experiment. Source: Reactome

nucleoplasm

Inferred from Experiment. Source: Reactome

   Molecular functionenzyme inhibitor activity

Traceable author statement. Source: ProtInc

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GCKP355572EBI-709948,EBI-709928

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 625624Glucokinase regulatory protein
PRO_0000214826

Regions

Domain93 – 259167SIS

Natural variations

Natural variant771E → G: dbSNP rs8179206.
VAR_018849
Natural variant2561G → S: dbSNP rs8179212.
VAR_018850
Natural variant4461P → L: dbSNP rs1260326.
VAR_008906
Natural variant5401R → Q: dbSNP rs8179249.
VAR_018851

Sequences

Sequence LengthMass (Da)Tools
Q14397-1 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: DE750462AC603C80

FASTA62568,685
        10         20         30         40         50         60 
MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV RLLGQCDAEI 

        70         80         90        100        110        120 
FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS 

       130        140        150        160        170        180 
FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE GTEDSALHGI EELKKVAAGK KRVIVIGISV 

       190        200        210        220        230        240 
GLSAPFVAGQ MDCCMNNTAV FLPVLVGFNP VSMARNDPIE DWSSTFRQVA ERMQKMQEKQ 

       250        260        270        280        290        300 
KAFVLNPAIG PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGIAASQR CLLEILRTFE 

       310        320        330        340        350        360 
RAHQVTYSQS PKIATLMKSV STSLEKKGHV YLVGWQTLGI IAIMDGVECI HTFGADFRDV 

       370        380        390        400        410        420 
RGFLIGDHSD MFNQKAELTN QGPQFTFSQE DFLTSILPSL TEIDTVVFIF TLDDNLTEVQ 

       430        440        450        460        470        480 
TIVEQVKEKT NHIQALAHST VGQTLPIPLK KLFPSIISIT WPLLFFEYEG NFIQKFQREL 

       490        500        510        520        530        540 
STKWVLNTVS TGAHVLLGKI LQNHMLDLRI SNSKLFWRAL AMLQRFSGQS KARCIESLLR 

       550        560        570        580        590        600 
AIHFPQPLSD DIRAAPISCH VQVAHEKEQV IPIALLSLLF RCSITEAQAH LAAAPSVCEA 

       610        620 
VRSALAGPGQ KRTADPLEIL EPDVQ 

« Hide

References

« Hide 'large scale' references
[1]"Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization."
Warner J.P., Leek J.P., Intody S., Markham A.F., Bonthron D.T.
Mamm. Genome 6:532-536(1995) [PubMed: 8589523] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Hepatoblastoma.
[2]"Organization of the human glucokinase regulator gene GCKR."
Hayward B.E., Dunlop N., Intody S., Leek J.P., Markham A.F., Warner J.P., Bonthron D.T.
Genomics 49:137-142(1998) [PubMed: 9570959] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION TO 393 AND 560, VARIANT LEU-446, TISSUE SPECIFICITY.
[3]"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."
Rieder M.J., Livingston R.J., Daniels M.R., Chung M.-W., Miyamoto K.E., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-77; SER-256; LEU-446 AND GLN-540.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-446.
+Additional computationally mapped references.

Cross-references

Sequence databases

Z48475 mRNA. Translation: CAA88367.1.
Y09593 Genomic DNA. Translation: CAA70779.2.
Y09592 Genomic DNA. Translation: CAB61828.1.
AY320034 Genomic DNA. Translation: AAP72013.1.
AC074117 Genomic DNA. Translation: AAY14850.1.
PIRS52485.
RefSeqNP_001477.1.
UniGeneHs.89771

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ14397.

PTM databases

PhosphoSiteQ14397.

Polymorphism databases

NIEHS-SNPsSearch...

Genome annotation databases

EnsemblENSG00000084734. Homo sapiens. [Contig view]
GeneID2646.
KEGGhsa:2646.

Organism-specific databases

H-InvDBHIX0030026.
HGNCHGNC:4196. GCKR.
MIM600842. gene.
PharmGKBPA28611.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ14397.
HOVERGENQ14397.

Enzyme and pathway databases

ReactomeREACT_1709. Metabolism of small molecules.

Gene expression databases

ArrayExpressQ14397.
CleanExHS_GCKR.
GermOnlineENSG00000084734. Homo sapiens.

Family and domain databases

InterProIPR005486. Glucokinase_regulatory_CS.
[Graphical view]
ProDomPD021526. GCKR_vertebrate. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS01272. GCKR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio10442.
SOURCESearch...

Entry information

Entry nameGCKR_HUMAN
AccessionPrimary (citable) accession number: Q14397
Secondary accession number(s): Q53RY6, Q99522
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 25, 2008
This is version 59 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents