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Protein

Leucine-rich repeat-containing protein 32

Gene

LRRC32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137507-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 32
Alternative name(s):
Garpin
Glycoprotein A repetitions predominant
Short name:
GARP
Gene namesi
Name:LRRC32
Synonyms:D11S833E, GARP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:4161. LRRC32.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 627ExtracellularSequence analysisAdd BLAST608
Transmembranei628 – 648HelicalSequence analysisAdd BLAST21
Topological domaini649 – 662CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2615.
OpenTargetsiENSG00000137507.
PharmGKBiPA28574.

Polymorphism and mutation databases

BioMutaiLRRC32.
DMDMi2498405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000002161520 – 662Leucine-rich repeat-containing protein 32Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi203N-linked (GlcNAc...)Sequence analysis1
Glycosylationi271N-linked (GlcNAc...)Sequence analysis1
Glycosylationi308N-linked (GlcNAc...)1 Publication1
Glycosylationi345N-linked (GlcNAc...)Sequence analysis1
Glycosylationi545N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ14392.
PaxDbiQ14392.
PeptideAtlasiQ14392.
PRIDEiQ14392.

PTM databases

iPTMnetiQ14392.
PhosphoSitePlusiQ14392.
SwissPalmiQ14392.

Expressioni

Tissue specificityi

Preferentially expressed in regulatory T-cells (T(regs)).1 Publication

Gene expression databases

BgeeiENSG00000137507.
CleanExiHS_LRRC32.
ExpressionAtlasiQ14392. baseline and differential.
GenevisibleiQ14392. HS.

Organism-specific databases

HPAiHPA065439.

Interactioni

Protein-protein interaction databases

BioGridi108885. 11 interactors.
DIPiDIP-48932N.
MINTiMINT-4657192.
STRINGi9606.ENSP00000260061.

Structurei

3D structure databases

ProteinModelPortaliQ14392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati50 – 73LRR 1Add BLAST24
Repeati74 – 95LRR 2Add BLAST22
Repeati98 – 119LRR 3Add BLAST22
Repeati125 – 145LRR 4Add BLAST21
Repeati150 – 171LRR 5Add BLAST22
Repeati174 – 195LRR 6Add BLAST22
Repeati198 – 219LRR 7Add BLAST22
Repeati220 – 240LRR 8Add BLAST21
Repeati244 – 265LRR 9Add BLAST22
Repeati266 – 286LRR 10Add BLAST21
Repeati316 – 339LRR 11Add BLAST24
Repeati340 – 363LRR 12Add BLAST24
Repeati364 – 385LRR 13Add BLAST22
Repeati387 – 408LRR 14Add BLAST22
Repeati411 – 432LRR 15Add BLAST22
Repeati444 – 465LRR 16Add BLAST22
Repeati467 – 488LRR 17Add BLAST22
Repeati492 – 513LRR 18Add BLAST22
Repeati515 – 536LRR 19Add BLAST22
Repeati537 – 558LRR 20Add BLAST22
Domaini571 – 620LRRCTAdd BLAST50

Sequence similaritiesi

Contains 20 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00710000106753.
HOGENOMiHOG000113368.
HOVERGENiHBG052348.
InParanoidiQ14392.
OMAiSCCGNGW.
OrthoDBiEOG091G0403.
PhylomeDBiQ14392.
TreeFamiTF317167.

Family and domain databases

Gene3Di3.80.10.10. 5 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 5 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 20 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPQILLLLA LLTLGLAAQH QDKVPCKMVD KKVSCQVLGL LQVPSVLPPD
60 70 80 90 100
TETLDLSGNQ LRSILASPLG FYTALRHLDL STNEISFLQP GAFQALTHLE
110 120 130 140 150
HLSLAHNRLA MATALSAGGL GPLPRVTSLD LSGNSLYSGL LERLLGEAPS
160 170 180 190 200
LHTLSLAENS LTRLTRHTFR DMPALEQLDL HSNVLMDIED GAFEGLPRLT
210 220 230 240 250
HLNLSRNSLT CISDFSLQQL RVLDLSCNSI EAFQTASQPQ AEFQLTWLDL
260 270 280 290 300
RENKLLHFPD LAALPRLIYL NLSNNLIRLP TGPPQDSKGI HAPSEGWSAL
310 320 330 340 350
PLSAPSGNAS GRPLSQLLNL DLSYNEIELI PDSFLEHLTS LCFLNLSRNC
360 370 380 390 400
LRTFEARRLG SLPCLMLLDL SHNALETLEL GARALGSLRT LLLQGNALRD
410 420 430 440 450
LPPYTFANLA SLQRLNLQGN RVSPCGGPDE PGPSGCVAFS GITSLRSLSL
460 470 480 490 500
VDNEIELLRA GAFLHTPLTE LDLSSNPGLE VATGALGGLE ASLEVLALQG
510 520 530 540 550
NGLMVLQVDL PCFICLKRLN LAENRLSHLP AWTQAVSLEV LDLRNNSFSL
560 570 580 590 600
LPGSAMGGLE TSLRRLYLQG NPLSCCGNGW LAAQLHQGRV DVDATQDLIC
610 620 630 640 650
RFSSQEEVSL SHVRPEDCEK GGLKNINLII ILTFILVSAI LLTTLAACCC
660
VRRQKFNQQY KA
Length:662
Mass (Da):71,979
Last modified:November 1, 1996 - v1
Checksum:i700B93ADCDF25960
GO

Sequence cautioni

The sequence AAH52210 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051113223L → V.Corresponds to variant rs35033061dbSNPEnsembl.1
Natural variantiVAR_051114311G → A.Corresponds to variant rs35130967dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24680 mRNA. Translation: CAA80847.1.
BC052210 mRNA. Translation: AAH52210.2. Different initiation.
BC070079 mRNA. Translation: AAH70079.1.
CCDSiCCDS8245.1.
PIRiS42799.
RefSeqiNP_001122394.1. NM_001128922.1.
NP_005503.1. NM_005512.2.
XP_005273959.1. XM_005273902.3.
XP_011543237.1. XM_011544935.2.
XP_016873016.1. XM_017017527.1.
UniGeneiHs.151641.

Genome annotation databases

EnsembliENST00000260061; ENSP00000260061; ENSG00000137507.
ENST00000404995; ENSP00000385766; ENSG00000137507.
ENST00000407242; ENSP00000384126; ENSG00000137507.
GeneIDi2615.
KEGGihsa:2615.
UCSCiuc001oxq.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24680 mRNA. Translation: CAA80847.1.
BC052210 mRNA. Translation: AAH52210.2. Different initiation.
BC070079 mRNA. Translation: AAH70079.1.
CCDSiCCDS8245.1.
PIRiS42799.
RefSeqiNP_001122394.1. NM_001128922.1.
NP_005503.1. NM_005512.2.
XP_005273959.1. XM_005273902.3.
XP_011543237.1. XM_011544935.2.
XP_016873016.1. XM_017017527.1.
UniGeneiHs.151641.

3D structure databases

ProteinModelPortaliQ14392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108885. 11 interactors.
DIPiDIP-48932N.
MINTiMINT-4657192.
STRINGi9606.ENSP00000260061.

PTM databases

iPTMnetiQ14392.
PhosphoSitePlusiQ14392.
SwissPalmiQ14392.

Polymorphism and mutation databases

BioMutaiLRRC32.
DMDMi2498405.

Proteomic databases

MaxQBiQ14392.
PaxDbiQ14392.
PeptideAtlasiQ14392.
PRIDEiQ14392.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260061; ENSP00000260061; ENSG00000137507.
ENST00000404995; ENSP00000385766; ENSG00000137507.
ENST00000407242; ENSP00000384126; ENSG00000137507.
GeneIDi2615.
KEGGihsa:2615.
UCSCiuc001oxq.5. human.

Organism-specific databases

CTDi2615.
DisGeNETi2615.
GeneCardsiLRRC32.
H-InvDBHIX0036396.
HGNCiHGNC:4161. LRRC32.
HPAiHPA065439.
MIMi137207. gene.
neXtProtiNX_Q14392.
OpenTargetsiENSG00000137507.
PharmGKBiPA28574.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00710000106753.
HOGENOMiHOG000113368.
HOVERGENiHBG052348.
InParanoidiQ14392.
OMAiSCCGNGW.
OrthoDBiEOG091G0403.
PhylomeDBiQ14392.
TreeFamiTF317167.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137507-MONOMER.

Miscellaneous databases

ChiTaRSiLRRC32. human.
GenomeRNAii2615.
PROiQ14392.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137507.
CleanExiHS_LRRC32.
ExpressionAtlasiQ14392. baseline and differential.
GenevisibleiQ14392. HS.

Family and domain databases

Gene3Di3.80.10.10. 5 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 5 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 20 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC32_HUMAN
AccessioniPrimary (citable) accession number: Q14392
Secondary accession number(s): Q86V06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.