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Protein

Leucine-rich repeat-containing protein 32

Gene

LRRC32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 32
Alternative name(s):
Garpin
Glycoprotein A repetitions predominant
Short name:
GARP
Gene namesi
Name:LRRC32
Synonyms:D11S833E, GARP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:4161. LRRC32.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 627608ExtracellularSequence analysisAdd
BLAST
Transmembranei628 – 64821HelicalSequence analysisAdd
BLAST
Topological domaini649 – 66214CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28574.

Polymorphism and mutation databases

BioMutaiLRRC32.
DMDMi2498405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 662643Leucine-rich repeat-containing protein 32PRO_0000021615Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence analysis
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence analysis
Glycosylationi308 – 3081N-linked (GlcNAc...)1 Publication
Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ14392.
PaxDbiQ14392.
PRIDEiQ14392.

PTM databases

PhosphoSiteiQ14392.
SwissPalmiQ14392.

Expressioni

Tissue specificityi

Preferentially expressed in regulatory T-cells (T(regs)).1 Publication

Gene expression databases

BgeeiQ14392.
CleanExiHS_LRRC32.
ExpressionAtlasiQ14392. baseline and differential.
GenevisibleiQ14392. HS.

Organism-specific databases

HPAiHPA065439.

Interactioni

Protein-protein interaction databases

BioGridi108885. 11 interactions.
DIPiDIP-48932N.
MINTiMINT-4657192.
STRINGi9606.ENSP00000260061.

Structurei

3D structure databases

ProteinModelPortaliQ14392.
SMRiQ14392. Positions 40-582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati50 – 7324LRR 1Add
BLAST
Repeati74 – 9522LRR 2Add
BLAST
Repeati98 – 11922LRR 3Add
BLAST
Repeati125 – 14521LRR 4Add
BLAST
Repeati150 – 17122LRR 5Add
BLAST
Repeati174 – 19522LRR 6Add
BLAST
Repeati198 – 21922LRR 7Add
BLAST
Repeati220 – 24021LRR 8Add
BLAST
Repeati244 – 26522LRR 9Add
BLAST
Repeati266 – 28621LRR 10Add
BLAST
Repeati316 – 33924LRR 11Add
BLAST
Repeati340 – 36324LRR 12Add
BLAST
Repeati364 – 38522LRR 13Add
BLAST
Repeati387 – 40822LRR 14Add
BLAST
Repeati411 – 43222LRR 15Add
BLAST
Repeati444 – 46522LRR 16Add
BLAST
Repeati467 – 48822LRR 17Add
BLAST
Repeati492 – 51322LRR 18Add
BLAST
Repeati515 – 53622LRR 19Add
BLAST
Repeati537 – 55822LRR 20Add
BLAST
Domaini571 – 62050LRRCTAdd
BLAST

Sequence similaritiesi

Contains 20 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00710000106753.
HOGENOMiHOG000113368.
HOVERGENiHBG052348.
InParanoidiQ14392.
OMAiSCCGNGW.
OrthoDBiEOG7ZGX2Q.
PhylomeDBiQ14392.
TreeFamiTF317167.

Family and domain databases

Gene3Di3.80.10.10. 5 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 6 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 20 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPQILLLLA LLTLGLAAQH QDKVPCKMVD KKVSCQVLGL LQVPSVLPPD
60 70 80 90 100
TETLDLSGNQ LRSILASPLG FYTALRHLDL STNEISFLQP GAFQALTHLE
110 120 130 140 150
HLSLAHNRLA MATALSAGGL GPLPRVTSLD LSGNSLYSGL LERLLGEAPS
160 170 180 190 200
LHTLSLAENS LTRLTRHTFR DMPALEQLDL HSNVLMDIED GAFEGLPRLT
210 220 230 240 250
HLNLSRNSLT CISDFSLQQL RVLDLSCNSI EAFQTASQPQ AEFQLTWLDL
260 270 280 290 300
RENKLLHFPD LAALPRLIYL NLSNNLIRLP TGPPQDSKGI HAPSEGWSAL
310 320 330 340 350
PLSAPSGNAS GRPLSQLLNL DLSYNEIELI PDSFLEHLTS LCFLNLSRNC
360 370 380 390 400
LRTFEARRLG SLPCLMLLDL SHNALETLEL GARALGSLRT LLLQGNALRD
410 420 430 440 450
LPPYTFANLA SLQRLNLQGN RVSPCGGPDE PGPSGCVAFS GITSLRSLSL
460 470 480 490 500
VDNEIELLRA GAFLHTPLTE LDLSSNPGLE VATGALGGLE ASLEVLALQG
510 520 530 540 550
NGLMVLQVDL PCFICLKRLN LAENRLSHLP AWTQAVSLEV LDLRNNSFSL
560 570 580 590 600
LPGSAMGGLE TSLRRLYLQG NPLSCCGNGW LAAQLHQGRV DVDATQDLIC
610 620 630 640 650
RFSSQEEVSL SHVRPEDCEK GGLKNINLII ILTFILVSAI LLTTLAACCC
660
VRRQKFNQQY KA
Length:662
Mass (Da):71,979
Last modified:November 1, 1996 - v1
Checksum:i700B93ADCDF25960
GO

Sequence cautioni

The sequence AAH52210.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti223 – 2231L → V.
Corresponds to variant rs35033061 [ dbSNP | Ensembl ].
VAR_051113
Natural varianti311 – 3111G → A.
Corresponds to variant rs35130967 [ dbSNP | Ensembl ].
VAR_051114

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24680 mRNA. Translation: CAA80847.1.
BC052210 mRNA. Translation: AAH52210.2. Different initiation.
BC070079 mRNA. Translation: AAH70079.1.
CCDSiCCDS8245.1.
PIRiS42799.
RefSeqiNP_001122394.1. NM_001128922.1.
NP_005503.1. NM_005512.2.
XP_005273959.1. XM_005273902.2.
XP_011543237.1. XM_011544935.1.
UniGeneiHs.151641.

Genome annotation databases

EnsembliENST00000260061; ENSP00000260061; ENSG00000137507.
ENST00000404995; ENSP00000385766; ENSG00000137507.
ENST00000407242; ENSP00000384126; ENSG00000137507.
GeneIDi2615.
KEGGihsa:2615.
UCSCiuc001oxq.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24680 mRNA. Translation: CAA80847.1.
BC052210 mRNA. Translation: AAH52210.2. Different initiation.
BC070079 mRNA. Translation: AAH70079.1.
CCDSiCCDS8245.1.
PIRiS42799.
RefSeqiNP_001122394.1. NM_001128922.1.
NP_005503.1. NM_005512.2.
XP_005273959.1. XM_005273902.2.
XP_011543237.1. XM_011544935.1.
UniGeneiHs.151641.

3D structure databases

ProteinModelPortaliQ14392.
SMRiQ14392. Positions 40-582.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108885. 11 interactions.
DIPiDIP-48932N.
MINTiMINT-4657192.
STRINGi9606.ENSP00000260061.

PTM databases

PhosphoSiteiQ14392.
SwissPalmiQ14392.

Polymorphism and mutation databases

BioMutaiLRRC32.
DMDMi2498405.

Proteomic databases

MaxQBiQ14392.
PaxDbiQ14392.
PRIDEiQ14392.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260061; ENSP00000260061; ENSG00000137507.
ENST00000404995; ENSP00000385766; ENSG00000137507.
ENST00000407242; ENSP00000384126; ENSG00000137507.
GeneIDi2615.
KEGGihsa:2615.
UCSCiuc001oxq.5. human.

Organism-specific databases

CTDi2615.
GeneCardsiLRRC32.
H-InvDBHIX0036396.
HGNCiHGNC:4161. LRRC32.
HPAiHPA065439.
MIMi137207. gene.
neXtProtiNX_Q14392.
PharmGKBiPA28574.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00710000106753.
HOGENOMiHOG000113368.
HOVERGENiHBG052348.
InParanoidiQ14392.
OMAiSCCGNGW.
OrthoDBiEOG7ZGX2Q.
PhylomeDBiQ14392.
TreeFamiTF317167.

Miscellaneous databases

ChiTaRSiLRRC32. human.
GenomeRNAii2615.
NextBioi10297.
PROiQ14392.
SOURCEiSearch...

Gene expression databases

BgeeiQ14392.
CleanExiHS_LRRC32.
ExpressionAtlasiQ14392. baseline and differential.
GenevisibleiQ14392. HS.

Family and domain databases

Gene3Di3.80.10.10. 5 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 6 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 20 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins."
    Ollendorff V., Noguchi T., Delapeyriere O., Birnbaum D.
    Cell Growth Differ. 5:213-219(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-308.
    Tissue: Liver.
  4. "Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32)."
    Chan D.V., Somani A.K., Young A.B., Massari J.V., Ohtola J., Sugiyama H., Garaczi E., Babineau D., Cooper K.D., McCormick T.S.
    BMC Biochem. 12:27-27(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SIGNAL SEQUENCE CLEAVAGE SITE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLRC32_HUMAN
AccessioniPrimary (citable) accession number: Q14392
Secondary accession number(s): Q86V06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.