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Q14330

- GPR18_HUMAN

UniProt

Q14330 - GPR18_HUMAN

Protein

N-arachidonyl glycine receptor

Gene

GPR18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-arachidonyl glycine receptor
    Short name:
    NAGly receptor
    Alternative name(s):
    G-protein coupled receptor 18
    Gene namesi
    Name:GPR18
    Synonyms:GPCRW
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:4472. GPR18.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28860.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331N-arachidonyl glycine receptorPRO_0000069537Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi94 ↔ 172PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ14330.
    PRIDEiQ14330.

    PTM databases

    PhosphoSiteiQ14330.

    Expressioni

    Tissue specificityi

    Most abundant in testis and spleen. Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells.1 Publication

    Gene expression databases

    ArrayExpressiQ14330.
    BgeeiQ14330.
    CleanExiHS_GPR18.
    GenevestigatoriQ14330.

    Organism-specific databases

    HPAiHPA013873.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000343428.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14330.
    SMRiQ14330. Positions 18-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 569CytoplasmicSequence Analysis
    Topological domaini78 – 9518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini117 – 13822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 19132ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini213 – 23220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini254 – 26815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 33142CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG116115.
    HOGENOMiHOG000112785.
    HOVERGENiHBG105013.
    InParanoidiQ14330.
    KOiK08410.
    OMAiYAKGEWP.
    OrthoDBiEOG7SBNP4.
    PhylomeDBiQ14330.
    TreeFamiTF330775.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028335. GPR18.
    [Graphical view]
    PANTHERiPTHR24232:SF1. PTHR24232:SF1. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14330-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITLNNQDQP VPFNSSHPDE YKIAALVFYS CIFIIGLFVN ITALWVFSCT    50
    TKKRTTVTIY MMNVALVDLI FIMTLPFRMF YYAKDEWPFG EYFCQILGAL 100
    TVFYPSIALW LLAFISADRY MAIVQPKYAK ELKNTCKAVL ACVGVWIMTL 150
    TTTTPLLLLY KDPDKDSTPA TCLKISDIIY LKAVNVLNLT RLTFFFLIPL 200
    FIMIGCYLVI IHNLLHGRTS KLKPKVKEKS IRIIITLLVQ VLVCFMPFHI 250
    CFAFLMLGTG ENSYNPWGAF TTFLMNLSTC LDVILYYIVS KQFQARVISV 300
    MLYRNYLRSM RRKSFRSGSL RSLSNINSEM L 331
    Length:331
    Mass (Da):38,134
    Last modified:March 7, 2006 - v2
    Checksum:i5B0B755A74FBBB36
    GO

    Sequence cautioni

    The sequence AAG44671.1 differs from that shown. Reason: Frameshift at positions 78, 81 and 129.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121P → T in AAB65819. (PubMed:9205118)Curated
    Sequence conflicti86 – 861E → A in AAB65819. (PubMed:9205118)Curated
    Sequence conflicti97 – 971L → I in AAB65819. (PubMed:9205118)Curated
    Sequence conflicti102 – 1021V → G in AAG44671. 1 PublicationCurated
    Sequence conflicti112 – 1121L → F in AAG44671. 1 PublicationCurated
    Sequence conflicti145 – 1451V → SS in AAG44671. 1 PublicationCurated
    Sequence conflicti310 – 3101M → L in AAB65819. (PubMed:9205118)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42324 Genomic DNA. Translation: AAB65819.1.
    AF261135 mRNA. Translation: AAG44671.1. Frameshift.
    BT009907 mRNA. Translation: AAP88909.1.
    AL160155 Genomic DNA. Translation: CAI14306.1.
    BC008569 mRNA. Translation: AAH08569.1.
    BC050646 mRNA. Translation: AAH50646.1.
    BC066927 mRNA. Translation: AAH66927.1.
    CCDSiCCDS9491.1.
    RefSeqiNP_001091670.1. NM_001098200.1.
    NP_005283.1. NM_005292.3.
    XP_006720009.1. XM_006719946.1.
    UniGeneiHs.741589.

    Genome annotation databases

    EnsembliENST00000340807; ENSP00000343428; ENSG00000125245.
    ENST00000397470; ENSP00000380610; ENSG00000125245.
    ENST00000397473; ENSP00000380613; ENSG00000125245.
    GeneIDi2841.
    KEGGihsa:2841.
    UCSCiuc001voe.4. human.

    Polymorphism databases

    DMDMi92087006.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42324 Genomic DNA. Translation: AAB65819.1 .
    AF261135 mRNA. Translation: AAG44671.1 . Frameshift.
    BT009907 mRNA. Translation: AAP88909.1 .
    AL160155 Genomic DNA. Translation: CAI14306.1 .
    BC008569 mRNA. Translation: AAH08569.1 .
    BC050646 mRNA. Translation: AAH50646.1 .
    BC066927 mRNA. Translation: AAH66927.1 .
    CCDSi CCDS9491.1.
    RefSeqi NP_001091670.1. NM_001098200.1.
    NP_005283.1. NM_005292.3.
    XP_006720009.1. XM_006719946.1.
    UniGenei Hs.741589.

    3D structure databases

    ProteinModelPortali Q14330.
    SMRi Q14330. Positions 18-295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000343428.

    Chemistry

    ChEMBLi CHEMBL2384898.
    DrugBanki DB00145. Glycine.
    GuidetoPHARMACOLOGYi 89.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q14330.

    Polymorphism databases

    DMDMi 92087006.

    Proteomic databases

    PaxDbi Q14330.
    PRIDEi Q14330.

    Protocols and materials databases

    DNASUi 2841.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340807 ; ENSP00000343428 ; ENSG00000125245 .
    ENST00000397470 ; ENSP00000380610 ; ENSG00000125245 .
    ENST00000397473 ; ENSP00000380613 ; ENSG00000125245 .
    GeneIDi 2841.
    KEGGi hsa:2841.
    UCSCi uc001voe.4. human.

    Organism-specific databases

    CTDi 2841.
    GeneCardsi GC13M099906.
    HGNCi HGNC:4472. GPR18.
    HPAi HPA013873.
    MIMi 602042. gene.
    neXtProti NX_Q14330.
    PharmGKBi PA28860.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG116115.
    HOGENOMi HOG000112785.
    HOVERGENi HBG105013.
    InParanoidi Q14330.
    KOi K08410.
    OMAi YAKGEWP.
    OrthoDBi EOG7SBNP4.
    PhylomeDBi Q14330.
    TreeFami TF330775.

    Enzyme and pathway databases

    Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii GPR18.
    GenomeRNAii 2841.
    NextBioi 11205.
    PROi Q14330.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14330.
    Bgeei Q14330.
    CleanExi HS_GPR18.
    Genevestigatori Q14330.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028335. GPR18.
    [Graphical view ]
    PANTHERi PTHR24232:SF1. PTHR24232:SF1. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis."
      Gantz I., Muraoka A., Yang Y.-K., Samuelson L.C., Zimmerman E.M., Cook H., Yamada T.
      Genomics 42:462-466(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18."
      Kohno M., Hasegawa H., Inoue A., Muraoka M., Miyazaki T., Oka K., Yasukawa M.
      Biochem. Biophys. Res. Commun. 347:827-832(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    3. "Novel genes expressed in human dendritic cell."
      Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Dendritic cell.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph and Testis.

    Entry informationi

    Entry nameiGPR18_HUMAN
    AccessioniPrimary (citable) accession number: Q14330
    Secondary accession number(s): Q6GTM3, Q96HI6, Q9H2L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3