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Q14330

- GPR18_HUMAN

UniProt

Q14330 - GPR18_HUMAN

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Protein

N-arachidonyl glycine receptor

Gene

GPR18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
N-arachidonyl glycine receptor
Short name:
NAGly receptor
Alternative name(s):
G-protein coupled receptor 18
Gene namesi
Name:GPR18
Synonyms:GPCRW
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:4472. GPR18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 569CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 9518ExtracellularSequence AnalysisAdd
BLAST
Transmembranei96 – 11621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini117 – 13822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 19132ExtracellularSequence AnalysisAdd
BLAST
Transmembranei192 – 21221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini213 – 23220CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini254 – 26815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 33142CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28860.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331N-arachidonyl glycine receptorPRO_0000069537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ14330.
PRIDEiQ14330.

PTM databases

PhosphoSiteiQ14330.

Expressioni

Tissue specificityi

Most abundant in testis and spleen. Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells.1 Publication

Gene expression databases

BgeeiQ14330.
CleanExiHS_GPR18.
ExpressionAtlasiQ14330. baseline and differential.
GenevestigatoriQ14330.

Organism-specific databases

HPAiHPA013873.

Interactioni

Protein-protein interaction databases

BioGridi109100. 12 interactions.
STRINGi9606.ENSP00000343428.

Structurei

3D structure databases

ProteinModelPortaliQ14330.
SMRiQ14330. Positions 18-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG116115.
GeneTreeiENSGT00730000110768.
HOGENOMiHOG000112785.
HOVERGENiHBG105013.
InParanoidiQ14330.
KOiK08410.
OMAiYAKGEWP.
OrthoDBiEOG7SBNP4.
PhylomeDBiQ14330.
TreeFamiTF330775.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028335. GPR18.
[Graphical view]
PANTHERiPTHR24232:SF1. PTHR24232:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14330-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITLNNQDQP VPFNSSHPDE YKIAALVFYS CIFIIGLFVN ITALWVFSCT
60 70 80 90 100
TKKRTTVTIY MMNVALVDLI FIMTLPFRMF YYAKDEWPFG EYFCQILGAL
110 120 130 140 150
TVFYPSIALW LLAFISADRY MAIVQPKYAK ELKNTCKAVL ACVGVWIMTL
160 170 180 190 200
TTTTPLLLLY KDPDKDSTPA TCLKISDIIY LKAVNVLNLT RLTFFFLIPL
210 220 230 240 250
FIMIGCYLVI IHNLLHGRTS KLKPKVKEKS IRIIITLLVQ VLVCFMPFHI
260 270 280 290 300
CFAFLMLGTG ENSYNPWGAF TTFLMNLSTC LDVILYYIVS KQFQARVISV
310 320 330
MLYRNYLRSM RRKSFRSGSL RSLSNINSEM L
Length:331
Mass (Da):38,134
Last modified:March 7, 2006 - v2
Checksum:i5B0B755A74FBBB36
GO

Sequence cautioni

The sequence AAG44671.1 differs from that shown. Reason: Frameshift at positions 78, 81 and 129. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121P → T in AAB65819. (PubMed:9205118)Curated
Sequence conflicti86 – 861E → A in AAB65819. (PubMed:9205118)Curated
Sequence conflicti97 – 971L → I in AAB65819. (PubMed:9205118)Curated
Sequence conflicti102 – 1021V → G in AAG44671. 1 PublicationCurated
Sequence conflicti112 – 1121L → F in AAG44671. 1 PublicationCurated
Sequence conflicti145 – 1451V → SS in AAG44671. 1 PublicationCurated
Sequence conflicti310 – 3101M → L in AAB65819. (PubMed:9205118)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42324 Genomic DNA. Translation: AAB65819.1.
AF261135 mRNA. Translation: AAG44671.1. Frameshift.
BT009907 mRNA. Translation: AAP88909.1.
AL160155 Genomic DNA. Translation: CAI14306.1.
BC008569 mRNA. Translation: AAH08569.1.
BC050646 mRNA. Translation: AAH50646.1.
BC066927 mRNA. Translation: AAH66927.1.
CCDSiCCDS9491.1.
RefSeqiNP_001091670.1. NM_001098200.1.
NP_005283.1. NM_005292.3.
XP_006720009.1. XM_006719946.1.
UniGeneiHs.741589.

Genome annotation databases

EnsembliENST00000340807; ENSP00000343428; ENSG00000125245.
ENST00000397470; ENSP00000380610; ENSG00000125245.
ENST00000397473; ENSP00000380613; ENSG00000125245.
GeneIDi2841.
KEGGihsa:2841.
UCSCiuc001voe.4. human.

Polymorphism databases

DMDMi92087006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42324 Genomic DNA. Translation: AAB65819.1 .
AF261135 mRNA. Translation: AAG44671.1 . Frameshift.
BT009907 mRNA. Translation: AAP88909.1 .
AL160155 Genomic DNA. Translation: CAI14306.1 .
BC008569 mRNA. Translation: AAH08569.1 .
BC050646 mRNA. Translation: AAH50646.1 .
BC066927 mRNA. Translation: AAH66927.1 .
CCDSi CCDS9491.1.
RefSeqi NP_001091670.1. NM_001098200.1.
NP_005283.1. NM_005292.3.
XP_006720009.1. XM_006719946.1.
UniGenei Hs.741589.

3D structure databases

ProteinModelPortali Q14330.
SMRi Q14330. Positions 18-295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109100. 12 interactions.
STRINGi 9606.ENSP00000343428.

Chemistry

BindingDBi Q14330.
ChEMBLi CHEMBL2384898.
DrugBanki DB00145. Glycine.
GuidetoPHARMACOLOGYi 89.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q14330.

Polymorphism databases

DMDMi 92087006.

Proteomic databases

PaxDbi Q14330.
PRIDEi Q14330.

Protocols and materials databases

DNASUi 2841.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340807 ; ENSP00000343428 ; ENSG00000125245 .
ENST00000397470 ; ENSP00000380610 ; ENSG00000125245 .
ENST00000397473 ; ENSP00000380613 ; ENSG00000125245 .
GeneIDi 2841.
KEGGi hsa:2841.
UCSCi uc001voe.4. human.

Organism-specific databases

CTDi 2841.
GeneCardsi GC13M099906.
HGNCi HGNC:4472. GPR18.
HPAi HPA013873.
MIMi 602042. gene.
neXtProti NX_Q14330.
PharmGKBi PA28860.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG116115.
GeneTreei ENSGT00730000110768.
HOGENOMi HOG000112785.
HOVERGENi HBG105013.
InParanoidi Q14330.
KOi K08410.
OMAi YAKGEWP.
OrthoDBi EOG7SBNP4.
PhylomeDBi Q14330.
TreeFami TF330775.

Enzyme and pathway databases

Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii GPR18.
GenomeRNAii 2841.
NextBioi 11205.
PROi Q14330.
SOURCEi Search...

Gene expression databases

Bgeei Q14330.
CleanExi HS_GPR18.
ExpressionAtlasi Q14330. baseline and differential.
Genevestigatori Q14330.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028335. GPR18.
[Graphical view ]
PANTHERi PTHR24232:SF1. PTHR24232:SF1. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis."
    Gantz I., Muraoka A., Yang Y.-K., Samuelson L.C., Zimmerman E.M., Cook H., Yamada T.
    Genomics 42:462-466(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18."
    Kohno M., Hasegawa H., Inoue A., Muraoka M., Miyazaki T., Oka K., Yasukawa M.
    Biochem. Biophys. Res. Commun. 347:827-832(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  3. "Novel genes expressed in human dendritic cell."
    Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Dendritic cell.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph and Testis.

Entry informationi

Entry nameiGPR18_HUMAN
AccessioniPrimary (citable) accession number: Q14330
Secondary accession number(s): Q6GTM3, Q96HI6, Q9H2L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 7, 2006
Last modified: November 26, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3