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Q14324

- MYPC2_HUMAN

UniProt

Q14324 - MYPC2_HUMAN

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Protein
Myosin-binding protein C, fast-type
Gene
MYBPC2, MYBPCF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. structural constituent of muscle Source: ProtInc

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. muscle filament sliding Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_16969. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein C, fast-type
Short name:
Fast MyBP-C
Alternative name(s):
C-protein, skeletal muscle fast isoform
Gene namesi
Name:MYBPC2
Synonyms:MYBPCF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:7550. MYBPC2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Thick filament

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31350.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11411141Myosin-binding protein C, fast-type
PRO_0000072691Add
BLAST

Proteomic databases

PaxDbiQ14324.
PRIDEiQ14324.

2D gel databases

REPRODUCTION-2DPAGEIPI00030104.

PTM databases

PhosphoSiteiQ14324.

Expressioni

Gene expression databases

BgeeiQ14324.
CleanExiHS_MYBPC2.
GenevestigatoriQ14324.

Organism-specific databases

HPAiHPA042991.
HPA046745.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MYBPC1Q008723EBI-5653200,EBI-5652924
TTNQ8WZ4214EBI-5653200,EBI-681210

Protein-protein interaction databases

BioGridi110691. 1 interaction.
IntActiQ14324. 30 interactions.
MINTiMINT-6174870.
STRINGi9606.ENSP00000350332.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi51 – 533
Beta strandi62 – 643
Beta strandi73 – 764
Turni77 – 793
Beta strandi80 – 823
Beta strandi87 – 904
Turni91 – 933
Beta strandi105 – 1106
Beta strandi112 – 1143
Beta strandi116 – 12510
Turni128 – 1303
Beta strandi134 – 1396
Beta strandi144 – 1496
Beta strandi152 – 1543
Beta strandi348 – 3503
Beta strandi355 – 3606
Beta strandi367 – 3704
Beta strandi377 – 3826
Beta strandi396 – 3994
Beta strandi401 – 4077
Helixi413 – 4153
Beta strandi417 – 4226
Beta strandi431 – 4355
Beta strandi835 – 8406
Turni844 – 8463
Beta strandi850 – 8567
Beta strandi858 – 86811
Beta strandi871 – 8766
Beta strandi887 – 8904
Beta strandi892 – 90110
Turni904 – 9063
Beta strandi908 – 9158
Beta strandi924 – 9307

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E7CNMR-A824-934[»]
2EDKNMR-A345-438[»]
2EDNNMR-A47-157[»]
ProteinModelPortaliQ14324.
SMRiQ14324. Positions 44-157, 213-246, 253-1035, 1046-1128.

Miscellaneous databases

EvolutionaryTraceiQ14324.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 153104Ig-like C2-type 1
Add
BLAST
Domaini255 – 34490Ig-like C2-type 2
Add
BLAST
Domaini345 – 43793Ig-like C2-type 3
Add
BLAST
Domaini438 – 538101Ig-like C2-type 4
Add
BLAST
Domaini539 – 638100Ig-like C2-type 5
Add
BLAST
Domaini641 – 73797Fibronectin type-III 1
Add
BLAST
Domaini739 – 83496Fibronectin type-III 2
Add
BLAST
Domaini838 – 93295Ig-like C2-type 6
Add
BLAST
Domaini935 – 103096Fibronectin type-III 3
Add
BLAST
Domaini1048 – 114194Ig-like C2-type 7
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiNOG146887.
HOGENOMiHOG000220906.
HOVERGENiHBG052560.
InParanoidiQ14324.
KOiK12558.
OMAiTGKWYKN.
OrthoDBiEOG7WX07H.
PhylomeDBiQ14324.
TreeFamiTF351819.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 7 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14324-1 [UniParc]FASTAAdd to Basket

« Hide

MPEAKPAAKK APKGKDAPKG APKEAPPKEA PAEAPKEAPP EDQSPTAEEP     50
TGVFLKKPDS VSVETGKDAV VVAKVNGKEL PDKPTIKWFK GKWLELGSKS 100
GARFSFKESH NSASNVYTVE LHIGKVVLGD RGYYRLEVKA KDTCDSCGFN 150
IDVEAPRQDA SGQSLESFKR TSEKKSDTAG ELDFSGLLKK REVVEEEKKK 200
KKKDDDDLGI PPEIWELLKG AKKSEYEKIA FQYGITDLRG MLKRLKKAKV 250
EVKKSAAFTK KLDPAYQVDR GNKIKLMVEI SDPDLTLKWF KNGQEIKPSS 300
KYVFENVGKK RILTINKCTL ADDAAYEVAV KDEKCFTELF VKEPPVLIVT 350
PLEDQQVFVG DRVEMAVEVS EEGAQVMWMK DGVELTREDS FKARYRFKKD 400
GKRHILIFSD VVQEDRGRYQ VITNGGQCEA ELIVEEKQLE VLQDIADLTV 450
KASEQAVFKC EVSDEKVTGK WYKNGVEVRP SKRITISHVG RFHKLVIDDV 500
RPEDEGDYTF VPDGYALSLS AKLNFLEIKV EYVPKQEPPK IHLDCSGKTS 550
ENAIVVVAGN KLRLDVSITG EPPPVATWLK GDEVFTTTEG RTRIEKRVDC 600
SSFVIESAQR EDEGRYTIKV TNPVGEDVAS IFLQVVDVPD PPEAVRITSV 650
GEDWAILVWE PPMYDGGKPV TGYLVERKKK GSQRWMKLNF EVFTETTYES 700
TKMIEGILYE MRVFAVNAIG VSQPSMNTKP FMPIAPTSEP LHLIVEDVTD 750
TTTTLKWRPP NRIGAGGIDG YLVEYCLEGS EEWVPANTEP VERCGFTVKN 800
LPTGARILFR VVGVNIAGRS EPATLAQPVT IREIAEPPKI RLPRHLRQTY 850
IRKVGEQLNL VVPFQGKPRP QVVWTKGGAP LDTSRVHVRT SDFDTVFFVR 900
QAARSDSGEY ELSVQIENMK DTATIRIRVV EKAGPPINVM VKEVWGTNAL 950
VEWQAPKDDG NSEIMGYFVQ KADKKTMEWF NVYERNRHTS CTVSDLIVGN 1000
EYYFRVYTEN ICGLSDSPGV SKNTARILKT GITFKPFEYK EHDFRMAPKF 1050
LTPLIDRVVV AGYSAALNCA VRGHPKPKVV WMKNKMEIRE DPKFLITNYQ 1100
GVLTLNIRRP SPFDAGTYTC RAVNELGEAL AECKLEVRVP Q 1141
Length:1,141
Mass (Da):128,072
Last modified:May 18, 2010 - v2
Checksum:i91F4B18C4367743A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291E → K.
Corresponds to variant rs57092106 [ dbSNP | Ensembl ].
VAR_061321
Natural varianti52 – 521G → S.
Corresponds to variant rs25669 [ dbSNP | Ensembl ].
VAR_014657
Natural varianti282 – 2821D → N.
Corresponds to variant rs35951152 [ dbSNP | Ensembl ].
VAR_056060
Natural varianti341 – 3411V → I.
Corresponds to variant rs58511181 [ dbSNP | Ensembl ].
VAR_061322
Natural varianti514 – 5141G → S.
Corresponds to variant rs8104931 [ dbSNP | Ensembl ].
VAR_056061
Natural varianti624 – 6241V → I.
Corresponds to variant rs25665 [ dbSNP | Ensembl ].
VAR_014658
Natural varianti1089 – 10891R → H.
Corresponds to variant rs25667 [ dbSNP | Ensembl ].
VAR_014659

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti517 – 5171L → LG in CAA51544. 1 Publication
Sequence conflicti820 – 8201S → T in CAA51544. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73113 mRNA. Translation: CAA51544.1.
AC020909 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW71866.1.
BC130536 mRNA. Translation: AAI30537.1.
BC136389 mRNA. Translation: AAI36390.1.
CCDSiCCDS46152.1.
PIRiS36845.
RefSeqiNP_004524.3. NM_004533.3.
UniGeneiHs.85937.

Genome annotation databases

EnsembliENST00000357701; ENSP00000350332; ENSG00000086967.
GeneIDi4606.
KEGGihsa:4606.
UCSCiuc002psf.2. human.

Polymorphism databases

DMDMi296439237.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73113 mRNA. Translation: CAA51544.1 .
AC020909 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW71866.1 .
BC130536 mRNA. Translation: AAI30537.1 .
BC136389 mRNA. Translation: AAI36390.1 .
CCDSi CCDS46152.1.
PIRi S36845.
RefSeqi NP_004524.3. NM_004533.3.
UniGenei Hs.85937.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2E7C NMR - A 824-934 [» ]
2EDK NMR - A 345-438 [» ]
2EDN NMR - A 47-157 [» ]
ProteinModelPortali Q14324.
SMRi Q14324. Positions 44-157, 213-246, 253-1035, 1046-1128.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110691. 1 interaction.
IntActi Q14324. 30 interactions.
MINTi MINT-6174870.
STRINGi 9606.ENSP00000350332.

PTM databases

PhosphoSitei Q14324.

Polymorphism databases

DMDMi 296439237.

2D gel databases

REPRODUCTION-2DPAGE IPI00030104.

Proteomic databases

PaxDbi Q14324.
PRIDEi Q14324.

Protocols and materials databases

DNASUi 4606.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357701 ; ENSP00000350332 ; ENSG00000086967 .
GeneIDi 4606.
KEGGi hsa:4606.
UCSCi uc002psf.2. human.

Organism-specific databases

CTDi 4606.
GeneCardsi GC19P050936.
H-InvDB HIX0040195.
HGNCi HGNC:7550. MYBPC2.
HPAi HPA042991.
HPA046745.
MIMi 160793. gene.
neXtProti NX_Q14324.
PharmGKBi PA31350.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146887.
HOGENOMi HOG000220906.
HOVERGENi HBG052560.
InParanoidi Q14324.
KOi K12558.
OMAi TGKWYKN.
OrthoDBi EOG7WX07H.
PhylomeDBi Q14324.
TreeFami TF351819.

Enzyme and pathway databases

Reactomei REACT_16969. Striated Muscle Contraction.

Miscellaneous databases

ChiTaRSi MYBPC2. human.
EvolutionaryTracei Q14324.
GenomeRNAii 4606.
NextBioi 17728.
PROi Q14324.
SOURCEi Search...

Gene expression databases

Bgeei Q14324.
CleanExi HS_MYBPC2.
Genevestigatori Q14324.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF00041. fn3. 3 hits.
PF07679. I-set. 7 hits.
[Graphical view ]
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment."
    Weber F.E., Vaughan K.T., Reinach F.C., Fischman D.A.
    Eur. J. Biochem. 216:661-669(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal skeletal muscle.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Solution structure of the first, third and 6th Ig-like domains from human myosin-binding protein c, fast-type."
    RIKEN structural genomics initiative (RSGI)
    Submitted (AUG-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 44-157; 345-438 AND 825-935.

Entry informationi

Entry nameiMYPC2_HUMAN
AccessioniPrimary (citable) accession number: Q14324
Secondary accession number(s): A1L4G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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