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Q14324

- MYPC2_HUMAN

UniProt

Q14324 - MYPC2_HUMAN

Protein

Myosin-binding protein C, fast-type

Gene

MYBPC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. structural constituent of muscle Source: ProtInc

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. muscle filament sliding Source: Reactome

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    ReactomeiREACT_16969. Striated Muscle Contraction.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin-binding protein C, fast-type
    Short name:
    Fast MyBP-C
    Alternative name(s):
    C-protein, skeletal muscle fast isoform
    Gene namesi
    Name:MYBPC2
    Synonyms:MYBPCF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:7550. MYBPC2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. myosin filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Thick filament

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31350.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11411141Myosin-binding protein C, fast-typePRO_0000072691Add
    BLAST

    Proteomic databases

    PaxDbiQ14324.
    PRIDEiQ14324.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00030104.

    PTM databases

    PhosphoSiteiQ14324.

    Expressioni

    Gene expression databases

    BgeeiQ14324.
    CleanExiHS_MYBPC2.
    GenevestigatoriQ14324.

    Organism-specific databases

    HPAiHPA042991.
    HPA046745.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MYBPC1Q008723EBI-5653200,EBI-5652924
    TTNQ8WZ4214EBI-5653200,EBI-681210

    Protein-protein interaction databases

    BioGridi110691. 1 interaction.
    IntActiQ14324. 30 interactions.
    MINTiMINT-6174870.
    STRINGi9606.ENSP00000350332.

    Structurei

    Secondary structure

    1
    1141
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi51 – 533
    Beta strandi62 – 643
    Beta strandi73 – 764
    Turni77 – 793
    Beta strandi80 – 823
    Beta strandi87 – 904
    Turni91 – 933
    Beta strandi105 – 1106
    Beta strandi112 – 1143
    Beta strandi116 – 12510
    Turni128 – 1303
    Beta strandi134 – 1396
    Beta strandi144 – 1496
    Beta strandi152 – 1543
    Beta strandi348 – 3503
    Beta strandi355 – 3606
    Beta strandi367 – 3704
    Beta strandi377 – 3826
    Beta strandi396 – 3994
    Beta strandi401 – 4077
    Helixi413 – 4153
    Beta strandi417 – 4226
    Beta strandi431 – 4355
    Beta strandi835 – 8406
    Turni844 – 8463
    Beta strandi850 – 8567
    Beta strandi858 – 86811
    Beta strandi871 – 8766
    Beta strandi887 – 8904
    Beta strandi892 – 90110
    Turni904 – 9063
    Beta strandi908 – 9158
    Beta strandi924 – 9307

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2E7CNMR-A824-934[»]
    2EDKNMR-A345-438[»]
    2EDNNMR-A47-157[»]
    ProteinModelPortaliQ14324.
    SMRiQ14324. Positions 44-157, 213-246, 253-1035, 1046-1128.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ14324.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 153104Ig-like C2-type 1Add
    BLAST
    Domaini255 – 34490Ig-like C2-type 2Add
    BLAST
    Domaini345 – 43793Ig-like C2-type 3Add
    BLAST
    Domaini438 – 538101Ig-like C2-type 4Add
    BLAST
    Domaini539 – 638100Ig-like C2-type 5Add
    BLAST
    Domaini641 – 73797Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini739 – 83496Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini838 – 93295Ig-like C2-type 6Add
    BLAST
    Domaini935 – 103096Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1048 – 114194Ig-like C2-type 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. MyBP family.Curated
    Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat

    Phylogenomic databases

    eggNOGiNOG146887.
    HOGENOMiHOG000220906.
    HOVERGENiHBG052560.
    InParanoidiQ14324.
    KOiK12558.
    OMAiTGKWYKN.
    OrthoDBiEOG7WX07H.
    PhylomeDBiQ14324.
    TreeFamiTF351819.

    Family and domain databases

    Gene3Di2.60.40.10. 10 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF00041. fn3. 3 hits.
    PF07679. I-set. 7 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 3 hits.
    SM00409. IG. 6 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14324-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPEAKPAAKK APKGKDAPKG APKEAPPKEA PAEAPKEAPP EDQSPTAEEP     50
    TGVFLKKPDS VSVETGKDAV VVAKVNGKEL PDKPTIKWFK GKWLELGSKS 100
    GARFSFKESH NSASNVYTVE LHIGKVVLGD RGYYRLEVKA KDTCDSCGFN 150
    IDVEAPRQDA SGQSLESFKR TSEKKSDTAG ELDFSGLLKK REVVEEEKKK 200
    KKKDDDDLGI PPEIWELLKG AKKSEYEKIA FQYGITDLRG MLKRLKKAKV 250
    EVKKSAAFTK KLDPAYQVDR GNKIKLMVEI SDPDLTLKWF KNGQEIKPSS 300
    KYVFENVGKK RILTINKCTL ADDAAYEVAV KDEKCFTELF VKEPPVLIVT 350
    PLEDQQVFVG DRVEMAVEVS EEGAQVMWMK DGVELTREDS FKARYRFKKD 400
    GKRHILIFSD VVQEDRGRYQ VITNGGQCEA ELIVEEKQLE VLQDIADLTV 450
    KASEQAVFKC EVSDEKVTGK WYKNGVEVRP SKRITISHVG RFHKLVIDDV 500
    RPEDEGDYTF VPDGYALSLS AKLNFLEIKV EYVPKQEPPK IHLDCSGKTS 550
    ENAIVVVAGN KLRLDVSITG EPPPVATWLK GDEVFTTTEG RTRIEKRVDC 600
    SSFVIESAQR EDEGRYTIKV TNPVGEDVAS IFLQVVDVPD PPEAVRITSV 650
    GEDWAILVWE PPMYDGGKPV TGYLVERKKK GSQRWMKLNF EVFTETTYES 700
    TKMIEGILYE MRVFAVNAIG VSQPSMNTKP FMPIAPTSEP LHLIVEDVTD 750
    TTTTLKWRPP NRIGAGGIDG YLVEYCLEGS EEWVPANTEP VERCGFTVKN 800
    LPTGARILFR VVGVNIAGRS EPATLAQPVT IREIAEPPKI RLPRHLRQTY 850
    IRKVGEQLNL VVPFQGKPRP QVVWTKGGAP LDTSRVHVRT SDFDTVFFVR 900
    QAARSDSGEY ELSVQIENMK DTATIRIRVV EKAGPPINVM VKEVWGTNAL 950
    VEWQAPKDDG NSEIMGYFVQ KADKKTMEWF NVYERNRHTS CTVSDLIVGN 1000
    EYYFRVYTEN ICGLSDSPGV SKNTARILKT GITFKPFEYK EHDFRMAPKF 1050
    LTPLIDRVVV AGYSAALNCA VRGHPKPKVV WMKNKMEIRE DPKFLITNYQ 1100
    GVLTLNIRRP SPFDAGTYTC RAVNELGEAL AECKLEVRVP Q 1141
    Length:1,141
    Mass (Da):128,072
    Last modified:May 18, 2010 - v2
    Checksum:i91F4B18C4367743A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti517 – 5171L → LG in CAA51544. (PubMed:8375400)Curated
    Sequence conflicti820 – 8201S → T in CAA51544. (PubMed:8375400)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291E → K.
    Corresponds to variant rs57092106 [ dbSNP | Ensembl ].
    VAR_061321
    Natural varianti52 – 521G → S.
    Corresponds to variant rs25669 [ dbSNP | Ensembl ].
    VAR_014657
    Natural varianti282 – 2821D → N.
    Corresponds to variant rs35951152 [ dbSNP | Ensembl ].
    VAR_056060
    Natural varianti341 – 3411V → I.
    Corresponds to variant rs58511181 [ dbSNP | Ensembl ].
    VAR_061322
    Natural varianti514 – 5141G → S.
    Corresponds to variant rs8104931 [ dbSNP | Ensembl ].
    VAR_056061
    Natural varianti624 – 6241V → I.
    Corresponds to variant rs25665 [ dbSNP | Ensembl ].
    VAR_014658
    Natural varianti1089 – 10891R → H.
    Corresponds to variant rs25667 [ dbSNP | Ensembl ].
    VAR_014659

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73113 mRNA. Translation: CAA51544.1.
    AC020909 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW71866.1.
    BC130536 mRNA. Translation: AAI30537.1.
    BC136389 mRNA. Translation: AAI36390.1.
    CCDSiCCDS46152.1.
    PIRiS36845.
    RefSeqiNP_004524.3. NM_004533.3.
    UniGeneiHs.85937.

    Genome annotation databases

    EnsembliENST00000357701; ENSP00000350332; ENSG00000086967.
    GeneIDi4606.
    KEGGihsa:4606.
    UCSCiuc002psf.2. human.

    Polymorphism databases

    DMDMi296439237.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73113 mRNA. Translation: CAA51544.1 .
    AC020909 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW71866.1 .
    BC130536 mRNA. Translation: AAI30537.1 .
    BC136389 mRNA. Translation: AAI36390.1 .
    CCDSi CCDS46152.1.
    PIRi S36845.
    RefSeqi NP_004524.3. NM_004533.3.
    UniGenei Hs.85937.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2E7C NMR - A 824-934 [» ]
    2EDK NMR - A 345-438 [» ]
    2EDN NMR - A 47-157 [» ]
    ProteinModelPortali Q14324.
    SMRi Q14324. Positions 44-157, 213-246, 253-1035, 1046-1128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110691. 1 interaction.
    IntActi Q14324. 30 interactions.
    MINTi MINT-6174870.
    STRINGi 9606.ENSP00000350332.

    PTM databases

    PhosphoSitei Q14324.

    Polymorphism databases

    DMDMi 296439237.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00030104.

    Proteomic databases

    PaxDbi Q14324.
    PRIDEi Q14324.

    Protocols and materials databases

    DNASUi 4606.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357701 ; ENSP00000350332 ; ENSG00000086967 .
    GeneIDi 4606.
    KEGGi hsa:4606.
    UCSCi uc002psf.2. human.

    Organism-specific databases

    CTDi 4606.
    GeneCardsi GC19P050936.
    H-InvDB HIX0040195.
    HGNCi HGNC:7550. MYBPC2.
    HPAi HPA042991.
    HPA046745.
    MIMi 160793. gene.
    neXtProti NX_Q14324.
    PharmGKBi PA31350.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146887.
    HOGENOMi HOG000220906.
    HOVERGENi HBG052560.
    InParanoidi Q14324.
    KOi K12558.
    OMAi TGKWYKN.
    OrthoDBi EOG7WX07H.
    PhylomeDBi Q14324.
    TreeFami TF351819.

    Enzyme and pathway databases

    Reactomei REACT_16969. Striated Muscle Contraction.

    Miscellaneous databases

    ChiTaRSi MYBPC2. human.
    EvolutionaryTracei Q14324.
    GenomeRNAii 4606.
    NextBioi 17728.
    PROi Q14324.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q14324.
    CleanExi HS_MYBPC2.
    Genevestigatori Q14324.

    Family and domain databases

    Gene3Di 2.60.40.10. 10 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF00041. fn3. 3 hits.
    PF07679. I-set. 7 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 3 hits.
    SM00409. IG. 6 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment."
      Weber F.E., Vaughan K.T., Reinach F.C., Fischman D.A.
      Eur. J. Biochem. 216:661-669(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal skeletal muscle.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Solution structure of the first, third and 6th Ig-like domains from human myosin-binding protein c, fast-type."
      RIKEN structural genomics initiative (RSGI)
      Submitted (AUG-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 44-157; 345-438 AND 825-935.

    Entry informationi

    Entry nameiMYPC2_HUMAN
    AccessioniPrimary (citable) accession number: Q14324
    Secondary accession number(s): A1L4G9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3