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Protein

Myosin-binding protein C, fast-type

Gene

MYBPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

GO - Molecular functioni

  • structural constituent of muscle Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000086967-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein C, fast-type
Short name:
Fast MyBP-C
Alternative name(s):
C-protein, skeletal muscle fast isoform
Gene namesi
Name:MYBPC2
Synonyms:MYBPCF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:7550. MYBPC2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Thick filament

Pathology & Biotechi

Organism-specific databases

DisGeNETi4606.
OpenTargetsiENSG00000086967.
PharmGKBiPA31350.

Polymorphism and mutation databases

BioMutaiMYBPC2.
DMDMi296439237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726911 – 1141Myosin-binding protein C, fast-typeAdd BLAST1141

Proteomic databases

EPDiQ14324.
PaxDbiQ14324.
PeptideAtlasiQ14324.
PRIDEiQ14324.

2D gel databases

REPRODUCTION-2DPAGEIPI00030104.

PTM databases

iPTMnetiQ14324.
PhosphoSitePlusiQ14324.

Expressioni

Gene expression databases

BgeeiENSG00000086967.
CleanExiHS_MYBPC2.
ExpressionAtlasiQ14324. baseline and differential.
GenevisibleiQ14324. HS.

Organism-specific databases

HPAiHPA042991.
HPA046745.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MYBPC1Q008723EBI-5653200,EBI-5652924
TTNQ8WZ4214EBI-5653200,EBI-681210

Protein-protein interaction databases

BioGridi110691. 1 interactor.
IntActiQ14324. 30 interactors.
MINTiMINT-6174870.
STRINGi9606.ENSP00000350332.

Structurei

Secondary structure

11141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi51 – 53Combined sources3
Beta strandi62 – 64Combined sources3
Beta strandi73 – 76Combined sources4
Turni77 – 79Combined sources3
Beta strandi80 – 82Combined sources3
Beta strandi87 – 90Combined sources4
Turni91 – 93Combined sources3
Beta strandi105 – 110Combined sources6
Beta strandi112 – 114Combined sources3
Beta strandi116 – 125Combined sources10
Turni128 – 130Combined sources3
Beta strandi134 – 139Combined sources6
Beta strandi144 – 149Combined sources6
Beta strandi152 – 154Combined sources3
Beta strandi348 – 350Combined sources3
Beta strandi355 – 360Combined sources6
Beta strandi367 – 370Combined sources4
Beta strandi377 – 382Combined sources6
Beta strandi396 – 399Combined sources4
Beta strandi401 – 407Combined sources7
Helixi413 – 415Combined sources3
Beta strandi417 – 422Combined sources6
Beta strandi431 – 435Combined sources5
Beta strandi835 – 840Combined sources6
Turni844 – 846Combined sources3
Beta strandi850 – 856Combined sources7
Beta strandi858 – 868Combined sources11
Beta strandi871 – 876Combined sources6
Beta strandi887 – 890Combined sources4
Beta strandi892 – 901Combined sources10
Turni904 – 906Combined sources3
Beta strandi908 – 915Combined sources8
Beta strandi924 – 930Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E7CNMR-A824-934[»]
2EDKNMR-A345-438[»]
2EDNNMR-A47-157[»]
ProteinModelPortaliQ14324.
SMRiQ14324.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14324.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 153Ig-like C2-type 1Add BLAST104
Domaini255 – 344Ig-like C2-type 2Add BLAST90
Domaini345 – 437Ig-like C2-type 3Add BLAST93
Domaini438 – 538Ig-like C2-type 4Add BLAST101
Domaini539 – 638Ig-like C2-type 5Add BLAST100
Domaini641 – 737Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST97
Domaini739 – 834Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini838 – 932Ig-like C2-type 6Add BLAST95
Domaini935 – 1030Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini1048 – 1141Ig-like C2-type 7Add BLAST94

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. MyBP family.Curated
Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IFCI. Eukaryota.
ENOG4110AYI. LUCA.
GeneTreeiENSGT00860000133685.
HOGENOMiHOG000220906.
HOVERGENiHBG052560.
InParanoidiQ14324.
KOiK12558.
OMAiKEHDFRT.
OrthoDBiEOG091G00ND.
PhylomeDBiQ14324.
TreeFamiTF351819.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 7 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 7 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEAKPAAKK APKGKDAPKG APKEAPPKEA PAEAPKEAPP EDQSPTAEEP
60 70 80 90 100
TGVFLKKPDS VSVETGKDAV VVAKVNGKEL PDKPTIKWFK GKWLELGSKS
110 120 130 140 150
GARFSFKESH NSASNVYTVE LHIGKVVLGD RGYYRLEVKA KDTCDSCGFN
160 170 180 190 200
IDVEAPRQDA SGQSLESFKR TSEKKSDTAG ELDFSGLLKK REVVEEEKKK
210 220 230 240 250
KKKDDDDLGI PPEIWELLKG AKKSEYEKIA FQYGITDLRG MLKRLKKAKV
260 270 280 290 300
EVKKSAAFTK KLDPAYQVDR GNKIKLMVEI SDPDLTLKWF KNGQEIKPSS
310 320 330 340 350
KYVFENVGKK RILTINKCTL ADDAAYEVAV KDEKCFTELF VKEPPVLIVT
360 370 380 390 400
PLEDQQVFVG DRVEMAVEVS EEGAQVMWMK DGVELTREDS FKARYRFKKD
410 420 430 440 450
GKRHILIFSD VVQEDRGRYQ VITNGGQCEA ELIVEEKQLE VLQDIADLTV
460 470 480 490 500
KASEQAVFKC EVSDEKVTGK WYKNGVEVRP SKRITISHVG RFHKLVIDDV
510 520 530 540 550
RPEDEGDYTF VPDGYALSLS AKLNFLEIKV EYVPKQEPPK IHLDCSGKTS
560 570 580 590 600
ENAIVVVAGN KLRLDVSITG EPPPVATWLK GDEVFTTTEG RTRIEKRVDC
610 620 630 640 650
SSFVIESAQR EDEGRYTIKV TNPVGEDVAS IFLQVVDVPD PPEAVRITSV
660 670 680 690 700
GEDWAILVWE PPMYDGGKPV TGYLVERKKK GSQRWMKLNF EVFTETTYES
710 720 730 740 750
TKMIEGILYE MRVFAVNAIG VSQPSMNTKP FMPIAPTSEP LHLIVEDVTD
760 770 780 790 800
TTTTLKWRPP NRIGAGGIDG YLVEYCLEGS EEWVPANTEP VERCGFTVKN
810 820 830 840 850
LPTGARILFR VVGVNIAGRS EPATLAQPVT IREIAEPPKI RLPRHLRQTY
860 870 880 890 900
IRKVGEQLNL VVPFQGKPRP QVVWTKGGAP LDTSRVHVRT SDFDTVFFVR
910 920 930 940 950
QAARSDSGEY ELSVQIENMK DTATIRIRVV EKAGPPINVM VKEVWGTNAL
960 970 980 990 1000
VEWQAPKDDG NSEIMGYFVQ KADKKTMEWF NVYERNRHTS CTVSDLIVGN
1010 1020 1030 1040 1050
EYYFRVYTEN ICGLSDSPGV SKNTARILKT GITFKPFEYK EHDFRMAPKF
1060 1070 1080 1090 1100
LTPLIDRVVV AGYSAALNCA VRGHPKPKVV WMKNKMEIRE DPKFLITNYQ
1110 1120 1130 1140
GVLTLNIRRP SPFDAGTYTC RAVNELGEAL AECKLEVRVP Q
Length:1,141
Mass (Da):128,072
Last modified:May 18, 2010 - v2
Checksum:i91F4B18C4367743A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti517L → LG in CAA51544 (PubMed:8375400).Curated1
Sequence conflicti820S → T in CAA51544 (PubMed:8375400).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06132129E → K.Corresponds to variant rs57092106dbSNPEnsembl.1
Natural variantiVAR_01465752G → S.Corresponds to variant rs25669dbSNPEnsembl.1
Natural variantiVAR_056060282D → N.Corresponds to variant rs35951152dbSNPEnsembl.1
Natural variantiVAR_061322341V → I.Corresponds to variant rs58511181dbSNPEnsembl.1
Natural variantiVAR_056061514G → S.Corresponds to variant rs8104931dbSNPEnsembl.1
Natural variantiVAR_014658624V → I.Corresponds to variant rs25665dbSNPEnsembl.1
Natural variantiVAR_0146591089R → H.Corresponds to variant rs25667dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73113 mRNA. Translation: CAA51544.1.
AC020909 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW71866.1.
BC130536 mRNA. Translation: AAI30537.1.
BC136389 mRNA. Translation: AAI36390.1.
CCDSiCCDS46152.1.
PIRiS36845.
RefSeqiNP_004524.3. NM_004533.3.
UniGeneiHs.85937.

Genome annotation databases

EnsembliENST00000357701; ENSP00000350332; ENSG00000086967.
GeneIDi4606.
KEGGihsa:4606.
UCSCiuc002psf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73113 mRNA. Translation: CAA51544.1.
AC020909 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW71866.1.
BC130536 mRNA. Translation: AAI30537.1.
BC136389 mRNA. Translation: AAI36390.1.
CCDSiCCDS46152.1.
PIRiS36845.
RefSeqiNP_004524.3. NM_004533.3.
UniGeneiHs.85937.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E7CNMR-A824-934[»]
2EDKNMR-A345-438[»]
2EDNNMR-A47-157[»]
ProteinModelPortaliQ14324.
SMRiQ14324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110691. 1 interactor.
IntActiQ14324. 30 interactors.
MINTiMINT-6174870.
STRINGi9606.ENSP00000350332.

PTM databases

iPTMnetiQ14324.
PhosphoSitePlusiQ14324.

Polymorphism and mutation databases

BioMutaiMYBPC2.
DMDMi296439237.

2D gel databases

REPRODUCTION-2DPAGEIPI00030104.

Proteomic databases

EPDiQ14324.
PaxDbiQ14324.
PeptideAtlasiQ14324.
PRIDEiQ14324.

Protocols and materials databases

DNASUi4606.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357701; ENSP00000350332; ENSG00000086967.
GeneIDi4606.
KEGGihsa:4606.
UCSCiuc002psf.3. human.

Organism-specific databases

CTDi4606.
DisGeNETi4606.
GeneCardsiMYBPC2.
H-InvDBHIX0040195.
HGNCiHGNC:7550. MYBPC2.
HPAiHPA042991.
HPA046745.
MIMi160793. gene.
neXtProtiNX_Q14324.
OpenTargetsiENSG00000086967.
PharmGKBiPA31350.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFCI. Eukaryota.
ENOG4110AYI. LUCA.
GeneTreeiENSGT00860000133685.
HOGENOMiHOG000220906.
HOVERGENiHBG052560.
InParanoidiQ14324.
KOiK12558.
OMAiKEHDFRT.
OrthoDBiEOG091G00ND.
PhylomeDBiQ14324.
TreeFamiTF351819.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000086967-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.

Miscellaneous databases

ChiTaRSiMYBPC2. human.
EvolutionaryTraceiQ14324.
GenomeRNAii4606.
PROiQ14324.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000086967.
CleanExiHS_MYBPC2.
ExpressionAtlasiQ14324. baseline and differential.
GenevisibleiQ14324. HS.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 7 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 7 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 7 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYPC2_HUMAN
AccessioniPrimary (citable) accession number: Q14324
Secondary accession number(s): A1L4G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.