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Q14324 (MYPC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myosin-binding protein C, fast-type

Short name=Fast MyBP-C
Alternative name(s):
C-protein, skeletal muscle fast isoform
Gene names
Name:MYBPC2
Synonyms:MYBPCF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1141 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

Sequence similarities

Belongs to the immunoglobulin superfamily. MyBP family.

Contains 3 fibronectin type-III domains.

Contains 7 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentThick filament
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Repeat
   LigandActin-binding
   Molecular functionMuscle protein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

muscle filament sliding

Traceable author statement. Source: Reactome

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

myosin filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 23414517. Source: IntAct

structural constituent of muscle

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11411141Myosin-binding protein C, fast-type
PRO_0000072691

Regions

Domain50 – 153104Ig-like C2-type 1
Domain255 – 34490Ig-like C2-type 2
Domain345 – 43793Ig-like C2-type 3
Domain438 – 538101Ig-like C2-type 4
Domain539 – 638100Ig-like C2-type 5
Domain641 – 73797Fibronectin type-III 1
Domain739 – 83496Fibronectin type-III 2
Domain838 – 93295Ig-like C2-type 6
Domain935 – 103096Fibronectin type-III 3
Domain1048 – 114194Ig-like C2-type 7

Natural variations

Natural variant291E → K.
Corresponds to variant rs57092106 [ dbSNP | Ensembl ].
VAR_061321
Natural variant521G → S.
Corresponds to variant rs25669 [ dbSNP | Ensembl ].
VAR_014657
Natural variant2821D → N.
Corresponds to variant rs35951152 [ dbSNP | Ensembl ].
VAR_056060
Natural variant3411V → I.
Corresponds to variant rs58511181 [ dbSNP | Ensembl ].
VAR_061322
Natural variant5141G → S.
Corresponds to variant rs8104931 [ dbSNP | Ensembl ].
VAR_056061
Natural variant6241V → I.
Corresponds to variant rs25665 [ dbSNP | Ensembl ].
VAR_014658
Natural variant10891R → H.
Corresponds to variant rs25667 [ dbSNP | Ensembl ].
VAR_014659

Experimental info

Sequence conflict5171L → LG in CAA51544. Ref.1
Sequence conflict8201S → T in CAA51544. Ref.1

Secondary structure

................................................................ 1141
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q14324 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 91F4B18C4367743A

FASTA1,141128,072
        10         20         30         40         50         60 
MPEAKPAAKK APKGKDAPKG APKEAPPKEA PAEAPKEAPP EDQSPTAEEP TGVFLKKPDS 

        70         80         90        100        110        120 
VSVETGKDAV VVAKVNGKEL PDKPTIKWFK GKWLELGSKS GARFSFKESH NSASNVYTVE 

       130        140        150        160        170        180 
LHIGKVVLGD RGYYRLEVKA KDTCDSCGFN IDVEAPRQDA SGQSLESFKR TSEKKSDTAG 

       190        200        210        220        230        240 
ELDFSGLLKK REVVEEEKKK KKKDDDDLGI PPEIWELLKG AKKSEYEKIA FQYGITDLRG 

       250        260        270        280        290        300 
MLKRLKKAKV EVKKSAAFTK KLDPAYQVDR GNKIKLMVEI SDPDLTLKWF KNGQEIKPSS 

       310        320        330        340        350        360 
KYVFENVGKK RILTINKCTL ADDAAYEVAV KDEKCFTELF VKEPPVLIVT PLEDQQVFVG 

       370        380        390        400        410        420 
DRVEMAVEVS EEGAQVMWMK DGVELTREDS FKARYRFKKD GKRHILIFSD VVQEDRGRYQ 

       430        440        450        460        470        480 
VITNGGQCEA ELIVEEKQLE VLQDIADLTV KASEQAVFKC EVSDEKVTGK WYKNGVEVRP 

       490        500        510        520        530        540 
SKRITISHVG RFHKLVIDDV RPEDEGDYTF VPDGYALSLS AKLNFLEIKV EYVPKQEPPK 

       550        560        570        580        590        600 
IHLDCSGKTS ENAIVVVAGN KLRLDVSITG EPPPVATWLK GDEVFTTTEG RTRIEKRVDC 

       610        620        630        640        650        660 
SSFVIESAQR EDEGRYTIKV TNPVGEDVAS IFLQVVDVPD PPEAVRITSV GEDWAILVWE 

       670        680        690        700        710        720 
PPMYDGGKPV TGYLVERKKK GSQRWMKLNF EVFTETTYES TKMIEGILYE MRVFAVNAIG 

       730        740        750        760        770        780 
VSQPSMNTKP FMPIAPTSEP LHLIVEDVTD TTTTLKWRPP NRIGAGGIDG YLVEYCLEGS 

       790        800        810        820        830        840 
EEWVPANTEP VERCGFTVKN LPTGARILFR VVGVNIAGRS EPATLAQPVT IREIAEPPKI 

       850        860        870        880        890        900 
RLPRHLRQTY IRKVGEQLNL VVPFQGKPRP QVVWTKGGAP LDTSRVHVRT SDFDTVFFVR 

       910        920        930        940        950        960 
QAARSDSGEY ELSVQIENMK DTATIRIRVV EKAGPPINVM VKEVWGTNAL VEWQAPKDDG 

       970        980        990       1000       1010       1020 
NSEIMGYFVQ KADKKTMEWF NVYERNRHTS CTVSDLIVGN EYYFRVYTEN ICGLSDSPGV 

      1030       1040       1050       1060       1070       1080 
SKNTARILKT GITFKPFEYK EHDFRMAPKF LTPLIDRVVV AGYSAALNCA VRGHPKPKVV 

      1090       1100       1110       1120       1130       1140 
WMKNKMEIRE DPKFLITNYQ GVLTLNIRRP SPFDAGTYTC RAVNELGEAL AECKLEVRVP 


Q 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment."
Weber F.E., Vaughan K.T., Reinach F.C., Fischman D.A.
Eur. J. Biochem. 216:661-669(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal skeletal muscle.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Solution structure of the first, third and 6th Ig-like domains from human myosin-binding protein c, fast-type."
RIKEN structural genomics initiative (RSGI)
Submitted (AUG-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 44-157; 345-438 AND 825-935.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X73113 mRNA. Translation: CAA51544.1.
AC020909 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW71866.1.
BC130536 mRNA. Translation: AAI30537.1.
BC136389 mRNA. Translation: AAI36390.1.
CCDSCCDS46152.1.
PIRS36845.
RefSeqNP_004524.3. NM_004533.3.
UniGeneHs.85937.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2E7CNMR-A824-934[»]
2EDKNMR-A345-438[»]
2EDNNMR-A47-157[»]
ProteinModelPortalQ14324.
SMRQ14324. Positions 44-157, 213-246, 253-1035, 1046-1128.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110691. 1 interaction.
IntActQ14324. 30 interactions.
MINTMINT-6174870.
STRING9606.ENSP00000350332.

PTM databases

PhosphoSiteQ14324.

Polymorphism databases

DMDM296439237.

2D gel databases

REPRODUCTION-2DPAGEIPI00030104.

Proteomic databases

PaxDbQ14324.
PRIDEQ14324.

Protocols and materials databases

DNASU4606.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357701; ENSP00000350332; ENSG00000086967.
GeneID4606.
KEGGhsa:4606.
UCSCuc002psf.2. human.

Organism-specific databases

CTD4606.
GeneCardsGC19P050936.
H-InvDBHIX0040195.
HGNCHGNC:7550. MYBPC2.
HPAHPA042991.
HPA046745.
MIM160793. gene.
neXtProtNX_Q14324.
PharmGKBPA31350.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146887.
HOGENOMHOG000220906.
HOVERGENHBG052560.
InParanoidQ14324.
KOK12558.
OMATGKWYKN.
OrthoDBEOG7WX07H.
PhylomeDBQ14324.
TreeFamTF351819.

Enzyme and pathway databases

ReactomeREACT_17044. Muscle contraction.

Gene expression databases

BgeeQ14324.
CleanExHS_MYBPC2.
GenevestigatorQ14324.

Family and domain databases

Gene3D2.60.40.10. 10 hits.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamPF00041. fn3. 3 hits.
PF07679. I-set. 7 hits.
[Graphical view]
SMARTSM00060. FN3. 3 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMYBPC2. human.
EvolutionaryTraceQ14324.
GenomeRNAi4606.
NextBio17728.
PROQ14324.
SOURCESearch...

Entry information

Entry nameMYPC2_HUMAN
AccessionPrimary (citable) accession number: Q14324
Secondary accession number(s): A1L4G9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM