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Protein

Myosin-binding protein C, fast-type

Gene

MYBPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

GO - Molecular functioni

  1. structural constituent of muscle Source: ProtInc

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. muscle filament sliding Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_16969. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein C, fast-type
Short name:
Fast MyBP-C
Alternative name(s):
C-protein, skeletal muscle fast isoform
Gene namesi
Name:MYBPC2
Synonyms:MYBPCF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:7550. MYBPC2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Thick filament

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31350.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11411141Myosin-binding protein C, fast-typePRO_0000072691Add
BLAST

Proteomic databases

PaxDbiQ14324.
PRIDEiQ14324.

2D gel databases

REPRODUCTION-2DPAGEIPI00030104.

PTM databases

PhosphoSiteiQ14324.

Expressioni

Gene expression databases

BgeeiQ14324.
CleanExiHS_MYBPC2.
GenevestigatoriQ14324.

Organism-specific databases

HPAiHPA042991.
HPA046745.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MYBPC1Q008723EBI-5653200,EBI-5652924
TTNQ8WZ4214EBI-5653200,EBI-681210

Protein-protein interaction databases

BioGridi110691. 1 interaction.
IntActiQ14324. 30 interactions.
MINTiMINT-6174870.
STRINGi9606.ENSP00000350332.

Structurei

Secondary structure

1
1141
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi51 – 533Combined sources
Beta strandi62 – 643Combined sources
Beta strandi73 – 764Combined sources
Turni77 – 793Combined sources
Beta strandi80 – 823Combined sources
Beta strandi87 – 904Combined sources
Turni91 – 933Combined sources
Beta strandi105 – 1106Combined sources
Beta strandi112 – 1143Combined sources
Beta strandi116 – 12510Combined sources
Turni128 – 1303Combined sources
Beta strandi134 – 1396Combined sources
Beta strandi144 – 1496Combined sources
Beta strandi152 – 1543Combined sources
Beta strandi348 – 3503Combined sources
Beta strandi355 – 3606Combined sources
Beta strandi367 – 3704Combined sources
Beta strandi377 – 3826Combined sources
Beta strandi396 – 3994Combined sources
Beta strandi401 – 4077Combined sources
Helixi413 – 4153Combined sources
Beta strandi417 – 4226Combined sources
Beta strandi431 – 4355Combined sources
Beta strandi835 – 8406Combined sources
Turni844 – 8463Combined sources
Beta strandi850 – 8567Combined sources
Beta strandi858 – 86811Combined sources
Beta strandi871 – 8766Combined sources
Beta strandi887 – 8904Combined sources
Beta strandi892 – 90110Combined sources
Turni904 – 9063Combined sources
Beta strandi908 – 9158Combined sources
Beta strandi924 – 9307Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E7CNMR-A824-934[»]
2EDKNMR-A345-438[»]
2EDNNMR-A47-157[»]
ProteinModelPortaliQ14324.
SMRiQ14324. Positions 44-157, 213-246, 253-1035, 1046-1128.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14324.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 153104Ig-like C2-type 1Add
BLAST
Domaini255 – 34490Ig-like C2-type 2Add
BLAST
Domaini345 – 43793Ig-like C2-type 3Add
BLAST
Domaini438 – 538101Ig-like C2-type 4Add
BLAST
Domaini539 – 638100Ig-like C2-type 5Add
BLAST
Domaini641 – 73797Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini739 – 83496Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini838 – 93295Ig-like C2-type 6Add
BLAST
Domaini935 – 103096Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini1048 – 114194Ig-like C2-type 7Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. MyBP family.Curated
Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiNOG146887.
GeneTreeiENSGT00760000119038.
HOGENOMiHOG000220906.
HOVERGENiHBG052560.
InParanoidiQ14324.
KOiK12558.
OMAiTGKWYKN.
OrthoDBiEOG7WX07H.
PhylomeDBiQ14324.
TreeFamiTF351819.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 7 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14324-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPEAKPAAKK APKGKDAPKG APKEAPPKEA PAEAPKEAPP EDQSPTAEEP
60 70 80 90 100
TGVFLKKPDS VSVETGKDAV VVAKVNGKEL PDKPTIKWFK GKWLELGSKS
110 120 130 140 150
GARFSFKESH NSASNVYTVE LHIGKVVLGD RGYYRLEVKA KDTCDSCGFN
160 170 180 190 200
IDVEAPRQDA SGQSLESFKR TSEKKSDTAG ELDFSGLLKK REVVEEEKKK
210 220 230 240 250
KKKDDDDLGI PPEIWELLKG AKKSEYEKIA FQYGITDLRG MLKRLKKAKV
260 270 280 290 300
EVKKSAAFTK KLDPAYQVDR GNKIKLMVEI SDPDLTLKWF KNGQEIKPSS
310 320 330 340 350
KYVFENVGKK RILTINKCTL ADDAAYEVAV KDEKCFTELF VKEPPVLIVT
360 370 380 390 400
PLEDQQVFVG DRVEMAVEVS EEGAQVMWMK DGVELTREDS FKARYRFKKD
410 420 430 440 450
GKRHILIFSD VVQEDRGRYQ VITNGGQCEA ELIVEEKQLE VLQDIADLTV
460 470 480 490 500
KASEQAVFKC EVSDEKVTGK WYKNGVEVRP SKRITISHVG RFHKLVIDDV
510 520 530 540 550
RPEDEGDYTF VPDGYALSLS AKLNFLEIKV EYVPKQEPPK IHLDCSGKTS
560 570 580 590 600
ENAIVVVAGN KLRLDVSITG EPPPVATWLK GDEVFTTTEG RTRIEKRVDC
610 620 630 640 650
SSFVIESAQR EDEGRYTIKV TNPVGEDVAS IFLQVVDVPD PPEAVRITSV
660 670 680 690 700
GEDWAILVWE PPMYDGGKPV TGYLVERKKK GSQRWMKLNF EVFTETTYES
710 720 730 740 750
TKMIEGILYE MRVFAVNAIG VSQPSMNTKP FMPIAPTSEP LHLIVEDVTD
760 770 780 790 800
TTTTLKWRPP NRIGAGGIDG YLVEYCLEGS EEWVPANTEP VERCGFTVKN
810 820 830 840 850
LPTGARILFR VVGVNIAGRS EPATLAQPVT IREIAEPPKI RLPRHLRQTY
860 870 880 890 900
IRKVGEQLNL VVPFQGKPRP QVVWTKGGAP LDTSRVHVRT SDFDTVFFVR
910 920 930 940 950
QAARSDSGEY ELSVQIENMK DTATIRIRVV EKAGPPINVM VKEVWGTNAL
960 970 980 990 1000
VEWQAPKDDG NSEIMGYFVQ KADKKTMEWF NVYERNRHTS CTVSDLIVGN
1010 1020 1030 1040 1050
EYYFRVYTEN ICGLSDSPGV SKNTARILKT GITFKPFEYK EHDFRMAPKF
1060 1070 1080 1090 1100
LTPLIDRVVV AGYSAALNCA VRGHPKPKVV WMKNKMEIRE DPKFLITNYQ
1110 1120 1130 1140
GVLTLNIRRP SPFDAGTYTC RAVNELGEAL AECKLEVRVP Q
Length:1,141
Mass (Da):128,072
Last modified:May 18, 2010 - v2
Checksum:i91F4B18C4367743A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti517 – 5171L → LG in CAA51544. (PubMed:8375400)Curated
Sequence conflicti820 – 8201S → T in CAA51544. (PubMed:8375400)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291E → K.
Corresponds to variant rs57092106 [ dbSNP | Ensembl ].
VAR_061321
Natural varianti52 – 521G → S.
Corresponds to variant rs25669 [ dbSNP | Ensembl ].
VAR_014657
Natural varianti282 – 2821D → N.
Corresponds to variant rs35951152 [ dbSNP | Ensembl ].
VAR_056060
Natural varianti341 – 3411V → I.
Corresponds to variant rs58511181 [ dbSNP | Ensembl ].
VAR_061322
Natural varianti514 – 5141G → S.
Corresponds to variant rs8104931 [ dbSNP | Ensembl ].
VAR_056061
Natural varianti624 – 6241V → I.
Corresponds to variant rs25665 [ dbSNP | Ensembl ].
VAR_014658
Natural varianti1089 – 10891R → H.
Corresponds to variant rs25667 [ dbSNP | Ensembl ].
VAR_014659

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73113 mRNA. Translation: CAA51544.1.
AC020909 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW71866.1.
BC130536 mRNA. Translation: AAI30537.1.
BC136389 mRNA. Translation: AAI36390.1.
CCDSiCCDS46152.1.
PIRiS36845.
RefSeqiNP_004524.3. NM_004533.3.
UniGeneiHs.85937.

Genome annotation databases

EnsembliENST00000357701; ENSP00000350332; ENSG00000086967.
GeneIDi4606.
KEGGihsa:4606.
UCSCiuc002psf.2. human.

Polymorphism databases

DMDMi296439237.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73113 mRNA. Translation: CAA51544.1.
AC020909 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW71866.1.
BC130536 mRNA. Translation: AAI30537.1.
BC136389 mRNA. Translation: AAI36390.1.
CCDSiCCDS46152.1.
PIRiS36845.
RefSeqiNP_004524.3. NM_004533.3.
UniGeneiHs.85937.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E7CNMR-A824-934[»]
2EDKNMR-A345-438[»]
2EDNNMR-A47-157[»]
ProteinModelPortaliQ14324.
SMRiQ14324. Positions 44-157, 213-246, 253-1035, 1046-1128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110691. 1 interaction.
IntActiQ14324. 30 interactions.
MINTiMINT-6174870.
STRINGi9606.ENSP00000350332.

PTM databases

PhosphoSiteiQ14324.

Polymorphism databases

DMDMi296439237.

2D gel databases

REPRODUCTION-2DPAGEIPI00030104.

Proteomic databases

PaxDbiQ14324.
PRIDEiQ14324.

Protocols and materials databases

DNASUi4606.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357701; ENSP00000350332; ENSG00000086967.
GeneIDi4606.
KEGGihsa:4606.
UCSCiuc002psf.2. human.

Organism-specific databases

CTDi4606.
GeneCardsiGC19P050936.
H-InvDBHIX0040195.
HGNCiHGNC:7550. MYBPC2.
HPAiHPA042991.
HPA046745.
MIMi160793. gene.
neXtProtiNX_Q14324.
PharmGKBiPA31350.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146887.
GeneTreeiENSGT00760000119038.
HOGENOMiHOG000220906.
HOVERGENiHBG052560.
InParanoidiQ14324.
KOiK12558.
OMAiTGKWYKN.
OrthoDBiEOG7WX07H.
PhylomeDBiQ14324.
TreeFamiTF351819.

Enzyme and pathway databases

ReactomeiREACT_16969. Striated Muscle Contraction.

Miscellaneous databases

ChiTaRSiMYBPC2. human.
EvolutionaryTraceiQ14324.
GenomeRNAii4606.
NextBioi17728.
PROiQ14324.
SOURCEiSearch...

Gene expression databases

BgeeiQ14324.
CleanExiHS_MYBPC2.
GenevestigatoriQ14324.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 7 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment."
    Weber F.E., Vaughan K.T., Reinach F.C., Fischman D.A.
    Eur. J. Biochem. 216:661-669(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal skeletal muscle.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Solution structure of the first, third and 6th Ig-like domains from human myosin-binding protein c, fast-type."
    RIKEN structural genomics initiative (RSGI)
    Submitted (AUG-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 44-157; 345-438 AND 825-935.

Entry informationi

Entry nameiMYPC2_HUMAN
AccessioniPrimary (citable) accession number: Q14324
Secondary accession number(s): A1L4G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 18, 2010
Last modified: January 7, 2015
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.