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Protein

Protein FAM50A

Gene

FAM50A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a DNA-binding protein or transcriptional factor.1 Publication

GO - Molecular functioni

GO - Biological processi

  • spermatogenesis Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM50A
Alternative name(s):
Protein HXC-26
Protein XAP-5
Gene namesi
Name:FAM50A
Synonyms:DXS9928E, HXC26, XAP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000071859.14
HGNCiHGNC:18786 FAM50A
MIMi300453 gene
neXtProtiNX_Q14320

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000071859
PharmGKBiPA134984709

Polymorphism and mutation databases

BioMutaiFAM50A
DMDMi12231058

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000682842 – 339Protein FAM50AAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Cross-linki100Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ14320
MaxQBiQ14320
PaxDbiQ14320
PeptideAtlasiQ14320
PRIDEiQ14320
ProteomicsDBi59964

PTM databases

iPTMnetiQ14320
PhosphoSitePlusiQ14320

Expressioni

Tissue specificityi

Expressed in all tissues examined. Mostly abundant in fetal brain, liver and kidney; in the adult, high levels were also observed in heart, skeletal muscle, spleen, thymus, prostate and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000071859
CleanExiHS_FAM50A
ExpressionAtlasiQ14320 baseline and differential
GenevisibleiQ14320 HS

Organism-specific databases

HPAiHPA003585

Interactioni

Protein-protein interaction databases

BioGridi114578, 10 interactors
IntActiQ14320, 3 interactors
STRINGi9606.ENSP00000377225

Structurei

3D structure databases

ProteinModelPortaliQ14320
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi152 – 155Nuclear localization signalSequence analysis4

Sequence similaritiesi

Belongs to the FAM50 family.Curated

Phylogenomic databases

eggNOGiKOG2894 Eukaryota
ENOG410XNXM LUCA
GeneTreeiENSGT00390000004735
HOGENOMiHOG000283611
HOVERGENiHBG000678
InParanoidiQ14320
KOiK13119
OMAiYQRNKHI
OrthoDBiEOG091G0KZY
PhylomeDBiQ14320
TreeFamiTF314738

Family and domain databases

InterProiView protein in InterPro
IPR007005 XAP5
PANTHERiPTHR12722 PTHR12722, 1 hit
PfamiView protein in Pfam
PF04921 XAP5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQYKGAASE AGRAMHLMKK REKQREQMEQ MKQRIAEENI MKSNIDKKFS
60 70 80 90 100
AHYDAVEAEL KSSTVGLVTL NDMKAKQEAL VKEREKQLAK KEQSKELQMK
110 120 130 140 150
LEKLREKERK KEAKRKISSL SFTLEEEEEG GEEEEEAAMY EEEMEREEIT
160 170 180 190 200
TKKRKLGKNP DVDTSFLPDR DREEEENRLR EELRQEWEAK QEKIKSEEIE
210 220 230 240 250
ITFSYWDGSG HRRTVKMRKG NTMQQFLQKA LEILRKDFSE LRSAGVEQLM
260 270 280 290 300
YIKEDLIIPH HHSFYDFIVT KARGKSGPLF NFDVHDDVRL LSDATVEKDE
310 320 330
SHAGKVVLRS WYEKNKHIFP ASRWEPYDPE KKWDKYTIR
Length:339
Mass (Da):40,242
Last modified:January 11, 2001 - v2
Checksum:i88BCA57E49B0AA32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166F → S in BAF85808 (PubMed:14702039).Curated1
Sequence conflicti330E → G in BAF85808 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AD001530 mRNA Translation: AAB81663.1
AK293119 mRNA Translation: BAF85808.1
AK313697 mRNA Translation: BAG36444.1
BX936365 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72708.1
BC000028 mRNA Translation: AAH00028.1
BC015499 mRNA Translation: AAH15499.1
D83389 Genomic DNA Translation: BAA11907.1
D83260 mRNA Translation: BAA11871.1
L44140 Genomic DNA Translation: AAA92649.1
CCDSiCCDS14751.1
PIRiJC5276
RefSeqiNP_004690.1, NM_004699.3
UniGeneiHs.54277

Genome annotation databases

EnsembliENST00000393600; ENSP00000377225; ENSG00000071859
GeneIDi9130
KEGGihsa:9130
UCSCiuc004fll.4 human

Similar proteinsi

Entry informationi

Entry nameiFA50A_HUMAN
AccessioniPrimary (citable) accession number: Q14320
Secondary accession number(s): A8KAQ4
, B2R997, Q5HY37, Q6PJH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: June 20, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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