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Q14318

- FKBP8_HUMAN

UniProt

Q14318 - FKBP8_HUMAN

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Protein
Peptidyl-prolyl cis-trans isomerase FKBP8
Gene
FKBP8, FKBP38
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.3 Publications

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).1 Publication

Cofactori

Calcium.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi149 – 1491Calcium
Metal bindingi151 – 1511Calcium

GO - Molecular functioni

  1. FK506 binding Source: RefGenome
  2. identical protein binding Source: IntAct
  3. metal ion binding Source: UniProtKB-KW
  4. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome
  5. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. chaperone-mediated protein folding Source: RefGenome
  3. intracellular signal transduction Source: ProtInc
  4. protein peptidyl-prolyl isomerization Source: RefGenome
  5. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Biological processi

Apoptosis, Host-virus interaction

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP8 (EC:5.2.1.8)
Short name:
PPIase FKBP8
Alternative name(s):
38 kDa FK506-binding protein
Short name:
38 kDa FKBP
Short name:
FKBP-38
Short name:
hFKBP38
FK506-binding protein 8
Short name:
FKBP-8
FKBPR38
Rotamase
Gene namesi
Name:FKBP8
Synonyms:FKBP38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:3724. FKBP8.

Subcellular locationi

Isoform 1 : Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side 3 Publications
Isoform 3 : Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side 3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei390 – 41021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: RefGenome
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi149 – 1491D → N: Abolishes calcium-binding and reduces affinity for BCL2; when associated with Asn-151. 1 Publication
Mutagenesisi151 – 1511D → N: Abolishes calcium-binding and reduces affinity for BCL2; when associated with Asn-149. 1 Publication

Organism-specific databases

PharmGKBiPA28165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Peptidyl-prolyl cis-trans isomerase FKBP8
PRO_0000075331Add
BLAST

Proteomic databases

MaxQBiQ14318.
PaxDbiQ14318.
PRIDEiQ14318.

PTM databases

PhosphoSiteiQ14318.

Expressioni

Tissue specificityi

Widely expressed. Highest levels seen in the brain. Highly abundant in the retina.1 Publication

Gene expression databases

ArrayExpressiQ14318.
BgeeiQ14318.
CleanExiHS_FKBP8.
GenevestigatoriQ14318.

Organism-specific databases

HPAiCAB025346.
HPA045177.

Interactioni

Subunit structurei

Homomultimers or heteromultimers Reviewed prediction. Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCL2L1/BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-724839,EBI-724839
Q9WMX28EBI-724839,EBI-6863748From a different organism.
EGFRP005333EBI-724839,EBI-297353
EGLN1Q9GZT96EBI-724839,EBI-1174818
HSP90AA1P079007EBI-724839,EBI-296047
NS5AO3947416EBI-724839,EBI-7016711From a different organism.
ZFYVE27Q5T4F44EBI-724839,EBI-3892947

Protein-protein interaction databases

BioGridi117270. 67 interactions.
IntActiQ14318. 23 interactions.
MINTiMINT-1338555.
STRINGi9606.ENSP00000222308.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi94 – 10815
Beta strandi111 – 1133
Beta strandi121 – 13111
Beta strandi136 – 14611
Turni147 – 1504
Helixi154 – 1574
Helixi160 – 1623
Beta strandi168 – 1736
Helixi175 – 1773
Helixi180 – 1823
Turni185 – 1873
Beta strandi190 – 1923
Beta strandi194 – 20411
Beta strandi208 – 2114

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AWGX-ray1.60A90-205[»]
2D9FNMR-A91-211[»]
2F2DNMR-A92-210[»]
2MF9NMR-A58-205[»]
3EY6X-ray1.05A92-210[»]
ProteinModelPortaliQ14318.
SMRiQ14318. Positions 58-368.

Miscellaneous databases

EvolutionaryTraceiQ14318.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini120 – 20485PPIase FKBP-type
Add
BLAST
Repeati221 – 25434TPR 1
Add
BLAST
Repeati272 – 30534TPR 2
Add
BLAST
Repeati306 – 33934TPR 3
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 9271Glu-rich
Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256105.
HOVERGENiHBG051626.
InParanoidiQ14318.
KOiK09574.
OrthoDBiEOG70S75T.
PhylomeDBiQ14318.
TreeFamiTF105295.

Family and domain databases

Gene3Di1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
PF00515. TPR_1. 2 hits.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14318-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASCAEPSEP SAPLPAGVPP LEDFEVLDGV EDAEGEEEEE EEEEEEDDLS    50
ELPPLEDMGQ PPAEEAEQPG ALAREFLAAM EPEPAPAPAP EEWLDILGNG 100
LLRKKTLVPG PPGSSRPVKG QVVTVHLQTS LENGTRVQEE PELVFTLGDC 150
DVIQALDLSV PLMDVGETAM VTADSKYCYG PQGRSPYIPP HAALCLEVTL 200
KTAVDGPDLE MLTGQERVAL ANRKRECGNA HYQRADFVLA ANSYDLAIKA 250
ITSSAKVDMT FEEEAQLLQL KVKCLNNLAA SQLKLDHYRA ALRSCSLVLE 300
HQPDNIKALF RKGKVLAQQG EYSEAIPILR AALKLEPSNK TIHAELSKLV 350
KKHAAQRSTE TALYRKMLGN PSRLPAKCPG KGAWSIPWKW LFGATAVALG 400
GVALSVVIAA RN 412
Length:412
Mass (Da):44,562
Last modified:July 1, 2008 - v2
Checksum:i887C25ADE71EBA8D
GO
Isoform 2 (identifier: Q14318-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-183: G → GS

Show »
Length:413
Mass (Da):44,649
Checksum:i0C32331CCBE5E4D9
GO
Isoform 3 (identifier: Q14318-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-256: Missing.

Note: Interacts with BCL2L1/BCLX.

Show »
Length:253
Mass (Da):27,545
Checksum:iF899112DC6BF5118
GO

Sequence cautioni

The sequence AAB00102.1 differs from that shown. Reason: The first part of the cDNA maps to the same locus, but in opposite orientation.
The sequence AAH09966.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAD98028.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871A → V.
Corresponds to variant rs11574806 [ dbSNP | Ensembl ].
VAR_044225

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei98 – 256159Missing in isoform 3.
VSP_047717Add
BLAST
Alternative sequencei183 – 1831G → GS in isoform 2.
VSP_034486

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1441V → A in CAD98028. 1 Publication
Sequence conflicti191 – 1911H → R in CAD98028. 1 Publication
Sequence conflicti206 – 2061G → R in BAD96558. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY225339 mRNA. Translation: AAO39020.1.
AY278607 mRNA. Translation: AAQ84561.1.
GQ372970 mRNA. Translation: ACU65096.1.
BX538124 mRNA. Translation: CAD98028.1. Different initiation.
BX647405 mRNA. No translation available.
AC005387 Genomic DNA. Translation: AAC28753.1.
CH471106 Genomic DNA. Translation: EAW84709.1.
L37033 mRNA. Translation: AAB00102.1. Sequence problems.
AK222838 mRNA. Translation: BAD96558.1.
BC009966 mRNA. Translation: AAH09966.1. Different initiation.
CCDSiCCDS32961.1. [Q14318-2]
RefSeqiNP_036313.3. NM_012181.3. [Q14318-2]
UniGeneiHs.173464.

Genome annotation databases

EnsembliENST00000222308; ENSP00000222308; ENSG00000105701. [Q14318-1]
ENST00000596558; ENSP00000472302; ENSG00000105701. [Q14318-1]
ENST00000597960; ENSP00000471700; ENSG00000105701. [Q14318-2]
ENST00000608443; ENSP00000476767; ENSG00000105701. [Q14318-2]
ENST00000610101; ENSP00000476586; ENSG00000105701. [Q14318-3]
GeneIDi23770.
KEGGihsa:23770.
UCSCiuc002njj.1. human. [Q14318-2]
uc002njk.1. human. [Q14318-1]

Polymorphism databases

DMDMi193806337.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY225339 mRNA. Translation: AAO39020.1 .
AY278607 mRNA. Translation: AAQ84561.1 .
GQ372970 mRNA. Translation: ACU65096.1 .
BX538124 mRNA. Translation: CAD98028.1 . Different initiation.
BX647405 mRNA. No translation available.
AC005387 Genomic DNA. Translation: AAC28753.1 .
CH471106 Genomic DNA. Translation: EAW84709.1 .
L37033 mRNA. Translation: AAB00102.1 . Sequence problems.
AK222838 mRNA. Translation: BAD96558.1 .
BC009966 mRNA. Translation: AAH09966.1 . Different initiation.
CCDSi CCDS32961.1. [Q14318-2 ]
RefSeqi NP_036313.3. NM_012181.3. [Q14318-2 ]
UniGenei Hs.173464.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2AWG X-ray 1.60 A 90-205 [» ]
2D9F NMR - A 91-211 [» ]
2F2D NMR - A 92-210 [» ]
2MF9 NMR - A 58-205 [» ]
3EY6 X-ray 1.05 A 92-210 [» ]
ProteinModelPortali Q14318.
SMRi Q14318. Positions 58-368.
ModBasei Search...

Protein-protein interaction databases

BioGridi 117270. 67 interactions.
IntActi Q14318. 23 interactions.
MINTi MINT-1338555.
STRINGi 9606.ENSP00000222308.

PTM databases

PhosphoSitei Q14318.

Polymorphism databases

DMDMi 193806337.

Proteomic databases

MaxQBi Q14318.
PaxDbi Q14318.
PRIDEi Q14318.

Protocols and materials databases

DNASUi 23770.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222308 ; ENSP00000222308 ; ENSG00000105701 . [Q14318-1 ]
ENST00000596558 ; ENSP00000472302 ; ENSG00000105701 . [Q14318-1 ]
ENST00000597960 ; ENSP00000471700 ; ENSG00000105701 . [Q14318-2 ]
ENST00000608443 ; ENSP00000476767 ; ENSG00000105701 . [Q14318-2 ]
ENST00000610101 ; ENSP00000476586 ; ENSG00000105701 . [Q14318-3 ]
GeneIDi 23770.
KEGGi hsa:23770.
UCSCi uc002njj.1. human. [Q14318-2 ]
uc002njk.1. human. [Q14318-1 ]

Organism-specific databases

CTDi 23770.
GeneCardsi GC19M018642.
HGNCi HGNC:3724. FKBP8.
HPAi CAB025346.
HPA045177.
MIMi 604840. gene.
neXtProti NX_Q14318.
PharmGKBi PA28165.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256105.
HOVERGENi HBG051626.
InParanoidi Q14318.
KOi K09574.
OrthoDBi EOG70S75T.
PhylomeDBi Q14318.
TreeFami TF105295.

Miscellaneous databases

ChiTaRSi FKBP8. human.
EvolutionaryTracei Q14318.
GeneWikii FKBP8.
GenomeRNAii 23770.
NextBioi 35483698.
PROi Q14318.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q14318.
Bgeei Q14318.
CleanExi HS_FKBP8.
Genevestigatori Q14318.

Family and domain databases

Gene3Di 1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProi IPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
PF00515. TPR_1. 2 hits.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis."
    Shirane M., Nakayama K.I.
    Nat. Cell Biol. 5:28-37(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH BCL2 AND BCL2L1/BCLXL, SUBCELLULAR LOCATION.
  2. "FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues."
    Bulgakov O.V., Eggenschwiler J.T., Hong D.-H., Anderson K.V., Li T.
    Development 131:2149-2159(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Characterization of a Bcl-XL-interacting protein FKBP8 and its splice variant in human RPE cells."
    Chen Y., Sternberg P., Cai J.
    Invest. Ophthalmol. Vis. Sci. 49:1721-1727(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), SUBCELLULAR LOCATION, INTERACTION WITH BCL2L1, TISSUE SPECIFICITY.
    Tissue: Retinal pigment epithelium.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon endothelium.
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs."
    Lam E., Martin M., Wiederrecht G.
    Gene 160:297-302(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-412 (ISOFORM 1).
  8. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-412 (ISOFORM 2).
    Tissue: Liver.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-412 (ISOFORM 1).
    Tissue: Pancreas.
  10. "Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2."
    Kang C.B., Feng L., Chia J., Yoon H.S.
    Biochem. Biophys. Res. Commun. 337:30-38(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. Cited for: CATALYTIC ACTIVITY, COFACTOR.
  12. "A reassessment of the inhibitory capacity of human FKBP38 on calcineurin."
    Weiwad M., Edlich F., Erdmann F., Jarczowski F., Kilka S., Dorn M., Pechstein A., Fischer G.
    FEBS Lett. 579:1591-1596(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ABSENCE OF DIRECT INTERACTION WITH CALCINEURIN.
  13. "The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)."
    Kang C.B., Tai J., Chia J., Yoon H.S.
    FEBS Lett. 579:1469-1476(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCL2.
  14. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression."
    Portier B.P., Taglialatela G.
    J. Biol. Chem. 281:40493-40502(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCL2.
  16. "Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells."
    Wang J., Tong W., Zhang X., Chen L., Yi Z., Pan T., Hu Y., Xiang L., Yuan Z.
    FEBS Lett. 580:4392-4400(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HCV NS5A.
  17. "Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse."
    Shirane M., Ogawa M., Motoyama J., Nakayama K.I.
    Genes Cells 13:635-651(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZFYVE27.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Solution structure of the FK506-binding domain of human FKBP38."
    Maestre-Martinez M., Edlich F., Jarczowski F., Weiwad M., Fischer G., Luecke C.
    J. Biomol. NMR 34:197-202(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 92-210.
  20. "Solution structure of RSGI RUH-047, an FKBP domain from human cDNA."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 91-205.
  21. "Structure of the human FK-506 binding protein 8."
    Structural genomics consortium (SGC)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 90-205.
  22. "A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding."
    Maestre-Martinez M., Haupt K., Edlich F., Neumann P., Parthier C., Stubbs M.T., Fischer G., Lucke C.
    J. Mol. Recognit. 24:23-34(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS) OF 92-210, METAL-BINDING SITES, MUTAGENESIS OF ASP-149 AND ASP-151.

Entry informationi

Entry nameiFKBP8_HUMAN
AccessioniPrimary (citable) accession number: Q14318
Secondary accession number(s): C8C9T5
, Q53GU3, Q7Z349, Q86YK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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